ABSTRACT The Newfoundland and Labrador real-time water quality (RTWQ) monitoring program operates a network of surface water monitoring stations, measuring physical water quality parameters in near real time. The network generates vast amounts of data that are too complex for many stakeholders to interpret. While the Canadian Council of Ministers of the Environment water quality index (WQI) has been a valuable tool to simplify and summarize the ambient quality of water, its usage in RTWQ is virtually non-existent. This is largely due to the lack of alignment/congruency between the limited number of parameters from real-time networks and the availability of aquatic water quality guidelines. This paper is the first attempt to outline a method of utilizing real-time water quality data to generate site-specific water quality guidelines using the background concentration method. Using these guidelines, we compute weekly WQI scores for select monitoring stations and examine various influences on the scores, including precipitation. The influence of each parameter on the WQI score is also plotted in the computation of the RTWQ WQI. Comparison is made between the yearly scores of the Canadian Environmental Sustainability Indicators WQI and RTWQ WQI. The paper also discusses the challenges and benefits of using this methodology as well as the sensitivity of WQI scoring at stations with various anthropogenic influences.