This article examines the transformative role of Machine Learning (ML) in Supply Chain Risk Management (SCRM), emphasizing its ability to enhance risk prediction and mitigation through real-time, data-driven insights. It demonstrates how ML applications like demand forecasting, inventory optimization, supplier risk assessment, and fraud detection improve supply chain resilience by analyzing large datasets to identify patterns, predict risks, and recommend proactive actions. However, the article also highlights key challenges, including data quality, availability, and privacy issues, which limit the effectiveness of ML models. Integrating ML with legacy systems poses additional technical and financial difficulties, particularly for smaller businesses. High implementation costs and scalability constraints further hinder widespread adoption. Ethical concerns, such as data bias and privacy, still need to be explored, raising questions about responsible ML use in supply chains. Future research should address these gaps by improving data governance frameworks for accuracy and privacy, developing scalable ML models suited to various supply chain environments, and exploring synergies with technologies like blockchain and the Internet of Things (IoT). These advancements will help realize ML’s full potential, fostering more agile, transparent, and resilient supply chains capable of navigating complex global risks. By tackling these challenges, ML can shift SCRM from reactive to proactive, ensuring long-term operational continuity and a competitive edge in the evolving global market.