Enhanced Specular Reflector Research Articles

Terahertz tomography for testing wrapped scintillating crystals

Terahertz time-domain spectroscopy (THz-TDS) is demonstrated to be effective in novel application, for 3D characterization of wrapped scintillator crystals in search for defects affecting the light-yield of these crystals. This is of special importance for fast scintillators currently in demand to be exploited in high-energy physics experiments and medical imaging devices. Typical inorganic (GAGG:Ce) and organic (BC-408) scintillators wrapped in polytetrafluoroethylene (PTFE) and enhanced specular reflector (ESR) tapes have been studied. Time-of-flight information extracted from THz-TDS data reveals positions of the interfaces between the materials, wrapping thickness variations, and allows for the wrapping inspection with resolution better than a single layer, typically ∼200 μm-thick, of PTFE, the currently most common wrapping material. The results are supported by the study of the properties of the wrapping materials in the THz range and evidence of the prospectiveness of THz-TDS technique as a novel tool for nondestructive inspection of wrapped scintillators.

Reduction of light output of plastic scintillator tiles during irradiation at cold temperatures and in low-oxygen environments

The advent of the silicon photomultiplier has allowed the development of highly segmented calorimeters using plastic scintillator as the active media, with photodetectors embedded in the calorimeter, in dimples in the plastic. To reduce the photodetector’s dark current and radiation damage, the high granularity calorimeter designed for the high luminosity upgrade of the CMS detector at CERN’s Large Hadron Collider will be operated at a temperature of about −30 °C. Due to flammability considerations, a low oxygen environment is being considered. However, the radiation damage to the plastic scintillator during irradiation in this operating environment needs to be considered. In this paper, we present measurements of the relative decrease of light output during irradiation of small plastic scintillator tiles read out by silicon photomultipliers. The irradiations were performed using a 60Co source both to produce the tiles’ light and as a source of ionizing irradiation at dose rates of 0.3, 1.3, and 1.6 Gy/h, temperatures of −30, −15, −5, and 0 °C, and with several different oxygen concentrations in the surrounding atmosphere. The effect of the material used to wrap the tile was also studied. Substantial temporary damage, which annealed when the sample was warmed, was seen during the low-temperature irradiations, regardless of the oxygen concentration and wrapping material. The relative light loss was largest with 3MTM Enhanced Specular Reflector Film wrapping and smallest with no wrapping, although due to the substantially higher light yield with wrapping, the final light output is largest with wrapping. The light loss was less at warmer temperatures. Damage with 3% oxygen was similar to that in standard atmosphere. Evidence of a plateau in the radical density was seen for the 0 °C data.

Improving the resolution and light yield in CsI(Tl) scintillators

In the search for Dark Matter, very low-energy sensitive detectors are needed that would be able to distinguish minute differences in closely residing energy peaks. To increase the ability of CsI(Tl) scintillator detectors to do so, a different wrapping material will be used on the innermost layer of the detector. This wrapping material is a 3MTM Enhanced Specular Reflector (ESR) material which is hypothesized to produce a higher light yield with better resolution than the PTFE wrapping of plumber’s tape due to its high reflectivity. Two different types of measurements were carried out to test this hypothesis. Each test was run on a different half of a CsI(Tl) rectangular crystal of volume 48 in3. First, a source of 60Co was used to test the difference between the wrappings. The test was run an hour for the PTFE and the ESR wrapping. We observe a 35% increase in the ADC count for each 60Co energy peak and 15% decrease in the value of the standard deviation around those peaks. Secondly, a source of 241Am was used to test the low-energy capabilities of the ESR material. Here also we see a significant increase in the ADC count for the two energy peaks of the 241Am source. Due to the high photon reflectivity capability of the ESR film, our detector is more capable of collecting photons created by low-energy interactions. As we know Dark Matter produces very low-energy recoils, while interacting with the detector target material, so the ability to contain a maximum number of photons within the detector volume will help us move one step closer to detecting the rare interaction. Because of this significant increase in light yield and general decrease in standard deviation, it is clear that the ESR material has a greater ability to gather higher resolution data than its predecessor. This could lead to a greater understanding of low-energy particles, which in turn could help us understand what Dark Matter really is.

Evaluation of plastic scintillating fibers coating technique for muon imaging detector using a Compton-coincidence-technique system

This study is devoted to studying the performance of plastic scintillating fibers (PSFs) for a high-position-resolution muon imaging detector. A test system based on the Compton coincidence technique is designed to study the light collection of the PSFs. When Compton scattering occurs between the PSFs and gamma ray emitted by the collimated radioactive source, the PSF detector has detected the definite energy of recoiled electrons, and the coincidence detector has detected the energy of scattered photons. Four groups of PSFs were tested, three of which were wrapped with the Enhanced Specular Reflector (ESR) in different ways. The experimental results show that the light collection of the PSF detector can be increased by wrapping the PSFs with ESR and leaving an air gap between the PSF and the ESR. Meanwhile, the light collection is increased while the position where Compton scattering occurs in the PSF is closer to the silicon photomultiplier (SiPM). This study provides a method for measuring the light collection in narrow PSFs. In conclusion, the presence and fine wrapping of the ESR ensure the isolation and position accuracy in the arrays of PSFs.

Scintillation characteristics of chemically processed Ce:GAGG single crystals.

We investigated the correlation between the surface finish and luminescence properties of chemically polished cerium-doped single-crystal Gd3Al2Ga3O12 scintillators (Ce:GAGG), from the crystallographic perspective. The intrinsic defects in the crystals were identified via photoluminescence spectroscopy followed by scanning electron microscopy and X-ray diffraction to analyze their surface morphologies. Finally, the samples were individually wrapped with an enhanced specular reflector (ESR), coupled with a photomultiplier tube, placed inside a dark box, connected to a digitizer, and irradiated with a 137Cs radioactive source to evaluate the relative light (signal) output and energy resolution of each sample. The as-cut (rough) Ce:GAGG single-crystal samples, that were chemically polished with phosphoric acid at 190°C in air for 60 min, demonstrated a 33.1% increase in signal amplitude (light output to photosensor) and 2.4% (absolute value) improvement in energy resolution, which were comparable to those obtained for the mechanically polished sample. For these samples, the surface roughness was found to be ~430 nm, which was approximately half of that of the mechanically polished sample. The chemical polishing method used in this study is a cost-effective and straightforward technique to improve structural imperfections and can facilitate the treatment of inorganic scintillators with complex shapes and/or on a large scale.

Position estimation using neural networks in semi-monolithic PET detectors

Objective. The goal of this work is to experimentally compare the 3D spatial and energy resolution of a semi-monolithic detector suitable for total-body positron emission tomography (TB-PET) scanners using different surface crystal treatments and silicon photomultiplier (SiPM) models. Approach. An array of 1 × 8 lutetium yttrium oxyorthosilicate (LYSO) slabs of 25.8 × 3.1 × 20 mm3 separated with Enhanced Specular Reflector (ESR) was coupled to an array of 8 × 8 SiPMs. Three different treatments for the crystal were evaluated: ESR + RR + B, with lateral faces black (B) painted and a retroreflector (RR) layer added to the top face; ESR + RR, with lateral faces covered with ESR and a RR layer on the top face and; All ESR, with lateral and top sides with ESR. Additionally, two SiPM array models from Hamamatsu Photonics belonging to the series S13361-3050AE-08 (S13) and S14161-3050AS-08 (S14) have been compared. Coincidence data was experimentally acquired using a 22Na point source, a pinhole collimator, a reference detector and moving the detector under study in 1 mm steps in the x- and DOI- directions. The spatial performance was evaluated by implementing a neural network (NN) technique for the impact position estimation in the x- (monolithic) and DOI directions. Results. Energy resolution values of 16 ± 1%, 11 ± 1%, 16 ± 1%, 15 ± 1%, and 13 ± 1% were obtained for the S1 3-ESR + B + RR, S1 3-All ESR, S14-ESR + B + RR, S14-ESR + RR, and S14-All ESR, respectively. Regarding positioning accuracy, mean average error of 1.1 ± 0.5, 1.3 ± 0.5 and 1.3 ± 0.5 were estimated for the x- direction and 1.7 ± 0.8, 2.0 ± 0.9 and 2.2 ± 1.0 for the DOI- direction, for the ESR + B + RR, ESR + RR and All ESR cases, respectively, regardless of the SiPM model. Significance. Overall, the obtained results show that the proposed semi-monolithic detectors are good candidates for building TB-PET scanners.

Organic glass scintillator formulations and mold development towards scalable and cast-in-place pixelated fabrications

Herein we describe the development of organic glass scintillator (OGS) additives to enable the rapid and simple fabrication of form factors necessitated by pixelated neutron detection systems. These systems, developed for national security purposes, utilize arrays of many (O(100–1000))​ bar-shaped scintillators which are optically isolated and coupled to photodetectors. We describe two overall methods to address the construction of pixelated scintillator arrays at scale: individual bars cast directly in single bar molds, reducing the need to cut the bars to size, and casting directly into pixelated molds, eliminating both the need to cut the bars to size and to fabricate the array from individual bars. The mechanical blending of pre-polymerized plastic pellets of polystyrene and polycarbonate in OGS can be formulated up to 5% by weight into OGS to rigidify high aspect-ratio bars capable of withstanding the additional stress of being cast simultaneously side by side in a single pour with a variety of new mold materials. In addition, the inclusion of 15%–20% of “2-(p-tolyl)-1,3,2-dioxaborinane” (TDB) can enable direct, cast-in-place of OGS bars into aluminum or acetal sheet molds of arrays. We also describe the developments into the new mold materials and assembly to support the casting into these form factors. As a proof of concept, we cast a single pixel directly into a mold lined with 3M’s enhanced specular reflector (ESR) and characterize its performance for neutron detection applications.

Study of optical reflectors for a 100ps coincidence time resolution TOF-PET detector design

Positron Emission Tomography (PET) reconstructed image signal-to-noise ratio (SNR) can be improved by including the 511 keV photon pair coincidence time-of-flight (TOF) information. The degree of SNR improvement from this TOF capability depends on the coincidence time resolution (CTR) of the PET system, which is essentially the variation in photon arrival time differences over all coincident photon pairs detected for a point positron source placed at the system center. The CTR is determined by several factors including the intrinsic properties of the scintillation crystals and photodetectors, crystal-to-photodetector coupling configurations, reflective materials, and the electronic readout configuration scheme. The goal of the present work is to build a novel TOF-PET system with 100 picoseconds (ps) CTR, which provides an additional factor of 1.5–2.0 improvement in reconstructed image SNR compared to state-of-the-art TOF-PET systems which achieve 225–400 ps CTR. A critical parameter to understand is the optical reflector’s influence on scintillation light collection and transit time variations to the photodetector. To study the effects of the reflector covering the scintillation crystal element on CTR, we have tested the performance of four different reflector materials: Enhanced Specular Reflector (ESR) –coupled with air or optical grease to the scintillator; Teflon tape; BaSO4 paint alone or mixed with epoxy; and TiO2 paint. For the experimental set-up, we made use of 3 × 3 × 10 mm3 fast-LGSO:Ce scintillation crystal elements coupled to an array of silicon photomultipliers (SiPMs) using a novel ‘side-readout’ configuration that has proven to have lower variations in scintillation light collection efficiency and transit time to the photodetector. Results: show CTR values of 102.0 ± 0.8, 100.2 ± 1.2, 97.3 ± 1.8 and 95.0 ± 1.0 ps full-width-half-maximum (FWHM) with non-calibrated energy resolutions of 10.2 ± 1.8, 9.9 ± 1.2, 7.9 ± 1.2, and 8.6 ± 1.7% FWHM for the Teflon, ESR (without grease), BaSO4 (without epoxy) and TiO2 paint treatments, respectively.

Simulations of light collection in long tapered CsI(Tl) scintillators using real crystal surface data and comparisons to measurement

Simulation results for light transport in long tapered CsI(Tl) crystals using look-up tables (LUTs) are presented. The LUTs were derived from the topography of a polished and a lapped surface of a CsI(Tl) crystal measured with atomic force microscopy. Simulations with different combinations of polished and lapped surfaces were performed, to extract the non-uniformity of light collection depending on the interaction point, and compared to experimental results. The simulations reproduce the general trend given by the measurements, and show that more homogeneous light collection is attained when all lateral sides of the crystal are lapped. For the lapped crystal the simulation model is most sensitive to the reflectivity of the enhanced specular reflector (ESR) foil surrounding the crystal, which is one of several properties influencing the light transport examined in this study. The sensitivity of the light-output non-uniformity to variations in the absorption length observed in a batch of CsI(Tl) crystals in a previous study is also discussed. Residual differences between the simulation and the measurements can potentially be attributed to the scattering of scintillation photons inside the materials used. Additional measurements to further advance the construction of the simulation model are suggested.

Performance evaluation of GAGG(Ce)/LFS scintillator ＋ MPPC array readout with ASIC

We constructed a gamma-ray detector by combining two types of scintillator array detectors with an MPPC array and evaluated the spectral performance by reading out the signals from the MPPC with a low-power integrated circuit (ASIC) manufactured by IDEAS in Norway. One of the two types of scintillators is a GAGG(Ce) (Ce-doped Gd3Al2Ga3O12) scintillator, and the other is an LFS scintillator. The scintillator array is 2.5 cm × 2.5 cm in size and is coated with BaSO4-based white paint for GAGG(Ce) and an enhanced specular reflector (ESR) for LFS except for the side optically coupled to the MPPC. The spectra derived from the array are affected by the MPPC photon saturations and light leakage from the adjacent pixels, and we carefully corrected for both effects in our data analysis. The energy resolution of 662 keV at 20 °C is 6.10 ± 0.04% for the GAGG(Ce) scintillator array and 8.57 ± 0.15% for the LFS scintillator array, this is equivalent to the typical energy resolution found in the references. The energy resolution depends on the temperature: the energy resolution improves as the temperature decreases. We found that the contribution of thermal noise from the MPPCs to the energy resolution is negligible within the range of −20 to 40 °C, and the energy resolution is mainly determined by the light yield of the crystals.

Preliminary study of passive radiative cooling under Singapore's tropical climate

Sub-ambient cooling can be achieved through radiative coolers that selectively emit radiation within the atmospheric window (8–13 μm) to outer space and suppress absorption/emission of other wavelengths. This study explores the feasibility of adopting radiative cooling in the hot and humid climate of Singapore through both numerical and experimental approaches. A theoretical simulation based on the heat transfer balance is first proposed to obtain the cooling power of the radiative cooler considering different solar spectral irradiance and total water vapor column. The larger solar irradiance in Singapore, especially within the ultraviolet and visible light spectrum where the absorbance of the material is relatively high, could counteract its cooling effects. Moreover, the increased atmospheric radiation induced by higher humidity and temperatures in Singapore could worsen cooling performances of the radiative material. Next, experimental investigations were conducted by measuring the steady-state temperatures of two radiative coolers (photonic radiative cooler and enhanced specular reflector film) under three typical weather conditions in Singapore, namely clear, partly cloudy and cloudy skies. While both radiative coolers were unable to achieve daytime cooling performance on a clear day, the enhanced specular reflector (ESR) film with higher solar reflectance can reach sub-ambient temperatures on a cloudy day. When it comes to night-time, the steady-state temperature of the photonic radiative cooler and ESR film was about 3.5 °C and 5 °C lower than ambient, respectively.

Compton PET: a layered structure PET detector with high performance

In most high-resolution PET detector designs, there is an inherent trade-off between spatial resolution and detector efficiency. We have developed and tested a new geometry for the detector module which avoids this trade-off. The module uses a layered structure, in which four crystal slabs are stacked in the depth direction and optically separated by enhanced specular reflector (ESR) film. The scintillation light within each layer is measured by 16 SiPMs located on the four sides of the crystal. Analog signals from all SiPMs (4 × 16) on the four sides of the crystal are digitized individually using a 64-channel TOFPET-2 module. The four-sided readout method reduces the problem of light trapping resulting from total internal reflection when reading out the end(s) of traditional scintillation crystal arrays, thus increasing the light collection efficiency. In this work, we demonstrate the readout of a complete layered detector with 4 layers. The high light collection efficiency results in a FWHM energy resolution of 10.3%, and a FWHM timing resolution of 348 ps. The distribution of scintillation light detected by the SiPMs was used to decode the interaction position of each gamma ray using a trained neural network. A FWHM spatial resolution of 1.1 ± 0.1 mm was achieved. This design allows the detection efficiency of the module to be increased by adding additional crystal slabs along the depth direction. Since the position, energy, and timing are measured for each layer independently, increasing the system sensitivity by adding more layers will not affect the spatial/energy/timing resolution. Furthermore, the layered structure allows partial recovery of position information for events that undergo Compton scatter within the detector.

Performance of long rectangular semi-monolithic scintillator PET detectors.

High-sensitivity and high-resolution depth-encoding positron emission tomography (PET) detectors are required to simultaneously improve the sensitivity and spatial resolution of a PET scanner so that the quantitative accuracy of PET studies can be improved. The semi-monolithic scintillator PET detector has the advantage of measuring the depth of interaction with single-ended readout as compared to the traditional pixelated scintillator detector, and significantly reducing the edge effect that deteriorates the spatial resolution at edges of the detector as compared to the monolithic scintillator detector if a long rectangular semi-monolithic detector is used. In this work, depth-encoding PET detector modules were built by using long rectangular semi-monolithic scintillators and single-ended readout by silicon photomultiplier (SiPM) arrays. The performance of the detector modules was measured. The rectangular semi-monolithic scintillator detector has an outside dimension of 11.6×37.6×10mm3 and consists of 11 polished lutetium-yttrium oxyorthosilicate (LYSO) slices measuring 1×37.6×10mm3 . The enhanced specular reflector (ESR) was glued on both cross-sectional surfaces of each crystal slice. For the face opposite to the SiPM array and the two end faces of the detectors, surface treatments with and without black paint were implemented for performance comparison. The bottom face of the semi-monolithic detector was coupled to a 4×12 SiPM array that was grouped along rows and columns separately into 16 signals. The four row signals were used to identify the slices, and the 12 column signals were used to estimate the y (monolithic direction) and z (depth direction) interaction positions. The detector was irradiated at multiple positions with a collimated 511keV gamma beam. The collimated beam was obtained with electronic collimation by using a 22 Na point source and a reference detector. The estimated width of the gamma beam is around 0.5mm. The flood histogram for crystal slices was measured by using the center of gravity (COG) method. The COG method and the squared COG method were used for y position estimation. The standard deviation of the column signals, the ratio of maximum to the sum of the column signals, and the sum of squared column signals were used for z position estimation. All slices were clearly resolved from the measured flood histograms for both detectors with different crystal surface treatments. The estimated y positions roughly linearly change with the true positions at the middle of the detector until ~5mm from both ends of the detector. The y and z spatial resolutions of the detectors were estimated for all middle positions located more than 5mm from both ends of the detector. The squared COG method provides better y position resolution than the COG method. The three z estimation methods provide similar depth of interaction (DOI) resolution. Surface treatment with black paint significantly improves both y and z position resolution but degrades the energy and timing resolution of the detectors. The average full width half maxima (FWHM) spatial resolution is improved from 1.77 to 1.07mm in the y direction by using the squared COG method and from 2.71 to 1.55mm in the z direction by using the standard deviation method. The slice-based average energy resolution degrades from 15.8% to 24.9%. The timing resolution of the entire detector module degrades from 596 to 788ps. The performance of rectangular semi-monolithic scintillator PET detectors with two different crystal surface treatments was measured. The detectors provide superior spatial resolution and depth-encoding capability and can be used to develop small animal and dedicated breast and brain PET scanners that can simultaneously achieve high spatial resolution, high sensitivity, and low cost.

Studies on sub-millimeter LYSO:Ce, Ce:GAGG, and a new Ce:GFAG block detector for PET using digital silicon photomultiplier

The spatial, timing, and energy resolutions of a detector affect the image quality of a positron emission tomography (PET) system. These parameters are in turn dependent on various factors, such as the choice of scintillator, photodetectors, reflector material, and surface treatment (rough or polished) of the scintillators. In this study, we investigated the performances of sub-millimeter scintillator array, LYSO:Ce (polished and rough surfaces with BaSO4reflector or enhanced specular reflector (ESR)), a gadolinium aluminum gallium garnet (Ce:GAGG, rough surface with BaSO4reflector), and a new gadolinium fine aluminum gallate (Ce:GFAG, rough surface with BaSO4reflector) detectors. The outer dimension of each scintillator block was ∼12 × 12 mm with a 12 × 12 matrix of 0.9 ×0.9× 6 mm3 crystal elements. These blocks were optically coupled to a digital silicon photomultiplier (dSiPM, DPC-3200-22-44) with a 1 mm thick optical guide. Experiments were conducted at a sensor temperature of ∼15 °C, and a two-dimensional position histogram for 22Na gamma photons showed that all pixels were clearly resolved for all block detectors (peak-to-valley ratios ranging from 5.3 to 11.1). The average energy resolutions for the LYSO (ESR, rough), LYSO (ESR, polished), LYSO (BaSO4, rough), LYSO (BaSO4, polished), GAGG (BaSO4, rough), and GFAG (BaSO4, rough) arrays were measured as 11.3%, 10.2%, 18.7%, 10.3%, 10.0%, and 13.2% full width at half maximum (FWHM), respectively. The coincidence resolving times (with 3 × 3 × 5 mm3 LYSO crystal as reference) for the LYSO (ESR, rough), LYSO (ESR, polished), LYSO (B aSO4, rough), LYSO (BaSO4, polished), GAGG (BaSO4, rough), and GFAG (BaSO4, rough) arrays were 209 ps, 222 ps, 197 ps, 230 ps, 321 ps, and 276 ps, respectively. In conclusion, the new GFAG scintillator may be a promising candidate for future high-resolution time-of-flight (ToF) PET systems, considering the tradeoff between its performance and potential to be grown at a lower cost.

Optimization, evaluation and calibration of a cross-strip DOI detector

This study depicts the evaluation of a SiPM detector with depth of interaction (DOI) capability via a dual-sided readout that is suitable for high-resolution positron emission tomography and magnetic resonance (PET/MR) imaging. Two different 12 × 12 pixelated LSO scintillator arrays with a crystal pitch of 1.60 mm are examined. One array is 20 mm-long with a crystal separation by the specular reflector Vikuiti enhanced specular reflector (ESR), and the other one is 18 mm-long and separated by the diffuse reflector Lumirror E60 (E60). An improvement in energy resolution from 22.6% to 15.5% for the scintillator array with the E60 reflector is achieved by taking a nonlinear light collection correction into account. The results are FWHM energy resolutions of 14.0% and 15.5%, average FWHM DOI resolutions of 2.96 mm and 1.83 mm, and FWHM coincidence resolving times of 1.09 ns and 1.48 ns for the scintillator array with the ESR and that with the E60 reflector, respectively. The measured DOI signal ratios need to be assigned to an interaction depth inside the scintillator crystal. A linear and a nonlinear method, using the intrinsic scintillator radiation from lutetium, are implemented for an easy to apply calibration and are compared to the conventional method, which exploits a setup with an externally collimated radiation beam. The deviation between the DOI functions of the linear or nonlinear method and the conventional method is determined. The resulting average of differences in DOI positions is 0.67 mm and 0.45 mm for the nonlinear calibration method for the scintillator array with the ESR and with the E60 reflector, respectively; Whereas the linear calibration method results in 0.51 mm and 0.32 mm for the scintillator array with the ESR and the E60 reflector, respectively; and is, due to its simplicity, also applicable in assembled detector systems.

A γ -photon detector based on liquid light guide for whole-body PET

Positron Emission Tomography (PET) is important for accurate diagnosis of critical diseases. The quality of PET imaging highly depends on the performance of the detector module. In this study, we present a new method to design and assemble light-sharing block detectors which utilizes liquid instead of optical glass as a light guide. An integrated framework glued with Enhanced Specular Reflector (ESR) was built to hold the discrete crystals. A GATE-based simulation algorithm has been developed to optimize the heights of the reflectors for a good decoding accuracy. We fabricated a prototype block detector with a 12 × 12 array of LYSO scintillators and performed experiments to characterize the energy resolution and crystal decoding accuracy of the detector. The average energy resolution of the detector is 14.4% with a variance of 1.2%. The average peak-valley ratio of the profile is 3.95. The results show that it is possible to fabricate high performance PET detectors using the liquid light guide.

Performance of a SiPM based semi-monolithic scintillator PET detector

A depth encoding PET detector module using semi-monolithic scintillation crystal single-ended readout by a SiPM array was built and its performance was measured. The semi-monolithic scintillator detector consists of 11 polished LYSO slices measuring 1 × 11.6 × 10 mm3. The slices are glued together with enhanced specular reflector (ESR) in between and outside of the slices. The bottom surface of the slices is coupled to a 4 × 4 SiPM array with a 1 mm light guide and silicon grease between them. No reflector is used on the top surface and two sides of the slices to reduce the scintillation photon reflection. The signals of the 4 × 4 SiPM array are grouped along rows and columns separately into eight signals. Four SiPM column signals are used to identify the slices according to the center of the gravity of the scintillation photon distribution in the pixelated direction. Four SiPM row signals are used to estimate the y (monolithic direction) and z (depth of interaction) positions according to the center of the gravity and the width of the scintillation photon distribution in the monolithic direction, respectively. The detector was measured with 1 mm sampling interval in both the y and z directions with electronic collimation by using a 0.25 mm diameter 22Na point source and a 1 × 1 × 20 mm3 LYSO crystal detector. An average slice based energy resolution of 14.9% was obtained. All slices of 1 mm thick were clearly resolved and a detector with even thinner slices could be used. The y positions calculated with the center of gravity method are different for interactions happening at the same y, but different z positions due to depth dependent edge effects. The least-square minimization and the maximum likelihood positioning algorithms were developed and both methods improved the spatial resolution at the edges of the detector as compared with the center of gravity method. A mean absolute error (MAE) which is defined as the probability-weighted mean of the absolute value of the positioning error is used to evaluate the spatial resolution. An average MAE spatial resolution of ~1.15 mm was obtained in both y and z directions without rejection of the multiple scattering events. The average MAE spatial resolution was ~0.7 mm in both y and z directions after the multiple scattering events were rejected. The timing resolution of the detector is 575 ps. In the next step, long rectangle detector will be built to reduce edge effects and improve the spatial resolution of the semi-monolithic detector. Thick detector up to 20 mm will be explored and the positioning algorithms will be further optimized.

Performance of a high-resolution depth encoding PET detector using barium sulfate reflector

Small animal positron emission tomography (PET) is a well-established imaging modality in preclinical biomedical research. The performance of current small animal PET scanners is mainly limited by the detector performance and depth-encoding detectors are required to simultaneously achieve high spatial resolution and high sensitivity. In this work, the performance of a high-resolution dual-ended readout lutetium-yttrium oxyorthosilicate (LYSO) array using barium sulfate powder (BaSO4) as the inter-crystal reflector was measured for the first time and compared to that of a LYSO array using the most commonly used enhanced specular reflector (ESR). Both LYSO arrays have 18 × 18 crystals and the crystal size is about 0.62 × 0.62 × 20 mm3. The LYSO arrays are readout by two position-sensitive photomultiplier tubes (PSPMTs) from both ends. The flood histograms, energy resolution, depth of interaction (DOI) resolution and timing resolution were measured. The flood histograms of the LYSO array with BaSO4 reflector is much better than that of the LYSO array with ESR reflector. For the BaSO4 array, all crystals can be clearly resolved. For the ESR array, all crystals in one direction can be clearly resolved, but the edge 2–3 columns of the crystals in the other direction cannot be resolved. The average energy resolution of the BaSO4 and ESR arrays are 15.2% and 15.3%, respectively. The average DOI resolution of the BaSO4 array is 2.19 mm, which is 24% worse than the 1.76 mm DOI resolution of the ESR array. The timing resolution of both arrays is ~1.6 ns. The LYSO array with the new BaSO4 reflector provided an much better flood histogram in a high resolution dual-ended readout PET detectors as compared to the ESR array, and will be used to develop a small animal PET scanner that can simultaneously achieve uniform high spatial resolution, high sensitivity and low cost.

실리콘 광증폭기와 반응깊이 측정방법을 이용한 수술용 베타 영상/감마 프로브 가능성 연구

Radiopharmaceutical agents for positron emission tomography (PET), such as -FDG and , have been used not only for whole-body PET imaging but also for intraoperative radionuclide-guided surgery due to their quantitative and sensitive imaging characteristics. Current intraoperative probes detect gamma or beta particles, but not both of them. Gamma probes have low sensitivities since a collimator has to be used to reduce backgrounds. Positron probes have a high tumor-to-background ratio, but they have a 1-2 mm depth limitation from the body surface. Most of current intraoperative probes produce only audible sounds proportional to count rates without providing tumor images. This research aims to detect both positrons and annihilation photons from using plastic scintillators and a GAGG scintillation crystal attached to silicon photomultiplier (SiPM). The depth-of-interaction (DOI) along the plastic scintillator can be used to obtain the 2-D images of tumors near the body surface. The front and rear part of the intraoperative probe consists of plastic scintillators () for positron detection and a Ce:GAGG scintillation crystal () for annihilation photon detection, respectively. The DOI resolution of along the plastic scintillator was obtained by using the 3M enhanced specular reflector (ESR) with rectangular holes between the plastic scintillators, which showed the feasibility of a 2-D image pixel size of (X-direction Y-direction).

Effects of reflector and crystal surface on the performance of a depth-encoding PET detector with dual-ended readout.

Depth encoding detectors are required to improve the spatial resolution and spatial resolution uniformity of small animal positron emission tomography (PET) scanners, as well as dedicated breast and brain scanners. Depth of interaction (DOI) can be measured by using dual-ended readout of lutetium oxyorthosilicate (LSO) scintillator arrays with position-sensitive avalanche photodiodes. Inter-crystal reflectors and crystal surface treatments play important roles in determining the performance of dual-ended detectors. In this paper, the authors evaluated five LSO arrays made with three different intercrystal reflectors and with either polished or unpolished crystal surfaces. The crystal size in all arrays was 1.5 mm, which is typical of the detector size used in small animal and dedicated breast scanners. The LSO arrays were measured with dual-ended readout and were compared in terms of flood histogram, energy resolution, and DOI resolution performance. The four arrays using enhanced specular reflector (ESR) and Toray reflector provided similar quality flood histograms and the array using Crystal Wrap reflector gave the worst flood histogram. The two arrays using ESR reflector provided the best energy resolution and the array using Crystal Wrap reflector yielded the worst energy resolution. All arrays except the polished ESR array provided good DOI resolution ranging from 1.9 mm to 2.9 mm. DOI resolution improved as the gradient in light collection efficiency with depth (GLCED) increased. The geometric mean energies were also calculated for these dual-ended readout detectors as an alternative to the conventional summed total energy. It was shown that the geometric mean energy is advantageous in that it provides more uniform photopeak amplitude at different depths for arrays with high GLCED, and is beneficial in event selection by allowing a fixed energy window independent of depth. A new method of DOI calculation that improved the linearity of DOI ratio vs depth and simplifies the DOI calibration procedure also was developed and tested. The results of these studies provide useful guidance in selecting the proper reflectors and crystal surface treatments when LSO arrays are used for high-resolution PET applications in small animal scanners or dedicated breast and brain scanners.