High selectivity and fast response for detrimental and carcinogenic Roxarsone (ROX) is always a challenge. Herein, a new luminescent Zn-based metal-organic frameworks {Zn2(XN)(BDC)2·H2O}n (compound 1) has been successfully harvested (XN: 4′-(4-pyridine)4,2′:2′,4′'-terpyridine, H2BDC: terephthalic acid), exhibiting excellent chemical stability and thermal stability. Moreover, luminescence investigation revealed that compound 1 could present nanomolar luminescence turn-off response to ROX (limit detection: 5.84 nM), which may be attributed to both photo-induced electron transfer (PET) and competitive energy absorption (CEA) between ROX and compound 1. Notably, the extraordinary luminescence quenching response to ROX of compound 1 is almost unaffected by the simulated serum and urine components, various antibiotics and even real chicken feed environment, demonstrating excellent interference immunity and selectivity. Importantly, sensor 1 with preeminent recyclability can be reused at least five times for detecting ROX without significant changes in luminescence intensity and structural integrity. This work provides a new synthetic strategy of recyclable metal-organic frameworks sensor with excellent sensitivity and selectivity, making it possible to detect in actual chicken feed.