The accurate estimation of deep-sea explosion loads is challenging due to the extreme conditions such as the ultra-hydrostatic pressure. The traditional Geers–Hunter model has acceptable accuracy in calculating underwater explosion load in conventional water depth, but it is not effective in deep-sea explosions. The model established by Zhang is applied to the underwater explosion load calculation in ultra-deep water. The model's accuracy is validated by both the deep-sea and the conventional explosion experimental results published and the Eulerian finite element method numerical results. The results show that, compared to the Geers–Hunter model, the present model can not only accurately calculate the conventional conditions, but also has better accuracy for calculating deep-sea explosion shock wave and bubble load, by providing more accurate shock wave attenuation and smoother connection between shock wave stage and bubble pulsation stage in deep sea.