AbstractGlobal agrifood supply chains are under increasing pressure to address sustainability issues due to growing concerns. However, numerous organizations within the agrifood industry are struggling to incorporate sustainable supply chain management practices and address the concerns. Therefore, this research is designed to identify the key critical factors, such as drivers, enablers, and barriers to adopting sustainable practices. This study considers the Ethiopian coffee industry, which is an important sector not only for the Ethiopian economy but also for the global agrifood supply chain. To accomplish the objectives of this study, we applied a systematic literature review and empirical survey. A systematic literature review was conducted to identify critical factors for adopting sustainability in agrifood supply chains. An empirical survey was then undertaken in the Ethiopian coffee industry to rank the key critical factors. Hence, the study has revealed that economic and productivity improvement, cost effectiveness and improvement in the overall performance, and difficulty in mindset and cultural changes as the key critical factors that determine the adoption of sustainability initiatives from the perspectives of the Ethiopian coffee supply chain. The findings can be used as input by government regulatory bodies and policymakers to craft strategies and policies to adopt sustainability initiatives and ensure sustainable development. Furthermore, the research is expected to contribute to the existing literature by bringing in the perspective of suppliers in developing countries.