The lattice structure has great application prospects in the field of energy absorption, but the high cost of numerical analysis makes it difficult to carry out related structural designs. Therefore, this article studies the feasibility of the homogenization analysis technique for the analysis of energy absorption processes in lattice-filled structures. In the study, compression experiments and numerical simulations were conducted for four different types of unit cells (including periodic truss-lattice cells and triply periodic minimal surface (TPMS cells). In the experiments, two compression samples with different numbers of periods were designed for the same unit cell structure. The research shows that the homogenized numerical model takes a lot less time to run than the classical beam and shell element models. The results of the simulation are also in line with the data from the experiments. On the other hand, the material curve constructed based on a small number of unit cell samples has excellent analytical accuracy. This means that relevant research can obtain the material experimental data required for homogenized analysis using lattice samples with low manufacturing costs. Understanding these phenomena can provide a basis for the design of energy absorption structures.