Emotional State Of Patients Research Articles

Comparative efficacy of inhaled nitric oxide therapy (Tianox device) in mild cognitive impairment

Chronic cerebrovascular diseases (CVD) and neurodegenerative diseases (NDD) are the most common causes of cognitive impairment (CI). The development of dementia is preceded by mild CI (MCI) over several years.Objective: to investigat the effect of inhaled nitric oxide therapy on cognitive function (CF) in patients with MCI due to CVD and NDD.Material and methods. The study included 94 patients (25 men and 69 women aged 50 to 76 years, mean age 65.3±8.9 years) with MCI due to CVD and/or NDD of the brain. The patients were randomized into two groups: the main group (therapy) and the control group. The control group comprised 22 patients with MCI (5 men and 17 women aged 50 to 76 years, mean age 62.3±8.5 years) who received standard therapy (antihypertensive, antithrombotic and other agents). The main group comprised 72 patients (20 men and 52 women aged 50 to 76 years, mean age 66.2±8.0 years) who additionally inhaled a nitric oxide-enriched air mixture for 30 minutes daily using the Tianox device. Each patient had from 7 to 10 inhalation sessions (the first trial session lasted 20 minutes, the following sessions 30 minutes). Neuropsychological tests, emotional state and sleep quality were examined at the beginning and 3 and 6 months after the end of treatment. Results. In the main group, after 3 and 6 months, a significant (p<0.05) improvement in CF was found according the Montreal Cognitive Assessment (MoCA-test), Frontal Assessment Battery, the Digit Forward and Backward Span Test, the Digit Symbol Substitution Test, the Munsterberg Test, the Literal Association Test and the 12-word Delayed Free Recall Test. A significant (p<0.05) decrease in anxiety and depression according to the Hospital Anxiety and Depression Scale, the Beck Depression Inventory and the Spielberger Anxiety Scale as well as an improvement in sleep quality according to the Insomnia Severity Index were also observed. The therapy was well tolerated, and no serious adverse events occurred. No significant improvement in CF, emotional state or sleep was observed in the control group.Conclusion. Brief therapy (7–10 sessions) with inhaled nitric oxide improves the CF and emotional state of patients with MCI on a background of CVD and NDD. Further studies on inhaled nitric oxide therapy in patients with MCI in a multicenter randomized trial with sham treatment are needed.

The application of integrating electroencephalograph-based emotion recognition technology into brain–computer interface systems for the treatment of depression: a narrative review

Dysregulation of the prefrontal cortex, amygdala, and hippocampus, along with alterations in P300 amplitude and abnormalities in the theta and beta bands, has been closely linked to the onset and pathophysiology of depression. Consequently, integrating electroencephalograph-based emotion recognition technology into brain‒computer interface systems offers the potential for real-time identification and modulation of emotional states through continuous interaction between the brain‒computer interface system and brain activity. This closed-loop system could precisely control neural stimulation in brain regions associated with emotional disorders, potentially alleviating the distressing memories of traumatic events. Although the efficacy of the brain‒computer interface in treating depression still requires validation through extensive clinical trials, its inherent real-time feedback and adaptive capabilities present a promising avenue for depression therapy. This review aims to explore the neuroanatomical mechanisms and neural activity patterns associated with depression and evaluate the potential of brain‒computer interface technology as a treatment modality. The objectives include summarizing key brain regions and neural networks involved in depression, analyzing their activity patterns, and assessing the impact of brain‒computer interface technology on these regions to provide theoretical support for future clinical trials. Significant functional abnormalities have been identified in the prefrontal cortex, amygdala, and hippocampus of patients with depression. The gray matter density, functional connectivity, and neural activity in these regions are closely associated with the severity of depressive symptoms. Common features in patients with depression include a reduced P300 amplitude and increased θ and α current density. Brain‒computer interface technology has demonstrated potential in modulating these abnormal neural activities, particularly in emotion recognition and regulation. When combined with techniques such as repetitive transcranial magnetic stimulation and deep brain stimulation, brain‒computer interface may provide effective interventions for managing emotional states in patients with depression. This review confirms the association between depression and functional abnormalities in specific brain regions and suggests that brain‒computer interface technology offers promising therapeutic potential by modulating abnormal neural activity. Brain‒computer interface could represent a novel treatment approach for depression. Future research should focus on validating the practical applications, efficacy, and safety of brain‒computer interface in treating depression.

The understanding and emotional state of patients about to undergo visceral surgery for cancer

The understanding and emotional state of patients about to undergo visceral surgery for cancer

Relationship between smoking, excessive androgen and negative emotions in women with polycystic ovary syndrome (PCOS)

BackgroundLifestyle intervention is the first-line treatment for PCOS. Numerous studies have investigated the effect of various lifestyle factors, including dietary habit, smoking, and alcohol consumption on PCOS women. These studies have found that such factors may be associated with physiological parameters such as androgen, and emotional states like anxiety or depression. Smoking, a harmful lifestyle habit widely recognized to contribute to various diseases, has also been found to be related to PCOS. Current research has not adequately compared the effects of smoking with other lifestyle habits on PCOS, and there is little mention of its relationship with the emotional states of patients with PCOS. To further elucidate the association between smoking and other lifestyle factors with clinical symptoms in patients with PCOS, we conducted a cross-sectional evaluation using data from Peking University Third Hospital, with a special focus on analyzing smoking habits and comparing it with a variety of lifestyle factors.MethodsThis cross-sectional study included 601 PCOS women and 184 healthy controls who underwent physical examinations, hormone profiles and psychological measures. We assessed the association between smoking and the clinical symptoms in PCOS women.ResultsWe found a significant correlation between smoking and the degree of depression in PCOS women among the three emotional states: anxiety, depression, and stress. Smoking was also significantly associated with testosterone level in PCOS participants, suggesting that PCOS women who smoke exhibited more severe depressive symptoms and higher testosterone level. In addition, compared to the control group, PCOS women had notably higher testosterone (T) and luteinizing hormone (LH) levels. Smoke and alcohol were statistically significantly more common in women with PCOS than the Control.ConclusionWomen with PCOS who smoke were found to have elevated testosterone levels and more severe depression. These findings suggest that clinicians should monitor smoking women with PCOS for symptoms of depression and assess their hyperandrogenic status.

Effect of clustered nursing on liver function indexes, nutrition, and emotional status of patients with severe liver failure.

Liver failure is a metabolic disorder caused by a variety of mixed factors. For such diseases, adopting cluster care can effectively improve the relevant symptoms of patients. To explore the nursing effect of nutritional nursing combined with clustered nursing for patients with severe liver failure. A total of 129 patients with severe liver failure were selected as retrospective study subjects. Nine cases were due to an end event, such as death. The other patients were divided into control group and observation group according to different nursing methods. Among them, the control group adopted nutrition nursing, and the observation group implemented cluster nursing on this basis. The differences of liver function, anxiety and depression score, gastrointestinal recovery, nutritional status, and sleep quality were compared between the 2 groups before and after nursing. After nursing, the total bilirubin, albumin, and aspartate aminotransferase of the observation group were significantly higher than those of the control group (P < .05). The nursing staff used Self-Rating Anxiety Scale and Self-Rating Depression Scale of the observation group, which were slightly lower than those of the control group. The difference was statistically significant after testing (P < .05). After nursing, the observation group's upper arm circumference, brachial tri-scalp fold thickness, and hemoglobin were better than those of the control group. Statistics showed that the difference was statistically significant (P < .05). The depth of sleep, time to fall asleep, number of awakenings, time to fall asleep after awakening, overall sleep quality, and intensive care unit environmental noise intensity in the Richards-Campbell Sleep Questionnaire sleep scale after nursing in the 2 groups were significantly higher than those before nursing, and the scores of the observation group were significantly lower than those in the observation group. In the control group, this difference was statistically significant (P < .05). Nutritional nursing combined with clustered nursing can effectively promote the recovery of gastrointestinal function in patients with severe liver failure.

Impact of hearing rehabilitation programs on presbycusis management: a systematic review and meta-analysis of randomized controlled trials.

In the field of audiology, numerous studies have sought to understand and improve hearing rehabilitation programs for older adults afflicted with presbycusis. Despite this, the field lacks uniform standards pertaining to the intervention methods, frequency, and duration of such programs. These discrepancies have led to varying test results and inconsistent findings across multiple studies. This meta-analysis aimed to evaluate the efficacy of hearing rehabilitation programs in enhancing the utilization of hearing aids among older adults with presbycusis. We conducted a comprehensive exploration of PubMed, Embase, Cochrane Library, and Web of Science to identify randomized controlled trials assessing the role of hearing rehabilitation programs for patients with age-related hearing loss. The search period spanned from the inception of each database to September 12, 2024. Outcomes were synthesized using RevMan 5.4 software. Eight studies met the inclusion criteria, involving 598 patients (290 in the intervention group and 308 in the control group). It was observed that hearing rehabilitation programs significantly diminished self-perceived hearing impairment [MD = -5.80, 95% CI = (-8.16, -3.44), p < 0.00001] and negative emotional states [MD = -1.66, 95% CI = (-3.02, -0.29), p = 0.02], while enhancing hearing aid utilization [MD = 0.22, 95% CI = (0.08, 0.36), p = 0.002]. Nonetheless, these programs did not significantly augment patients' satisfaction with their hearing aids [MD = 0.09, 95% CI = (-0.17, 0.26), p = 0.66]. Hearing rehabilitation programs significantly improve hearing aid outcomes, reduce self-perceived hearing impairment, and alleviate negative emotional states in patients. However, the current body of evidence is insufficient to conclusively indicate that these programs enhance patient satisfaction with daily hearing aid usage.

Причины обращения за психологической помощью в стационаре скорой помощи

&lt;p&gt;Psychological assistance to patients in an emergency multidisciplinary hospital is increasingly relevant due to the influence of mental disorders and emotional maladjustment on treatment, the patient&amp;rsquo;s internal perception of their illness, and adherence to treatment. Since hospitalization is inherently a stressful factor that can contribute to the development of anxiety and depressive symptoms, psychological support for patients and often their loved ones is an integral part of the treatment process. However, studies on the emotional state of patients at the time of hospitalization are limited and primarily focus on assessing the level of current stress. Patients admitted to the hospital often experience symptoms of emotional maladjustment long before hospitalization, which can significantly impact their adaptation to the hospital environment and the treatment process as a whole. This article analyzes the reasons for seeking psychological help during hospitalization in an emergency hospital and examines the relationship between these reasons and the level of emotional maladjustment. The analysis of primary issues was conducted by coding each case according to the most prominent problem presented. A total of 379 consultations were analyzed, identifying problems associated with psychological distress. The sample consisted of 122 men and 257 women, with an average age of 50 years. Also, some patients completed the Hospital Anxiety and Depression Scale (HADS), including 30 men and 50 women. The results of the study showed that one of the most common reasons for seeking psychological help was related to situational reactions to stress. However, the majority of patients in this group did not have elevated scores on the Hospital Anxiety and Depression Scale. In addition, a significant percentage (37% of all consultations) of patients were referred for psychological consultation due to emotional problems that had been present before hospitalization. Notably, patients in this group were most often among those with clinically significant levels of anxiety and depression. The data obtained may indicate that the main reason for the deterioration of the emotional state at the time of hospitalization is not hospitalization itself, but problems that the patient has encountered outside the hospital walls.&lt;/p&gt;

A Nanoparticle-Based Artificial Ear for Personalized Classification of Emotions in the Human Voice Using Deep Learning.

Artificial intelligence and human-computer interaction advances demand bioinspired sensing modalities capable of comprehending human affective states and speech. However, endowing skin-like interfaces with such intricate perception abilities remains challenging. Here, we have developed a flexible piezoresistive artificial ear (AE) sensor based on gold nanoparticles, which can convert sound signals into electrical signals through changes in resistance. By testing the sensor's performance at both frequency and sound pressure level (SPL), the AE has a frequency response range of 20 Hz to 12 kHz and can sense sound signals from up to 5 m away at a frequency of 1 kHz and an SPL of 126 dB. Furthermore, through deep learning, the device achieves up to 96.9% and 95.0% accuracy in classification and recognition applications for seven emotional and eight urban environmental noises, respectively. Hence, on one hand, our device can monitor the patient's emotional state by their speech, such as sudden yelling and screaming, which can help healthcare workers understand patients' condition in time. On the other hand, the device could also be used for real-time monitoring of noise levels in aircraft, ships, factories, and other high-decibel equipment and environments.

Exploring the efficacy of structured nursing via web-based interaction platforms in sustaining hemodialysis patients.

Discussed based on the network interactive platform of structured care for patients with chronic renal failure (CRF) in the process of hemodialysis. This study seeks to elucidate the application value of structured nursing, deployed through network interaction platforms, in sustaining patients undergoing maintenance hemodialysis. A total of 62 patients diagnosed with Chronic Renal Failure (CRF) between April 2022 and August 2023 were randomly allocated into two distinct care groups: conventional and structured nursing care based on a web-interactive platform. Both cohorts were comparatively analyzed with respect to psychological states, quality of life within therapeutic interventions, and relationships with complications. Renal function indicators, including Creatinine Clearance (Ccr), Serum Creatinine (SCr), and Blood Urea Nitrogen (BUN), were subjected to Pearson analysis to appraise their predictive value in prognostication, while Receiver Operating Characteristic (ROC) curve analysis was constructed to further discern their diagnostic precision. Post-intervention, notable improvements were observed in the emotional states of patients in both cohorts, with the structured care group exhibiting significantly lower Self-rating Anxiety Scale (SAS) and Self-rating Depression Scale (SDS) scores (p< 0.05). Furthermore, patients under the web-interactive structured nursing regimen demonstrated superior overall adherence, a reduced incidence rate of complications, and markedly higher scores in quality of life assessments compared to those under conventional care (p< 0.05). The derived cut-off values for Ccr, SCr, and BUN were 32.5 ml/min, 251.5 umol/L, and 14.5 mmol/L, respectively, with sensitivities and specificities pegged at 0.645% and 0.645% for Ccr, 0.774% and 0.548% for SCr, and 0.774% and 0.774% for BUN. The corresponding areas under the ROC curve (AUC) for each parameter were 0.816, 0.653, and 0.856, respectively. Comprehensive hemodialysis care for patients with chronic renal failure can improve self-care ability to improve quality of life and reduce the incidence of complications, which has great potential for clinical progress and is worthy of further research.

An Evaluation of the Quality of Life and Emotional Status of Patients With Implantable Cardioverter Defibrillators at the Vilnius University Hospital, Lithuania.

Background and objective An arrhythmia is a disorder of the heart rate or rhythm. An implantable cardioverter defibrillator (ICD) is a small electronic device connected to the heart to continuously keep track of and help control rapid and sometimes life-threatening electrical problems with the heart. However, it may result in psychological tension in patients' lives, eventually affecting their quality of life (QoL). In light of this, we aimed to assess the QoL ofpatients with ICDat the Vilnius University Hospital, Lithuania. Methods We employed the following three questionnaires in this study: an originally prepared questionnaire including sociodemographic and health factors; the 36-item Short Form HealthSurvey questionnaire(SF-36); and the Hospital Anxiety and Depression Scale (HADS) to assess depression and anxiety. Data analysis was performed usingSPSS Statistics v. 13.00 (IBM Corp., Armonk, NY). Results Of the patients evaluated in all areas of QoL, males demonstrated higher scores compared to females. A statistically significant difference was found when assessing the domains of physical activity, social function, pain, and physical and mental health QoL. Conclusions Based on our findings, the majority of ICD patients can achieve their desired QoL and psychosocial outcomes. Our results show that patients with ICDs have the potential to return to a normal life. Depression and anxiety manifested more commonly inrespondents with a disease duration of up to five years.

Effects of Virtual Rehabilitation Training on Post-Stroke Executive and Praxis Skills and Depression Symptoms: A Quasi-Randomised Clinical Trial.

Apraxia is a neurological disorder that is common after a stroke and impairs the planning and execution of movements. In the rehabilitation field, virtual reality (VR) presents new opportunities and offers advantages to both rehabilitation teams and individuals with neurological conditions. Indeed, VR can stimulate and improve cognitive reserve and abilities, including executive function, and enhance the patient's emotional status. The objective of this research is to determine the effectiveness of VR in improving praxis skills and behavioural functioning in individuals with severe stroke. A total of 20 stroke patients were enrolled from February 2022 to March 2023 and divided by the order of their recruitment into two groups: the experimental group (EG: n = 10) received training to improve their praxis skills using VR whereas the control one (CG: n = 10) received the same amount of standard training. All patients underwent an evaluation using a psychometric battery that consisted of the Hamilton Rating Scale for Depression (HRS-D), Mini-Mental State Examination (MMSE), Frontal Assessment Battery (FAB), Spinnler and Tognoni test, and De Renzi and Faglioni test. Valuations were performed before rehabilitation (T0) and after its completion (T1). Both groups demonstrated significant improvements post-intervention. The EG showed a greater enhancement in their MMSE scores (p = 0.002), and reductions in both ideomotor and constructive apraxia (p = 0.002 for both), compared to the CG. The VR-based training also resulted in significant improvements in their depression symptoms (HRSD scores improved, p = 0.012 in EG vs. p = 0.021 in CG). This pilot study suggests that VR could help reduce cognitive, constructive apraxia and ideomotor apraxia symptoms caused by stroke injury.

Association between personality type and patient-reported outcomes (PRO) in patients with atrial fibrillation

BackgroundAtrial Fibrillation (AF) is known to be associated with a negative emotional state. Patient-reported outcomes (PROs) are important tools for evaluating the endpoints of AF management. This study aims to examine the correlation between personality types and PROs in patients with AF.MethodsAll included subjects were newly diagnosed with AF fewer than one month, and their personality types were assessed using the Eysenck Personality Questionnaire (EPQ). Quality of life (QoL) was measured using the Atrial Fibrillation Effect on Quality of Life (AFEQT) questionnaire. Anxiety and depression were assessed using the General Anxiety Scale (GAD-7) and the 9-item Patient Health Questionnaire (PHQ-9), respectively. We constructed stepwise linear regression analyses for factors related to the QoL and emotional state in patients with AF.ResultsA total of 531 AF patients completed the survey and were categorized into four groups based on their personality types. Of these patients (mean age: 67.12 ± 10.93 years, 50.28% male), 357 (67.23%) had paroxysmal AF, and 16.95% (n = 90) had a sanguine personality. Compared to patients with other personality types, those with a sanguine personality had the highest average AFEQT scores (P < 0.001) and the lowest scores of GAD-7 and PHQ-9 scales (P < 0.05). Furthermore, multiple linear regression analyses suggested that sanguine personality was also independently associated with better QoL and emotional states (P < 0.05).ConclusionThere is a significant association between the personality types and PROs in AF patients.

Impact of the COVID-19 pandemic on the patients&amp;rsquo; emotional state in general practice in Bulgaria

The study aimed to evaluate and analyze the impact of the COVID-19 pandemic on the emotional state of patients in General Medical Practice in Bulgaria. In July-December 2022, a survey was organized among 306 GPs working in primary health care (PHC) in Bulgaria. They represent about 8% of the country&amp;rsquo;s general practitioners and work in eight regions. An individual self-completion questionnaire was offered. After obtaining permission from the Ethics Committee, respondents were randomly selected. The data was processed with a specialized statistical software package, SPSS 22. The COVID-19 pandemic has increased the number of patients with anxiety and depressive symptoms in the period 2020&amp;ndash;2022, according to 95.3% (286) of the GPs surveyed. According to the GPs, the reasons for this were social isolation &amp;ndash; 79.4%, negative information from the media &amp;ndash; 73.1%, uncertainty &amp;ndash; 65%, financial worries &amp;ndash; 51.7%, uncertainty about the future &amp;ndash; 38.8%, and other &amp;ndash; 2.1%. The population of Bulgaria has been greatly affected by the COVID-19 pandemic. The pandemic has increased the number of patients with anxiety and depression in the General Medical Practice for the period 2020&amp;ndash;2022. Bulgarians often resort to self-medication despite the easy access to general practitioners and the possibility of consultation with a psychiatrist.

A Comparative Sentiment Analysis of Greek Clinical Conversations Using BERT, RoBERTa, GPT-2, and XLNet.

In addressing the critical role of emotional context in patient-clinician conversations, this study conducted a comprehensive sentiment analysis using BERT, RoBERTa, GPT-2, and XLNet. Our dataset includes 185 h of Greek conversations focused on hematologic malignancies. The methodology involved data collection, data annotation, model training, and performance evaluation using metrics such as accuracy, precision, recall, F1-score, and specificity. BERT outperformed the other methods across all sentiment categories, demonstrating its effectiveness in capturing the emotional context in clinical interactions. RoBERTa showed a strong performance, particularly in identifying neutral sentiments. GPT-2 showed promising results in neutral sentiments but exhibited a lower precision and recall for negatives. XLNet showed a moderate performance, with variations across categories. Overall, our findings highlight the complexities of sentiment analysis in clinical contexts, especially in underrepresented languages like Greek. These insights highlight the potential of advanced deep-learning models in enhancing communication and patient care in healthcare settings. The integration of sentiment analysis in healthcare could provide insights into the emotional states of patients, resulting in more effective and empathetic patient support. Our study aims to address the gap and limitations of sentiment analysis in a Greek clinical context, an area where resources are scarce and its application remains underexplored.

Contribution of obesity, insulin resistance and diabetes mellitus to cognitive impairment

Obesity is a vivid example of one of the most common chronic non-infectious multifactorial diseases in today’s world. Not only the conventional elements of an “unhealthy lifestyle” such as hypodynamia and overeating, but also external socio-economic and psychosocial factors play an important role in the development of this disease. This review summarizes the main pathogenetic components that combine the development of both metabolic and vascular, including cerebrovascular, complications of obesity. The authors present the current classification of obesity adopted by domestic endocrinologists, which includes an assessment of the risk of obesity-associated complications. The mechanisms of pathological effects of insulin resistance, which morphological substrate is visceral obesity, are considered in detail. Its key role in the initiation and progression of diabetes mellitus, cardiovascular and cerebrovascular diseases has been shown. The mechanisms involved in the development of cognitive impairment in patients with obesity, insulin resistance and diabetes mellitus are described. Due to the urgency of the problem raised, the prospective of choosing a therapeutic and preventive approach to the management of such patients are assessed. With regard to this category of patients, the use of fonturacetam was discussed. Fonturacetam has been shown to have the proven clinical effects that not only improve the cognitive and emotional status in patients with cerebrovascular pathology, but also have a direct effect on the potential root cause of the development and progression of vascular and metabolic disorders, i.e. on the obesity. Fonturacetam that has an anorexigenic effect can also be prescribed as a weight corrector in addition to the diet therapy. Thus, the use of fonturacetam can become a promising trend in the treatment and prevention of today’s most common diseases.

SlowR50-SA: A Self-Attention Enhanced Dynamic Facial Expression Recognition Model for Tactile Internet Applications

Emotion recognition from facial expressions is a challenging task due to the subtle and nuanced nature of facial expressions. Within the framework of Tactile Internet (TI), the integration of this technology has the capacity to completely transform real-time user interactions, by delivering customized emotional input. The influence of this technology is far-reaching, as it may be used in immersive virtual reality interactions and remote tele-care applications to identify emotional states in patients. In this paper, a novel emotion recognition algorithm is presented that integrates a Self-Attention (SA) module into the SlowR50 backbone (SlowR50-SA). The experiments on the DFEW and FERV39K datasets demonstrate that the proposed model achieves good performance in terms of both Unweighted Average Recall (UAR) and Weighted Average Recall (WAR) metrics, achieving a UAR (WAR) of 57.09% (69.87%) on the DFEW dataset, and UAR (WAR) of 39.48% (49.34%) on the FERV39K dataset. Notably, SlowR50-SA operates with only eight frames of input at low temporal resolution, highlighting its efficiency. Furthermore, the algorithm has the potential to be integrated into Tactile Internet applications, where it can be used to enhance the user experience by providing real-time emotion feedback. SlowR50-SA can also be used to enhance virtual reality experiences by providing personalized haptic feedback based on the user’s emotional state. It can also be used in remote tele-care applications to detect signs of stress, anxiety, or depression in patients.

Quality of life and mental health of patients with coronary heart disease

According to WHO, cardiovascular diseases are the leading cause of death in the world. The most common form of heart disease is coronary heart disease (CHD). IHD is the most acute medical problem in most countries of the world, including Russia, due to high morbidity, mortality, persistent and temporary disability among the most productive part of the population, which causes significant economic damage to modern society [1, 2, 3]. Target. To study factors influencing the quality of life and mental health of patients with coronary artery disease. Results. The prevalence of risk factors among patients with coronary artery disease is analyzed, the impact of the disease on the physical and emotional state of patients is considered, and the influence of rehabilitation measures that help improve the quality of life of patients with coronary artery disease is shown.Conclusion. To improve the quality of life of patients with coronary artery disease, it is necessary to develop new forms of rehabilitation assistance and methods of financial support, and create rehabilitation centers at the place of residence and work.

Comparison of perceptions about COVID-19 disease in patients and in medical professionals during the pandemic

IntroductionThe COVID-19 pandemic poses a serious threat to mental well-being both for patients who have suffered from coronavirus disease and for medical workers of this period. The difference in perceptions about COVID-19 in patients and those who care for them reflects the peculiarities of assessing the coronavirus pandemic and their own coping capabilities.ObjectivesThe aim of the research was to compare the perceptions about COVID-19 in patients and medical professionals during the pandemic.MethodsA Short questionnaire of Disease Perception (E. Broadbent) was used to study patients’ perceptions about COVID-19 disease. The same questionnaire was modified for the perceptions about the COVID-19 pandemic to study the peculiarities of the perceptions about COVID-19 by medical professionals.The study was conducted from January 2021 to November 2022. The sample consisted of 314 medical workers (57 men and 255 women), whose average age was 36.97±11.93, and 390 patients (64 men and 326 women), whose average age was 28.58±10.74. 35 people (11%) of the surveyed medical workers worked in the red zone.ResultsMedical professionals and patients tend to assess the impact of the pandemic on life in the same way. However, according to medical professionals, the COVID-19 pandemic will last longer than according to patients (4.93±2.81 vs 3.18±2.29, p=0.000). Doctors assess their ability to control the pandemic significantly worse than patients assess their disease as a result of coronavirus infection (2.82±2.28 vs 5.30±2.88, p=0.000). Medical workers have a worse assessment of the effectiveness of the measures taken to combat the pandemic (4.75±2.63 vs 5.50±2.67, p=0.000). Doctors are less likely to find symptoms of coronavirus (2.88±2.32 vs 4.98±2.75, p=0.000) and less concerned about the spread of COVID-19 (3.75±2.55 vs 4.20±2.63, p=0.023). Whereas patients have a worse understanding of what COVID-19 is (6.32±2.87 vs 5.52±2.83, p=0.000), and they believe that COVID-19 affects their emotional state to a greater extent than doctors did (3.60±2.66 vs 4.39±2.90, p=0.000).ConclusionsThus, the specifics of the perceptions about COVID-19 may largely depend on whether a person is faced with a coronavirus in the role of a patient or a medical worker. The emotional state of patients is more affected by the pandemic combined with a worse understanding of COVID-19, while medical workers feel less control and tend to regard the measures taken to combat the pandemic as less effective.Disclosure: Research is supported by the Russian Science Foundation, project No. 21-18-00624.Disclosure of InterestNone Declared

Effects of perioperative intravenous lidocaine and esketamine on the quality of recovery and emotional state of patients after thyroidectomy: A randomised, double-blind, controlled trial.

Perioperative intravenous (IV) infusions of lidocaine and esketamine reduce postoperative pain, but there are few studies on the quality of recovery and patients' emotional states postoperatively. We aimed to explore the effects of perioperative IV lidocaine and esketamine on the quality of recovery and emotional state after thyroidectomy. In this randomised trial, 137 patients undergoing thyroidectomy were randomly assigned to three groups: a lidocaine group (Group L), an esketamine group (Group E) and a normal saline placebo group (Group C). The primary outcome was the Quality of Recovery 40 (QoR-40) on postoperative days (PODs) 1 and 2. The secondary outcomes included Self-Rating Anxiety Scale (SAS) and Self-Rating Depression Scale (SDS) scores on days 1 and 2 after surgery, pain scores, opioid consumption and incidence of postoperative nausea and vomiting (PONV). Statistical analysis was performed using the one-way analysis of variance (ANOVA), the Kruskal-Wallis and Chi-square tests. The global QoR-40 scores in groups L and E on POD 1 and POD 2 were significantly higher than in group C (P < 0.001). The SAS and SDS scores on POD 1 and POD 2 in groups L and E were significantly lower than in group C (P < 0.05). There were statistically significant differences in Numerical Rating Scale (NRS) scores among the three groups at 1 h, 2 h, 6 h and 12 h (P < 0.05). Perioperative IV lidocaine and esketamine improve the quality of postoperative recovery and the emotional state of patients undergoing thyroidectomy.

Correlation between the degree of cognitive impairment and emotional state in patients with Alzheimer’s disease.

This study aimed to investigate the correlation between cogni-tive dysfunction and emotional state in patients with Alzheimer’s disease and then propose intervention strategies. One hundred twenty-five patients with Alzheimer’s disease from June 2019 to May 2022 were selected as the study subjects and divided into two groups based on the degree of cognitive impair-ment, both receiving routine drug treatment and cognitive rehabilitation in-tervention. The Montreal Cognitive Assessment (MoCA) and the Positive and Negative Affect Scale (PANAS) were used to evaluate the cognitive function and emotional status of two groups of patients before the intervention and four and eight weeks of intervention and to analyze the correlations between the two. The results showed statistically significant differences between the two groups MoCA and PANAS scores (P&lt;0.05). Before the intervention, the patient’s MoCA score was positively correlated with the PANAS positive emo-tion score and negatively correlated with the PANAS negative emotion score (P&lt;0.05). After four and eight weeks of intervention, the patient’s MoCA score was positively correlated with the PANAS positive emotion score (P&lt;0.05) and negatively correlated with the PANAS negative emotion score (P&lt;0.05).