Endogenous Pathology Research Articles

Dynamics of c-kit immunopositive pancreatic beta cells influenced by exogenous factors or endogenous pathology

Dynamics of c-kit immunopositive pancreatic beta cells influenced by exogenous factors or endogenous pathology

Endogenous pathology in tauopathy mice progresses via brain networks

Endogenous pathology in tauopathy mice progresses via brain networks

Circadian dysregulation and Alzheimer’s disease: A comprehensive review

Alzheimer’s disease (AD), the foremost variant of dementia, has been associated with a menagerie of risk factors, many of which are considered to be modifiable. Among these modifiable risk factors is circadian rhythm, the chronobiological system that regulates sleep‐wake cycles, food consumption timing, hydration timing, and immune responses amongst many other necessary physiological processes. Circadian rhythm at the level of the suprachiasmatic nucleus (SCN), is tightly regulated in the human body by a host of biomolecular substances, principally the hormones melatonin, cortisol, and serotonin. In addition, photic information projected along afferent pathways to the SCN and peripheral oscillators regulates the synthesis of these hormones and mediates the manner in which they act on the SCN and its substructures. Dysregulation of this cycle, whether induced by environmental changes involving irregular exposure to light, or through endogenous pathology, will have a negative impact on immune system optimization and will heighten the deposition of Aβ and the hyperphosphorylation of the tau protein. Given these correlations, it appears that there is a physiologic association between circadian rhythm dysregulation and AD. This review will explore the physiology of circadian dysregulation in the AD brain, and will propose a basic model for its role in AD‐typical pathology, derived from the literature compiled and referenced throughout.

Te role of disturbances of the psychosexual spherein schizophrenia in diagnosing of paraphilias

Te article is concerned with the study of disturbances in psychosexual sphere, which are specifc for schizophrenia spectrum disorders. Te results of a comparison of two groups are presented: 29 people were diagnosed with schizophrenia and schizotypal disorder and a comparison group of 34 people without endogenous pathology. Te study outcomes of their gender self-consciousness with methods «MF», «CTAT», «Coding» are shown that the presence of endogenous disorder changes the psychosexual profle of patients on a number of signs. Persons with schizophrenia and schizotypal disorder, regardless of their comorbide diagnosis of paraphilia are characterized by lower value of masculinity, high distinction with the male role, absence of intention to line up with the man-image, in some cases instability of identity, altered emotional attitudes to sex-role stereotypes, emotional ambivalence.

Neuropsychological and psychometric analysis of the defect at children and adolescents with endogenous mental pathology

This article presents a compound neuropsychological/psychometric analysis of manifestations of defects in children and adolescents with endogenous pathologies. The research was organized among children with diagnosed schizophrenia spectrum disorders: child type schizophrenia, schizotypal personality disorder and other forms of schizophrenia. All patients were on the stationary treatment and had verified diagnosis, defect in cognitive sphere was close to oligofrenic like defect. The experimental group (EG) - 74 children (52 boys), average age - 11,0 ± 2,9 years. Control group (CG) - children and adolescents (64 children, among them 38 boys) from Moscow schools, average age - 11,1 ± 3,0 years. The neuropsychological research was taken on 20 children from EG and on 15 children from CG. Qualitative and quantitative analyses of data included the formulation of criteria of marks of the psychometric and neuropsychological results. Based on our research data we distinguish specific compounds of manifestations of certain cerebrum structure dysfunctions and cognitive dysfunctions that are common in children with schizophrenia spectrum disorders. We also illustrate the differences in localization (in interhemispheric cooperation, cortical structures, subcortical structures) of primary dysfunctions in patients diagnosed with various schizophrenia spectrum disorders. Neuropsychological and psychometric analysis had shown that patients by their functional status are heterogeneous group. The defection of intellectual activity is not total but partial with gradual involvement of different aspects.