A novel seismic resilient brace, integrating a replaceable friction damper mechanism with an assembled self-centering device of combination disc springs, has been developed and investigated through experimental research. This brace can be named as the Assembled Pre-pressed Disc-springs Self-centering Replaceable Energy Dissipation (APD-SRED) brace. The working principles, structural configurations, fabrication process and mechanical behaviors of this bracing system were discussed and analyzed firstly in detail. Subsequently, five brace specimens were designed incorporating different axial pre-compression forces within a combination disc springs system and varying friction forces in the damper device. Test results exhibit a stable and repeatable flag-shaped hysteretic responses with satisfactory energy dissipation, which can be implemented under the low cyclic reversed loading. Additionally, it can be noted that the excellent seismic resilience performance can be obtained by maintaining a relative balance between self-centering and energy dissipation characteristics. The stiffness and strength of this brace can withstand cyclical loading without degradation, making superiorities against sequential design earthquakes without the replacement or repair, and facilitating replacement of the friction energy dissipation components to meet different demands. Moreover, the proposed calculation model can be validated accurately predicting the mechanical behavior of the APD-SRED brace by considering friction effects in disc-springs. This validation was achieved through comparisons with experimental results, and several crucial design factors influencing the brace's behavior were analyzed and discussed for practical application in a parametric design. Finally, drawing upon a combination of experimental and analytical studies, this study ultimately presented practical design recommendations.