Abstract Issue The 2022 EU global health strategy recognizes health as a global common good and sets twenty guiding principles, including the need to support a stronger, effective and accountable WHO as the indispensable cornerstone of the multilateral health system. Description Mixed-methods study using documentary, quantitative, and qualitative analyses to answer two questions: 1) Is the current EC DG INTPA-WHO partnership adequate to support the role envisaged for WHO in the new EU global health strategy)? and 2) How should the EC-DG INTPA-WHO partnership be restructured?. Documentary analysis includes review of academic literature, historical/contemporary documentation on EC-WHO collaboration agreements, monitoring reports of DG INTPA funded interventions since 2016, and selected WHO projects since 2010. Key informant in-depth interviews are conducted with 10 EC senior officials. Guided by results-oriented monitoring frameworks, we analyse interview notes/transcripts and key documents using NVIVO software. Projects are classified by geographic areas and mapped against priorities outlined in the strategy. Results WHO's essential role to provide global public health goods is hampered by insufficient authority and core funds to implement its constitutional mandate. As EU member states see the value of holding a common position, the EU can increase its political role in global health. The EC focusses on specific health threats while also adopting a health system strengthening approach including longstanding collaboration between WHO and the Directorate General for International Partnerships. With remarkable overall achievements, a clear pattern of strengths and weaknesses emerges with key cross cutting areas where the EU has extensive expertise to be strengthened (e.g., evaluation, visibility, inequality markers). Lessons Supporting the development of monitoring and evaluation frameworks could be useful to enhance the visibility and added value of the EC DG INTPA /WHO partnership. Key messages • As a new global health order emerges, the EU must contribute to shape it through a more strategic, coordinated, and effective cooperation with WHO. • To enhance the EC DG INTPA/WHO partnership it is important to support the development of visibility strategies, as well as the further development of monitoring and evaluation frameworks.
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