BACKGROUND AND AIM: We previously observed associations in the Center for the Assessment of Mothers and Children of Salinas (CHAMACOS) cohort study between pesticide exposure (including organophosphate metabolites in children’s urine and residential proximity to agricultural sulfur use) and respiratory symptoms and lung function at 7-years of age. In the current analysis, we examined respiratory health in relation to residential proximity to agricultural use of manganese (Mn) containing pesticides while accounting for other pesticide exposures previously associated with these outcomes in this cohort. METHODS: Our population includes participants with pesticide exposure estimates available that completed the 7-year assessment. We evaluated agricultural use of Mn pesticides within 1 and 3 km of residences during pregnancy, early life (birth to 6y of age) and the year prior to the assessment (6 to 7y of age) using a Geographic Information System to link residential histories with California’s Pesticide Use Reporting data. We assessed probable asthma from maternal report of symptoms and conducted lung function measurements using spirometry. The number of participants ranged from 276 – 330 for probable asthma and 204 – 265 for lung function measurements. We adjusted regression models for potential confounders and exposures that have been associated with these outcomes in this cohort. RESULTS: We observed an association between residential proximity to Mn pesticide use and probable asthma. A two-fold increase in use within 1 km during the year prior to the assessment was associated with a relative risk for probable asthma of 2.1 (95% confidence interval = 1.4, 3.1) after adjusting for other exposures previously related to this outcome in this cohort. We did not observe any associations with proximity to use and lung function impairment at 7-years of age. CONCLUSIONS: We observed a higher risk of probable asthma with residential proximity to higher Mn pesticide use.