Environmental Exposure Of Children Research Articles

Exploring the impact of lifestyle and environmental exposures on appetite hormone levels in children and adolescents: An observational study

BackgroundAppetite hormones are considered a promising target in fighting obesity as impaired appetite hormone levels have already been associated with obesity. However, further insights in the drivers of appetite hormone levels are needed. ObjectivesIn this study, we investigated the associations of fasting appetite hormone levels with lifestyle and environmental exposures in children and adolescents. MethodsA total of 534 fasting blood samples were collected from children and adolescents (4-16y,50% boys) and appetite hormone levels (glucagon-like peptide-1 (GLP-1), peptide YY (PYY), pancreatic polypeptide (PP), leptin and ghrelin) were measured. Exposures included dietary quality (fiber-rich food intake, sugar propensity, fat propensity), psychosocial stress (happiness, negative emotions, negative life events and emotional problems), sleep duration, physical activity and environmental quality (long term black carbon (BC), particulate matter <2.5 μM (PM2.5), nitrogen dioxide (NO2) exposure, and green space in a 100 m and 2000 m radius around the residence). A multi-exposure score was calculated to combine all the exposures at study in one measure. Associations of individual exposures and multi-exposure score with appetite hormone levels were evaluated using linear mixed regression models adjusting for sex, age, socioeconomic status, waist-to-height ratio and multiple testing. ResultsGLP-1 was associated with air pollution exposure (NO2 β* = -0.13, BC β* = -0.15, PM2.5 β* = -0.16, all p < 0.001). Leptin was associated with green space in a 100 m radius around the residence (β* = -0.11; p = 0.002). Ghrelin was associated with negative emotions (active ghrelin β* = -0.16; p = 0.04, total ghrelin β* = -0.23; p = 0.0051) and happiness (active ghrelin β* = 0.25; p < 0.001, total ghrelin β* = 0.26; p < 0.001). Furthermore, total ghrelin levels were associated with the multi-exposure score, reflecting unhealthy exposures and lifestyle (β* = -0.22; p = 0.036). DiscussionOur findings provide new insights into the associations of exposures with appetite hormone levels, which are of high interest for preventive obesity research. Further research is crucial to reveal the underlying mechanisms of the observed associations.

Asthma prevalence and environmental exposure in children and adolescent in Slovenia – a pilot study

Abstract Background The last data on asthma prevalence (13.9 and 17.4%) in children in Slovenia is from 2002. The aim is to assess the asthma prevalence and environmental risk factors in two selected schools in Slovenia, as a pilot study for a national cross-sectional survey. Methods We conducted a cross-sectional pilot study in two primary schools in Slovenia. Observed population were children and adolescents aged 6-7 and 12-13 years. Observed outcome was current asthma diagnosed by a physician, reported by parents. To get the desired information we formulated a new questionnaire which was content validated. In the School 1 teacher distributed the questionnaires for parents to fulfill it. In the School 2 the questionnaires were delivered to parents at the parental meeting together with the presentation of the study and short lecture. We calculated the response rate, the prevalence of asthma, asthma symptoms, allergy, genetic background and exposure to environmental risk factors. Results Response rate in the School 1 was 24%, in the School 2 was 100%. We got data about 53 out of 127 children and adolescent. None of the parents reported a diagnosed asthma in their child or adolescent, 17% reported symptoms of asthma, 11% wheezing, 8% allergic rhinitis, 40% of children were living within 200 meters of a busy road, 34% were exposed to moisture and mold, 9% had chronic respiratory infection in their early childhood and 13% mothers smoked during pregnancy. Conclusions Newly developed questionnaire efficiently acquired information about exposure to environmental risk factors and asthma or allergy symptom. To get higher response rate, delivering the questionnaires at the parental meeting was more effective. Considering the reported symptoms of asthma in undiagnosed cases, further investigation of health records is needed to recognize the potential undiagnosed asthma cases. The latter suggests the benefits of the HIS / HES (Health Interview / Examination Survey) methodology. Key messages • HIS (Health Interview Survey) and HES (Health Examination Survey) design type methodology ensure us the quality data on asthma prevalence. • To efficiently assess the asthma prevalence, the adherence to medical guidelines and unification of the methodology to diagnose asthma in children by pediatricians is of an extreme importance.

Trauma rates in children in Saint Petersburg and inpatient trauma care

BACKGROUND:Increasing rates of childhood trauma, poisoning, and sequelae of environmental exposure not only reduce the quality of life of children and their families but also lead to disability and death. Statistical analysis of childhood trauma data makes it possible to define risk age groups among children and adolescents, identify the causes of the decrease or increase in the rates, estimate the level of medical care, and make necessary management decisions.&#x0D; AIM:To assess the state of childhood trauma in St. Petersburg and its changes in 5 years (20162020) and the provision of inpatient trauma care.&#x0D; MATERIALS AND METHODS:Data on childhood trauma in St. Petersburg were analyzed based on the analysis of Federal statistical observation forms submitted by the St. Petersburg State Budgetary Institution Medical Center for Information and Analysis, collections of N.N. Priorov National Medical Research Center for Traumatology and Orthopedics of the Ministry of Health of the Russian Federation Trauma, orthopedic morbidity, the state of trauma and orthopedic care for the population, edited by Acad. S.P. Mironov, RAS, and data from the Federal State Statistics Service.&#x0D; RESULTS:From 2016 to 2019, the frequency of trauma, poisoning, and sequelae of environmental exposure in children of St. Petersburg slightly increased. In 2020, owing to the COVID-19 pandemic, childhood trauma rates decreased, and the most significant decrease in trauma rates was recorded at 32%36% in adolescents aged 1517 years. Despite the overall decrease in childhood trauma in 2020, the structure of trauma due to environmental exposure revealedan81% increase in transport accidents, compared with previous years, anda39% increase in trauma due to injuries with undetermined intentions. For 5 years, the number of beds was reduced, and by 2020, the provision of trauma, and orthopedic beds for children in St. Petersburg was 1.4 beds per 10 thousand children, which corresponds to the data for Russia.&#x0D; CONCLUSIONS:The incidence of traumatic injuries slightly increased in children in St. Petersburg, mostly in children aged 04 years, and mortality from environmental exposure also increased in adolescence.Acorrelation was found between the COVID-19 pandemic andadecrease in the number of visits and hospital admissions of children with trauma to medical institutions. Moreover, the incidence of severe, high-energy injuries that require more serious treatment approaches also increased, as evidenced by the annual increase in the number of surgical interventions in children with traumatic injuries. The new form of statistical reporting does not allow us to determine all causes of trauma. The provision of trauma care for children in St. Petersburg remains atanappropriate level.

Respiratory Symptoms, Allergies, and Environmental Exposures in Children with and without Asthma.

Background: Epidemiological data concerning the level of asthma morbidity indicate that in Poland, asthma is diagnosed in 5–10% of the pediatric population. Aim The purpose of this study was to compare the prevalence of respiratory symptoms and allergies in a group of children with and without asthma and to evaluate the association between exposure to environmental factors and the prevalence of bronchial asthma in a pediatric population. Material and Methods: A cross-sectional study was conducted on a group of 995 children attending primary schools in the province of Silesia in 2018–2019. The research tool was an anonymous questionnaire developed based on the form used in The International Study of Asthma and Allergies in Childhood (ISAAC). Children’s health status, the prevalence of bronchial asthma, and the performance of allergic skin tests were assessed based on parents’ indications in a questionnaire. Environmental exposures such as mold and dampness in apartments or ETS were similarly assessed. Analyses were performed using Statistica 13.0; p < 0.05. Results: A total of 88 subjects (8.8%) suffered from bronchial asthma. Parents of children with asthma, compared to parents of children without the disease, were more likely to rate their children’s health as rather good (43.2% vs. 38.0%) or average (21.6% vs. 3.1%). All analyzed respiratory symptoms, as well as allergies, were statistically more frequent in children with bronchial asthma. Conclusions: The parent’s subjective assessment of the child’s health varied significantly according to the asthma diagnosis. Asthma is also associated with other diseases: allergic reactions to pollen, house dust, hay fever, and AD (atopic dermatitis) were statistically significantly more frequent among children diagnosed with bronchial asthma.

Family life stress, maternal depression and child behavioral health in industrialized Italian cities

Abstract Although family life stress adversely impacts child health, few tools measure its relationship to child outcomes in the setting of maternal variables. This study validates the Italian version of Crisis in Family Systems-Revised (CRISYS-R) and characterizes relationships between family life stress, maternal depression and child behavior in two Italian cities. This cross-sectional study was nested in current research on health impacts of neurotoxic environmental exposures in children. 101 mother-child pairs (child age=9.91±2.17yrs; 53% female) and children's teachers were enrolled in Taranto (south Italy) and Brescia (north Italy). Mothers performed the Italian CRISYS-R and PHQ9; teachers completed Child Behavior Checklist (CBCL/6-18). Spearman's rank correlation coefficients showed associations of family CRISYS-R, maternal PHQ9 and child CBCL/6-18. Wilcoxon Rank-Sum test compared groups of continuous variables. Mothers with depressive symptoms (PHQ9≥5) reported higher ongoing stress and proportion of negative stressors on CRISYS-R than non-depressed mothers (p &amp;lt; 0.05). Children of depressed mothers performed worse in all CBCL/6-18 domains: Internalizing Problems, Externalizing Problems and Total Problems (p &amp;lt; 0.01). Specifically, children of depressed mothers scored higher on subscales of Anxious-Depressed (p &amp;lt; 0.05), Withdrawn-Depressed (p &amp;lt; 0.01), Rule-Breaking (p &amp;lt; 0.01) and Aggressive Behavior (p &amp;lt; 0.05). Maternal depressive symptoms correlated with ongoing stress (rs = 0.27; p &amp;lt; 0.01), child Internalizing Problems (rs = 0.34; p &amp;lt; 0.001), Externalizing Problems (rs = 0.28; p &amp;lt; 0.01) and Total Problems (rs = 0.35; p &amp;lt; 0.001). This study describes links among maternal depression, family life stress, and child behavioral health. It is first to validate Italian CRISYS-R and to explore these factors conjointly in Italian contexts with known neurotoxic exposures. Findings support considering maternal depression and family life stress in child behavioral and environmental health research and policy. Key messages Family life stress, maternal depressive symptoms, and preadolescent behavioral health were highly interrelated in two industrialized Italian cities. The Italian version of CRISYS-R is a useful instrument for assessing and understanding family life stress, a crucial yet under-explored contributor to child behavioral health outcomes.

Current knowledge of environmental exposure in children during the sensitive developmental periods

ObjectiveThis study aims to identify the scientific evidence on the risks and effects of exposure to environmental contaminants in children during sensitive developmental periods. Data sourceThe search was performed in the Bireme database, using the terms: children's health, environmental exposure, health vulnerability, toxicity pathways and developmental disabilities in the LILACS, MEDLINE and SciELO systems. Data synthesisChildren differ from adults in their unique physiological and behavioral characteristics and the potential exposure to risks caused by several threats in the environment. Exposure to toxic agents is analyzed through toxicokinetic processes in the several systems and organs during the sensitive phases of child development. The caused effects are reflected in the increased prevalence of congenital malformations, diarrhea, asthma, cancer, endocrine and neurological disorders, among others, with negative impacts throughout adult life. ConclusionTo identify the causes and understand the mechanisms involved in the genesis of these diseases is a challenge for science, as there is still a lack of knowledge on children's susceptibility to many environmental contaminants. Prevention policies and more research on child environmental health, improving the recording and surveillance of environmental risks to children's health, should be an ongoing priority in the public health field.

Current knowledge of environmental exposure in children during the sensitive developmental periods

ObjectiveThis study aims to identify the scientific evidence on the risks and effects of exposure to environmental contaminants in children during sensitive developmental periods. Data sourceThe search was performed in the Bireme database, using the terms: children's health, environmental exposure, health vulnerability, toxicity pathways and developmental disabilities in the LILACS, MEDLINE and SciELO systems. Data synthesisChildren differ from adults in their unique physiological and behavioral characteristics and the potential exposure to risks caused by several threats in the environment. Exposure to toxic agents is analyzed through toxicokinetic processes in the several systems and organs during the sensitive phases of child development. The caused effects are reflected in the increased prevalence of congenital malformations, diarrhea, asthma, cancer, endocrine and neurological disorders, among others, with negative impacts throughout adult life. ConclusionTo identify the causes and understand the mechanisms involved in the genesis of these diseases is a challenge for science, as there is still a lack of knowledge on children's susceptibility to many environmental contaminants. Prevention policies and more research on child environmental health, improving the recording and surveillance of environmental risks to children's health, should be an ongoing priority in the public health field.

Economic impacts of environmentally attributable childhood health outcomes in the European Union

There is increasing evidence of the role that exposure to industrial chemicals plays in the development of childhood disease. The USA and the European Union (EU) have taken divergent policy approaches to managing this issue, and economic estimates of disease costs attributable to environmental exposures in children are available in the USA but not the EU. We undertook the first economic evaluation of the impacts of childhood environmental chemical exposures in the EU. We used a cost-of-illness approach to estimate health care system costs, and used environmentally attributable fraction modelling to estimate the proportion of childhood disease due to environmental exposures. We analysed data on exposures, disease prevalence and costs at a country level, and then aggregated costs across EU member states to estimate overall economic impacts within the EU. We found the combined environmentally attributable costs of lead exposure, methylmercury exposure, developmental disabilities, asthma and cancer to be $70.9 billion in 2008 (range: $58.9-$90.6 billion). These costs amounted to ~0.480% of the gross domestic product of the EU in 2008. Childhood chemical exposures present a significant economic burden to the EU. Our study offers an important baseline of disease costs before the implementation of Registration, Evaluation and Authorization of Chemicals, which is important for studying the impacts of this policy regime.

ESTIMATING PERSONAL EXPOSURE TO INDOOR AND OUTDOOR AIR POLLUTANTS DURING SCHOOL DAY IN PRIMARY SCHOOLS

Background and Aims: Studies that characterize personal exposure to indoor and outdoor air quality of school children have been limited. This study aimed to extend the knowledge of air quality in schools, develop methodology for estimating personal exposure to air pollutants during school day, and contribute to the current international need for further research in indoor air quality. Methods: Four primary schools in southern England were selected for the study, in urban, suburban and rural environments. Air quality monitoring was conducted in three rounds (autumn, winter, summer) during the academic year 2009-2010. Each round involved monitoring for one week in four locations typical of children’s exposure. Measurements were carried out for particulate matter count of size range 0.5-5.0μm (PM0.5-5.0), carbon dioxide (CO2), carbon monoxide (CO), nitrogen dioxide (NO2), formaldehyde (HCHO), and total volatile organic compounds (tVOC). Time-activity patterns of children in schools were recorded, and used to create a representative personal exposure matrix for each child according to time spent in different environments. Statistical testing compared estimated personal exposure and measured concentrations in school classrooms. Results: We found important differences between personal exposure and measured concentrations during the summer round in all schools, in particular for CO (t-test p-value range: 0.004-0.11), NO2 (&lt;0.001-0.13), HCHO in two schools (0.001-0.15), and PM0.5-5.0 for one school (0.08-0.11). We observed no significant differences during autumn and winter rounds. Results, however, suggested an increase in the weekly variability of greater than 50% in pollutant levels for PM0.5-5.0, NO2, and tVOC in three of the four schools, comparing personal exposure to measured concentrations. Conclusions: These findings show the importance of characterization of personal exposure to indoor and outdoor air pollutants in schools. The findings provide useful methodology that will lead to better quantification of environmental exposures in children, thus strengthening the estimation of the exposure-risk association.

Assessment of airborne bacteria and fungi in an indoor and outdoor environment

Airborne indoor and outdoor bacteria and fungi were assessed during the spring season using conven- tional methods to investigate the enumeration and identification of airborne micro-organisms. This was determined through air quality sampling using the 'open plate technique'. The air samples were collected during the spring season (March-May) from four different locations. Conventional enumeration of airborne micro-organisms relies on culture- based or microscopic methods. Although a culture-based analysis is most widely used for bio-aerosol, four public places located in urban residential areas were selected for indoor/outdoor air bio-pollutant measurement. The public places included kitchens, classrooms, recreational areas, laboratories. Public parks are an important facility associated with the environmental exposure of children. Cultivation and total microscopic enumeration methods were employed for the sample analysis. 26 groups of bacteria and fungi, either of human or environmental origin were detected. Environmental agents generally predominated while significantly higher counts were detected as the level of hygiene or standard of housing dropped. Seven genera of fungi, mainly members of the genus Aspergillum, were isolated from all residents. Bacteria shows higher growth numbers as opposed to the slow growing fungi. Sample collection and pretreatment, determination techniques and performance results are summarized and discussed.

Review Series: What goes around, comes around: childhood influences on later lung health?: Relationship between environmental exposures in children and adult lung disease: The case for outdoor exposures

There is a growing understanding that chronic respiratory diseases in adults have their origins in early life. Adverse environmental exposures occurring in vulnerable periods during lung growth and development in the fetal period and in early childhood that alter lung structure and limit the growth in lung function may have lifelong consequences. Evidence is increasing that exposure to the ambient environment, including air pollutants, persistent toxic substances, water pollutants and respiratory viral infections, can inhibit lung function growth and predispose to chronic non-malignant lung diseases. These exposures generally interact with a genetic predisposition, and gene-environment interactions and epigenetic phenomena are attracting considerable study. An understanding of how ambient exposures impact on normal lung growth and development will aid in understanding of how chronic respiratory diseases of adults develop and may lead to new preventative strategies.

Somatic mutant frequency at theHPRT locus in children associated with a pediatric cancer cluster linked to exposure to two superfund sites

The somatic mutant frequency (Mf) of the hypoxanthine phosphoribosyl transferase (HPRT) gene has been widely used as a biomarker for the genotoxic effects of exposure but few studies have found an association with environmental exposures. We measured background Mfs in 49 current and former residents of Dover Township, New Jersey, who were exposed during childhood to industrially contaminated drinking water. The exposed subjects were the siblings of children who developed cancer after residing in Dover Township, where the incidence of childhood cancer has been elevated since 1979. Mfs from this exposed group were compared to Mfs in 43 age-matched, presumably unexposed residents of neighboring communities with no known water contamination and no increased cancer incidence. Statistical comparisons were based on the natural logarithm of Mf (lnMF). The mean Mf for the exposed group did not differ significantly from the unexposed group (3.90 x 10(-6) vs. 5.06 x 10(-6); P = 0.135), but unselected cloning efficiencies were higher in the exposed group (0.55 vs. 0.45; P = 0.005). After adjustment for cloning efficiency, lnMf values were very similar in both groups and age-related increases were comparable to those previously observed in healthy children. The results suggest that HPRT Mf may not be a sensitive biomarker for the genotoxic effects of environmental exposures in children, particularly when substantial time has elapsed since exposure.

The environmental history in pediatric practice: a study of pediatricians' attitudes, beliefs, and practices.

We conducted a mail survey of practicing pediatricians in Georgia to assess their knowledge, attitudes, and behaviors regarding recording patients' environmental histories. Of 477 eligible pediatricians, 266 (55.8%) responded. Fewer than one in five reported having received training in environmental history-taking. Pediatricians reported that they strongly believe in the importance of environmental exposures in children's health, and 53.5% of respondents reported experience with a patient who was seriously affected by an environmental exposure. Pediatricians agreed moderately strongly that environmental history-taking is useful in identifying potentially hazardous exposures and in helping prevent these exposures. Respondents reported low self-efficacy regarding environmental history-taking, discussing environmental exposures with parents, and finding diagnosis and treatment resources related to environmental exposures. The probability of self-reported history-taking varied with the specific exposure, with environmental tobacco smoke and pets most frequently queried and asbestos, mercury, formaldehyde, and radon rarely queried. The pediatricians' preferred information resources include the American Academy of Pediatrics, newsletters, and patient education materials. Pediatricians are highly interested in pediatric environmental health but report low self-efficacy in taking and following up on environmental histories. There is considerable opportunity for training in environmental history-taking and for increasing the frequency with which such histories are taken.

Assessing environmental exposure in children: immunotoxicology screening.

Environmental exposure to a number of xenobiotics, including pesticides, can have serious effects on the immune system of children, thus rendering them susceptible to infections or other disease states. To study this problem, a recycling chromatographic system for assessing cytokine profiles in humans has been developed and used for the measurement of immune system function in children with documented exposure to residential pesticides. The system is capable of measuring 30 different analytes in a single sample thus enabling the same time examination of representative markers of immune differentiation and function. In the present study, a cohort of 25 exposed children were examined and shown to exhibit a number of features; all subjects demonstrated some abnormalities in cytokines associated with hematopoiesis. Additionally, elevations in pro-inflammatory cytokines and neuropeptides indicated a state of generalized and neurogenic inflammation. Further analysis indicated that a depression of the cellular arm of the immune system that correlated with clinical indicators of lowered host resistance to infection could also be detected in a subgroup of the exposed subjects. All exposed children demonstrated evidence of hyperstimulation of the humoral immune system as indicated by elevated IL-5 concentrations and clinical allergy. The degree of immune dysregulation in the exposed children was found to be quite marked when compared to similar studies performed on age-matched controls.

Recurrent respiratory tract infections in paediatric patients.

Paediatric respiratory tract infections are one of the most common reasons for physician visits and hospitalisation, and are associated with significant morbidity and mortality. The role of physicians and other healthcare professionals has expanded from merely treating disease to implementing measures aimed at health maintenance and disease prevention. Therefore, children with recurrent respiratory tract infections represent a great challenge for the paediatrician, from both therapeutic and preventive standpoints. The paediatrician must first determine whether these recurrent infections are because of host-derived factors or are the result of increased environmental exposure. Host-derived factors may be nonimmunological or related to host immunodeficiency. The leading cause of recurrent respiratory tract infections throughout the world is increased environmental exposure in children attending nursery school or daycare centres. Acute otitis media in children is of particular concern because of its high incidence, frequent recurrence, and serious long term sequelae, e.g. hearing loss. The socioeconomic impact of these recurrent infections is staggering, and there remains much scope for devising methods for their treatment and prevention. Recent approaches have included the encouragement of breastfeeding, the use of intravenous immunoglobulin and respiratory syncytical virus immune globulin, as well as methods of stimulating immunity, such as ribosomal immunotherapy.

Age-specific carcinogenesis: environmental exposure and susceptibility.

Environmental exposures in children may occur through many routes, including diet, air, and the ingestion of various nonfood items such as medications and household materials. This article focuses on dietary exposure, but it does highlight the importance of considering other routes of exposure when assessing exposure in children. It presents many of the findings in the two recent reports, Pesticides in the Diets of Infants and Children and Science and Judgment in Risk Assessment of the National Academy of Sciences (NAS)/National Research Council (NRC). Diet is an important source of exposure for children to potential carcinogens. The trace quantities of chemicals present on or in foodstuffs are termed residues. In addition, there are substances that children may be exposed to in air and water that should be considered in a total exposure analysis. To minimize exposure of the general population to chemical residues in food, water, and air, the U.S. government has instituted regulatory controls. These are intended to limit exposures to residues while ensuring an abundant and nutritious food supply, and safe drinking water and air. The legislative framework for these controls was established by the Congress through various local and state laws and such federal laws as the Insecticide, Fungicide, and Rodenticide Act (FIFRA), the Federal Food, Drug, and Cosmetic Act (FFDCA), the Safe Drinking Water Act (SDWA), and the Clean Air Act (CAA). This article summarizes current approaches to assessing exposure and susceptibility in children.

Race and Gender Differences in Respiratory Illness Prevalence and Their Relationship to Environmental Exposures in Children 7 to 14 Years of Age

Race and gender differences in respiratory illness prevalence rates were assessed in a cohort of 8,322 white children and 1,056 black children 7 to 14 yr of age from four U.S. cities. Boys had higher rates of wheeze, asthma, cough, phlegm, and bronchitis than girls. Black children had higher rates of persistent wheeze, shortness of breath with wheeze, asthma, chronic cough, and chronic phlegm than white children. We examined whether the racial disparity in respiratory illness prevalence could be accounted for by environmental exposures and socioeconomic factors. The proportion of families without a parent who had graduated from high school was higher for blacks than for whites, as was the proportion of single-parent households. Black children took up smoking less frequently; their mothers smoked fewer cigarettes. Personal and maternal smoking predicted higher rates of persistent wheeze, chronic cough, chronic phlegm, and chest illness. The relative odds for persistent wheeze were 1.34 (1.07, 1.69) for smoking children compared with nonsmoking children. The relative odds for persistent wheeze were 1.35 (1.13, 1.60) for children whose mother smoked > 30 cigarettes per day versus children with no maternal smoke exposure. Other predictors of respiratory illnesses included parental respiratory illness, parental education, only-child status, single-parent household, air conditioner use, and body mass index. Nevertheless, adjustment for socioeconomic factors, environmental exposures, and body habitus did not significantly reduce the excess respiratory illness prevalence observed among black children. The adjusted relative odds were 1.47 (1.25, 1.74) for persistent wheeze and 1.57 (1.17, 2.10) for asthma for black children versus white children.(ABSTRACT TRUNCATED AT 250 WORDS)

The feasibility of using lead in hair concentration in monitoring environmental exposure in children.

The feasibility of lead in hair as an indicator of lead exposure has been compared to that of lead in blood and zinc protoporphyrin in blood levels in 1--3-year-old children living within 1 km of a lead smelter. Lead exposure was measured as lead in house dust, outdoor and indoor lead in air concentrations, outdoor and indoor lead depositions, and subjective assessment of indoor dustiness. Lead in blood ranged from 51-353 microgram/l and lead in hair from 0.8-114 microgram/g. It can be concluded that within the range of environmental exposure studied, and for the age group concerned, measurement of lead in blood and of the zinc protoporphyrin in blood levels appear to be better biological parameters to assess both total environmental exposure and health risk than measurement of lead in hair level alone.

Bedside Etiology of Childhood Cancer

The following topics are discussed: adenocarcinomas of the vagina in young women exposed prenatally to diethylstilbestrol; neuroblastoma in children exposed prenatally to hydantoin; increased frequency of leukemia in Japanese children surviving the atomic bomb; cancer in adults following administration of /sup 224/Ra during childhood; increased risk of lung cancer following environmental exposure of children to asbestos; lung cancer in adults following exposure to lead, copper, zinc, and arsenic; association of chromosomal aberrations with leukemia in children exposed to x radiation and benzene; immunosuppression in lymphoma patients; renal dysplasia in patients with Wilms' tumor; and aggregation of neoplasms in families. (HLW)