Equivalent Zone Research Articles

Assessing the criterion validity of the activPAL CREA v1.3 algorithm and ActiPASS 2023.12 software for detecting steps during a progressive treadmill-based laboratory protocol

ABSTRACT Thigh-worn accelerometry is commonly implemented to measure step cadence. The default activPAL CREA algorithm is a valid measure of cadence during walking, but its validity during running is unknown. The ActiPASS software is designed to analyse tri-axial accelerometry data from various brands. We tested the validity of CREA v1.3 and ActiPASS 2023.12 to measure step cadence against manually-counted steps. Forty-five participants (26♀, 23.4 ± 4.6 years) completed 5 walking (6 min each, 2–4 mph) and 5 running treadmill (5–7 mph) stages (423 total stages completed). Based on equivalence testing, walking cadence (stages 1–5: 92–124 steps/min) from CREA was statistically equivalent (zone: <±2.2% of the manually-counted mean) to manual counts (92–125 steps/min). However, CREA underpredicted cadence during running stages (stages 6–10: 143–135 steps/min) by ~ 11–20 steps/min (p < 0.001). The ActiPASS-derived cadences were equivalent (zone: <±3.3%) to manual counts for all walking stages (99–127 steps/min) except Stage 1 (zone: ±10.5%). ActiPASS underpredicted cadences during running (stages 6–10: 137–153 steps/min) by ~ 10–16 steps/min (p < 0.001) compared to manual counts (stages 6–10: 154–164 steps/min). The CREA v1.3 algorithm is a valid measure of cadence during walking while ActiPASS 2023.12 is a valid measure of cadence during medium-fast walking. Further research is required to improve step cadence estimation across ambulation speeds.

Integrated Time Nanosecond Pulse Irreversible Electroporation (INSPIRE): Assessment of Dose, Temperature, and Voltage on Experimental and Clinical Treatment Outcomes.

This study sought to investigate a novel strategy using temperature-controlled delivery of nanosecond pulsed electric fields as an alternative to the 50-100 microsecond pulses used for irreversible electroporation. INSPIRE treatments were carried out at two temperatures in 3D tumor models using doses between 0.001 s and 0.1 s. The resulting treatment zones were quantified using viability staining and lethal electric field intensities were determined numerically. Computational modeling was then used to determine parameters necessary for INSPIRE treatments to achieve equivalent treatment zones to clinical electroporation treatments and evaluate the potential for these treatments to induce deleterious thermal damage. Lethal thresholds between 1109 and 709 V/cm were found for nominal 0.01 s treatments with pulses between 350 ns and 2000 ns at physiological temperatures. Further increases in dose resulted in significant decreases in lethal thresholds. Given these experimental results, treatment zones comparable to clinical electroporation are possible by increasing the dose and voltage used with nanosecond duration pulses. Temperature-controlled simulations indicate minimal thermal cell death while achieving equivalent treatment volumes to clinical electroporation. Nanosecond electrical pulses can achieve comparable outcomes to traditional electroporation provided sufficient electrical doses or voltages are applied. The use of temperature-controlled delivery may minimize thermal damage during treatment. Intense muscle stimulation and the need for cardiac gating have limited irreversible electroporation. Nanosecond pulses can alleviate these challenges, but traditionally have produced significantly smaller treatment zones. This study suggests that larger ablation volumes may be possible with the INSPIRE approach and that future in vivo studies are warranted.

Prediction of peel strength of sandwich sheets made of aluminium alloys fabricated by friction stir spot welding based hybrid process using cohesive zone modeling and finite element simulations

The present work examines the fabrication and numerical modelling of honeycomb core sandwich sheets utilizing Friction Stir Spot Welding (FSSW) techniques as prospective substitutes for adhesive-bonded structures. Here, the sandwich sheet contains AA5052-H32 skins and AA3003 honeycomb core. Two strategies, FSSW with disc insert (FSSW_D) and FSSW with disc insert and adhesive bonding (FSSW_D_AB), were evaluated against traditional adhesive-bonded sandwiches using peel test performance and finite element (FE) simulation with cohesive zone modelling (CZM). In the CZM, a homogenized core with an equivalent cohesive layer was substituted for the honeycomb core and cohesive layer. The utilization of FSSW_D and FSSW_D_AB methods resulted in substantial improvements in maximum load capacity, with enhancements in the hybrid sandwich specimen ranging from 254 % to 399 % compared to adhesive-bonded connections. The maximum load of hybrid joints (FSSW_D_AB) was 15 %–23 % higher than that of ordinary spot-welded joints (FSSW_D). An approach to model the hybrid sandwich specimen using both the homogenized core and equivalent cohesive zone model accurately was proposed. FE analysis, including peel tests of adhesive-bonded, spot-welded, and hybrid joints, was performed, and the numerical predictions agreed satisfactorily with the experimental values for all the joint types.

Estimation of STEADI performance using inertial measurement unit

IntroductionFalls present a significant public health concern in the United States as a primary cause of unintentional injury-related deaths among older adults. A fall risk assessment toolkit STEADI developed by the CDC has been shown to predict future falls. However, STEADI has issues with accurate evaluations due to the disagreement on cut-off scores in functional assessments and history-taking questionnaires. Wearable sensor technology offers a practical and quantifiable alternative for assessing an individual's movement performance in real-world environments. The use of Inertial Measurement Units (IMUs) offers considerable potential to enhance fall risk screening. PurposeThe primary aim of this study is to test the agreement of STEADI functional assessment performance measured by the IMUs in comparison to human-based measurements. Method27 participants (Age: 74.37 ± 7.21) performed STEADI, including the Four-Stage Balance Test (4SBT), Timed Up & Go Test (TUG), 30-second Chair Stand (30sCS) with IMU placed at the fifth lumbar vertebra which is the proxy location of whole-body Center of Mass. By adopting an equivalent test, the STEADI agreement was tested between the human rater and IMU measurements, giving α = 0.05. ResultBetween the results from evaluators and IMU, the difference in TUG is -0.23 s, and the difference in 30sCS is 0.37, which is equivalent to within 4 % and 8 % for TUG and 30sCS, respectively. The difference in single-leg stance during the 4SBT is 0.59 s; however, the calculated equivalence zone is larger (22.7 %). ConclusionThis study demonstrates the feasibility of using IMU sensors to enhance fall risk screening protocols based on the STEADI. Future refinement may still need to enable broader application and effective screening practices on a larger scale of the population.

Experimental and numerical insights into fatigue crack propagation of railway component with gradient residual stress

As a representative structure with an acute radial gradient in terms of residual stress (RS) and grains, the induction-hardened railway S38C axle exhibits excellent mechanical properties and fatigue resistance. To investigate the effect of gradient features on fatigue crack growth (FCG) behaviors, we designed three-point bending (TPB) tests with different gradient features, including the negative-gradient, positive-gradient, and matrix specimens. Finite element modeling was introduced to simulate the FCG of the TPB specimens in terms of the cyclic J-integral (ΔJ) and equivalent plastic strain at the growing crack tip. The results reveal that the FCG rates in both negative- and positive-gradient structures decrease and a more pronounced tendency of decline is achieved in the positive-gradient ones. The substantial compressive residual stress (CRS) within the negative-gradient structure directly influences the crack tip area, while the CRS in the positive-gradient structure indirectly mitigates the crack driving force by impeding the overall structural deformation. Coarser grains aid in enhancing energy absorption along the zigzag crack path, thereby diminishing the crack driving force. ΔJ and the equivalent plastic zone surrounding the crack tip indicate significant reductions in the presence of CRS.

PRODUCTION OF POLYCLONAL ANTIBODIES AGAINST INDIAN PAPER WASP ROPALIDIA MARGINATA VENOM TOXINS AND THEIR EFFICACY IN THE REVERSAL OF TOXIC EFFECTS

Objective: In this study, albino mice were injected with a sub-lethal dosage of purified wasp Ropalidia Marginata venom toxins to assess the effectiveness of polyclonal anti-venom antibodies. Methods: To neutralize the toxic effects, polyclonal antibodies were generated by immunizing albino mice. The antibody underwent partial purification using ammonium sulphate treatment and octanoic acid precipitation. To detect the presence of antibodies in the antiserum, an immunodouble diffusion test was conducted using Ouchterlony's method (1962). This involved allowing both antigens and antibodies to diffuse radially towards each other from their respective wells. When they reached an equivalence zone, a precipitation complex of antigen and antibody became visible as a concentric band, indicating the development of the combination. To quantitatively determine the amount of antibodies in the antiserum, the equivalency zone approach was used. Results: Experimental mice were injected with a combination containing 400, 800, and 1200 µg of pure antibody, which had been treated serum biomolecules, including metabolic enzymes, completely reversed in the experimental with 40% of the LD50 of wasp venom the elevated serum parameters were glucose, pyruvic acid, lipid, protein and free amino acid, reached to normal (100%) in the treated with 40% of LD50 of the venom and polyclonal treated after 6 h of administration. Anti-serum treatment also successfully normalized the alteration in serum enzyme just after 4h. Similarly, anti-serum treatment also successfully normalized the alteration in serum enzyme just after 4h treated with 40% of LD50 of the venom. Serum ACP content was obtained as 125.35% after 40% of LD50 venom injection, which was get normalized up to 102.81% after 4 h of the anti-venom treatment. Serum ALP content of 114.8% elevation was reversed back to 102.40% after anti-venom treatment. The GPT level significantly reversed up to 102.5%, while it was 130% in the venom-treated mice. A complete reversal was obtained in GPT level, which was obtained as 104.54% in the venom-treated animal. Similarly, LDH which was elevated up to 112.45 % in venom-injected mice was successfully reversed up to 100.25% after anti-venom treatment. Similarly, Ache concentration was fully recovered after anti-venom treatment 6 h, all animals (group B-E) that had received 40% of the LD50 of venom treated with pure antiserum. Conclusion: The venom-injected group showed a complete restoration of serum protein, free amino acid, uric acid, cholesterol, pyruvic acid, total lipid, and glucose level in experimental mice.

Plastic Properties of Prestressed High-Strength Steel Reinforced Concrete Continuous Beams

In this paper, the plastic properties of prestressed high-strength steel reinforced concrete (PHSSRC) beams are studied, by performing static load tests on eight built-in Q460 and Q690 prestressed high-strength steel reinforced concrete continuous beams and one built-in Q355 prestressed steel reinforced concrete (PSRC) continuous beam. The design parameters of the specimens were the steel strength grade, the steel ratio, the comprehensive reinforcement ratio, and the stirrup ratio. The failure mode, load–deflection curve, internal force redistribution ability, curvature ductility, plastic hinge performance, and moment modification coefficient of continuous beams under the influence of various parameters were analyzed to measure the plastic performance of the continuous beams. These results show that after the plastic hinge is formed in the middle support and mid-span of the prestressed high-strength steel reinforced concrete continuous beam, the test beam eventually becomes a rotating mechanism and is destroyed with increasing load. The built-in high-strength steel can significantly improve the bearing capacity of the specimen, and the maximum increase in the bearing capacity is 37.3%. The specimen still has a high bearing capacity after reaching the ultimate bearing capacity. With a decrease in the steel ratio, the degree of internal force redistribution is deepened, the curvature ductility is improved, and the plastic performance is enhanced. Increasing the comprehensive reinforcement ratio and the stirrup ratio can improve the plastic performance of the specimen. The calculation formula of the equivalent plastic hinge zone length is proposed. The calculation formula of the moment modification coefficient, with the relative plastic rotation angle and relative compression zone height as independent variables, is established. When the relative plastic rotation angle is not greater than 0.829 × 10−5, the moment modification coefficient increases with increasing plastic rotation angle and is not greater than 0.37. In the range of 0.3~0.4, the moment modification coefficient decreases with increasing height of the relative compression zone.

Comparison of Sleep and Physical Activity Metrics From Wrist-Worn ActiGraph wGT3X-BT and GT9X Accelerometers During Free-Living in Adults

Background: ActiGraph accelerometers can monitor sleep and physical activity (PA) during free-living, but there is a need to confirm agreement in outcomes between different models. Methods: Sleep and PA metrics from two ActiGraphs were compared after participants (N = 30) wore a GT9X and wGT3X-BT on their nondominant wrist for 7 days during free-living. PA metrics including total steps, counts, average acceleration—Euclidean Norm Minus One (ENMO) and Mean Amplitude Deviation, intensity gradient, the minimum acceleration value of the most active 10 and 30 min (M10, M30), time spent in activity intensities from vector magnitude (VM) counts, and ENMO cut points and sleep metrics (sleep period time window, sleep duration, sleep onset, and waking time) were compared. Results: Excellent agreement was evident for average acceleration-Mean Amplitude Deviation, counts, total steps, M10, and light PA (VM counts) with good agreement evident from the remaining PA metrics apart from moderate–vigorous PA (VM counts) which demonstrated moderate agreement. Mean bias for all PA metrics were low, as were the limits of agreement for the intensity gradient, average acceleration-Mean Amplitude Deviation, and inactive time (ENMO and VM counts). The limits of agreement for all other PA metrics were &gt;10%. Excellent agreement, low mean bias, and narrow limits of agreement were evident for all sleep metrics. All sleep and PA metrics demonstrated equivalence (equivalence zone of ≤10%) apart from moderate–vigorous PA (ENMO) which needed an equivalence zone of 16%. Conclusions: Equivalent estimates of almost all PA and sleep metrics are provided from the GT9X and wGT3X-BT worn on the nondominant wrist.

Evaluation of coal mines’ rock mass gas permeability in the equivalent stress zone

Purpose. Based on a comparative analysis of the internal mechanism of shape change of rock samples, which were loaded in specified deformations mode, and geomechanical and gas-dynamic processes in coal mass, to establish a causal link between these phenomena. To qualitatively characterise their gas permeability as a function of the rock’s volume expansion. To justify the possibility of using a full “stress-strain” diagram as a technogenic methane deposit formation model and its spatial localisation. Methodology. Theoretical research is based on using the solid mechanic constitutive principles and results of studying the rock samples failure in the mode of specified strains. Findings. The ability to use a full “stress-strain” diagram for detecting and localising methane reservoirs during the coal seams excavation was proved during the research. It was found that the compaction threshold coincides with the bearing pressure maximum in front of the longwall face. This area corresponds to the rock mass with minimal porosity and minimal filtration, which allows considering it as an envelope of an artificial gas deposit. Regularities that connect the three-dimensional equivalent stress state with the final gas permeability of the gas-saturated coal mass were obtained. These data allow creating a predictive numerical geomechanical model of methane migration paths. Originality. The ability to use a full “stress-strain” diagram in the controlled strain mode for numerical modelling of gas permeability of a methane-saturated coal mass during the mining of coal seams and the determination of technogenic gas deposit boundaries are justified. Dependences of the current and final gas permeability on the rock’s mechanical characteristics in a post-peak strain state are obtained. Practical value. Functional dependencies based on geomechanical models are obtained that allow the identification and localisation of technogenic methane reservoirs in mines during coal seam excavation, with subsequent utilisation of the extracted gas. Furthermore, methane removal enhances mining safety by reducing the risk of gas dynamic phenomena while decreasing gas emissions into the atmosphere contributes to reducing the greenhouse effect.

Gone with the wind? Wind farm-induced wakes and regulatory gaps

Wind farm-induced wakes can propagate dozens of kilometres, decreasing the power production and the fatigue lifetime of wind turbines between neighbouring farms. This phenomenon termed hereinafter “wind theft”, may lead to legal conflicts between wind farm operators and even States as power production from a wind farm is affected by the wake effects generated by another, reducing power output. Wind theft can substantially slow down the development of offshore wind if it is not regulated by a clear legal framework. In this study, we present the case of Sørlige Nordsjø II, a large offshore area that opened for wind turbine licensing application in 2020, is explored. This area is located in the Norwegian exclusive economic zone (EEZ) on the border to the Danish equivalent zone. Using state-of-the-art reanalysis data covering 1992–2020, it is shown that long farm-induced wake will likely propagate regularly from SN2 into the Danish EEZ and vice versa. This research shows how the United Nations Law of the Sea Convention 1982 leaves a regulatory gap regarding cross-border wind wake effects. As Europe crucially needs to expand its renewable energy production and work towards its net zero objectives by 2050, coastal States should cooperate to find regulatory solutions to wake effects such that wind resource management can be optimised. While some North Sea coastal States demonstrate a political will to cooperate, such policies must proliferate into legal instruments which lend certainty and predictability to wind resource management.

Finite element analysis of sagittal screw expander appliance in the treatment of anterior maxillary hypoplasia.

The skeletal anterior crossbite is a common malocclusion in clinic. However, there have been no reports on the maxillary sagittal expansion to correct the premaxillary hypoplasia, which greatly influences the facial morphology and masticatory function, using finite element analysis. In the present study, a three-dimensional finite element model of craniomaxillofacial complex with maxillary sagittal hypoplasia is constructed and the treatment for premaxillary hypoplasia by the sagittal screw expander appliance is simulated. The hypoplasia of the left premaxilla is more serious than that of the right and thus the size of the left part of premaxillary expander baseplate is designed to be larger than that of the right part and the loading is applied at 10° leftward to the sagittal plane and 30° forward and downward to the maxillary occlusal plane. The displacements or equivalent stress distributions of the maxilla, teeth and their periodontal ligaments, are analyzed under the loads of 5.0N, 10.0N, 15.0N, and 20.0N. Consequently, as the load increases, the displacements or equivalent stresses of the maxilla, teeth and their periodontal ligaments all increase. Almost the whole premaxilla markedly move forward, downward, and leftward while other areas in the craniomaxillofacial complex remain almost static or have little displacement. The equivalent stress concentration zone of the maxilla mainly occurs around and in front of the incisive foramina. The displacements of left premaxilla are generally greater than those of the right under the loading forces. The maximum equivalent stress on the teeth and their periodontal ligaments are 2.34E-02MPa and 2.98E-03MPa, respectively. Taken together, the sagittal screw expander appliance can effectively open the premaxillary suture to promote the growth of the premaxilla. An asymmetrical design of sagittal screw expander appliance achieves the asymmetric expansion of the premaxilla to correct the uneven hypoplasia and obtains the more symmetrical aesthetic presentation. This study might provide a solid basis and theoretical guidance for the clinical application of sagittal screw expander appliance in the efficient, accurate, and personalized treatment of premaxillary hypoplasia.

Influences of concentration gradients and ignition positions on unconfined inhomogeneous hydrogen explosion

This work aims at investigating the inhomogeneous hydrogen cloud explosion in unconfined spaces. The influences of concentration gradient and ignition position on the explosion were studied. Different initial inhomogeneous hydrogen clouds with vertical concentration gradients were prepared by controlling the injection rate and ignition time. Results show that the explosion flame at the equivalent concentration zone has higher temperature, faster propagation and more intense combustion reaction. With the decrease of the concentration gradient, the flame is faster and higher in temperature. The max explosion temperature increases from 905.9 °C to 1000.8 °C. The shapes of flame and temperature field in the gas cloud change from mushroom-shaped to ellipsoidal and then to spherical. The maximum overpressure (Pmax), maximum rise rate of overpressure ((dP/dt)max) and positive impulse (I) increase significantly with the decrease of concentration gradient. While ignited with different ignition positions, the flame propagation from the equivalent concentration zone to the flammability limit zone is inhibited by the concentration gradient. Central ignition induces the most intense and shortest explosion process and causes the highest temperature. Generally, central ignition induces larger Pmax and I in the vicinity of the cloud. Non-central ignition extends the impact areas of explosion.

An equivalent cohesive zone model for a wide range of ductile and brittle adhesives

AbstractThis paper aims to propose an equivalent trapezoidal traction–separation law (ET‐TSL) of the cohesive zone model applicable to a wide range of ductile and brittle adhesives using equivalent and fictitious material concepts. The ET‐TSL can reduce the analysis time and cost of complex problems without degrading the prediction accuracy. To experimentally validate the proposed ET‐TSL, double‐cantilever beam (DCB) samples were fabricated with glass fiber‐reinforced polymer substrates and a highly ductile adhesive and then tested. The fracture behavior of the specimens was modeled using the proposed ET‐TSL. Moreover, the accuracy and comprehensiveness of the proposed model were verified by employing the proposed ET‐TSL for different adhesive joints made of different adhesives ranging from brittle to ductile adhesives and different substrates found in the literature. It was found that the proposed ET‐TSL can provide reasonable accuracy in simulating the fracture response of different types of adhesive joints with brittle and ductile adhesives.

Studies on modulation of hemocyte surface antigen through agglutination reaction under arsenic toxicity in edible mudcrab (Scylla serrata)

Scylla serrata (Crustacea: Decapoda), which is widely spread on the intertidal mudflat of West Bengal, India's Sundarbans Biosphere Reserves, is a potential aqua crop and an economically significant edible species. One of the larger crab groups in the mangrove swamp of the Sundarbans is thought to be this one. The S. serrata's multifaceted immune response is directly tied to its diverse habitat and survival technique. It lives in dangerous surroundings and is constantly in danger of physiological stress brought on by various xenobiotics, such as arsenic. By producing a number of polyclonal antisera in rabbits (New Zealand White, albino), the study attempted to evaluate the surface antigen against crab hemocytes and murine lymphocytes. Control hemocytes and hemocytes treated to 1 ppm expressed very identical reactivity to antihemocyte sera for the agglutination reaction. The control results, however, shifted when exposed to 2 and 3 ppm of sodium arsenite, indicating arsenic-induced hemocyte surface modification. The agglutination reaction from the control sets of hemocytes that reacted with murine anti-lymphocyte sera gradually, shifted as the quantity of sodium arsenite in the medium of the treatment sets increased. The maximum equivalence zone of murine lymphocyte and hemocyte agglutination 98.6% and 99% respectively suggested a potential epitope sharing between two phylogenetically separate species. The situation may lead to a possible alteration of immune status and make opportunity for pathogenic foreign invaders within the mud crab body. Chronic arsenic exposure indicated a steady decline of edible and demandable S. serrata in the natural habitat of Sundarbans.

Impact of zone geometry on the introduction of myopic defocus in young adult eyes wearing multi-zone lenses.

Multizone contact lenses control myopia progression by proposed introduction of myopic defocus. This project investigated how much of the pupil area and how many dioptres of myopic defocus are introduced by different lens zone geometries with near- and off-axis viewing. Ten young myopic adults (18-25 years) binocularly wore four soft contact lenses including a single vision (SV), concentric-ring dual-focus (DF), centre-distance multifocal (MF) and a RingBoost™ (RB) multi-zone design containing a combination of coaxial and non-coaxial zones. A modified aberrometer captured aberrations and pupil sizes at four target vergences between -0.25 and -4.00 D (on-axis) and across the central ±30° of the horizontal retina (off-axis). Defocus was quantified as the difference between the measured refractive state and the target vergence within each zone of a multi-zone design within the pupil and compared with that of equivalent zone areas of the SV lens. The percentage of the pupil containing myopic defocused light for each lens was calculated. Defocus within the distance correction zones of multi-zone lenses was similar to that of the SV lens. When viewing on-axis at -0.25 D target vergence, on average 11% of the pupil was myopic with SV, whereas 62%, 84% and 50% of the pupil was myopic for the DF, MF and RB designs, respectively. At -4.00 D target vergence, all lenses exhibited a systematic decrease in the percentage of pupil area having myopic defocus (SV: 3%; DF: 18%; MF: 5% and RB: 26%). The off-axis proportions were similar across multi-zone lenses; however, multi-zone lenses retained approximately 1.25-3.0× more myopic defocus than the SV lens. Subjects accommodated using the distance-correction zones of multi-zone lenses. Multi-zone contact lenses introduced significant myopic defocus on-axis and across the central ±30° retina. However, the magnitude and proportion of defocus were influenced by zone geometry, add power and pupil size.

Lower Permian (Late Kungurian) conodonts from the Sibumasu Terrane, Malaysia: paleoecological, paleobiogeographical and tectonic implications

AbstractLate Kungurian (Lower Permian) conodonts are described from the Kanthan Limestone, Perak, Peninsular Malaysia and for the first time from the Sibumasu Terrane of the Malay Peninsula. The co-occurrence of Gullodus duani, Gullodus hemicircularis, Gullodus sicilianus, Mesogondolella lamberti and Mesogondolella siciliensis represent the Mesogondolella lamberti International Conodont Zone and the broadly equivalent Mesogondolella siciliensis Regional Conodont Zone. A small fault-bounded basal Pennsylvanian (basal Bashkirian) conodont fauna including Gnathodus girtyi simplex and Declinognathodus inaequalis is also reported. The late Kungurian conodonts from the Kanthan Limestone were deposited in a relatively deep-water environment on the northern passive margin of the Sibumasu Terrane of the eastern Cimmerian Continent located at c. 35oS latitude. Biogeographically, the fauna represents the southern peri-Gondwana Cool Water Province which is consistent with its palaeogeographic location. A new scheme, utilizing characteristics of P1 elements, including position of the 1st denticle, location of 2nd and 3rd denticles, platform shape, platform cross-section, denticle shape in cross-section, and lateral denticle development is proposed for distinguishing between species of the hindeodid genera Gullodus, Hindeodus and Isarcicella. The late Kungurian fauna from the Kanthan Limestone represents the southern peri-Gondwana Cool Water Province supporting palaeogeographic reconstructions placing the Sibumasu Terrane in moderate southern palaeolatitudes in the Kungurian.

Pitfalls in the diagnosis of Cryptococcal Meningoencephalitis. (P1-10.001)

<h3>Objective:</h3> We report a case of cryptococcal meningoencephalitis which challenges the prevailing theory of antigen detection being more sensitive for the diagnosis than CSF biofire. <h3>Background:</h3> 60 year old immunocompetent male was admitted with episodes of unsteady gait, staring and picking at his clothes. Examination revealed lethargy and constructional apraxia. MRI brain showed ventriculomegaly. CSF analysis showed opening pressure 34cm H2O, protein 134, WBC count 62 with 98% lymphocytes. CSF multiplex PCR panel and Cryptococcal antigen were negative. He was started on Topiramate and Acetazolamide. As he did not improve, repeat lumbar puncture was obtained six days after admission. Repeat CSF PCR panel was positive for cryptococcal DNA, however both serum and CSF cryptococcal antigen were negative. CD4 count was 977 cells/uL. He was started on induction therapy for Cryptococcal meningoencephalitis. A lumbar drain was placed for secondary hydrocephalus. He completed 12 months of maintenance therapy and is doing well on follow up. <h3>Design/Methods:</h3> N/A <h3>Results:</h3> Detection of the capsular antigen by lateral flow assay has widely been believed to be the most reliable diagnostic method for Cryptococcal Meningoencephalitis. The cryptococcal antigen in the specimen diluent binds to gold conjugated anticryptococcal monoclonal antibodies on the test strip, producing a detection line. This test is based on an optimal antigen-antibody ratio, known as the zone of equivalence. A false negative result might be obtained in case of antigen levels greater than 0.14 mg/L (postzone phenomenon), as the excess antigen binds colloidal gold instead of immobilized antibody in the test area of the strip. Hospital laboratories do not routinely test for this occurrence, which can lead to a missed diagnosis. <h3>Conclusions:</h3> Using a greater dilution ratio of 1:5 (semi quantitative) or 1:9, instead of 1:2 (qualitative) can bring the antigen titer in the zone of equivalence. Using an alternate diagnostic method such as CSF biofire is another option. <b>Disclosure:</b> Dr. Nene has nothing to disclose. Dr. Mahapatra has nothing to disclose. Dr. Duleep has nothing to disclose.

Мотивированность языка как проявление тенденциозности когниции (на примере знаков для номинации результата депозиционирования объекта в паре языков «русский-китайский»)

Introduction. The article demonstrates the logical vulnerability of the opinion that ‘language categorizes the world in different ways’, and considers the existing idea of language motivation as interrelation and interdependence of various phenomena — and as proof of inseparability of the cognizer, what can/is to be cognized, and what has been cognized. Goals. Based on the fact that the common beginning of cognition for various linguistic collectives is neither some objective external world nor the inner world of a person, but rather the presence of the cognitive ability inherent in all humankind, the work articulates and tests a hypothesis that cognitive bias be a predetermining factor of linguistic categorization and incomplete interlanguage equivalence. Materials and methods. The paper provides comparative insights into groups of situations involving the use of signs denoting a result of an object’s position shift in Russian and Chinese. The main research method is deduction. Results. The non-equivalence of the considered signs from the two languages is predetermined by that Russian is characterized by the strategy of a person who ACTS and concentrates directly on the dynamics of his/her movement. The signs associated with the preliminary assessment of the initial arrangement of objects and the selection of an appropriate direction of movement become significant. Chinese is dominated by the strategy of a person who OBSERVES, which includes the latter’s own position in the coordinate system and shows much more interest in the relocated object’s position to the subject proper. The two strategies can be sometimes compatible and sometimes contradictory. Accordingly, there is both a zone of conditional equivalence and a zone of lacunarity for the examined signs. Conclusions. The paper shows that language categorizes no world independent of a person but rather — the person’s experience from interacting with the environment. And since at the moment of interaction with the environment a person necessarily performs a certain role, cognitive bias proves inevitable. Awareness of the features underlying linguistic categorization depends on the role of the individual in this interaction.

Effective Boundary Conditions and Stochastic Crack Distribution for Modelling Guided Waves Scattering by a Partially Closed Interfacial Delamination in a Laminate

Cohesive and adhesive bindings degrade during operation and maintenance even if contacting materials in a manufactured laminated structure are perfectly matched at the interfaces. Two modelling approaches for describing partially closed delaminations or imperfect contact zones, which often occurs at the interfaces, are examined and considered. To confirm the adequateness of the applicability of the effective spring boundary conditions for guided wave scattering by a finite length delamination, guided wave propagation through a damaged zone with a distribution of micro-cracks is compared with an equivalent cohesive zone model, where the spring stiffnesses for the effective boundary conditions are calculated using the properties of the considered crack distribution. Two kinds of local interfacial decohesion zones with an imperfect contact at the interfaces are considered: uniform partially closed delaminations and bridged cracks. The possibility of the employment of the effective spring boundary conditions to substitute a distribution of micro-cracks is analysed and discussed. Two algorithms of generation of a distribution of open micro-cracks providing characteristics equivalent to the effective boundary conditions are presented and examined. The influence of the characteristics of a delamination on wave characteristics (eigenfrequencies, eigenforms, transmission coefficient) is investigated for several kinds of partially closed delaminations.

The Stryd Foot Pod Is a Valid Measure of Stepping Cadence During Treadmill Walking and Running

Stepping cadence is an important determinant of activity intensity, with faster stepping associated with the most health benefits. The Stryd monitor provides real-time feedback on stepping cadence. The limited existing literature has neither validated the Stryd across slow walking to fast running speeds nor strictly followed statistical guidelines for monitor validation studies. We assessed the criterion validity of the Stryd monitor to detect stepping cadence across multiple walking and jogging/running speeds. It was hypothesized that the Stryd monitor would be an accurate measure of stepping cadence across all measured speeds. Forty-six participants (23 ± 5 years, 26 females) wore the Stryd monitor on their shoelaces during a 10-stage progressive treadmill walking (Speeds 1–5) and jogging/running (Speeds 6–10) protocol (criterion: manually counted video-recorded cadence; total stages: 438). Standardized guidelines for physical activity monitor statistical analyses were followed. A two-way repeated-measure analysis of variance revealed the Stryd monitor recorded a slightly higher cadence (&lt;1 steps/min difference, all p &lt; .001) at 2 miles/hr (92.1 ± 6.2 steps/min vs. 91.5 ± 6.4 steps/min, p &lt; .001), 2.5 miles/hr (101.3 ± 6.1 steps/min vs. 100.7 ± 6.4 steps/min), and 3.5 miles/hr (117.4 ± 5.9 steps/min vs. 117.0 ± 6.0 steps/min). However, equivalence testing demonstrated high equivalence of the Stryd and manually counted cadence (equivalence zone required: ≤± 2.6%) across all speeds. The Stryd activity monitor is a valid measure of stepping cadence across walking, jogging, and running speeds. By providing real-time cadence feedback, the Stryd monitor has strong potential to help guide the general public monitor their stepping intensity to promote more habitual activity at faster cadences.