European Map Of Axial Spondyloarthritis Research Articles

Patient-Reported Impact of Axial Spondyloarthritis on Working Life: Results From the European Map of Axial Spondyloarthritis Survey.

ObjectiveTo evaluate work‐related issues (WRIs) and their determinants in patients with axial spondyloarthritis (SpA) across Europe.MethodsThe European Map of Axial Spondyloarthritis is a cross‐sectional online survey (2017–2018) of unselected patients with self‐reported axial SpA from 13 European countries. Participants were classified as active or inactive members of the labor force according to the International Labor Organization standards. Those employed reported WRIs due to axial SpA in the past 12 months. Sociodemographic characteristics and patient‐reported outcomes were compared between patients with and without WRIs. Stepwise regression analysis was conducted to identify independent determinants of WRIs.ResultsThe sample comprised 2,846 patients with axial SpA, 1,653 were active members of the labor force, 1,450 were employed, and of those employed, 67.7% reported at least 1 WRI. The most frequently reported WRIs were taking sick leave (56.3%), difficulty fulfilling working hours (44.6%), and missing work for doctor’s appointments (34.6%). Of the total sample, 74.1% declared that they had faced or would face difficulties finding a job due to axial SpA. Patients with WRIs were more often female, were less likely to be married or in a relationship, and had a higher educational level, poorer patient‐reported outcomes, and a greater prevalence of anxiety and depression. Multivariable regression showed that WRIs were associated with a higher Bath Ankylosing Spondylitis Disease Activity Index score (odds ratio [OR] 1.30 [95% confidence interval (95% CI) 1.16–1.45]) and the 12‐item General Health Questionnaire score (OR 1.15 [95% CI 1.09–1.22]), and were negatively associated with inflammatory bowel disease (OR 0.58 [95% CI 0.36–0.91]).ConclusionApproximately two‐thirds of employed patients experienced WRIs due to axial SpA. Association between disease activity and psychological distress with WRIs suggests the need to ensure that axial SpA patients receive the required support to cope with their working life.

Identifying parameters associated with delayed diagnosis in axial spondyloarthritis: data from the European map of axial spondyloarthritis.

ObjectiveTo identify the parameters associated with self-reported diagnostic delay (DD) in axial spondyloarthritis (axSpA) patients across Europe.MethodsData from 2652 patients from 13 countries who participated in the European Map of Axial Spondyloarthritis (EMAS) were collected through an online survey (2017–2018). DD was calculated as the difference between age at diagnosis and age at symptom onset reported by participants. Associations between DD and sociodemographic characteristics, as well as disease-related factors were explored through univariable and multivariable linear regression analysis.ResultsAverage DD was 7.4 (8.4) years with a variation between countries. The variables associated with longer DD in the final multivariable regression model were: younger age at symptom onset (b = −0.26; 95% CI: −0.28, −0.23), female gender (b = 1.34; 95% CI: 0.73, 1.96) and higher number of health-care professionals (HCPs) seen before diagnosis (b = 1.19; 95% CI: 0.95, 1.43). There was a significant interaction between the female gender and the number of HCPs seen before diagnosis. A substantial variation of the DD across European countries was observed.ConclusionIn this sample of axSpA patients, average DD was greater than 7 years. Younger age at symptom onset, female gender, higher number of HCPs seen before diagnosis, and being diagnosed by rheumatologist were the parameters associated with a longer DD in axSpA. These findings indicate a need for continuing efforts dedicated to recognition of patients with a high probability of axSpA on the level of non-rheumatology specialists and facilitating referral to a rheumatologist for timely diagnosis.

Gender differences in patient journey to diagnosis and disease outcomes: results from the European Map of Axial Spondyloarthritis (EMAS)

Introduction/objectivesTo evaluate the journey to diagnosis, disease characteristics and burden of disease in male and female patients with axial spondyloarthritis (axSpA) across Europe.MethodData from 2846 unselected patients participating in the European Map of Axial Spondyloarthritis (EMAS) study through an online survey (2017–2018) across 13 countries were analysed. Sociodemographic characteristics, lifestyle, diagnosis, disease characteristics and patient-reported outcomes (PROs) [disease activity –BASDAI (0–10), spinal stiffness (3–12), functional limitations (0–54) and psychological distress (GHQ-12)] were compared between males and females using chi-square (for categorical variables) and student t (for continuous variables) tests.ResultsIn total, 1100 (38.7%) males and 1746 (61.3%) females participated in the EMAS. Compared with males, females reported considerable longer diagnostic delay (6.1 ± 7.4 vs 8.2 ± 8.9 years; p < 0.001), higher number of visits to physiotherapists (34.5% vs 49.5%; p < 0.001) and to osteopaths (13.3% vs 24.4%; p < 0.001) before being diagnosed and lower frequency of HLA-B27 carriership (80.2% vs 66.7%; p < 0.001). In addition, females reported higher degree of disease activity in all BASDAI aspects and greater psychological distress through GHQ-12 (4.4 ± 4.2 vs 5.3 ± 4.1; p < 0.001), as well as a greater use of alternative therapies.ConclusionThe patient journey to diagnosis of axSpA is much longer and arduous in females, which may be related to physician bias and lower frequency of HLA-B27 carriership. Regarding PROs, females experience higher disease activity and poorer psychological health compared with males. These results reflect specific unmet needs in females with axSpA needing particular attention.Key Points• Healthcare professionals’ perception of axSpA as a predominantly male disease may introduce some bias during the diagnosis and management of the disease. However, evidence about male-female differences in axSpA is scarce.• EMAS results highlight how female axSpA patients report longer diagnostic delay and higher burden of the disease in a large sample of 2846 participants of 13 European countries.• Results reflect unmet needs of European female patients. Healthcare professionals should pay close attention in order to accurately diagnose and efficiently manage axSpA cases while further research should be developed on the cause of reported gender differences.

RHEUMATOID SPONDYLITIS: A STUDY OF 1,035 CASES

Article1 February 1947RHEUMATOID SPONDYLITIS: A STUDY OF 1,035 CASESHOWARD F. POLLEY, M. D., CHARLES H. SLOCUMB, M.D.HOWARD F. POLLEY, M. D.Search for more papers by this author, CHARLES H. SLOCUMB, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-26-2-240 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptStudy of more than 1,000 cases of rheumatoid spondylitis encountered at the Mayo Clinic has yielded data which may help to clarify certain aspects of this disease and may help the physician to answer a few of the questions frequently asked concerning the condition. The erythrocyte sedimentation rate and the roentgenographic findings in cases of rheumatoid spondylitis also will be discussed briefly.SEX, AGE AT ONSET, SYMPTOMS AND COURSEWhat is the incidence of this disease in men as compared to women?In our series there was a total of 931 men and 104 women. The ratio of men to... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Rochester, Minnesota*Read at the meeting of the American Rheumatism Association, New York City, May 24-25, 1946.Abridgment of portion of thesis submitted by Dr. Polley to the Faculty of the Graduate School of the University of Minnesota in partial fulfillment of the requirements for the degree of M. S. in Medicine. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPatients with Axial Spondyloarthritis are Great Consumers of Healthcare Resources, Especially Young and Women: Results from the Spanish AtlasDemographic Profile of Survey RespondentsAn Overview to Ankylosing Spondylitis and SpondyloarthropathiesGender differences in patient journey to diagnosis and disease outcomes: results from the European Map of Axial Spondyloarthritis (EMAS)Gender difference in ASAS HI among patients with ankylosing spondylitisEpidemiology of Axial SpondyloarthritisIs there any gender-specific difference in the cut-off values of ankylosing spondylitis disease activity score in patients with axial spondyloarthritis?Gender-attributable differences in outcome of ankylosing spondylitis: long-term results from the Outcome in Ankylosing Spondylitis International StudyGenetics of ankylosing spondylitisFemale patients with ankylosing spondylitis: analysis of the impact of gender across treatment studiesClinical characteristics of anterior chest wall pain in spondyloarthritis: An analysis of 275 patientsGender Differences in Clinical Features and Anti-TNF Agent Use in Korean Ankylosing Spondylitis PatientsPharmacoeconomics of adalimumab for rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis and Crohn’s diseaseWomen with ankylosing spondylitis: A reviewAndrogens and Ankylosing Spondylitis: A Role in the Pathogenesis?The seronegative spondyloarthropathiesJUVENILE ANKYLOSING SPONDYLITISAnkylosing spondylitisChronic functional involvement of pancreas in systhemic lupus erythematosus (SLE)Ankylosing Spondylitis: Early Diagnosis Based on the Natural HistoryAnkylosing Spondylitis: Clinical Aspects, Comparisons, Men versus Women, Hospitalized versus Epidemiological PatientsRheumatology in GeriatricsSustained-release indomethacin in the management of ankylosing spondylitisSpinal ankylosing spondylitis: a variant form of ankylosing spondylitis or a distinct disease entity?Clinical study of Thai patients with ankylosing spondylitisRoentgenological features of ankylosing spondylitis. A comparison between patients attending hospital and cases selected through an epidemiological surveyThe natural disease course of ankylosing spondylitisSpondylitis ankylosansUse of the B27 test in the diagnosis of ankylosing spondylitis: a statistical evaluationAnkylosing SpondylitisSacro-Iliitis And Salpingitis: Quantitative 99m Tc Pertechnetate Scanning in the Study of Sacro-iliitis in WomenHip involvement in ankylosing spondylitisIncomplete Reiter's Syndrome: Discriminating Features and HL-A W27 in DiagnosisFRANK C. ARNETT, M.D., O. EDWIN McCLUSKY, BERNICE Z. SCHACTER, Ph.D., ROBERT E. LORDONSpondylitis Ankylopoetica. Die sogenannte Bechterewsche Krankheit und ihre Differentialdiagnose (einschließlich Spondylosis hyperostotica, Spondylitis psoriatica und chronisches Reiter-Syndrom)Erbfaktoren bei häufigen KrankheitenAnkylosing spondylitisJuvenile ankylosing spondylitisAnkylosing SpondylitisVariants of Rheumatoid ArthritisEin Beitrag zur Differentialdiagnose des Morbus Str�mpel-Marie-BechterewAnkylosing Spondylitis with Subcutaneous NodulesSacro-Iliitis in Still's DiseaseJuvenile Ankylosing Spondylitis�ber die funktionelle Therapie der Spondylitis ancylopoetica in Verbindung mit Thorium X-GabenRHEUMATOID SPONDYLITIS: MANIFESTATIONS AND MANAGEMENT*AARON M. LEFKOVITS, M.D., F.A.C.P., J. R. THOMAS, M.D.Uveitis and Rheumatic DiseasesRHEUMATISM AND ARTHRITIS REVIEW OF AMERICAN AND ENGLISH LITERATURE OF RECENT YEARS (TENTH RHEUMATISM REVIEW)* Part IIWILLIAM D. ROBINSON, M.D., F.A.C.P., EDWARD W. BOLAND, M.D., F.A.C.P., JOSEPH J. BUNIM, M.D., F.A.C.P., DARRELL C. CRAIN, M.D., F.A.C.P., EPHRAIM P. ENGLEMAN, M.D., F.A.C.P., WALLACE GRAHAM, M.D., F.R.C.P. (C), L. MAXWELL LOCKIE, M.D., F.A.C.P., MAX M. MONTGOMERY, M.D., F.A.C.P., CHARLES RAGAN, M.D., F.A.C.P., MARIAN W. ROPES, M.D., F.A.C.P., EDWARD F. ROSENBERG, M.D., F.A.C.P., CHARLEY J. SMYTH, M.D.THE INHERITANCE OF SPONDYLITIS RHIZOMELIQUE (ANKYLOSING SPONDYLITIS) IN THE K. FAMILY*HERMAN H. RIECKER, M.D., F.A.C.P., JAMES V. NEEL, Ph.D., M.D., AVERY TEST, Ph.D.Familial Incidence of Rheumatoid SpondylitisAnkylosing Spondylitis and Pregnancy 1 February 1947Volume 26, Issue 2Page: 240-249KeywordsAnkylosing spondylitisErythrocyte sedimentation rateGraduate medical education ePublished: 1 December 2008 Issue Published: 1 February 1947 PDF downloadLoading ...