High-speed maneuvering target inverse synthetic aperture radar (ISAR) imaging is always a hot topic in signal processing. High-speed maneuvering targets often have high-order maneuvering characteristics, such as translational and rotational characteristics, which destroy the signal structure of stationary targets and make basic imaging processing methods such as range-Doppler (RD) algorithm no longer suitable. In this paper, a high-resolution imaging method for high-speed maneuvering targets is proposed, which uses the fast sparse Bayesian learning (SBL) algorithm and the minimum entropy algorithm for ISAR high-resolution imaging and motion parameter estimation, respectively. Because SBL makes full use of the characteristics of the target and the environment, it can obtain an ISAR high-resolution image of the maneuvering target. However, the high computational complexity caused by matrix inversion and some matrix operations in SBL iteration limit the practical application of SBL in ISAR imaging. In view of the special structure of the matrix required to be inverted, we propose a fast SBL algorithm, which uses a new decomposition method to obtain the decomposition formula of the inverse matrix. Based on the decomposition factors, the multiplication operation involving the inverse matrix can be quickly calculated using fast Fourier transform (FFT), which greatly improves the computational efficiency. Image entropy represents the sharpness and focusing degree of an image, and so the minimum entropy algorithm can estimate the motion parameters of maneuvering targets more accurately. We combine the minimum entropy algorithm with the fast SBL algorithm to realize phase error correction and high-resolution imaging, which has better noise sensitivity and can obtain the best focusing degree image. Finally, simulation results prove the effectiveness of this algorithm.