A main challenge in the design of hull structures of floating wind turbines (FWTs) is to properly estimate the load effects and resistance to perform the safety design check. While great efforts have been devoted to the load effects in terms of global motions, there is a lack of effective methods to calculate internal loads and lateral pressures of hulls in a fully coupled aero-hydro-servo-elastic environment, which should serve as the basis for the assessment of load effects in hulls. Moreover, very limited knowledge and experience exist in the current guidelines and research publications to deal with the detailed design of hull structures of FWTs. This study outlines an effective methodology and procedure to determine load effects for structural design of semi-submersible hulls, and demonstrates their application in a case study of column design based on the ultimate limit state (ULS) criteria. First, a novel multi-body floater model is established in a fully coupled FWT numerical system, which is capable of calculating floater internal loads. Second, the environmental contour approach is employed to initially choose load cases for ULS design, based on important wind speed conditions and criterial wave periods. Next, a screening of the critical load cases is made based on Von Mises stress analysis of columns considering global loads. Then, lateral pressure on columns is calculated, and a detailed design check is made based on combined global loads and lateral pressure as well as relevant safety factors for loads and resistance. Furthermore, the relative influence of global loads and lateral pressure on ULS performance of columns is investigated, which serves as the basis to reset the critical load cases for ULS design check. Subsequently, sensitivity analysis of ULS performance with respect to column design parameters, extreme value estimation, and shell buckling design checks, are performed to determine the plate thickness and ring stiffener distances of central and outer columns. Finally, optimized ring stiffener dimensions are estimated for different design cases based on panel buckling design criteria, and detailed design parameters for the central and outer columns are obtained. The methodology and procedure established and applied in a case study in this work, contribute to improving engineering practice and establishing improved design standards.