To address the issue of uneven heat transfer in parabolic trough solar collectors, this study introduces an innovative insert (composed of vortex generators) layout. The vortex generators are strategically placed in areas with high heat flux density, while their number is reduced in regions with low heat flux density. By adjusting the position of the central rod, the inserts are defined as three different layout strategies (central structure, low eccentric structure, and upper eccentric structure), and their thermal performance is analyzed. The differences in fluid flow and heat transfer induced by different structures are also compared. The results show that the upper eccentric structure can induce unevenly distributed high-intensity mixing vortices, and through the ejection and sweeping movements of these vortices, the high-temperature fluid in areas with high heat flux density is transported to positions with low geothermal flow. Among all the studied configurations, the upper eccentric structure achieves a Nusselt number increase ranging from 1.16 to 2.34 times and a friction number value increase between 1.47 and 5.38 times. In terms of heat transfer performance, the highest value is 1.43 when the number of vortex generators is 6 and Reynold number is 13,750. Additionally, the thermal performance of the inserted tubes is analyzed using the field synergy principle and entropy generation method.