At present, pancreatic cancer morbidity continues to grow at an accelerated rate worldwide. At the same time the five-year survival rate of patients with pancreatic cancer remains low, occupying a significant position in the mortality structure. This is mainly due to late diagnosis, as well as to the increasing proportion of the elderly population. Factors influencing the prognosis include age, sex, blood group, family history and genetic predisposition, diabetes, smoking, alcohol, chronic pancreatitis, and obesity. Objective: to present up-to-date data on pancreatic cancer epidemiology in the world, Russian Federation and Omsk region. Materials and methods: the article analyzes the data of morbidity, mortality and five-year survival rate of patients with pancreatic cancer for the years 2020-2021. Results: the growth of morbidity and persistent low survival rates emphasize the necessity of determining methods of screening patients with high risk of pancreatic cancer, developing methods of early detection and improving both surgical and drug treatment of these patients, as well as prophylaxis.