Essential Elements Research Articles

Advances in the Synthesis and Bioactivity of Polysaccharide Selenium Nanoparticles: A Review.

Selenium, an essential trace element of the human body, is pivotal in human health and disease prevention. Nevertheless, the narrow therapeutic index of selenium, where the toxic and therapeutic doses are close, limits its clinical utility. Significantly, nanoscale selenium synthesized by different methods using polysaccharides as stabilizers has low toxicity properties and exhibits excellent bioactivity. Its biological activities, such as anti-tumor, anti-inflammatory, antioxidant, antibacterial, and immune function enhancement, are improved compared with traditional organic and inorganic selenium compounds, conferring greater potential for application in biomedicine. Therefore, this review evaluates the advancements in various synthesis methodologies for polysaccharide selenium nanoparticles (Se NPs) and their biological activities. It aims to provide a comprehensive theoretical basis and research directions for the future development of highly efficient, minimally toxic, and biocompatible polysaccharide-Se NPs and the application of polysaccharide-Se NPs in biomedicine.

Nano-drug-based Targeted Therapy Alleviates Ferroptosis-induced Liver Toxicity

Abstract: Iron is an essential inorganic element for an organism, with several metabolic activities. The glycoproteins ferritin and transferrin, which assist in carrying iron to various body parts, are used to store iron. In terms of iron uptake, storage, and excretion, equilibrium should be preserved. Ferroptosis is an iron-dependent form of cell death with traits like lipid peroxidation buildup and ROS generation. It is distinct from other forms of cell death visually and biochemically. Many cancer cells block ferroptosis by controlling different cell survival pathways. Compared to healthy, normal cells, cancer cells are more dependent on iron. A subgroup of tumor cells known as cancer stem cells has stem-like characteristics. These are in charge of metastasis and recurrence. The liver plays a significant part in the body's detoxifying process and is the primary iron storage organ. Numerous liver disorders are frequently accompanied by excessive iron accumulation. Due to excessive iron deposits, the liver is more vulnerable to oxidative damage, which can occasionally result in liver failure. Chemotherapy, which involves administering several medications to treat cancer, may be hazardous to the body's other cells. The ferroptosis condition and high iron accumulation can potentially impair liver function. A tailored drug delivery method may ameliorate the impact of excessive iron accumulation and favorably correlate with liver damage, consequently enhancing liver function.

7 Essential Elements for Successful Hard- and Soft-Tissue Regeneration in Immediate Implants with TERUPLUG®Collagen

7 Essential Elements for Successful Hard- and Soft-Tissue Regeneration in Immediate Implants with TERUPLUG®Collagen

Recent Advances in Biomaterial Design for Bone Regenerative Therapy: A Mini Review

Abstract: Longevity has been associated with morbidity and an increase in age-related illnesses, linked to tissue degeneration and gradual loss of biological functions. Bone is an important organ that gradually degenerates with increasing lifespan. The remodeling phase plays a huge role in maintaining the ability of bone to regenerate and maintain its stability and function throughout life. Hence, bone health represents one of the major challenges to elderly citizens due to the increase of injury associated with bone degeneration, such as fragility and risks of fractures. In the virtue of improving the regenerative function of bone tissues, a specialized field of bone tissue engineering (BTE) has been introduced to improve the current strategies in treating bone degenerative disorders. Most of the research performed in BTE focuses on the optimization of key components to generate new bone formation, including the scaffold. A scaffold plays a significant role in establishing the structural form that interconnects major elements of the tissue engineering triad. To date, many types of biomaterials have been explored in BTE, ranging from natural and synthetic materials to nanocomposites. However, ideal scaffolds that display excellent biocompatibility and mechanical properties, approved for clinical practices are yet available. This paper aims to describe the up-to-date advancements in scaffold for new bone generation, highlighting the essential elements and strategies in selecting suitable biomaterials for bone repair.

Fostering social cohesion in ethnolinguistic communities through mother tongue-based initiatives in Nepal

In Nepal and other regions, fostering social cohesion within ethnolinguistic communities is recognized as a vital factor for fostering social prosperity. This research paper presents an integrated framework developed through an extensive literature survey, incorporating the perspectives of ethnolinguistics and social cohesion. The study examines social cohesion using mixed methods, exploring its domains and correlation with linguistic theories. Special attention is given to the role of social prosperity and how this study impacts attitudinal and behavioral aspects of social cohesion. The study’s findings underscore the significance of interconnected social relations, a sense of connectedness, and shared common goods as essential elements for fostering practical social harmony. Notably, the research emphasizes the critical role of mother tongue-based educational activities in empowering ethnolinguistic communities, catalyzing sociocultural transformation, and promoting identity. It is revealed that these initiatives contribute to poverty reduction and foster gender equality and social inclusion. Moreover, the research advocates language-based interventions as a pivotal strategy for enhancing social cohesion. By recognizing language as a critical element that binds communities, this study aims to create a more fruitful investigation and provide practical, scientific, and managerial contributions in fostering social cohesion within ethnolinguistic contexts.

A randomized wait-list controlled trial of Men in Mind: Enhancing mental health practitioners' self-rated clinical competencies to work with men.

Improved engagement of men in psychotherapy is an essential element in improving male health outcomes. This trial examined whether the Men in Mind intervention improved practitioners' self-rated clinical competencies to engage and respond to male clients in therapy. A parallel, single-blind, wait-list randomized controlled trial was conducted with Australian-based mental health practitioners, currently administering psychotherapy to males, fluent in English, and not currently completing their undergraduate degree. Participants were randomly assigned 1:1, through variable-sized blocks stratified by gender, to either the intervention (Men in Mind) or wait-list control. Men in Mind was offered as a self-led 6-week, five-module online program to upskill practitioners to engage and respond to male clients. The primary outcome was self-reported competency in engaging men in psychotherapy, measured by the Engaging Men in Therapy Scale (EMITS) at 6 weeks. All analyses were by intention-to-treat. Between January 16 and March 17, 2022, 587 participants were randomly assigned to the intervention (n = 300) or wait-list control (n = 287). In total, 492 (84%) participants completed the primary endpoint assessment at 6 weeks. Men in Mind demonstrated a large effect of improved EMITS scores compared to the control group (d = 2.63, 95% CI [2.39, 2.87], p < .001). Men in Mind was effective at increasing mental health practitioners' self-reported efficacy to work with men, which is potentially a key change mechanism in their ability to improve health outcomes for male clients. A limitation of the trial was the use of a bespoke, self-reported primary outcome, while a strength was the gender-responsive intervention design. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

Feature importance for software development effort estimation using multi level ensemble approaches

Feature importance strategy that substantially impacts software development effort estimation (SDEE) can help lower the dimensionality of dataset size. SDEE models developed to estimate effort, time, and wealth required to accomplish a software product on a limited budget are used more frequently by project managers as decision-support tool effort estimation algorithms trained on a dataset containing essential elements to improve their estimation accuracy. Earlier research worked on creating and testing various estimation methods to get accurate. On the other hand, ensemble produces superior prediction accuracy than single approaches. Therefore, this study aims to identify, develop, and deploy an ensemble approach feasible and practical for forecasting software development activities with limited time and minimum effort. This paper proposed a collaborative system containing a multi-level ensemble approach. The first level grabs the optimal features by adopting boosting techniques that impact the decided target; this subset features forward to the second level developed by a stacked ensemble to compute the product development effort concerning lines of code (LOC) and actual. The proposed model yields high accuracy and is more accurate than distinct models.

MouseClicker: Exploring Tactile Feedback and Physical Agency for People with Hand Motor Impairments

Assistive technology (AT) design is critical in enabling functionality for people with disabilities, blending essential elements of both practical utility and user experience. Traditionally, AT has successfully addressed core functional needs, such as enabling cursor movement and clicking actions with devices like computer mice. However, a comprehensive approach to AT design also necessitates a thorough consideration of sensory feedback, including tactile sensations, ergonomics, and auditory cues like button click sounds. These aspects are not merely supplementary but are integral to the device’s functionality, enhancing user interaction and long-term comfort, especially for individuals with motor impairments. In this work, we present MouseClicker, a mechatronic AT to surrogate physical agency over a computer mouse and to foster the haptic sensory experience of clicking on it tailored specifically for an individual with Spinal Muscular Atrophy (SMA) who faces challenges in using a standard mouse due to severe hand motor impairments. Our design aims at replicating the holistic experience of clicking a mouse, from its functional mechanical actions to its nuanced tactile and auditory feedback. This work details the MouseClicker’s design and reports on an exploratory user study aimed at identifying optimal vibrotactile feedback parameters – such as location, and intensity – that represent mouse button clicks. MouseClicker presents a step forward in AT design by integrating the functionality, sensory feedback, and the overall experience of taking control over non-AT devices.

Legal Consequences of the Judgment of the Court of Justice of the European Union in Case C-432/21

This article synthetically discusses the judgment of the Court of Justice of the European Union of 2 March 2023 in case C-432/21. It aims to familiarise international readers with this issue, which might be a contribution to an academic, international discussion in this field, significant in the era of climate change. The author first indicates the role of forests in climate policy and considers the socio-economic conditions of the current situation of forests in Poland. Then, the international reader will be introduced to the most critical issues related to the judgment that concern the Polish legal order, i.e., forest management and the code of good practices in forests. In the next part, she moves on to the essential elements of the legal basis for the complaint filed by the European Commission against Poland and shows grounds of action and the operative part of the judgment. Then, the most important points of the parties’ arguments were briefly presented. In addition, reference will be made to the legal consequences of issuing the judgment in question.

DİJİTAL VATANDAŞLIĞIN DOKUZ BOYUTU VE E-DEVLET UYGULAMALARI

Dijitalleşme ile birlikte toplumsal yaşamda bir değişim yaşanmaktadır. Bu değişimlerden biri de vatandaşlık olgusudur. Geleneksel vatandaşlıktan dijital vatandaşlığa geçiş ile birlikte vatandaşlık anlayışı bazı noktalarda dönüşmektedir. Nitekim bazı geleneksel vatandaşlık uygulamaları dijital vatandaşlıkta varlığını devam ettirmekle birlikte dijital vatandaşlık, dijital çağ konseptine uygun olarak her geçen gün kendisini güncellemekte ve yeni uygulamalar ile alanını genişletmektedir. Dijital çağa uygun konsept geliştiren devletler daha etkili iletişim ağı ve kamu yönetimi politikası ile vatandaşlarına daha hızlı ve kolay bir şekilde ulaşmaktadır. Bu durum devlet ve vatandaş arasındaki iletişimin artmasına, demokrasinin gelişmesine ve katılımcı bir toplumun ortaya çıkmasına neden olmaktadır. Bu araştırmanın amacı Türkiye’de e-Devlet uygulamaları ve dijital vatandaşlık arasındaki ilişkiyi saptamaktır. Dijital vatandaşlık tanımına ilişkin farklı kavramsal çerçeveler bulunmak ile birlikte çalışmada temel olarak Mike Ribble tarafından oluşturulan “Dijital Vatandaşlığın Dokuz Boyutu” temel kavramsal çerçeve olarak ele alınmıştır. Çalışmada Türkiye’de e-Devlet uygulamaları bu kavramsal çerçeveye göre nitel araştırma yöntemi olan doküman analizi ile incelenmiştir. Çalışmada mevcut Türkiye’de e-Devlet uygulamalarının dijital vatandaşlığın pratik boyutunda hayata geçtiği ve bu uygulamaların vatandaşlık bilincinin ve demokrasi kültürünün alanını genişlettiği vurgulanmıştır.

Dietary Iron Overload Triggers Hepatic Metabolic Disorders and Inflammation in Laying Hen.

Iron, an essential trace element, is involved in various physiological processes; however, consumption of excessive iron possesses detrimental effects. In practical feed production, the iron content added to feeds often far exceeds the actual demand, resulting in an excess of iron in the body. The liver as a central regulator of iron homeostasis is susceptible to damage caused by disorders in iron metabolism. A model of hepatic iron overload in laying hens was developed in this study by incorporating iron into their diet, and the specific mechanisms underlying iron overload-induced hepatic injury were investigated. Firstly, this study revealed that a high-iron diet resulted in hepatic iron overload, accompanied by impaired liver function. Next, assessment of oxidative stress markers indicated a decrease in activities of T-SOD and CAT, coupled with an increase in MDA content, pointing to the iron-overloaded liver oxidative stress. Thirdly, the impact of iron overload on hepatic glycolipid and bile acid metabolism-related gene expressions were explored, including PPAR-α, GLUT2, and CYP7A1, highlighting disruptions in hepatic metabolism. Subsequently, analyses of inflammation-related genes such as iNOS and IL-1β at both protein and mRNA levels demonstrated the presence of inflammation in the liver under conditions of dietary iron overload. Overall, this study provided comprehensive evidence that dietary iron overload contributed to disorders in glycolipid and bile acid metabolism, accompanied by inflammatory responses in laying hens. Further detailing the specific pathways involved and the implications of these findings could offer valuable insights for future research and practical applications in poultry nutrition.

Exploring an innovative decellularization protocol for porcine nerve grafts: a translational approach to peripheral nerve repair.

Peripheral nerves are frequently affected by lesions caused by traumatic or iatrogenic damages, resulting in loss of motor and sensory function, crucial in orthopedic outcomes and with a significant impact on patients' quality of life. Many strategies have been proposed over years to repair nerve injuries with substance loss, to achieve musculoskeletal reinnervation and functional recovery. Allograft have been tested as an alternative to the gold standard, the autograft technique, but nerves from donors frequently cause immunogenic response. For this reason, several studies are focusing to find the best way to decellularize nerves preserving either the extracellular matrix, either the basal lamina, as the key elements used by Schwann cells and axons during the regenerative process. This study focuses on a novel decellularization protocol for porcine nerves, aimed at reducing immunogenicity while preserving essential elements like the extracellular matrix and basal lamina, vital for nerve regeneration. To investigate the efficacy of the decellularization protocol to remove immunogenic cellular components of the nerve tissue and to preserve the basal lamina and extracellular matrix, morphological analysis was performed through Masson's Trichrome staining, immunofluorescence, high resolution light microscopy and transmission electron microscopy. Decellularized porcine nerve graft were then employed in vivo to repair a rat median nerve lesion. Morphological analysis was also used to study the ability of the porcine decellularized graft to support the nerve regeneration. The decellularization method was effective in preparing porcine superficial peroneal nerves for grafting as evidenced by the removal of immunogenic components and preservation of the ECM. Morphological analysis demonstrated that four weeks after injury, regenerating fibers colonized the graft suggesting a promising use to repair severe nerve lesions. The idea of using a porcine nerve graft arises from a translational perspective. This approach offers a promising direction in the orthopedic field for nerve repair, especially in severe cases where conventional methods are limited.

A Cross-Cultural Exploration of Student Development in Higher Education: Acknowledging, Exercising, and Enhancing Agency

Purpose Students develop and grow throughout higher education. However, the underlying mechanism remains unclear. Building on the premise that individuals develop and grow through interacting with the world, this study explores how students develop, grow, and become empowered in higher education through the lens of I–world interactions. Design/Approach/Methods This study employs a multicultural and multidisciplinary approach by first examining different cultural philosophical approaches to I–world interactions. This is followed by an elaboration of what the interactions mean for individual development and growth in higher education by drawing on psychology, sociology, and educational research. Findings This study argues that there are three essential elements of I–world interactions across three philosophical approaches: acknowledged, exercised, and enhanced individual agency. In higher education, students are strong agents, as demonstrated by sociological theories of agency and psychological evidence of agentic human functioning. Students actively exercise their agency, particularly when interacting with the environment. If organized and practiced well, universities can help students enhance their agency. Originality/Value The three shared elements and empirical evidence together form the foundation for understanding how students become empowered in higher education and for positioning the enhancement of students’ agency at the center of higher education across contexts.

Primary and residual impacts of phosphoric acid modified biochar on growth and concentrations of essential and non-essential elements in lettuce and second crop arugula

The study aimed to explore how phosphoric acid-modified rice husk biochar (PBC) affects the growth and concentrations of essential and non-essential elements in two crops: lettuce as the primary crop and arugula as the secondary crop. The treatments consisted of a no P fertilized control and 250 mg P kg−1 sourced either from PBC, triple super phosphate (TSP) or phosphoric acid (PA). When subjected to phosphorus (P) sources, both lettuce and arugula exhibited a noteworthy rise in their dry weights compared to the control plants. PBC treatments significantly increased P concentration in both plants. Although the PBC treatment decreased lettuce nitrogen (N) concentration, it had no impact on arugula N concentration. Phosphorus treatments resulted in a decrease in lettuce K concentration, whereas it increased in arugula. Calcium (Ca), magnesium (Mg) and sulfur (S) concentrations in both plants were not affected by P sources. The zinc (Zn) concentrations of the plants notably decreased with P treatments. Moreover, P treatments led to a reduction in manganese (Mn) concentration specifically in arugula. PBC significantly increased the silicon (Si) concentrations of lettuce plants. The application of PA significantly increased the vanadium (V) concentration in arugula. Phosphoric acid treatments resulted in an increase in the plant bromine (Br) concentrations. To conclude, PBC may serve as an alternative P source, potentially being as effective as or even more effective than other P sources in influencing plant nutrition, without causing an undesirable elevation of non-essential elements in plants.

Assessment of Benilde Associates towards a Dynamic Business Continuity Model in Disruptive Times

Business continuity and disaster recovery planning are comprised of activities that an organization must perform to resume operations in an unexpected event. The De La Salle College of Saint Benilde SMIT research study adopted the Business Continuity Model and identified gaps that will lead to the proposed Dynamic Business Continuity Model in disruptive times. From this problem, the research question is to what extent BCM factors impact levels (depth and breadth) of the Business Continuity Model during disruptive times. Data was collected by surveying Benilde associates in various academic positions and the Office Center. The data collected was treated using Exploratory Factor Analysis and Multiple Regression for causal relationships. DLS CSB SMIT identified gaps and challenges for faculty and staff in several dimensions in the existing Business Continuity Model factors and the ff are: a. Systems/Data Recovery b. Organizational Support c. Employee Engagement d. Forecasting Capacity and among the identified gaps- “Organizational Support ‘ is considered the most significant among the 4 factors. This consists of Student Support Services, Hunan Resource, and Registrar’s Office. To prevent the interruption in DLS CSB SMIT operations and the survival of an organization during disruptive times, Transparency of the BCM Strategy cascaded to Benilde associates, the importance of creating awareness and being prepared for the unexpected. Business Continuity Model is an essential element that should form part of every critical business process within the College. It is imperative to understand the factors that were identified as gaps that the Institution could be faced with and also understand the steps that should be taken to address and manage these risks. This dissertation paper led to the development of a Dynamic Business Continuity Model which is essential to prepare DLS CSB for any disaster or crisis. The Model serves as a guide for all Centers on what they should do in such an event to ensure that the organizations will survive during the fortuitous event and how to restore the Business and Institution to normalcy. This Research study could provide a Business Continuity Model framework for leaders to assess their organization’s capacity from an unexpected disruption and be used by organizational leaders to assign contingency planning responsibilities or hire business continuity and disaster recovery planning professionals. Keywords: Business Continuity, Disruptive, Dynamic Business Model, Systems/Data Recovery, Organizational Support, Employee Engagement, Forecasting Capacity

Ion‐Engineered Microcryogels via Osteogenesis‐Angiogenesis Coupling and Inflammation Reversing Augment Vascularized Bone Regeneration

AbstractNative bone inherently requires a balanced ionic microenvironment to maintain bone homeostasis. Hence, scaffolds designed for the sustained release of therapeutic ions into bone defects hold great promise for bone regeneration. Magnesium (Mg) and silicon (Si) are essential elements, which play crucial roles in the process of bone regeneration, impacting immunomodulation, angiogenesis, and osteogenesis. Herein, porous cryogel‐type organic–inorganic composite microspheres are developed as injectable microscaffolds (denoted as GMN). GMN enables sustained release of Mg/Si ions at an optimized ratio, achieving the most significant synergistic effect on vascularized bone regeneration. Various conditioned media are obtained to explore angiogenesis‐osteogenesis coupling, as well as the crosstalk between bone marrow mesenchymal stromal cells (BMSCs) and macrophages. Meanwhile, autocrine and paracrine effects simultaneously play synergistic modulating functions in determining cell fates under the guidance of Mg/Si ions and biofactors secreted by cells. Overall, the Mg/Si ion‐engineering microscaffolds create a conducive microenvironment to efficiently augment the regeneration of vascularized bone tissue in vivo, offering a versatile platform for tissue engineering.

Monitoring of Essential and Toxic Elements in Multivitamin/Mineral Effervescent Tablet Supplements and Safety Assessment.

Multivitamin/mineral (MVM) supplements are the most commonly utilized dietary supplements by many populations. However, there is a severe concern about their adverse effects due to elemental impurities. In the present study, it was aimed to determine the levels of 11 elemental impurities (Cd, Pb, As, Hg, Co, V, Ni, Se, Mo, Cu, and Cr) by inductively coupled plasma-mass spectrometry (ICP-MS) and evaluate the human health risk associated with the consumption of 33 MVM effervescent tablet supplements available in Turkey. The precision of the method in terms of relative standard deviation (RSD) was less than 4.6%. The accuracy of the method was tested with recovery experiments, and the results ranged between 86 and 107%. The impurity levels for Cd, Pb, As, Co, V, Ni, Se, Mo, Cu, and Cr were found between 0.011-0.050, 0.025-0.098, 0.018-0.056, 0.010-0.626, 0.027-0.290, 0.026-1.65, 1.92-21.83, 0.034-34.09, 0.140-183.9, and 0.033-13.10µg/g, respectively, and Hg was not detected in any sample. The calculated concentrations for elemental impurities complied with EMA and USP guidelines, except one supplement for Se (21.83µg/g) with a permitted limit of 15µg/g. The hazard quotient (HQ) and hazard index (HI) levels were below 1 for all samples within the ranges of 3.4 × 10-1-1.4 × 10-6 for HQ and 7.8 × 10-1-1.4 × 10-6 for HI indicating that there is no risk for consumption. The carcinogenic risk (CR) of As was between 1.7 × 10-6 and 5.9 × 10-6, below the threshold value of 1 × 10-4. The results showed that there is no risk to human health.

Compounding effects of stress on diet, physical activity, and wellbeing among African American parents: a qualitative study to inform the LEADS health promotion trial.

The purpose of the study was to conduct in-depth qualitative interviews to understand the lived experiences of African American parents of overweight adolescents who had previously participated in a family-based weight loss program and to utilize these insights to inform the essential elements of the LEADS trial, an integrated resilience stress management and health promotion intervention. Participants (N = 30) were African American parents and/or caregivers (96.7% female; Mage = 49.73, SD = 10.88; MBMI = 37.63, SD = 8.21) of adolescents with overweight and/or obesity. Interviews were transcribed and coded using inductive and deductive approaches for themes by two independent coders. Inter-rater reliability was acceptable (r = 0.70-0.80) and discrepancies were resolved to 100% agreement. Prominent stress themes included caregiver responsibilities, work, interpersonal family conflict, and physical and emotional consequences of chronic stress. Participants also noted decreases in physical activity and poor food choices due to stress. Coping mechanisms included prayer/meditation, church social support, and talking with family/partner. Results highlight the importance of mitigating stress among African American parents through stress management and cultural/familial resilience approaches to increase the likelihood of engagement in behavioral strategies in health promotion programs. Future studies should assess the utility of incorporating stress management components and health promotion techniques to improve health outcomes among African American families.

Mixture effects of trace element levels on cardiovascular diseases and type 2 diabetes risk in adults using G-computation analysis

There is an increasing concern about the health effects of exposure to a mixture of pollutants. This study aimed to evaluate the associations between serum levels of heavy/essential metals ([Arsenic (As), Cadmium (Cd), Mercury (Hg), Lead (Pb), Nickel (Ni), Chromium (Cr), Copper (Cu), Iron (Fe), and Zinc (Zn)]) and the risk of developing cardiovascular diseases (CVDs) and type 2 diabetes mellitus (T2D). Data were collected from 450 participants (150 with CVDs, 150 with T2D, and 150 healthy subjects) randomly selected from the Ravansar Non-Communicable Disease (RaNCD) cohort in Western Iran, covering the years 2018–2023. Trace element levels in the serum samples were assayed using ICP-MS. Logistic regression was performed to estimate the adjusted risk of exposure to single and multi-metals and CVD/T2D. Odds ratios were adjusted for age, sex, education, residential areas, hypertension, and BMI. The mixture effect of exposure to multi-metals and CVD/T2D was obtained using Quantile G-computation (QGC). In the logistic regression model, chromium, nickel, and zinc levels were associated with CVD, and significant trends were observed for these chemical quartiles (P < 0.001). Arsenic, chromium, and copper levels were also associated with T2D. The weight quartile sum (WQS) index was significantly associated with both CVD (OR 4.17, 95% CI 2.16–7.69) and T2D (OR 11.96, 95% CI 5.65–18.26). Cd, Pb, and Ni were the most heavily weighed chemicals in these models.The Cd had the highest weight among the metals in the CVD model (weighted at 0.78), followed by Hg weighted at 0.197. For T2D, the serum Pb (weighted at 0.32), Ni (weighted at 0.19), Cr (weighted at 0.17), and Cd (weighted at 0.14) were the most weighted in the G-computation model. The results showed the significant role of toxic and essential elements in CVDs and T2D risk. This association may be driven primarily by cadmium and mercury for CVDs and Pb, Ni, Cr, and Cd for T2D, respectively. Prospective studies with higher sample sizes are necessary to confirm or refute our preliminary results as well as to determine other important elements.

Impact of Yoga On Sports Fitness

If you are a competitive athlete, it is best to tailor your yoga practice to your training schedule because a particular sport can develop certain muscle groups while ignoring others. Over time, this process causes imbalances in the muscles and joints, leading to overuse injuries. Yoga helps the muscles, tendons, and ligaments move through a full range of motion, thus cultivating balance and core strength which is a huge benefit to athletes in their chosen sports. A tri-athlete from San Diego, Heidi Resiert said, “I'm glad I found yoga and added it to my weekly workout routine. Not only do I feel stronger, but I also feel more confident that I will continue to be injury free." Another essential element in yoga is breath work (pranayama). The attention to breath during yoga can be considered one of the most important benefits to athletes. Learning to stay focused and centered through uncomfortable poses by concentrating on even inhalations and exhalations sets up the athlete to stay focused during a race or challenging workout. The mind-body connection in yoga is essential to helping athletes develop mental acuity and concentration. In addition, yoga helps you to relax not just tight muscles, but also anxious and overstressed minds. Yoga works not just in the sagittal plane, but in the frontal and transverse planes as well, ensuring well-rounded development. Being more relaxed will also aid in athletic performance. So, why not enhance your game performance and prevent injury by adding yoga to your training plan now.