AbstractA severe persistent drought occurred in South China during autumn–winter 2020/2021, causing enormous economic losses and severe water shortage in South China. Focusing on this event, this study analyzed the climate anomalies associated with this event, and investigated the underlying mechanisms as well as their relationship with the leading modes of the autumn and winter precipitation in eastern China. The results suggest that the drought in South China during autumn 2020 is mainly attributed to the water vapor divergence anomalies induced by an anomalous anticyclone over eastern China and an anomalous cyclone over the South China Sea, which are caused by an anomalous Eurasian atmospheric wave‐train triggered by the negative sea ice anomalies in the Barents Sea‐Kara Sea region and a La Niña‐like condition in the tropical Pacific sea surface temperatures, respectively. The continued drought in South China during winter 2020/2021 is mainly attributed to the water vapor divergence anomalies induced by an anomalous cyclone over the western North Pacific, which is caused by the continued La Niña‐like condition. The mechanisms of the first two leading modes of autumn precipitation in eastern China both contributed to the drought in South China during autumn 2020, whereas the mechanisms of the first leading mode of winter precipitation in eastern China played an important role in causing the drought in South China during winter 2020/2021. Numerical experiments demonstrate important impact of the ENSO and Arctic sea ice anomalies on the East Asian climate anomalies during autumn–winter 2020/2021.