Silicon nanoparticles (Si NPs) have an eminent role in improving plant yield through improving yield. The present study was conducted to find the effect of Si NPs on plant yield, biochemical attributes, and minerals of different cucumber cultivars. The greenhouse experiment with foliar application of Si NPs (100, 200, and 300 mg L-1) was carried out on cucumber cultivars (Emilie, Mirsoltan, Mitio, and Viola). The application of Si NPs at 300 mg L-1 led to the highest fruit yield, with a 17% increase in fruit production compared to the control. Fruit firmness differed by 31% between Emilie and Si NPs at 100 mg L-1 and Mito at 300 mg L-1. Plants experiencing Si NPs at 300 mg L-1 had the greatest chlorophyll (Chl) a+b. Compared to the other cultivars, Mito had a greater fruit yield and Chl content. The Si NPs increased TSS by 11% while lowering TA by 24% when compared to the control at 300 mg L-1. Foliar application of Si NPs reduced the value of TSS/TA. The largest value of K was reached in the Mito cultivar with Si NPs at 200 mg L-1, with a 22% increase in comparison to the control, indicating that Si NPs considerably boosted the K content. The Si NPs at 200 mg L-1 significantly increased leaf N and P in the Mito cultivar by 16 and 50%, respectively. By using agglomerative hierarchy clustering (AHC), Emilie and Mito were located in two separate clusters, whilst Viola and Mirsoltan were grouped in one cluster. In conclusion, Si NPs at 200-300 mg L-1 enhanced fruit yield, and Mito showed the highest yield when compared to other cultivars.