Introduction: The current study was conducted to investigate the effect of attending major wards on the level of burnout and boredom of medical interns in Iran during the COVID-19 pandemic. Methods: The present study was a cross-sectional descriptive research on all medical interns at the Kerman University of Medical Sciences of Iran who entered the major wards for the first time. Demographic questionnaires, Maslach and Jackson job burnout, and Multidimensional Boredom Scale (MSBS) were completed at the entrance and after two months. The mean scores (with the Wilcoxon test) were compared with each other, and their relationship (with Pearson Chi-squared test and Kendall's tau B) was investigated. Results: Investigations showed that emotional exhaustion significantly increased (p < 0.001), but Depersonalization significantly reduced after 2 months. The mean scores of individual dysfunction were not obvious (p>0.05). In addition, the fact that the intern is attending which ward (internal, surgery, or obstetrics and gynecology) did not affect the amount of burnout (p>0.05). The mean of the boredom scores increased significantly (p < 0.01). Conclusion: It is necessary to take serious measures to reduce emotional exhaustion in interns, especially in epidemic or pandemic conditions.