England Medical Center Hospital Research Articles

S.3.03 Inter-individual differences in impulsivity and underlying neurobiology

The association between orbital frontal cortex (OFC) volume and aggression and impulsivity was investigated among a heterogeneous group of non-psychotic psychiatric clients. Fifteen non-psychotic subjects from two different psychiatric clinics (New England Medical Center and Lemuel Shattuck Hospital) with a variety of diagnoses were sequentially referred for magnetic resonance imaging (MRI) for clinical purposes. This convenience sample, clinically stable at the time of evaluation, received a standardized psychiatric diagnostic interview, aggression and impulsivity psychometrics (Barratt Impulsivity, Lifetime History of Aggression, and Buss-Perry Aggression scales), and an MRI protocol with image analysis. OFC gray matter volume, total as well as left and right, was significantly and positively associated with motor impulsivity. OFC asymmetry was associated with aggression, though total, left, and right OFC volume measurements were not. For subjects without affective disorder, there was a strong and positive association of the OFC to motor and no-planning subscales of the Barratt Impulsivity Scale. For subjects with affective disorder, there was a strong association of OFC asymmetry to both of the aggression psychometrics. Consistent with expectation, results are suggestive of OFC involvement in the neural circuitry of impulsivity and aggression. The findings suggest a dissociation of the role of the OFC in relation to aggression and impulsivity, such that the OFC may play a part in the regulation of aggressive behavior and a generative role in impulsive behavior.

Review of the initiation and development of the conception of clinical pathway

Dupont, an American company, used the concept of "pathway" in industry to improve the quality of their products in 1957. In the 1970s, under the pressure of a rise in medical costs, some people realized the concept of the "key pathway" could be used in medicine too. In 1985, the Boston New England Medical Center Hospital (NEMC) succeeded in using the concept of the clinical pathway in medical practice, and afterwards the concept gradually found worldwide application. In 1996, the Fourth Military Medical University in China reported the application of clinical pathway in America. The West China Hospital began to try out the clinical pathway in 1998 and the concept gradually found application in China.

Dietary influences on the synthesis of neurotransmitters in the brain.

Journal Article Dietary Influences on the Synthesis of Neurotransmitters in the Brain Get access John H. Growdon, M.D., John H. Growdon, M.D. Assistant Professor at Tufts University School of Medicine and Assistant Neurologist at Tufts New England Medical Center Hospital, Boston, Massachusetts. Search for other works by this author on: Oxford Academic PubMed Google Scholar Richard J. Wurtman, M.D. Richard J. Wurtman, M.D. Professor of Endocrinology and Metabolism, Department of Nutrition and Food Science, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02139. Search for other works by this author on: Oxford Academic PubMed Google Scholar Nutrition Reviews, Volume 37, Issue 5, May 1979, Pages 129–136, https://doi.org/10.1111/j.1753-4887.1979.tb06649.x Published: 01 May 1979

Plasma Aβ42 levels and depression in the elderly

International Journal of Geriatric PsychiatryVolume 22, Issue 9 p. 930-930 Letter to the Editor Plasma Aβ42 levels and depression in the elderly Wei Qiao Qiu M.D., Ph.D., Wei Qiao Qiu M.D., Ph.D. Department of Psychiatry, Tufts University School of Medicine/New England Medical Center Hospitals, UKSearch for more papers by this authorPaul Summergrad, Paul Summergrad Department of Psychiatry, Tufts University School of Medicine/New England Medical Center Hospitals, UKSearch for more papers by this authorMarshal Folstein, Marshal Folstein Department of Psychiatry, Tufts University School of Medicine/New England Medical Center Hospitals, UKSearch for more papers by this author Wei Qiao Qiu M.D., Ph.D., Wei Qiao Qiu M.D., Ph.D. Department of Psychiatry, Tufts University School of Medicine/New England Medical Center Hospitals, UKSearch for more papers by this authorPaul Summergrad, Paul Summergrad Department of Psychiatry, Tufts University School of Medicine/New England Medical Center Hospitals, UKSearch for more papers by this authorMarshal Folstein, Marshal Folstein Department of Psychiatry, Tufts University School of Medicine/New England Medical Center Hospitals, UKSearch for more papers by this author First published: 23 August 2007 https://doi.org/10.1002/gps.1762Citations: 4AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat No abstract is available for this article.Citing Literature Volume22, Issue9September 2007Pages 930-930 RelatedInformation

Orbitofrontal correlates of aggression and impulsivity in psychiatric patients

The association between orbital frontal cortex (OFC) volume and aggression and impulsivity was investigated among a heterogeneous group of non-psychotic psychiatric clients. Fifteen non-psychotic subjects from two different psychiatric clinics (New England Medical Center and Lemuel Shattuck Hospital) with a variety of diagnoses were sequentially referred for magnetic resonance imaging (MRI) for clinical purposes. This convenience sample, clinically stable at the time of evaluation, received a standardized psychiatric diagnostic interview, aggression and impulsivity psychometrics (Barratt Impulsivity, Lifetime History of Aggression, and Buss-Perry Aggression scales), and an MRI protocol with image analysis. OFC gray matter volume, total as well as left and right, was significantly and positively associated with motor impulsivity. OFC asymmetry was associated with aggression, though total, left, and right OFC volume measurements were not. For subjects without affective disorder, there was a strong and positive association of the OFC to motor and no-planning subscales of the Barratt Impulsivity Scale. For subjects with affective disorder, there was a strong association of OFC asymmetry to both of the aggression psychometrics. Consistent with expectation, results are suggestive of OFC involvement in the neural circuitry of impulsivity and aggression. The findings suggest a dissociation of the role of the OFC in relation to aggression and impulsivity, such that the OFC may play a part in the regulation of aggressive behavior and a generative role in impulsive behavior.

Clinical Decision-Making Rounds at the Tufts-New England Medical Center Hospital

Clinical Decision-Making Rounds at the Tufts-New England Medical Center Hospital

Dietary assessment methods: where do we go from here?

Douglas Taren*, Johanna Dwyer, Laurence Freedman and Noel W Solomons University of Arizona, Mel and Enid Zuckerman College of Public Health, Division of Health Promotion Sciences, 2231 East Speedway Boulevard, Tucson, AZ 85719, USA: Schools of Medicine, Nutrition and the Jean Mayer Human Nutrition Research Center on Aging at Tufts University, and Frances Stern Nutrition Center, Tufts–New England Medical Center Hospital, Boston, MA, USA: Bar Ilan University, Ramat Gan, and Gertner Institute for Epidemiology and Health Policy Research, Tel Hashomer, Israel: Center for Studies on Sensory Impairment, Aging and Metabolism (CeSSIAM), Guatemala City, Guatemala

OUT WITH THE OLD, IN WITH THE NEW

Johanna Dwyer, DSc, RD, is Professor of Medicine and Community Health at Tufts University Schools of Medicine and Nutrition and Editor of Nutrition Today. Address correspondence to her at Tufts University Schools of Nutrition and Medicine, Frances Stern Nutrition Center, New England Medical Center Hospital, 750 Washington Street, Boston, MA 02111.

Fever, Endogenous Pyrogen, and lnterleukin-1

Charles Dinarello is professor of Medicine at the University of Colorado School of Medicine in Denver. Until 1996, he was professor of Medicine and Pediatrics at Tufts University School of Medicine and the New England Medical Center Hospitals in Boston. Dr. Dinarello received his medical degree from Yale University and his clinical training at the Massachusetts General Hospital. From 1971 to 1974, he was a clinical associate, and from 1975 to 1977 he was a senior investigator at the NIH. Dr. Dinarello has authored more than 450 original research articles and 200 reviews and book chapters on cytokines, particularly on interleukin-1 (IL-1). The Institute for Scientific Information listed him as the world's third most cited life scientist (1981-1994). The recipient of several awards for his contributions to the field of infectious diseases and cytokines, he received the Ernst Jung Prize in Medicine in 1993. He donated the prize money to universities and research institutes in the United States and in Israel, and he established the Sheldon M. Wolff Professorship at Tufts University to honor his late mentor. In 1998, Dr. Dinarello was elected to the United States National Academy of Sciences

TECHNETIUM-99M MAG-3 DIURETIC RENAL SCINTIGRAPHY IN TERM AND PRETERM INFANTS

Departments of Radiology and Urology, New England Medical Center Hospitals, Tufts University School of Medicine, Boston, MA.

5476767 Isolated nucleic acid molecule coding for toxin associated with Kawasaki Syndrome and uses thereof : Leung Donald; Schlievert Patrick; Meissner Cody; Fulton David Englewood, CO, United States assigned to Regents of the University of Minnesota; New England Medical Center Hospital Inc National Jewish Center for Immunology and Respiratory Medicine

5476767 Isolated nucleic acid molecule coding for toxin associated with Kawasaki Syndrome and uses thereof : Leung Donald; Schlievert Patrick; Meissner Cody; Fulton David Englewood, CO, United States assigned to Regents of the University of Minnesota; New England Medical Center Hospital Inc National Jewish Center for Immunology and Respiratory Medicine

5541071 Assay for identifying antagonists of gastrin and CCK-B receptors : Kopin Alan S Wellesley, MA, United States Assigned to New England Medical Center Hospitals Inc

5541071 Assay for identifying antagonists of gastrin and CCK-B receptors : Kopin Alan S Wellesley, MA, United States Assigned to New England Medical Center Hospitals Inc

5470716 Method for diagnosing Kawasaki syndrome : Leung Donald; Schlievert Patrick; Meissner Cody; Fulton David Englewood, CO, United States assigned to National Jewish Center For Immunology and Respiratory Medicine; New England Medical Center Hospital Inc University of Minnesota Regents of the University of Minnesota

5470716 Method for diagnosing Kawasaki syndrome : Leung Donald; Schlievert Patrick; Meissner Cody; Fulton David Englewood, CO, United States assigned to National Jewish Center For Immunology and Respiratory Medicine; New England Medical Center Hospital Inc University of Minnesota Regents of the University of Minnesota

Clinical Strategies for Use of the Implantable Cardioverter Defibrillator: The Impact of Current Trials

Pacing and Clinical ElectrophysiologyVolume 19, Issue 7 p. 1011-1015 Clinical Strategies for Use of the Implantable Cardioverter Defibrillator: The Impact of Current Trials N.A. MARK ESTES III, Corresponding Author N.A. MARK ESTES III From Tufts University School of Medicine and the Cardiac Arrhythmia Service, New England Medical Center Hospital, Boston, MassachusettsAddress for reprints: N.A. Mark Estes, III, M.D., Professor of Medicine, Tufts University School of Medicine, Director, Cardiac Arrhythmia Service, New England Medical Center Hospital, Boston, MA 02111. Fax: (617) 636-5913.Search for more papers by this author N.A. MARK ESTES III, Corresponding Author N.A. MARK ESTES III From Tufts University School of Medicine and the Cardiac Arrhythmia Service, New England Medical Center Hospital, Boston, MassachusettsAddress for reprints: N.A. Mark Estes, III, M.D., Professor of Medicine, Tufts University School of Medicine, Director, Cardiac Arrhythmia Service, New England Medical Center Hospital, Boston, MA 02111. Fax: (617) 636-5913.Search for more papers by this author First published: July 1996 https://doi.org/10.1111/j.1540-8159.1996.tb03406.xCitations: 3AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Citing Literature Volume19, Issue7July 1996Pages 1011-1015 RelatedInformation

Maternal cigarette smoking and placenta previa

To identify the relationship between maternal cigarette smoking and ultrasound-confirmed placenta previa. A matched case-control design was used. Cases were drawn from the New England Medical Center and Cambridge Hospital from July 1992 through March 1994. Each case was delivered by cesarean after 24 weeks' gestation and had an antenatal ultrasound examination confirming placenta previa. Matched controls were obtained by requesting records on the first three deliveries by the referring provider the same month as the index case. Data on potential risk factors were drawn from the records of the initial prenatal visit, before previa was diagnosed. The data were analyzed with conditional logistic regression. Thirty-two cases of ultrasound-documented placenta previa were identified. A number of potential confounders were associated with previa: age (odds ratio [OR] 1.15, 95% confidence interval [CI] 1.05-1.26), gravidity (OR 1.4, 95% CI 1.1-1.7), parity (OR 1.4, 95% CI 1.1-1.9), prior spontaneous abortion (OR 3.1, 95% CI 1.3-7.4), prior elective abortion (OR 3.0, 95% CI 1.2-7.6), and prior cesarean delivery (OR 3.5, 95% CI 1.3-9.9). The crude OR for current smoking was 3.0 (95% CI 1.1-8.6). The OR for smoking ranged from 2.6-4.4, despite controlling for confounders. Current cigarette smoking is associated with a 2.6-4.4-fold increased risk of placenta previa.

Human leukocyte antigen associations of epidemic Kaposiʼs sarcoma

Division of Geographic Medicine and Infectious Diseases and Division of Clinical Care Research and Biostatistics Research Center, New England Medical Center Hospitals, Tufts University School of Medicine, 750 Washington St, Boston, MA 02111, USA.

Effect of intravenous lipid emulsions enriched with γ‐linolenic acid on plasma n‐6 fatty acids and prostaglandin biosynthesis after burn and endotoxin injury in rats MD KARLSTAD, SJ DEMICHELE, WD LEATHEM, ET AL University of Tennessee Medical Center, Knoxville, TN; Ross Products Division, Abbott Laboratories, Columbus, OH; New England Medical Center Hospitals, Tufts School of Medicine, Boston

Effect of intravenous lipid emulsions enriched with γ‐linolenic acid on plasma n‐6 fatty acids and prostaglandin biosynthesis after burn and endotoxin injury in rats MD KARLSTAD, SJ DEMICHELE, WD LEATHEM, ET AL University of Tennessee Medical Center, Knoxville, TN; Ross Products Division, Abbott Laboratories, Columbus, OH; New England Medical Center Hospitals, Tufts School of Medicine, Boston

Analysis of metal binding by the HPN protein of Helicobacter pylori: Joanne V. Gilbert, Andrew Wright, F. William Sunderman, Jr., and [formula omitted]. Department of Medicine and the GRASP Digestive Disease Center, Tufts-New England Medical Center Hospital, Department of Molecular Biology and Microbiology, Tufts Univ. School of Medicine, Boston MA 02111, and Departments of Laboratory Medicine and Pharmacology, Univ. of

Analysis of metal binding by the HPN protein of Helicobacter pylori: Joanne V. Gilbert, Andrew Wright, F. William Sunderman, Jr., and [formula omitted]. Department of Medicine and the GRASP Digestive Disease Center, Tufts-New England Medical Center Hospital, Department of Molecular Biology and Microbiology, Tufts Univ. School of Medicine, Boston MA 02111, and Departments of Laboratory Medicine and Pharmacology, Univ. of

Emulsifiers in antifoam/anti-gas preparations are bactericidal in vitro for Helicobacter pylori: [formula omitted] and Andrew G. Plaut, Department of Medicine and GRASP Digestive Disease Center, Tufts-New England Medical Center Hospital, Boston, MA 02111

Emulsifiers in antifoam/anti-gas preparations are bactericidal in vitro for Helicobacter pylori: [formula omitted] and Andrew G. Plaut, Department of Medicine and GRASP Digestive Disease Center, Tufts-New England Medical Center Hospital, Boston, MA 02111

Principles of Mammorgraphic Follow-up

Dr. Homer is Professor of Radiology. Tufts University School of Medicine, and Chief, Mammongraphy Section, New England Medical Center Hospitals, Boston, MA 02111.