European COST Research Articles

Assessment of risk intensity in the triffa plain aquifer: Integration of hazard quantification, land use analysis, dynamic vulnerability GCITF, and DRASTIC method

This study aims to assess the level of groundwater pollution risk in the Triffa Plain, stemming from various pollution sources, with a specific focus on agricultural intensification and excessive pesticide use. Data were collected from ABHM (the Moulouya Hydraulic Basin Agency) and ORMVAM (Regional Office of Moulouya Agricultural Development), and a field visit was conducted in July 2023. The study utilized two main methodologies for mapping risk intensity: the COST 620 action and overlaying vulnerability maps with the land use (LU) factor. Vulnerability maps were generated using the original DRASTIC method and the new dynamic vulnerability assessment method, GCITF.The research approach involved comparing the COST 620 risk index (Ri) and the land use risk index (LU) to identify the most suitable method for the study area. Due to challenges in inventorying various point sources of pollution, the study focused on mapping the primary sources of pollution (diffuse, point, and linear). The key findings indicate that the predominant pollution intensity in the region is high, covering 60.66% of the total surface area. These results closely align with those obtained using the European COST 620 approach and the spatial distribution of nitrates. The study demonstrates the reliability of integrating the GCITF method in assessing groundwater contamination risk, highlighting the significant negative impacts of agricultural activities on the Triffa Plain aquifer, primarily due to uncontrolled pesticide and fertilizer use and point sources of pollution.This study suggests that implementing targeted technical solutions for specific pollution sources is crucial for reducing contamination in the Triffa Plain. These pollution risk intensity maps can assist planners and decision-makers in understanding the origin of pollution and identifying necessary actions to minimize contamination risk, contributing to better groundwater management and protection in the region.

Stronger vasoconstriction and weaker vasodilation in mesenteric arteries of Ossabaw than Göttingen minipigs before manifestation of metabolic syndrome

The metabolic syndrome predisposes and contributes to the development and progression of atherosclerosis. The minipig strain “Ossabaw” is characterized by a polygenic predisposition to develop metabolic syndrome and diffuse atherosclerosis in response to a hypercaloric atherogenic diet. The aim of this study was to investigate whether Ossabaw minipigs exhibit an altered vasomotor function even before they develop their diseased phenotype. Mesenteric arteries of adult Ossabaw (n=30) and Göttingen minipigs (n=40), a pig strain without genetic predisposition to a metabolic syndrome, were harvested postmortem, dissected, and mounted on a myograph for isometric force measurements. Maximal vasoconstriction to smooth muscle cell depolarization with potassium chloride (KClmax) was repeatedly induced (twice 0.6×10−1 mol/L and twice 1.2×10−1 mol/L). Cumulative concentration-response curves were determined in response to 1×10−9 -1×10−4 mol/L norepinephrine. Endothelium-dependent and -independent vasodilation were analyzed in response to carbachol and nitroprusside, respectively (1×10−9 - 1×10−4 mol/L, each) after pre-constriction by norepinephrine. The baseline diameter of mesenteric arteries from Ossabaw minipigs was smaller than that from Göttingen minipigs (329±20 vs. 435±11 μm), and mesenteric arteries of Ossabaw minipigs developed a higher baseline force of contraction than mesenteric arteries of Göttingen minipigs (6.2±0.7 vs. 3.6±0.3 mN). The maximal vasoconstrictor response to KCl was comparable between the minipig strains. Vasoconstriction in response to norepinephrine was more pronounced in Ossabaw than in Göttingen minipigs (143±9 vs. 108±6% KClmax). Endothelium-dependent vasodilation (46.4±5.5 vs. 16.0±3.0% of norepinephrine-induced preconstriction) and -independent vasodilation (36.7±4.9 vs. 2.3±0.6% of norepinephrine-induced preconstriction) were less pronounced in Ossabaw than in Göttingen minipigs. Neither the differences in baseline diameter nor in baseline developed force of contraction had any effect on the above data, as analyzed in retrospectively matched subsets of mesenteric arteries with a comparable baseline diameter or a comparable baseline developed force of contraction, respectively. Even before the development of metabolic syndrome, vasomotor function is shifted to more vasoconstriction and less vasodilation in Ossabaw minipigs, suggesting a genetic predisposition for the early development of vascular dysfunction. Thus, Ossabaw minipigs may be a suitable model to reflect the human situation of a heterogeneous, genetically determined primordial risk constellation for vascular dysfunction. This work was supported by the German Research Foundation [SFB 1116 B08 to G.H. and P.K.] and the European COST ACTION in CARDIOPROTECTION [CA16225 to G.H. and IG16225 to G.H. and P.K.]. This is the full abstract presented at the American Physiology Summit 2024 meeting and is only available in HTML format. There are no additional versions or additional content available for this abstract. Physiology was not involved in the peer review process.

ATM strategies for, and impacts of, space launches

There is a rapid growth of national space launch ambitions and capabilities, e.g. delivering satellites into low-earth and sun-synchronous orbits. With vertical and horizontal delivery methods, and numerous locations under consideration in several continents, the industry has faced early challenges, such as failed launches and licencing timescales. This paper explores the increasing intersection between aviation and air traffic management (ATM) with higher airspace operations (HAOs). It introduces the background and principles of space launches, before addressing the particular impacts on aviation and ATM. The strategic challenges of planning launch windows to align both with orbiting asset congestion and ATM demands, plus promulgating such information to airspace users, is discussed. In the tactical phase, the consequences of impacts on airspace users (such as the re-routing of flights) and on air navigation service providers (such as the demands of coordinating airspace closures in the context of considerable re-entry/splashdown uncertainty) are discussed. A key contribution we make in this paper is the first aircraft-specific, fuel and operating cost analysis of HAO impacts, and the first such European cost assessment, with basic impact geometries. We also propose improved aircraft-specific impact models, which include passenger-centric costs.

Rectal Sensory and Compliance Testing: A Method Comparison Study between High-Resolution Anorectal Manometry and Barostat Investigations.

Abnormal visceral perception and motor function are often observed in patients with fecal incontinence, evacuation disorders and irritable bowel syndrome. The international anorectal physiology working group has proposed a standardization for anorectal function assessment, where rectal sensitivity testing is performed using an elastic balloon attached to a high-resolution anorectal manometry (HRAM) catheter. Rectal compliance, another component of rectal function evaluation, is a pressure-volume relationship that refers to the rectum's ability to stretch and expand as it receives and holds fecal matter. There are no data available regarding the possibility of compliance testing using HRAM, although this is theoretically possible by correcting for the elastic balloon's intrinsic properties. The gold standard for measurement of visceral sensitivity and compliance is the rectal barostat, according to the procedure described by the European COST action GENIEUR group. Data on the agreement between the two different procedures are scarce. Hence, we performed a comparative study of the HRAM and barostat investigations in 26 healthy individuals. We hypothesized that by inflating the balloon before the examination, rectal compliance can be measured with HRAM investigations, and we examined correlations and levels of agreement between the methods. Our results demonstrate that assessing rectal compliance with HRAM is technically possible; however, a strong correlation with the rectal barostat was only observed at the maximum tolerable volume (Spearman's rho = 0.7, p = 0.02). We only found moderate correlations (Spearman's rho = 0.562, p = 0.019) for compliance according to the barostat methodology and for rectal sensibility testing (Spearman's rho = 0.57, p = 0.03 for maximum tolerable volume). Bland-Altman plots showed poor levels of agreement between the methods. We conclude that HRAM and the rectal barostat cannot be used interchangeably for compliance or sensitivity assessments. We suggest the development of a non-elastic balloon with a fixed size and shape to assess rectal sensory function and compliance in HRAM testing.

A new framework for indoor air chemistry measurements: Towards a better understanding of indoor air pollution

This paper reports on the findings from INDAIRPOLLNET (INDoor AIR POLLution NETwork), a recently completed European COST Action network. INDAIRPOLLNET ran from September 2018 to March 2023 with more than 200 indoor and outdoor air quality scientists from universities, large and small companies, and research institutes around Europe and beyond. The expertise of our interdisciplinary network members covered chemistry, biology, standardisation, household energy, particulate matter characterisation, toxicology, exposure assessment, air cleaning, building materials, building physics and engineering (including ventilation and energy), and building design. The aim of INDAIRPOLLNET was to design a framework for future indoor air chemistry field campaigns, building on our improved understanding of indoor air chemistry. The main focus of our network was to better understand the sources, transformations and fate of chemical pollutants found in the air in buildings. In this paper, we present the main findings from our network, which include a call for greater spatial and temporal coverage of measurements indoors, the need for standardised techniques for indoor measurements and the impact of occupants on indoor air quality. We also present a checklist of building parameters that should be measured in any future indoor air campaign. Finally, we present our new framework, focusing on 5 key research areas: reactivity in indoor environments; mapping organic constituents indoors; the role of the occupant in indoor air chemistry; indoor modelling studies and novel materials and technologies indoors. We hope this framework will be of use to the indoor air quality community, enabling healthier buildings for the future.

The value of advanced flood models, damage costs and land use data in cost-effective climate change adaptation

Damage costs from coastal flooding are high and are expected to increase further due to rising sea levels. The associated risks suggest a need for developing methodologies and models to assess damage costs in coastal areas as a basis for decision-making on climate change adaptation. The accuracy of damage cost estimates is critical in cost-effective decision-making on adaptation measures, reflecting climate hazards, flood levels, and associated damage costs. However, detailed models require extended work compared to simpler models due to demands on input data, including land use, damage costs, and adaptation options and costs. In the paper, varying levels of resolution, damage costs and flood models are assessed for coastal flooding risks for two Danish urban areas. Two damage cost models are used: a detailed, context-specific model using local high-resolution land use- and flood damage cost data and a less detailed model with lower-resolution land use data and damage costs based on generic European cost curves. Two flood models are used for the assessment using the detailed damage cost model based on a dynamic and a static flood approach, respectively. For the coarser model, only a static flood model is used. Significant differences are identified between the modelling approaches: The flood area varies up to a factor of ten for static floods due to the digital elevation map (DEM) model alone and a factor of 17 when changing both the DEM and using a dynamic flood. Corresponding factors for resulting damage costs are four and five, respectively.

The Spicy Science of Dendrimers in the Realm of Cancer Nanomedicine: A Report from the COST Action CA17140 Nano2Clinic.

COST Action CA17140 Cancer Nanomedicine-from the bench to the bedside (Nano2Clinic,) is the first, pan-European interdisciplinary network of representatives from academic institutions and small and medium enterprises including clinical research organizations (CROs) devoted to the development of nanosystems carrying anticancer drugs from their initial design, preclinical testing of efficacy, pharmacokinetics and toxicity to the preparation of detailed protocols needed for the first phase of their clinical studies. By promoting scientific exchanges, technological implementation, and innovative solutions, the action aims at providing a timely instrument to rationalize and focus research efforts at the European level in dealing with the grand challenge of nanomedicine translation in cancer, one of the major and societal-burdening human pathologies. Within CA17140, dendrimers in all their forms (from covalent to self-assembling dendrons) play a vital role as powerful nanotheranostic agents in oncology; therefore, the purpose of this review work is to gather and summarize the major results in the field stemming from collaborative efforts in the framework of the European Nano2Clinic COST Action.

Lack of guidelines and translational knowledge is hindering the implementation of psychiatric genetic counseling and testing within Europe – A multi-professional survey study

Genetic research has identified a large number of genetic variants, both rare and common, underlying neurodevelopmental disorders (NDD) and major psychiatric disorders. Currently, these findings are being translated into clinical practice. However, there is a lack of knowledge and guidelines for psychiatric genetic testing (PsychGT) and genetic counseling (PsychGC). The European Union-funded COST action EnGagE (CA17130) network was started to investigate the current implementation status of PsychGT and PsychGC across 35 participating European countries. Here, we present the results of a pan-European online survey in which we gathered the opinions, knowledge, and practices of a self-selected sample of professionals involved/interested in the field.We received answers from 181 respondents. The three main occupational categories were genetic counselor (21.0%), clinical geneticist (24.9%), and researcher (25.4%). Of all 181 respondents, 106 provide GC for any psychiatric disorder or NDD, corresponding to 58.6% of the whole group ranging from 43.2% in Central Eastern Europe to 66.1% in Western Europe. Overall, 65.2% of the respondents reported that genetic testing is offered to individuals with NDD, and 26.5% indicated the same for individuals with major psychiatric disorders. Only 22.1% of the respondents indicated that they have guidelines for PsychGT. Pharmacogenetic testing actionable for psychiatric disorders was offered by 15%. Interestingly, when genetic tests are fully covered by national health insurance, more genetic testing is provided for individuals with NDD but not those with major psychiatric disorders.Our qualitative analyses of responses highlight the lack of guidelines and knowledge on utilizing and using genetic tests and education and training as the major obstacles to implementation. Indeed, the existence of psychiatric genetic training courses was confirmed by only 11.6% of respondents. The question on the relevance of up-to-date education and training in psychiatric genetics on everyday related practice was highly relevant.We provide evidence that PsychGC and PsychGT are already in use across European countries, but there is a lack of guidelines and education. Harmonization of practice and development of guidelines for genetic counseling, testing, and training professionals would improve equality and access to quality care for individuals with psychiatric disorders within Europe.

Perception and management of cancer predisposition in pediatric cancer centers: A European-wide questionnaire-based survey.

The European Union-funded COST Action (LEukaemia GENe Discovery by data sharing, mining, and collaboration) LEGEND was an international and multidisciplinary collaboration between clinicians and researchers that covered a range of aspects of genetic predisposition in childhood leukemia. Within this framework, we explored the perception and handling of genetic predisposition in the daily practice of European treatment centers. Herein, we present the results of our questionnaire-based survey. We found that the overall awareness is quite high, and respondents remarked that identification and treatment of the most common predisposition syndromes were present. Nevertheless, high demand for continuous education and routinely updated resources remains.

Smart Thinking on Co-Creation and Engagement: Searchlight on Underground Built Heritage

This paper aims to explore public participation for activating underground built heritage (UBH). It describes and analyses practices of stakeholders’ engagement in different UBH assets, based on experiences gathered in the scope of the European COST Action ‘Underground4value’. It brings together five inspiring cases from Italy, Portugal, Spain, Switzerland and the United Kingdom, in which digital and mobile technologies were used as tools to improve community experiences in UBH. Thus, the paper discusses ‘smartness’ from the perspective of people and communities around cultural assets, where ‘smartness’ becomes a new connotation and a pathway to advance (local) knowledge and know-how. Therefore, this paper takes on the challenge to define a smart city as an ecosystem for people’s empowerment and participation, and, in particular, to explore social tools for creating new values in heritage placemaking—where sharing knowledge becomes a fundamental principle.

EE313 Intensity of Colorectal Cancer Screening Strategies and the Optimal Policy Choice: A Systematic Review of European Cost Effectiveness Analyses

EE313 Intensity of Colorectal Cancer Screening Strategies and the Optimal Policy Choice: A Systematic Review of European Cost Effectiveness Analyses

Epigenetics for crop adaptation to climate change

Epigenetics for crop adaptation to climate change

Examining the evidence on complementary and alternative therapies to treat peripartum depression in pregnant or postpartum women: study protocol for an umbrella review of systematic reviews and meta-analyses

IntroductionComplementary and alternative therapies (CATs) refer to a diverse range of approaches that can be used as add-on or an alternative to conventional therapies. While a number of individual studies...

Swiss Priority Setting on Implementing Medication Adherence Interventions as Part of the European ENABLE COST Action.

COMMENTARY Int J Public Health, 12 August 2022 https://doi.org/10.3389/ijph.2022.1605204

Assessing US Pharmaceutical Policy and Pricing Reform Legislation in Light of European Price and Cost Control Strategies.

This article compares the pharmaceutical pricing policies employed by public and private insurers in the United States with seven price and spending control strategies employed in the United Kingdom, France, and Germany. Differences between American and European policies explain why American pharmaceutical prices and per capita spending are higher than in European nations. The article then analyzes two recent bills as examples of significant American reform ideas-H.R. 3, the Elijah E. Cummings Lower Drug Costs Now Act (introduced in 2019) and the Build Back Better Act (BBBA, introduced in 2021)-and compares them with European cost control strategies. Key drug price provisions of the BBBA were incorporated into the recently enacted Inflation Reduction Act (IRA). H.R. 3 would have used an international (mostly European) price index to cap U.S. prices; the BBBA would cap Medicare prices at a discount from average U.S. market prices. Neither bill would employ the key cost control strategies that European nations do. Both bills would have significantly less impact on prices than legislation that employs European-style cost controls. This article proposes steps that Congress could take in line with European strategies to lower purchase prices and costs for patients. These measures would have to overcome political obstacles that currently stymie reform.

Impact of energy communities on the European electricity and heating system decarbonization pathway: Comparing local and global flexibility responses

This paper investigates how the European electricity and heating system is impacted when medium-scale energy communities (ECs) are developed widely across Europe. We study the response on the capacity expansion of the cross-border transmission and national generation and storage within the European electricity and heating system with and without ECs in selected European countries. The representation of ECs has a special focus on flexibility, and we analyze the difference between flexibility responses by ECs towards local versus global cost minimization. Results show that EC development decreases total electricity and heating system costs on the transition towards a decarbonized European system in line with the 1.5 °C target, and less generation and storage capacity expansion is needed on a national scale to achieve climate targets. We also identify a conflict of interest between optimizing EC flexibility towards local cost minimization versus European cost minimization.

Editorial

Welcome at Challenging Glass 8!We gradually emerge from two difficult years of the covid-19 pandemic raging through the world in waves of constantly changing intensities. The associated uncertainties really put the ‘challenging’ into Challenging Glass this time. Still, some of our peers are not able to join us in Ghent, and they will be sorely missed. Nevertheless, we are happy to be able to return this year to the ‘real thing’: a live event which allows the international glass community to finally meet again in person. An excellent opportunity, especially within the UN-declared International Year of Glass 2022. We look forward to reconnect with international colleagues and old friends, but we also want to extend a particularly warm welcome to new and young peers who perhaps have not yet had many opportunities to build their professional network. Dedicated as we are to the high standards of the Challenging Glass Conferences, we are once again proud to present a very promising programme. No less than five keynote speakers will share their original insights on glass with us: Stéphany Le Rhun on glass and circularity; Julian Jones on glass and bio-based materials; Markus Feldmann on the oncoming Eurocode on the Design of Glass Structures; and finally Robert Capel and Iris Rombouts on their latest glass projects. In addition, over 70 papers will be presented by experts from around the world, showcasing the latest findings in academia, practice and industry. Moreover, a special session on adhesive bonding in glass construction is organised by the European COST Action CertBond CA18120 - Reliable roadmap for certification of bonded primary structures. All papers have been peer reviewed by our scientific committee and are published Open Access in Volume 8 of the online Challenging Glass Conference Proceedings. A selection of papers has been subjected to a separate double-blind peer-review process and is published in the special Challenging Glass issue of the Glass Structures & Engineering journal (SpringerNature). Many thanks go to our sponsors, Scientific Committee members, authors and attendees to make it happen. Let’s enjoy together! Jan Belis, Freek Bos & Christian LouterConference OrganisersJune 2022

CURRENT PRACTICES OF BP MEASUREMENT IN CHILDREN AND ADOLESCENTS ACROSS EUROPEAN COUNTRIES: A SURVEY BY THE HYPERCHILDNET COST ACTION WG ON DEVICES

Objective: Objective: The main objective was to carry out a survey on current practices of BP measurement used among health care providers involved in the care of children and adolescents. Design and method: Design and methods: A 22 questions survey was released online from September 2, 2021 to September 27, 2021. The survey's link was sent to primary care physicians and pediatricians from the 22 European COST country members and it was also posted on the HyperChildNET website. Results: Results: The survey was assessed by 476 individuals and fully completed by 293. It was answered by general practioneers and pediatricians as well as pediatric nephrologists, pediatric cardiologists and pediatric endocrinologists, half of them working in primary care and the other half in hospital settings. Office BP measurement was used for clinical decision-making by 49% of the survey respondents while 29.7% used ABPM (Ambulatory BP Monitoring) and 16% home BP measurements. Only 11% routinely screen for high BP in normotensive children (Figure). Auscultatory and oscillometric devices were used in 57% and 41% of the settings, respectively. The main reason for selecting a BP device was availability in the institution in 60%, ease to use in 25.5% and validation in the relevant age group in 11.5%. Cuff size was selected according to individual child or adolescent mid arm circumference by 55% of the responders. A usual pitfall was combining cuffs from different devices and manufactures reported by 47.7% of the responders. Moreover, 42% performed only one BP measurement at each office BP visit. There was heterogeneity on the reference values used to evaluate the BP status with 27.4% using country specific BP reference tables and the rest different guidelines’ staging schemes. Eighty-three % used published reference values and 15.4% internet-based application for BP staging in children and adolescents. Conclusions: Conclusions: Variation in practices among health care providers show the emerging need of defining criteria to benchmark the different BP measurement devices, as well as to promote awareness for the evaluation of hypertensive children across Europe.

Land Policy for Flood Risk Management—Toward a New Working Paradigm

AbstractFlood risk management (FRM) aims to integrate necessary technical measures with environmental and societal approaches. Focusing on the process and governance of how to plan, implement, and maintain solutions therefore becomes essential. Among the different stakeholders, landowners are a key group to be considered. This contribution elaborates on the interconnections between land policy, FRM and private land ownership. It is based on the European COST Action network LAND4FLOOD, which brings together academics and stakeholders from various disciplines and more than 35 countries. We argue for a less project oriented and more process oriented approach, a focus on land management and more emphasis on small‐scale measures. This represents a break with some of the recent working paradigms of FRM.

Development of the European Healthcare and Social Cost Database (EU HCSCD) for use in economic evaluation of healthcare programs

IntroductionCosts are one of the critical factors for the transferability of the results in health technology assessment and economic evaluation. The objective is to develop a cost database at the European level to facilitate cross-border cost comparisons in different settings and explains the factors that lead to differences in healthcare costs in different countries, taking into account the differences between health systems and other factors.MethodologyThe core of the database is compounded of three main categories (primary resources, composite goods and services, and complex processes and interventions) organized into 13 subcategories. A number of elements providing as detailed information of unit cost as possible were identified in order to mitigate the problem of comparability. Consortium partners validated both the database structure and selected costing items.ResultsTwenty-seven costing items included in the EU HCSCD resulted in 1450 unit costs when taking into account all item subtypes and countries. Cross-country differences in costs are driven by the type of resources included in the costing items (e.g., overhead costs in case of complex processes and interventions) or by the variety of existing brands and/or models and the type of unit value in most of the primary resources.ConclusionThe EU HCSCD is the only public unit healthcare and social cost database at European level that gather data on unit costs and explains differences in costs across countries. Its maintenance and regular data updating will enable establishing specific systems for generating and recording information that will meet many of its current limitations.