Direct Evaporative Cooling Systems (DECS) offer a promising solution for mitigating heat stress in greenhouses located in arid and semi-arid regins. To implement DECS efficiently in these regions, it is crucial to understand their impact on greenhouse microclimate parameters. This study investigates the influence of DECS on the microclimate within a canarian greenhouse and identifies key factors affecting their efficiency. Through Computational Fluid Dynamics (CFD) simulations using Ansys, we examined the effects of DECS on temperature, relative humidity, and air velocity within the greenhouse under semi-arid conditions.The results indicate that DECS efficiency is affected by several factors, including fan placement, evaporative pad height, fan spacing, and inlet air fan speed. Higher fan placement cools the upper canopy but increases humidity near the ceiling, whereas lower placement improves temperature uniformity but may require additional humidification. Closer fan spacing results in uneven air velocity, while wider spacing leads to stagnant zones within the greenhouse. Optimal placement of the the evaporative pad is crucial for maximizing the cooling coverage area and minimizes the temperature gradients. Inlet air fan speed also significantly impacts the microclimate, with higher speeds reducing both temperature and humidity. By optimizing these parameters, the DECS system was able to significantly decrease air temperature, increase humidity, and improve air velocity inside the greenhouse. With a pad height of 1.5 m, fans positioned at a height of 2 m, a distance of 6 m between each fan, and an air speed of 1.5 m/s at the entrance – the DECS enhances the local climate. Under these conditions, the mean air temperature drops from 40°C −in greenhouse with natural ventilation- to 21 °C using DECS, while relative humidity increases from 23 % −in greenhouse with natural ventilation- to 67 % using DECS, creating a more favorable environment for plant growth and potentially increasing crop yield and quality. Additionally, energy and environmental analyses show that implementing DECS in Canarian greenhouses, instead of traditional electrical cooling systems, results in substantial energy savings of 123,818.112 kWh/year annually and reduces carbon dioxide emissions by approximately 1.785 tons/year over a 20-year operational lifespan in a semi-arid climate.