The building industry needs new design approaches to minimize resource consumption and negative environmental impacts. This study proposes a lightweight hybrid profile that combines a thin steel shell and a polymeric lattice core. The core density and internal structure variation possibilities control the slender steel profile’s load-bearing capacity and optimize the hybrid structure’s weight because of a synergy of the composite section components. The test campaign employs a 3D printing technology for prototyping the lattice core because the manufacturing preciseness (including the internal stiffener structure) is vital for structural optimization and developing adequate numerical models. A straightforward example illustrates the proposed concept. Lateral compression tests on 100 mm long fragments of the slender rectangular hollow section (RHS) 200/100/4 mm (height/width/thickness) profile prove the mechanical efficiency of the proposed hybrid section concept. Reducing the RHS fragment length ensures the experimental identification of the stiffening mechanism in the polymeric insert using a digital image correlation (DIC) technique and simplifies the numerical model. The 3D-printed lattice polymeric core added only 28% to the weight of the hybrid RHS fragment and increased its mechanical resistance twice compared to the reference empty shell fragments. This effect is equivalent to raising the profile thickness from 4 mm to 6 mm, resulting in a 1.5-times increase in weight. Using recycled plastics, adhesive connecting the inserts, and optimizing the internal geometry of the core stiffeners, depending on the loading conditions, may further increase the economic benefits of the proposed hybrid profile concept.