ABSTRACT Exploring the impact of different monitoring angles from unmanned aerial vehicle (UAV) on the monitoring accuracy of soil moisture content (SMC) is crucial for precision irrigation. To this end, experiment was conducted to monitor the SMC of winter wheat at different growth stages under different irrigation treatments in Yangling, Shaanxi, China. At a solar zenith angle of 45°, multispectral remote sensing data from a UAV were collected at thirteen different monitoring zenith angles. Simultaneously, the SMC in the wheat root zone was measured. From the UAV multispectral images, spectral reflectance was extracted for the construction of vegetation indices. Then the correlation between the vegetation indices and the measured SMC was analyzed. With the vegetation indices as input variables, SMC monitoring models were constructed using Extreme Learning Machine (ELM), Random Forest (RF), and Back Propagation Neural Network (BPNN). The study also examined the effect of specific angles (hotspot and dark spot angles) on the estimation accuracy of the SMC at the nadir angle. The results indicated that different monitoring angles significantly impact the SMC estimation accuracy. Band reflectance and vegetation indices exhibited significant peak values and angular effects at the monitoring zenith angle of 45°. The models achieved the optimal inversion accuracy at the hotspot angle (at a monitoring zenith angle of 45° in the solar principal plane), and the accuracy was ranked as follows: BPNN (R2 = 0.71; RMSE = 1.69) > ELM (R2 = 0.52; RMSE = 1.94) > RF (R2 = 0.48; RMSE = 2.10). By eliminating shadows at the nadir angle through the threshold of dark spot, inversion accuracy similar to the hotspot direction is achieved. This study provides a basis for appropriate selection of UAV flight angles for the monitoring of SMC in the root zone of winter wheat.