Endogenous Changes Research Articles

Spatial externalities, R&D spillovers, and endogenous technological change

Forward-looking economic agents operating in a finite continuous geographic area choose how much to innovate at each point in time and space. Based on this assumption, the present study incorporates spatial interactions in endogenous growth models, addressing the criticism that such models are inconsistent with empirical evidence. More specifically, we introduce spatial production spillovers, knowledge diffusion across space, and the capability for spatial heterogeneity into a standard expanding variety growth model based on R&D. We study the properties of equilibrium and optimal allocations and argue that the characteristics are different from those of the non-spatial model, which alter the appropriate policy measures. Finally, we provide numerical examples demonstrating the importance of spatial dependent policy measures in achieving a balanced regional development.

The Future Politics of Social Protection in Africa

International organisations and their local allies continue to press for the further expansion of social protection across Africa, often in the face of resistance. The future politics of social protection in Africa will be shaped by endogenous and exogenous changes. Endogenous changes involve feedback effects from the past and continuing expansion of social protection; these can be either positive or negative in terms of further expansion. Exogenous effects result from the changing structural context, including especially population growth, urbanisation, and climate change. As the Covid-19 pandemic and related lockdowns showed, even those exogenous shocks which reveal gaps in current provision need not prompt enduring expansions of social protection. Neither endogenous nor exogenous changes are likely to shift African countries off their current varied pathways; considerable political obstacles to the further expansion of social protection will persist.

Events, turns, and critical junctures: unpacking the temporality of supporter rights and democracy in English football

ABSTRACT The future of professional men’s football in England stands at a critical juncture. In the wake of a global pandemic, the national game has been beset by volatility and upheaval. In April 2021, six of the most storied clubs in England announced they would be joining a new breakaway European Super League (ESL). These proposals triggered vehement opposition from fan movements, catalysing the intervention of the UK government who established a fan-led review of football governance (FLR) to consult fans on future regulatory reform and the security and safety of supporters at major events. Emerging out of these exogenous shocks and endogenous change, the governance of English football is set to be radically transformed via the establishment of a new regulatory regime. In this article, we employ eventful sociology and historical institutionalism to operationalise the concept of critical juncture and apply this through an analysis of two temporal periods (1985-1990) and (2020-2024). In doing so, we show how the current ‘regulatory turn’ is interdependently linked to prior historical transformative events, namely the Heysel and Hillsborough stadium disasters and the subsequent neoliberal transformation of English football across the last four decades. Incorporating a more nuanced understanding of change and continuity in the governance of English football, we argue that new regulatory frameworks, despite their transformative potential, may continue to exhibit institutional legacies of the existing regime and prevailing political economy.

Integrated transcriptome and endogenous hormone analyses reveal the factors affecting the yield of Camellia oleifera

Camellia oleifera is an important woody oil tree in China, in which the flowers and fruits appear during the same period. The endogenous hormone changes and transcription expression levels in different parts of the flower tissue (sepals, petals, stamens, and pistils), flower buds, leaves, and seeds of Changlin 23 high-yield (H), Changlin low-yield (L), and control (CK) C. oleifera groups were studied. The abscisic acid (ABA) content in the petals and stamens in the L group was significantly higher than that in the H and CK groups, which may be related to flower and fruit drops. The high N6-isopentenyladenine (iP) and indole acetic acid (IAA) contents in the flower buds may be associated with a high yield. Comparative transcriptome analysis showed that the protein phosphatase 2C (PP2C), jasmonate-zim-domain protein (JAZ), and WRKY-related differentially expressed genes (DEGs) may play an important role in determining leaf color. Gene set enrichment analysis (GSEA) comparison showed that jasmonic acid (JA) and cytokinin play an important role in determining the pistil of the H group. In this study, endogenous hormone and transcriptome analyses were carried out to identify the factors influencing the large yield difference in C. oleifera in the same year, which provides a theoretical basis for C. oleifera in the future.

The Link between Endogenous Pain Modulation Changes and Clinical Improvement in Fibromyalgia Syndrome: A Meta-Regression Analysis.

Conditioned pain modulation (CPM) and temporal summation (TS) tests can measure the ability to inhibit pain in fibromyalgia syndrome (FMS) patients and its level of pain sensitization, respectively. However, their clinical validity is still unclear. We studied the association between changes in the CPM and TS tests and the clinical improvement of FMS patients who received therapeutic intervention. We systematically searched for FMS randomized clinical trials with data on therapeutic interventions comparing clinical improvement (pain intensity and symptom severity reduction), CPM, and TS changes relative to control interventions. To study the relationship between TS/CPM and clinical measures, we performed a meta-regression analysis to calculate odds ratios. We included nine studies (484 participants). We found no significant changes in TS or CPM by studying all the interventions together. Our findings show that this lack of difference is likely because pharmacological and non-pharmacological interventions resulted in contrary effects. Non-pharmacological interventions, such as non-invasive neuromodulation, showed the largest effects normalizing CPM/TS. Meta-regression was significantly associated with pain reduction and symptom severity improvement with normalization of TS and CPM. We demonstrate an association between clinical improvement and TS/CPM normalization in FMS patients. Thus, the TS and CPM tests could be surrogate biomarkers in FMS management. Recovering defective endogenous pain modulation mechanisms by targeted non-pharmacological interventions may help establish long-term clinical recovery in FMS patients.

Effect of postharvest cold storage and subsequent shelf-life on fruit quality and endogenous phytohormones in nectarine fruit

Cold storage is the main approach to extend the postharvest storage period of nectarines. The objective of this study was to investigate fruit quality (flavor and nutrition) and endogenous phytohormone changes and their related transcriptional changes in nectarine fruit after cold storage and subsequent shelf-life, which was performed metabolome, transcriptome and physiological analysis. Cold storage led to irreversible flavor loss due to the inhibition of aroma biosynthesis genes at low temperature. Sugar and organic acid content was affected, with an increase in glucose, fructose and malic acid, and a decrease in sorbitol and citric acid after cold storage or shelf-life. For fruit nutritional quality, total flavonoids or total carotenoids was not significantly affected by cold storage, whereas shelf-life process enhanced their accumulation. The activities of key enzymes for flavonoid biosynthesis, PAL and C4H, were enhanced during the shelf-life process, resulting in a significant increase in flavonoids and enhanced free radicals scavenging capacity. Meanwhile, shelf-life process increased carotenoids content by improving the expression of carotenoid biosynthesis genes PSY, ZDS and ZISO. Additionally, cold storage significantly increased the IAA content and ethylene production, thereby inducing the up-regulation of related signaling transduction genes. The shelf-life process further increased ethylene production, as well as salicylic acid and jasmonic acid content. This study unravels these crucial physiological and associated transcriptional changes of nectarines after cold storage, and may provide a theoretical foundation for improving fruit quality of peaches after cold storage.

Endogenous Political Legitimacy: The Tudor Roots of England’s Constitutional Governance

This paper highlights the importance of endogenous changes in the foundations of legitimacy for political regimes. It focuses on the central role of legitimacy changes in the rise of constitutional monarchy in England. It first defines legitimacy and briefly elaborates a theoretical framework enabling a historical study of this unobservable variable. It proceeds to substantiate that the low-legitimacy, post-Reformation Tudor monarchs promoted Parliament to enhance their legitimacy, thereby changing the legislative process from the “crown and Parliament” to the “crown in Parliament” that still prevails in England. The break with Rome permanently altered England’s political development.

Paclobutrazol Enhanced Stem Lodging Resistance of Direct-Seeded Rice by Affecting Basal Internode Development.

The objectives of this study were to explore the mechanism of stem mechanical strength in direct-seeded rice (DSR) as affected by paclobutrazol, especially its related endogenous hormone and cell wall component changes in culm tissue and response to the application of paclobutrazol. Field experiments were conducted in Changchun County, Jilin Province, China, by using two japonica rice varieties, Jiyujing and Jijing305, with soaking seeds in paclobutrazol at concentrations of (0 mg L-1, S0; 50 mg L-1; S1; 100 mg L-1; S2; 150 mg L-1, S3; 200 mg L-1, S4) in 2021 and 2022. The results suggest that the application of paclobutrazol increased the grain yield and reduced the lodging rate of DSR. Compared with the S0 treatments, soaking the seeds in paclobutrazol treatments rapidly shortened the length of the basal internode by decreasing the endogenous indole acetic acid (IAA) and gibberellin A3 (GA3) contents in culm tissue. The larger breaking strength (M) was attributed to a higher section modulus (SM) and bending stress (BS). The higher mechanical tissue thickness in culm tissue under paclobutrazol treatments, which was raised by higher endogenous zeatin and zeatin riboside (Z+ZR) content in culm tissue, increased the culm diameter, culm wall thickness, and section modulus (SM) of the internode. Compared with the S0 treatments, soaking the seeds in paclobutrazol treatments increased the cellulose content, lignin content, activities of lignin-related enzymes, and expression of key genes in lignin biosynthesis, as well as resulted in a higher bending stress (BS) to enhance the culm breaking strength (M).

Institutional change and ecological structural change

The paper presents a model discussing the political economy dimension of the green transition. There are brown sectors whose share in value-added and employment should contract and green sectors whose share should increase. Green technological changes require more skilled workers, potentially exacerbating inequalities between them and unskilled workers. Trade unions advocate for a “Just Transition”, ensuring income protection and creating new “green jobs”. However, the green restructuring of the economy demands highly subsidized investments in the short run. A political economy problem arises: how to regulate brown capitalists, support green capitalists, and prevent unskilled workers from joining forces with brown capitalists to block the green transition. The solution can be positive feedback between green technical change, non-price competitiveness, and employment. The BOPCG model allows for highlighting the role of catching up in green technologies in non-price competitiveness and endogenous institutional change to give rise to a growth path consistent with the idea of a “just green transition”.

Combination of biotransformation and metabolomics reveals tolfenpyrad-induced hepatocytotoxicity

Tolfenpyrad (TFP) is an extensively used pesticide that inevitably leads to human exposure to both TFP and its transformation product residues. However, the biotransformation of TFP in humans has not been elucidated, and the toxicity of TFP along with its biotransformation products remains largely unknown. In this study, the biotransformation process of TFP was investigated using human liver microsomes and human hepatic cells. Endogenous metabolic changes in the cells were studied to investigate the hepatocytotoxicity of TFP at environmentally relevant concentrations. Fourteen phase I biotransformation products and four phase II TFP products were characterized, among which twelve products were identified for the first time. The oxidative product tolfenpyrad-benzoic acid (PT-CA) was particularly abundant and stable. Further hepatotoxicity assessments and metabolic studies demonstrated comparable metabolic profiles for TFP and PT-CA in HepG2 cells, with both significantly disrupting purine and glutathione metabolism. These processes are closely associated with oxidative stress, mitochondrial damage, and cell death. Our results provide novel perspectives on the biotransformation, metabolism, and hepatotoxicity of TFP, thereby highlighting the non-negligible toxicity of its crucial biotransformation product PT-CA in environmental risk assessments.

Hormones, Hypertrophy, and Hype: An Evidence-Guided Primer on Endogenous Endocrine Influences on Exercise-Induced Muscle Hypertrophy.

We review the evidence indicating that endogenous changes in these hormones, including testosterone, growth hormone, insulin growth factor-1, and estrogen, and their proposed anabolic effects contribute to and augment resistance exercise training (RET)-induced hypertrophy. Additionally, we provide recommendations for gold-standard methodological rigor to establish best practices for verifying menstrual phases as part of their research, ultimately enhancing our understanding of the impact of ovarian hormones on RET-induced adaptations.

Bioelectret Materials and Their Bioelectric Effects for Tissue Repair: A Review.

Biophysical and clinical medical studies have confirmed that biological tissue lesions and trauma are related to the damage of an intrinsic electret (i.e., endogenous electric field), such as wound healing, embryonic development, the occurrence of various diseases, immune regulation, tissue regeneration, and cancer metastasis. As exogenous electrical signals, such as conductivity, piezoelectricity, ferroelectricity, and pyroelectricity, bioelectroactives can regulate the endogenous electric field, thus controlling the function of cells and promoting the repair and regeneration of tissues. Materials, once polarized, can harness their inherent polarized static electric fields to generate an electric field through direct stimulation or indirect interactions facilitated by physical signals, such as friction, ultrasound, or mechanical stimulation. The interaction with the biological microenvironment allows for the regulation and compensation of polarized electric signals in damaged tissue microenvironments, leading to tissue regeneration and repair. The technique shows great promise for applications in the field of tissue regeneration. In this paper, the generation and change of the endogenous electric field and the regulation of exogenous electroactive substances are expounded, and the latest research progress of the electret and its biological effects in the field of tissue repair include bone repair, nerve repair, drug penetration promotion, wound healing, etc. Finally, the opportunities and challenges of electret materials in tissue repair were summarized. Exploring the research and development of new polarized materials and the mechanism of regulating endogenous electric field changes may provide new insights and innovative methods for tissue repair and disease treatment in biological applications.

A mitochondria-targeted fluorescent sensor for imaging endogenous peroxynitrite changes in acute lung injury

Acute lung injury (ALI) is a serious pulmonary inflammatory disease resulting from excessive reactive oxygen species (ROS) which could cause the damage of the alveolar epithelial cells and capillary endothelial cells. Peroxynitrite, as one of short-lived reactive oxygen species, is closely related to the process of ALI. Thus, it is important to monitor the fluctuation of peroxynitrite in living system for understanding the process of ALI. Herein, the novel mitochondria-targeted fluorescent probe BHMT was designed to respond to peroxynitrite and pH with distinct fluorescence properties respectively. The absorption spectrum of the probe BHMT exhibited a notable red shift as the pH value declined from 8.8 to 2.6. Upon reaction with peroxynitrite, BHMT had a significant increase of fluorescence intensity (63-fold) with maintaining a detection limit of only 43.7 nM. Furthermore, BHMT could detect the levels of endogenous peroxynitrite and image the intracellular pH in ratiometric channels utilizing cell imaging. In addition, BHMT was successfully applied to revealing the relationship between the peroxynitrite and the extent of ALI. Thus, these results indicated the probe BHMT could be a potential tool for diagnosing the early stage of ALI and revealed the peroxynitrite was likely to be a crucial therapeutic target in ALI treatment.

Exacerbations of bronchiectasis.

Bronchiectasis presents a significant challenge due to its rising prevalence, associated economic burden and clinical heterogeneity. This review synthesises contemporary understanding and literature of bronchiectasis exacerbations, addressing the transition from stable state to exacerbations, underlining the importance of early and precise recognition, rigorous severity assessment, prompt treatment, and prevention measures, as well as emphasising the need for strategies to assess and improve early and long-term patient outcomes. The review highlights the interplay between stable state phases and exacerbations in bronchiectasis, introducing the concept of "exogenous and endogenous changes in airways homeostasis" and the "adapted island model" with a particular focus on "frequent exacerbators", a group of patients associated with specific clinical characteristics and worse outcomes. The pathophysiology of exacerbations is explored through the lens of microbial and nonmicrobial triggers and the presence and the activity of comorbidities, elaborating on the impact of both exogenous insults, such as infections and pollution, and endogenous factors such as inflammatory endotypes. Finally, the review proposes a multidisciplinary approach to care, integrating advancements in precision medicine and biomarker research, paving the way for tailored treatments that challenge the traditional antibiotic paradigm.

Development Process of Unification Education Policy: Focusing on University and Society

Purpose: Unification education is greatly influenced by policy depending on its target. This unification education policy has characteristics that vary depending on the target. Accordingly, the development process of the unification education policy was reviewed, focusing on universities and society. Method: This study first reviewed laws related to unification education policy. Next, we looked at the contents of unification education related to these laws. Based on this, the model of unification education was reviewed. Results: In order to increase the effectiveness of unification education policies targeting universities and social education, efforts are needed to analyze and present the characteristics of unification education in universities and society, and to develop unification education by reflecting the characteristics of individual entities involved. These efforts will converge into public value. Conclusion: In order to induce endogenous changes in a positive direction along with the sustainability of our society related to unification education, the results of unification education being developed in elementary and middle schools should be deepened through university and social education, and through this, the unification policy of our society will be improved. The formation of a bottom-up unification policy that allows this to be formed is required. To this end, various policy efforts will be needed to ensure that the currently developing university and social unification education is developed more actively.

Role of Flavohemoglobins in the Development and Aflatoxin Biosynthesis of Aspergillus flavus.

Aspergillus flavus is notorious for contaminating food with its secondary metabolite-highly carcinogenic aflatoxins. In this study, we found that exogenous nitric oxide (NO) donor could influence aflatoxin production in A. flavus. Flavohemoglobins (FHbs) are vital functional units in maintaining nitric oxide (NO) homeostasis and are crucial for normal cell function. To investigate whether endogenous NO changes affect aflatoxin biosynthesis, two FHbs, FHbA and FHbB, were identified in this study. FHbA was confirmed as the main protein to maintain NO homeostasis, as its absence led to a significant increase in intracellular NO levels and heightened sensitivity to SNP stress. Dramatically, FHbA deletion retarded aflatoxin production. In addition, FHbA played important roles in mycelial growth, conidial germination, and sclerotial development, and response to oxidative stress and high-temperature stress. Although FHbB did not significantly impact the cellular NO level, it was also involved in sclerotial development, aflatoxin synthesis, and stress response. Our findings provide a new perspective for studying the regulatory mechanism of the development and secondary mechanism in A. flavus.

Antimicrobial Pharmacokinetic Considerations in Extracorporeal Membrane Oxygenation.

Critical illness creates challenges for healthcare providers in determining the optimal treatment of severe disease, particularly in determining the most appropriate selection and dosing of medications. Critically ill patients experience endogenous physiologic changes that alter the pharmacokinetics (PKs) of medications. These alterations can be further compounded by mechanical support modalities such as extracorporeal membrane oxygenation (ECMO). Specific components of the ECMO circuit have the potential to affect drug PKs through drug sequestration and an increase in the volume of distribution. Factors related to the medications themselves also play a role. These PK alterations create problems when trying to properly utilize antimicrobials in this patient population. The literature seeking to identify appropriate antimicrobial dosing regimens is both limited and difficult to evaluate due to patient variability and an inability to determine the exact role of the ECMO circuit in reduced drug concentrations. Lipophilic and highly protein bound medications are considered more likely to undergo significant drug sequestration in an ECMO circuit, and this general trend represents a logical starting point in antimicrobial selection and dosing in patients on ECMO support. This should not be the only consideration, however, as identifying infection and evaluating the efficacy of treatments in this population is challenging. Due to these challenges, therapeutic drug monitoring should be utilized whenever possible, particularly in cases with severe infection or high concern for drug toxicity.

An extended Goodwin model with endogenous technical change and labor supply

This paper extends the Goodwin model of distributive cycles by incorporating the simultaneous endogeneity of technical change and labor supply within a classical-Marxian framework. It reinterprets induced innovation, suggesting that firms optimize mechanization to maximize cost reduction, obtaining a micro-founded relationship between mechanization and the wage share. Additionally, it assumes a positive relationship between labor supply and the employment rate. The resulting three-dimensional dynamical system includes wage share, employment rate, and capital-output ratio as state variables. The Hopf bifurcation theorem reveals the emergence of limit cycles as the employment rate's effect on labor productivity (reserve-army-creation effect) approximates a critical value from below. Numerical simulations for 10 OECD countries illustrate the cyclical nature of the model and its consistency with empirical patterns. Furthermore, a sensitivity analysis explores the effect of parameters variations, emphasizing the social dimensions of productivity and labor supply as critical factors defining the stability of distributive cycles.

FEATURES OF COPD STRUCTURE IN ELDERLY PATIENTS

Currently, there is a clear trend towards an increase in the elderly population. Their share in the population of many countries has exceeded 20%. Prevention of aging is one of the most actively and dynamically developing new areas of medicine in recent years. Factors such as decreased metabolism, dysfunction of the endocrine system and immunity, impaired microcirculation and neurohumoral regulation play a role in the process of natural aging. The age-related decrease in estrogen levels in a woman's body plays an important role in the development of endogenous changes in COPD. Skin aging plays an important role in the mechanism of the overall biological aging process of the body. On the one hand, the mucous membrane of the oral cavity determines metabolic, structural and functional changes common to the entire body, and the condition of the skin as a whole may indicate the degree of aging of the body. On the other hand, the oral cavity is an organ that is constantly in contact with the external environment, as a result of which signs of aging can appear much earlier than in other organs.

Ultra-high signal-to-noise ratio near-infrared chemiluminescent probe for in vivo sensing singlet oxygen

Singlet oxygen (1O2), as the primary reactive oxygen species in photodynamic therapy, can effectively induce excessive oxidative stress to ablate tumors and kill germs in clinical treatment. However, monitoring endogenous 1O2 is greatly challenging due to its extremely short lifetime and high reactivity in biological condition. Herein, we report an ultra-high signal-to-ratio near-infrared chemiluminescent probe (DCM-Cy) for the precise detection of endogenous 1O2 during photodynamic therapy (PDT). The methoxy moiety was removed from enolether unit in DCM-Cy to suppress the potential self-photooxidation reaction, thus greatly eliminating the photoinduced background signals during PDT. Additionally, the compact cyclobutane modification of DCM-Cy resulted in a significant 6-fold increase in cell permeability compared to conventional adamantane-dioxane probes. Therefore, our “step-by-step” strategy for DCM-Cy addressed the limitations of traditional chemiluminescent (CL) probes for 1O2, enabling effectively tracking of endogenous 1O2 level changes in living cells, pathogenic bacteria and mice in PDT.