Carbonate landscapes make up one-fifth of the terrestrial land area, a better understanding of the coupling relationship between the soil–epikarst form and hydrological function is imperative for hydrology and landscape evolution modeling. In this study, we monitored a total of 158 rainfall-runoff events on a karst slope between 2019/4 and 2022/5 in southwest China, while simultaneously examining the soil–epikarst architecture (924 pairs of soil thickness and epikarst weathering degree). The results indicated that soil thickness increased with the underlying epikarst weathering degree, and soil thickness was positively correlated with epikarst thickness (P<0.001). Additionally, a significant positive relationship (P<0.001) was observed between surface runoff (SR) and soil thickness, as well as a significant negative relationship (P=0.0018) between subsurface runoff (SSR) and soil thickness. These findings imply the dominance of SR and SSR (under normal rainfall conditions) in runoff plots with deep soil layers and thin soil layers, respectively. The soil thickness threshold at which the hillslope discharge shifted from being SSR-dominated to SR-dominated was approximately 50 cm. Nonetheless, a positive relationship was found between SR and SSR under extreme rainfall events, indicating the establishment of hydrological connectivity between the surface and subsurface. Moreover, the hillslope discharge when the rainfall depth is lower than 50 mm is primarily composed of either SR or SSR from different plots. In other words, the hillslope discharge is typically influenced by both SR and SSR when the rainfall depth exceeds 50 mm. We finally proposed a positive feedback loop among soil thickness, epikarst weathering degree, and the hydrological function of the soil–epikarst system (water storage and release). These findings enhance our understanding of the complex interactive relationships in hillslope hydrology by illuminating the physical links between critical zone structures and hydrological processes on the karst slope.