In recent decades, expansion in urban areas has faced issues such as management of public waste, noise, mobility, and air quality, among others. In this scenario, Internet of Things (IoT) and Wireless Sensor Network (WSN) scenarios are being considered for Smart Cities solutions based on the deployment of wireless remote sensor nodes to monitor large urban areas. However, as the number of nodes increases, the amount of data to be routed increases significantly as well, meaning that the choice of the data routing process has great importance in terms of the energy consumption and lifetime of the network. In this work, we describe and evaluate the energy consumption of routing protocols for WSN-based Smart Cities applications in LoRa-based mesh networks, then propose a novel energy-saving radio power adjustment (RPA) routing protocol. The Cupcarbon network simulator was used to evaluate the performance of different routing protocols in terms of their data package delivery rate, average end-to-end delay, average jitter, throughput, and load consumption of battery charge. Additionally, a novel tool for determining the range of nodes based on the Egli propagation model was designed and integrated into Cupcarbon. The routing protocols used in this work are Ad Hoc On-Demand Distance Vector (AODV), Dynamic Source Routing (DSR), and Distance Vector Routing (DVR). Our simulation results show that AODV presents the best overall performance, DSR achieves the best results for power consumption, and DVR is the best protocol in terms of latency. Finally, the proposed RPA routing protocol presents power savings of 11.32% compared to the original DSR protocol.