Data driven transmission line fault location methods have the potential to more accurately locate faults by extracting fault information from available data. However, most of the data driven fault location methods in the literature are not validated by field data for the following reasons. On one hand, the available field data during faults are very limited for one specific transmission line, and using field data for training is close to impossible. On the other hand, if simulation data are utilized for training, the mismatch between the simulation system and the practical system will cause fault location errors. To this end, this paper proposes a physics-informed data-driven fault location method. The data from a practical fault event are first analyzed to extract the ranges of system parameters such as equivalent source impedances, loading conditions, fault inception angles (FIA) and fault resistances. Afterwards, the simulation system is constructed with the ranges of parameters, to generate data for training. This procedure merges the gap between simulation and practical power systems, and at the same time considers the uncertainty of system parameters in practice. The proposed data-driven method does not require system parameters, only requires instantaneous voltage and current measurements at the local terminal, with a low sampling rate of several kHz and a short fault time window of half a cycle before and after the fault occurs. Numerical experiments and field data experiments clearly validate the advantages of the proposed method over existing data driven methods.