Encapsulated Iron Oxide Research Articles

Effective activation of PMS by encapsulating monodispersed Fe3O4 within N, S heteroatoms co-doped carbon chamber for ROX removal dominated by the non-radical pathway

Developing the eco-friendly catalyst-adsorption iron-based materials with improved catalytic activity and minimal Fe leaching is fascinating for roxarsone (ROX) removal. Herein, Fe3O4 nanoparticles were encapsulated in flexible N, S-modified carbon chamber (Fe3O4@NS4C) through the “hydrothermal + pyrolysis” process to form a catalyst with multi-active sites. ROX could be degraded nearly 100 % at pH 5.0 −11.0 and secondary inorganic As species concentration is lower than 0.09 mg/L by efficient adsorption. Especially, the Fe ion leaching concentration in Fe3O4@NS4C/PMS after ROX removal is decreased to 0.08 mg/L. Combined with quenching experiment, EPR, Raman spectroscopy and electrochemical analysis, the non-radical activation mechanism dominated by 1O2 and electron transfer was determined. The synergistic interaction between the N doped sites and the S anchored sites within the carbon matrix not only improves the adsorption of PMS on the catalyst but also facilitates the direct activation of PMS to 1O2, while the surface electron transfer improves the Fe2+/Fe3+ redox cycling in PMS activation. The active sites of ROX attacked by 1O2 were examined through Fukui function computations. Combined with HPLC-MS, the ROX degradation pathway was determined, and the toxicity of intermediates was evaluated. Furthermore, the removal performance of ROX in Fe3O4@NS4C/PMS system was also assessed in different environment for practical application, indicating that the advantages in the synergy between N, S co-doping carbon chamber and encapsulated iron oxide for water purification.

Power dependent tunable optical nonlinearity in Iron oxide/Borophene core-shell nanoparticles under ultrashort laser excitation

Two-dimensional (2D) nanomaterials find immense applications in ultrafast photonics and optical switching systems due to their fascinating nonlinear optical (NLO) characteristics. This work presents a systematic investigation of laser power-dependent nonlinear optical characteristics of borophene nanosheets in a core-shell nanostructure. For this purpose, we have synthesized Borophene encapsulated Iron oxide (Fe3O4) core-shell nanoparticles (Fe3O4/Borophene CSNPs). The CSNPs were synthesized by mixing and annealing sodium borohydride (NaBH4) as a boron precursor with iron oxide nanoparticles (Fe3O4 NPs) in a controlled environment using chemical vapor deposition technique (CVD) followed by characterization using XRD, FTIR Spectroscopy, UV–vis absorption spectroscopy, TEM, SEM, and EDX techniques. Magnetic properties were analyzed by a vibrating sample magnetometer (VSM) which shows that the saturation magnetization of Fe3O4 NPs increases after being encapsulated in borophene nanosheets. The role of borophene in modifying the NLO characteristics of Fe3O4/Borophene CSNPs was studied using a power-dependent Z-scan technique utilizing ultrashort (femtosecond) laser pulses at a wavelength of 800 nm in both open and close aperture configuration. It was found that borophene-coated Fe3O4 NPs reveal tunable NLO properties that resemble the NLO characteristics of borophene nanosheets with enhanced features. This provides insights into an interaction between materials in NLO phenomena and illustrates the distinctive performance of the core-shell nanostructure. The tunable NLO properties of Fe3O4/Borophene CSNPs offer an innovative approach for developing optoelectronics and ultrafast nonlinear photonic devices.

Engineering Magnetic Extracellular Vesicles Mimetics for Enhanced Targeting Chemodynamic Therapy to Overcome Ovary Cancer.

Chemodynamic therapy (CDT), employing metal ions to transform endogenous H2O2 into lethal hydroxyl radicals (•OH), has emerged as an effective approach for tumor treatment. Yet, its efficacy is diminished by glutathione (GSH), commonly overexpressed in tumors. Herein, a breakthrough strategy involving extracellular vesicle (EV) mimetic nanovesicles (NVs) encapsulating iron oxide nanoparticles (IONPs) and β-Lapachone (Lapa) was developed to amplify intracellular oxidative stress. The combination, NV-IONP-Lapa, created through a serial extrusion from ovarian epithelial cells showed excellent biocompatibility and leveraged magnetic guidance to enhance endocytosis in ovarian cancer cells, resulting in selective H2O2 generation through Lapa catalysis by NADPH quinone oxidoreductase 1 (NQO1). Meanwhile, the iron released from IONPs ionization under acidic conditions triggered the conversion of H2O2 into •OH by the Fenton reaction. Additionally, the catalysis process of Lapa eliminated GSH in tumor, further amplifying oxidative stress. The designed NV-IONP-Lapa demonstrated exceptional tumor targeting, facilitating MR imaging, and enhanced tumor suppression without significant side effects. This study presents a promising NV-based drug delivery system for exploiting CDT against NQO1-overexpressing tumors by augmenting intratumoral oxidative stress.

Insights into the Ligand Effect in β-CD@Fe3O4 Composites to Activate Peroxymonosulfate for Efficient Degradation of Pharmaceutical Contaminants: A Study Employing Density Functional Theory

This study presents a detailed investigation into the use of β-cyclodextrin (β-CD) encapsulated iron oxide nanoparticle (β-CD@Fe3O4) composites, modified with different ligands, to activate peroxymonosulfate (PMS) for the degradation of pharmaceutical contaminants, namely, diclofenac, carbamazepine, and erythromycin. The focus is on understanding the ligand effect, particularly using citric acid (CIT), polyethyleneimine (PEI), and cetyl trimethyl ammonium bromide (CTAB), on the degradation performance of these composites. Employing density functional theory (DFT) calculations, this work examines the electronic structure and charge distributions of β-CD@Fe3O4 composites, providing insights into their interaction with various pollutants. The study reveals that the β-CD@PEI@Fe3O4 composite demonstrates superior degradation efficiency due to optimal electrostatic interactions, regardless of the pollutant’s hydrophobicity. On the other hand, β-CD@CIT@Fe3O4 shows moderate efficiency, and β-CD@CTAB@Fe3O4 exhibits selective efficiency, particularly for hydrophobic compounds. These findings underscore the significant role of surface chemistry in modulating the activation of PMS and the degradation of contaminants, opening avenues for designing tailored β-CD composites for environmental remediation.

Enhanced Magnetic Properties of Iron Oxide Nanoparticles Encapsulated in Cobalt Nanopowder Derived from Sunur-Pariaman Beach Sand

Cobalt encapsulated iron oxide nanoparticles based on Sunur-Pariaman beach sand were prepared using ball milling method. Cobalt nanoparticles with concentration of 0, 5,10 and 15 wt.% were added to the iron oxide nanoparticles. Un-encapsulated iron oxide nanoparticles revealed as pure cubic structure of magnetite phase well matched to JCPDS No. 03-0863 with crystallite size in the range of 30.86 -34.91 nm confirmed by X-Ray diffractometer (XRD). Saturation, remanance magnetization and coercivity increase with an increase of cobalt concentration for Co-encapsulated iron oxide nanopartcles showed good magnetic properties. These findings display excellence performance of cobalt encapsulated iron oxide nanparticles compared to un-encapsulated iron oxide nanoparticles and has been considered to be a potential candidate to be used as catalyst for degradation of methylene blue. The concentration of iron (Fe) and titanium (Ti) increase after being milled 100h. However, non iron oxide nanoparticles decrease.

Magnetic resonance imaging of pancreatic islets using tissue–adhesive particles containing iron oxide nanoparticles

Post–transplantation tracking of pancreatic islets is a prerequisite for advancing cell therapy to treat type 1 diabetes. Magnetic resonance imaging (MRI) has emerged as a safe and non–invasive technique for visualizing cells in clinical applications. In this study, we proposed a novel MRI contrast agent formulation by encapsulating iron oxide nanoparticles (IONPs) in poly(lactic–co–glycolic acid) (PLGA) particles functionalized with a tissue adhesive polydopamine (PD) layer (IONP–PLGA–PD MS). Intriguingly, our particles facilitated efficient and robust labeling through a one–step process, allowing for the incorporation of a substantial amount of IONPs without detrimental impacts on the viability and functionality of pancreatic islets. The MRI signals emanating from islets labeled using our particles were found to be stable over 30 days in vitro and 60 days when transplanted under kidney capsules of diabetic mice. These results suggest that our approach provides a potential platform for monitoring the fate of pancreatic islets after transplantation.

Synthesis of carbon nanotube-iron oxide composites via combustion waves for hybrid Li-ion battery anodes

The design and synthesis of suitable transition metal oxide (TMO) with carbonaceous material are crucial to produce high-performance anodes for Lithium-ion batteries (LIBs). Here, we show a facile synthesis method for iron oxide and carbon nanotube (CNT) composite via CNT-guided combustion waves. The combustion waves propagate through a freestanding film composed of multi-walled CNTs (MWCNTs), iron nitrate, and combustible nitrocellulose, synthesizing the composite in one-pot within a few seconds. The resulting composite consists of MWCNT networks encapsulating iron oxide submicron particles (CFs). The composite electrode employing optimized CFs provides exceptional initial specific capacity and rate capability (792 mAh/g at 0.1C and 588 mAh/g at 5C) and an increased capacity of 1215 mAh/g after 500 charge–discharge cycles at 1C. The morphological and electrochemical characterization reveal pulverized nanoparticles encapsulated within MWCNT networks, entailing hybrid capacities of redox conversion and pseudocapacitance. This facile synthesis method for TMO–MWCNT composites provides a feasible family of low-cost composite electrodes for high-performance LIBs.

Sodium alginate encapsulated iron oxide decorated with thymoquinone nanocomposite induces apoptosis in human breast cancer cells via PI3K-Akt-mTOR pathway

The present study investigated the cytotoxicity and proapoptotic properties of iron oxide-sodium-alginate-thymoquinone nanocomposites against breast cancer MDA-MB-231 cells in vitro and in silico. This study used chemical synthesis to formulate the nanocomposite. Electron microscopies such as scanning (SEM) and transmission (TEM), Fourier transform infrared (FT-IR), Ultraviolet-Visible, Photoluminescence spectroscopy, selected area (electron) diffraction (SAED), energy dispersive X-ray analysis (EDX), and X-ray diffraction studies (XRD) were used to characterize the synthesized ISAT-NCs and the average size of them was found to be 55 nm. To evaluate the cytotoxic, antiproliferative, and apoptotic potentials of ISAT-NCs on MDA-MB-231 cells, MTT assays, FACS-based cell cycle studies, annexin-V-PI staining, ELISA, and qRT-PCR were used. PI3K-Akt-mTOR receptors and thymoquinone were predicted using in-silico docking studies. Cell proliferation is reduced in MDA-MB-231 cells due to ISAT-NC cytotoxicity. As a result of FACS analysis, ISAT-NCs had nuclear damage, ROS production, and elevated annexin-V levels, which resulted in cell cycle arrest in the S phase. The ISAT-NCs in MDA-MB-231 cells were found to downregulate PI3K-Akt-mTOR regulatory pathways in the presence of inhibitors of PI3K-Akt-mTOR, showing that these regulatory pathways are involved in apoptotic cell death. We also predicted the molecular interaction between thymoquinone and PI3K-Akt-mTOR receptor proteins using in-silico docking studies which also support PI3K-Akt-mTOR signaling inhibition by ISAT-NCs in MDA-MB-231 cells. As a result of this study, we can conclude that ISAT-NCs inhibit the PI3K-Akt-mTOR pathway in breast cancer cell lines, causing apoptotic cell death.

Magnetic gelatin nanoparticles as a biocompatible carrier system for small interfering RNA in human colorectal cancer: Synthesis, optimization, characterization, and cell viability studies

Iron oxide-based nanoparticles have gained tremendous attention in developing next-generation personalized medicine modalities. Gelatin can be a good alternative for encapsulating iron oxide nanoparticles with its biocompatibility, biodegradability, low immunogenicity, and richness of functional groups. Herein, magnetic iron oxide nanoparticles (MNPs) were synthesized, coated with gelatin (Gel-MNPs), and loaded with mammalian target of rapamycin (mTOR)-silencing siRNA to induce the in vitro therapeutic effect in colorectal cancer (CRC) cells. To the best of our knowledge, this study is the first report using Gel-MNPs as siRNA carriers. We first optimized several experimental conditions for the preparation of MNPs and Gel-MNPs and the resulting optimized nanoparticles showed a narrow size and size distribution. Gelatin-coating increased the storage stability by preventing the aggregation of MNPs and did not alter the magnetic characteristics of MNPs significantly. siRNA encapsulation abilities of Gel-MNPs were determined in the range of 18.4 and 41.5% in varying siRNA amounts. Bare Gel-MNPs were highly cytocompatible against CRC cells, Caco-2, while Gel-MNPs-mTOR-siRNA exhibited a significant anticancer effect to kill these cells. Comparison with HiPerFect, a commercial siRNA transfection reagent, demonstrated that Gel-MNPs-mTOR-siRNA inhibited cell viability almost similar to or better than HiPerFect-mTOR-siRNA. Taken together, our data indicated that Gel-MNPs could potentially be used in further gene silencing approaches as a safe and multifunctional siRNA carrier candidate.

Preparation of magnetic microcapsules of α-amylase and α-glucosidase for dual-target affinity screening of active components from Toona sinensis

Natural products are an important source of drug development and have good prospects in the treatment of many diseases. However, the efficacy of many natural drugs is achieved through multi-targets, which poses a huge obstacle to their development. In this study, a bienzyme microcapsule system based on α-amylase and α-glucosidase was constructed for the ligand fishing of natural compounds. The microcapsules were formed on the surface of calcium carbonate particles by self-polymerization of dopamine, which physically encapsulated iron oxide and α-glucosidase. Then, α-amylase was immobilized on the surface of magnetic material with glutaraldehyde as crosslinking agent, and calcium carbonate template was removed by EDTA to form a bienzyme system for affinity screening of active components from Toona sinensis. The results showed that two compounds, 1,2,3,4,6-penta-O-galloyl-β-D-glucose and quercitrin were affinity screened from the extracts of Toona sinensis. In vitro activity experiment proved that they were α-amylase and α-glucosidase inhibitors, respectively. Moreover, both of them were mixed type inhibitors that can interact with active centers of corresponding enzymes through multiple hydrogen bonds, van der Waals forces, etc. This study not only proved the effectiveness of the bienzyme system, but also provided a successful example for multi-target screening of natural products.

Self-assembly of C@FeO nanopillars on 2D-MOF for simultaneous removal of microplastic and dissolved contaminants from water

Environmental pollution is a significant contributor to diseases in living organisms, with water being crucial to humans, plants, and aquatic’s survival. However, removing both solid and dissolved contamination in water remains a significant challenge. Small size solids are most concerning due to the difficulty in detecting and removing them using current technologies. Therefore, developing an innovative and cost-effective method becomes a high priority. Herein, we developed a novel approach to remove solids and dissolved contaminants simultaneously using nanopillared structures composed of two-dimensional (2D) metal–organic framework (MOF) separated by carbon encapsulated iron oxide (C@FeO) nanopillars. The nanopillared structure features a high surface area (749.7 m2/g), abundant active sites, and magnetic properties for separation of pollutants. 2D MOF@C@FeO removed ∼100 % micro-plastic (MP) only in 60 min with high kinetics as quantified by dynamic light scattering, UV–vis, and thermogravimetric analysis. Further, in a binary system (solid and dissolved pollutants), 2D MOF@C@FeO successfully removed both MP and methylene blue (MB) in 60 min. Zeta potential, ex situ scanning electron microscopy, and X-ray photoelectron spectroscopy analysis and 2nd-order kinetics isotherm supported chemosorption mechanism of removal. 2D MOF@C@FeO showed 6 adsorption cycles reusability with 90 % removal capacity. The stability and the pereservance of the structure of 2D MOF@C@FeO after six cycle was proved by ex situ transmission electron microscopy, Brunauer-Emmett-Teller, and Energy-dispersive X-ray spectroscopy. The results suggest a promising pathway to addressing the removal of mixed contaminants from water in a single process and highlighting its potential in resolving critical industrial and domestic wastewater treatment.

Carbon encapsulated iron oxide for simultaneous Fenton degradation and adsorption of cationic and anionic dyes from water

Adsorption and Fenton oxidation processes are considered the most effective ways to treat industrial dye effluent. However, the separation of adsorbent materials and the leaching of secondary pollutants are big hurdles. To resolve these issues, here, we have developed a unique hybrid structure (Fe3O4 @C) by encapsulating iron oxide into carbon shells using olive mill waste in a one-step process. The resulting unique core-shell Fe3O4 @C structure possessed both tunned surface functional groups (carboxylic, carbonyl, and amines) and magnetic properties, which can be easily separated from treated water using a magnet. Upon using Fe3O4 @C as a catalyst, it simultaneously removed/ degraded both Congo red (CR) and methylene blue (MB) up to 94% through Fenton oxidation. ICP-MS analysis detected negligible (6.6 ppb) iron leaching even in Fenton degradation, which is far lower than the allowable leaching limit of 300 ppb showing the efficacy of the developed structure. This is due to the core-shell structure where Fe3O4 remains active inside the core due to dual protection by encapsulating inside a semicrystalline carbon shell, which is then protected by a porous carbon matrix. This double protection assists high adsorption and maintains efficient charge transfer that favors high catalytic activity with limited iron leaching. Further to prove this Fe3O4 @C was used in 5 consecutive adsorption cycles, where it removed 94.4% MB after 5th cycle and even preserved the pristine core-shell structure and chemical bonds as indicated by ex-situ Energy-dispersive X-ray spectroscopy, High-angle annular dark field, High-angle annular bright field, and X-ray photoelectron spectroscopy analysis. Hence, this study successfully showed that olive waste could be converted into a functional material that can further be used at a large scale for pollutant removal from wastewater.

Dielectric relaxation of α-Fe2O3/Gd2O3 core-shell nanoparticle obtained through the polyol method

The design of core-shell nanostructures is a potential approach to obtaining advanced dielectric nanocomposites. The frequency-dependent dielectric dispersion of gadolinium oxide (Gd2O3) encapsulated iron oxide (Fe2O3) core-shell nanoparticles (Fe2O3/Gd2O3 CSNPs) synthesized by the polyol route is investigated in the temperature range from 303 K to 553 K and in the frequency range from 42 Hz to 1.1 MHz. The phase formation of the materials is evaluated by X-ray diffraction analysis. Synthesized Fe2O3/Gd2O3 CSNPs have multi-core nature are found by Transmission electron microscopy (TEM). Relaxation time corresponding to dielectric loss is found to obey Arrhenius law with an activation energy of 0.26 eV. Dielectric relaxation is analyzed in the electric modulus formalism. The frequency-dependent conductivity spectra follow the Jonscher power law.

Self-regulating novel iron oxide nanoparticle-based magnetic hyperthermia in swine: biocompatibility, biodistribution, and safety assessments.

Studies demonstrating the successful and safe application of magnetic hyperthermia in large animals are scarce. A therapeutic approach for advanced cancer comprising multicore encapsulated iron oxide (IO) Sarah Nanoparticles (SaNPs), that uniquely self-regulate their temperature, was developed thus overcoming the safety challenges of hyperthermia. SaNPs are intravenously injected and accumulate in tumor tissue, leading to selective heating upon exposure to an external alternating magnetic field (AMF). A series of studies were conducted in healthy swine to assess SaNPs' safety, alone or combined with AMF application. Administration of single high (up to 22mg IO/kg) or low (3.6mg IO/kg) SaNP doses had no adverse effects, including no infusion reactions. Vital signs remained stable with no significant clinical pathology changes, and no treatment-associated toxicities. Biodistribution analysis indicated that SaNPs predominantly accumulate in the lungs and clear in a dose- and time-dependent manner. In minipigs that received a single SaNP no-observed-adverse-effect-level (NOAEL)-based dose (3.6mg IO/kg) with AMF, the average percentage remaining in vital organs after 90days was 13.7%. No noticeable clinical signs were noted during the 87 to 92-day observation period following irradiation, and no inflammation, necrosis, nor thermal damage were found in the histopathology evaluation. In another minipig, ~ 90days after three recurrent high doses (14mg IO/kg), without AMF, almost half of the injected SaNPs were cleared with no residual detrimental effects. We demonstrate that the approach is safe and well tolerated in swine, opening potential avenues as a novel therapeutic modality for cancer patients.

Carbon Encapsulated Iron Oxide for Simultaneous Fenton Degradation and Adsorption of Cationic and Anionic Dyes from Water

Carbon Encapsulated Iron Oxide for Simultaneous Fenton Degradation and Adsorption of Cationic and Anionic Dyes from Water

Carbon Encapsulated Iron Oxide for Simultaneous Fenton Degradation and Adsorption of Cationic and Anionic Dyes from Water

Carbon Encapsulated Iron Oxide for Simultaneous Fenton Degradation and Adsorption of Cationic and Anionic Dyes from Water

Modified Polyethylene Glycol Encapsulated Iron Oxide Nanoparticles for Accelerated Wound Healing Application

One of the key factors required in tissue engineering/ regeneration is to create a dynamic platform to increase the interaction of cells in response to various stimuli. In this context, facile synthesis of modified polyethylene glycol (FL PEG) encapsulated Iron Oxide nanoparticles [PoeM (Fe) NPs] is reported for its wound healing application in presence of an external magnetic field. Iron Oxide nanoparticles (8 ± 2nm) are synthesized and coated with FL PEG resulting in the formation of PoeM (Fe) NPs. The synthesized nanoparticles are characterized for their UV-Vis absorbance, DLS and TEM. These PoeM (Fe) NPs show excellent biocompatibility and enhanced wound healing activity in L929 fibroblasts when compared with control groups. This study could pave the way for the development of novel biomimetic nanosystems for wound healing applications.

Study of the Effectiveness of Chitosan Encapsulated Iron Oxide Nanoparticles

The magnetic iron oxide nanoparticles have been synthesized by using co-precipitation approach. Chitosan coated nanoparticles compare the effect of surface coating on the stability and toxicity of nanoparticles. Invitro cytotoxicity of the nanoparticles are evaluated by three-(four-5) dimethyl thiazole-2-yl and -two,5, diphenyl thiazoniam bromide (MTT assay) along with glide cytometry examine for cell viability. Does dependent reduction was observed in SKMEL cancer cells administered with different concentration of the sample. I50 value obtained for the Iron nanoparticle is 217.75µg/Ml. The fluorescence primarily based real time opposite transcription PCR(RT-PCR) is widely used for the quantification of constant state mRNA ranges and is a crucial device for primary research molecular medicine and biotechnology. FTIR amino companies were acted as capping sites for the iron nanoparticles stabilization. In antibacterial studies Gentamycin 80mcg showed the higher activity of Iron nanoparticles.

Cytostatic and Cytotoxic Effects of Hollow-Shell Mesoporous Silica Nanoparticles Containing Magnetic Iron Oxide.

Among the different types of nanoparticles used in biomedical applications, Fe nanoparticles and mesoporous siliceous materials have been extensively investigated because of their possible theranostic applications. Here, we present hollow-shell mesoporous silica nanoparticles that encapsulate iron oxide and that are prepared using a drug-structure-directing agent concept (DSDA), composed of the model drug tryptophan modified by carbon aliphatic hydrocarbon chains. The modified tryptophan can behave as an organic template that allows directing the hollow-shell mesoporous silica framework, as a result of its micellisation and subsequent assembly of the silica around it. The one-pot synthesis procedure facilitates the incorporation of hydrophobically stabilised iron oxide nanoparticles into the hollow internal silica cavities, with the model drug tryptophan in the shell pores, thus enabling the incorporation of different functionalities into the all-in-one nanoparticles named mesoporous silica nanoparticles containing magnetic iron oxide (Fe3O4@MSNs). Additionally, the drug loading capability and the release of tryptophan from the silica nanoparticles were examined, as well as the cytostaticity and cytotoxicity of the Fe3O4@MSNs in different colon cancer cell lines. The results indicate that Fe3O4@MSNs have great potential for drug loading and drug delivery into specific target cells, thereby overcoming the limitations associated with conventional drug formulations, which are unable to selectively reach the sites of interest.

Facile bioinspired synthesis of iron oxide encapsulating silica nanocapsules

Iron oxide nanoparticles have been extensively studied for a wide variety of applications. However, there remains a challenge in developing hierarchical magnetic iron oxide nanoparticles as existing synthetic techniques require harsh, toxic chemical conditions and high temperatures or give poorly defined product with weak magnetic properties. In addition, drug loading is limited to post-loading methods such as chemical conjugation or surface adsorption that have poor loading efficiency and are prone to premature drug release. We report a facile biomimetic method for making iron oxide nanoparticle-loaded silica nanocapsules based on a bimodal catalytic peptide surfactant stabilized nanoemulsion template. Iron oxide nanoparticles can be preloaded into the oil phase of the nanoemulsion at tunable concentrations, and the excellent surface activity of the designed bimodal peptide in combination with sufficient electrostatic repulsion promotes the stability of the nanoemulsions. Biosilicification induced by the catalytic peptide module leads to the formation of silica shell nanocapsules containing a magnetic oil core. The bioinspired silica nanocapsules encapsulating iron oxide nanoparticles demonstrate the next-generation of magnetic nanostructures for drug delivery applications.