This paper investigates the effect of score-line on work-rate in English FA Premier League soccer. Player movement data from 110 matches where a goal was scored between 15 minutes and the end of the first half were captured by the ProzoneTM player tracking system. The number of V-cut path changes performed per minute declined more after the first goal in matches that were won by one of the sides than in drawn matches (p < 0.017). V-cut path changes involve players changing direction more than 135° to the left or the right. There was also a significant interaction of match type (won, drawn or lost by the team scoring first), period of the match (before and after the first goal), venue and the relative quality of the teams on the total number of path changes performed (p < 0.05). Players from the scoring and conceding teams spent significantly less time in the middle third of the pitch after the first goal then before (p < 0.017). This suggests that variability in work-rate is influenced by a combination of factors. The results suggest that the first goal has an influence on teams’ tactics and work-rate. However, the study did not find any differences in work-rate between teams achieving different outcomes having scored first.