During the optimization and control processes of variable flow rate heating, ventilation, and air conditioning (HVAC) systems, the medium temporal and spatial characteristics often significantly influence the control effectiveness and energy efficiency of the overall system. Unfortunately, much of the existing research predominantly concentrates on enhancing the performance of specific individual components, neglecting the impact of medium temporal and spatial characteristics on the overall HVAC system performance. Consequently, issues such as energy efficiency trade-offs in practical systems remain inadequately addressed. In this paper, the medium spatiotemporal characteristics of HVAC systems are systematically illustrated and modeled. A novel optimization method based on these characteristics is proposed to improve the overall performance of the HVAC system. This method adopts an event-driven optimization strategy to determine the optimal timing with consideration of temporal characteristics, and an adaptive hybrid algorithm is proposed to determine the optimal setpoints with consideration of spatial characteristics. By comparing to conventional methods with constant setpoints, genetic algorithm (GA) based setpoints, and differential evolution (DE) based setpoints in both simulation test and experiment, the proposed method demonstrates the ability to reduce electricity consumption by 21.2%, 13.1%, and 10.0%, respectively. The methodology in this research provides significant guidance for engineers to promote the decoupling control and overall optimization of HVAC systems. Additionally, the results have referable values for implementing the most appropriate algorithm in practice.
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