This research paper aims to analyze the significant contributions of enterprise architecture (EA) in leveraging digital transformation (DT) success at an international level. The paper adopts a meta-analytical approach, examining the patterns of EA’s strategic alignment and operational impact. EA plays a crucial role in managing digital ecosystem complexity, which is a key factor in successful DT. The methodology also focuses on the systematic review and meta-analysis of the relationships between EA and other advanced technological systems such as AI, IoT, and Blockchain to reveal how these technologies improve EA’s flexibility and strategic approaches. The paper emphasizes the importance of organizational culture, technological incorporation, and regional economic factors as critical determinants of EA practices in DT activities. It underscores the necessity for customized EA approaches to DT success within different cultural and economic contexts and their impact on sustainable management. This practical insight is a crucial contribution of the paper, providing a strategic roadmap for organizations aiming to optimize their digital transformation strategies through enhanced EA practices.