The objective of this study was to explore the preparation and characterisation of acetate cellulose laurate ester in sodium acetate/zinc chloride systems. The cellulose used in the study was obtained from oil palm empty fruit bunch and oil palm frond. The characterization of both the isolated cellulose and the acetate cellulose laurate ester was carried out using Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), Differential thermogravimetric (DTG), and Thermogravimetric analysis (TGA). The FT-IR analysis of the acetate cellulose laurate ester revealed the presence of C=O, confirming its modification. The crystallinity of the isolated cellulose and the acetate cellulose laurate ester was found to be 67-72% and 51-54%, respectively. The thermal stability of the isolated and modified cellulose esters was found to be 360-340 ℃ and 380-365 ℃, respectively. The solubility test showed that the prepared acetate cellulose laurate esters were soluble in different solvents. However, this study found that the synthesis of acetate cellulose laurate ester in an aqueous medium is not feasible. The improved hydrophobic character, good thermal stability, water retention value, and excellent solubility in different solvents of the acetate cellulose laurate ester reported in this study make it a potential material for applications in bioplastics, and packaging materials.