Supersaturated designs (SSDs) offer a potentially useful way to investigate many factors with only few experiments in the preliminary stages of experimentation. This paper explores how to construct E ( f NOD ) -optimal mixed-level SSDs using k-cyclic generators. The necessary and sufficient conditions for the existence of mixed-level k-circulant SSDs with the equal occurrence property are provided. Properties of the mixed-level k-circulant SSDs are investigated, in particular, the sufficient condition under which the generator vector produces an E ( f NOD ) -optimal SSD is obtained. Moreover, many new E ( f NOD ) -optimal mixed-level SSDs are constructed and listed. The method here generalizes the one proposed by Liu and Dean [2004. k -circulant supersaturated designs. Technometrics 46, 32–43] for two-level SSDs and the one due to Georgiou and Koukouvinos [2006. Multi-level k-circulant supersaturated designs. Metrika 64, 209–220] for the multi-level case.