Routine evaluation and surveillance imaging after pituitary adenoma (PA) endoscopic endonasal transsphenoidal resection (EETS) is a neurosurgical practice to identify tumor recurrence. This study aims to identify social and clinical factors that may contribute to patients missing their initial one-year follow-up appointment and provide guidance for targeted education to improve patient adherence with postoperative treatment plans, ultimately reducing unknown adenoma recurrence. The authors performed a single-center retrospective review of patients who underwent EETS for PAs from 2007 to 2023. Patients who were analyzed for sociodemographic factors, presenting symptoms, time to surgery, surgical outcomes, and adherence to postoperative follow-up visits at one-year following surgery. 256 patients with PAs treated by EETS met inclusion criteria. 218 (85%) of these patients attended one-year follow-up; 38 (15%) missed this visit. Twenty-nine (76%) individuals who missed their one-year follow up were males (p-value=0.006). Divorced/widowed/separated patients were two times more likely to miss their follow-up compared to their married counterparts (p-value=0.008). Additional significant risk factors included older age, as the mean age for patients who missed their one-year appointment was 60.1 years compared to 54.7 years (p-value=0.028). Patients with visual field deficits at initial presentation were also less likely to follow-up at one-year (p-value=0.03). Risk factors of missed one-year follow-up appointments after PA resection include male sex, divorced/widowed/separated marital status, older age, and the presence of visual deficits at initial presentation. Increased education efforts can be selectively aimed at these at-risk patient cohorts to improve patient compliance and reduce consequences of undetected tumor recurrence.