With the arrival of the information society, multifunctional integrated devices based on two-dimensional (2D) materials are crucial for promoting advanced technology. However, the impact of coupling of various physical effects on their performance remains unexplored. Herein, the influence of coupling of piezoelectricity, photoexcitation and ferroelectricity within 2D ferroelectric CuInP2S6 (CIPS), that is, the piezo-phototronic effect and the bulk photovoltaic effect, on the device photoelectric performance have been investigated. Our experiments show that the piezo-phototronic effect can improve the photoelectric performance of the poled devices by 1.36 times, and ferroelectric polarization in turn increases the impact of the piezo-phototronic effect on the performance of the poled devices by 3.8 times. Systematically band diagram analysis reveals that this mutual enhancement mechanism can be attributed to the contribution of piezoelectric polarization charges and Cu+ ions movement to carrier migration, which was supported by Kelvin probe force microscope, STEM, and first-principles calculations. Furthermore, an architecture monitoring system based on a CIPS device was constructed to detect building tilt in real-time. Our work provides a paradigm for enhancing the photoelectric performance of 2D ferroelectrics and has profound significance in investigating multi-physics effects coupling mechanisms in a single material.