Background. In patients with cyanotic congenital heart defects, pulmonary blood flow is maintained by a functioning patent ductus arteriosus (PDA). Most patients with complex ductal-dependent cyanotic defects require intermediate staged treatment before radical correction of the defect. Timely and comprehensive outpatient monitoring by a pediatrician and pediatric cardiologist are important for patient survival following palliative treatment, along with determining optimal timing for consultations at specialized cardiac surgical centers. Objective: to present the outcomes of using two methods for increasing pulmonary blood flow (systemic-to-pulmonary artery shunt (SPAS) and PDA stenting), as well as the features of outpatient cardiological observation and treatment in these patients. Materials and methods. From 2000 to February 2024, 22 patients underwent SPAS, and 25 — PDA stenting at the State Institution “Scientific and Practical Medical Center of Pediatric Cardiology and Cardiac Surgery” of the Ministry of Health of Ukraine. Results. After interventions, the mean arterial oxygen saturation (SatO2) increased in both groups, significantly higher in the PDA stenting group (p < 0.05). The average length of stay in the intensive care unit in the SPAS group was 19.6 ± 11.1 (range: 5 to 91) days compared to 12.8 ± 6.3 (range: 4 to 37) days in those with PDA stenting (p = 0.05). The duration of artificial lung ventilation in the SPAS group was 290.3 ± 215.3 (range: 63 to 751) hours, and in the PDA stenting group, it was shorter, 151.8 ± 75.5 (range: 39 to 549) hours (p < 0.05). Early (30-day) postoperative mortality in the SPAS group was 13.6 % (3/22 patients), with a late mortality of 18 % (4/22). In contrast, there was not early (30-day) postoperative mortality in the PDA stenting group, and late mortality was 8 % (2/25). Before the subsequent stage of surgical correction, sufficient growth of pulmonary artery branches was noted (Nakata index increased from 156.9 ± 33.3 mm2/m2 to 277.0 ± 35.9 mm2/m2 in the SPAS group and from 142.7 ± 55.2 mm2/m2 to 289.1 ± 149.2 mm2/m2 in the PDA stenting group), and the left ventricular end-diastolic index has increased (from 51.2 ± 32.4 mm2/m2 to 67.5 ± 15.5 mm2/m2 in the SPAS group and from 50.8 ± 24.9 mm2/m2 to 56.7 ± 28.5 mm2/m2 in the PDA stenting group). Thirteen patients in the SPAS group underwent the next stage of surgical correction (Glenn shunt or total repair of the congenital heart defect), while in the PDA stenting group — 17 patients. Conclusions. For cyanotic congenital heart defects, which have ductus-dependent pulmonary blood flow, both described methods are quite effective.