Emotional Processing Research Articles

The aging of emotional words processing in implicit and explicit emotion task: an ERP study

Abstract This study examined how cognitive aging affects emotional word processing using event-related potential technique. Young and older adults completed both implicit lexical decision and explicit emotion categorization tasks involving positive, negative, and neutral words. Behaviorally, older adults displayed a negative emotion effect in the implicit task, which was absent in young adults. While both age groups exhibited both positive and negative emotion effects in the explicit task, older adults demonstrated a greater positivity bias compared to young adults. Event-related potential technique data revealed that young adults exhibited an early negative emotion effect on the P2 and a late emotion effect on the late positivity potentials in the implicit task. In contrast, older adults exhibited an early negativity bias effect on the P2, as well as both negative and positive emotion effects on the N400, and positive emotion effects on the late positivity potentials. In the explicit task, young adults showed both early and late negative emotion effects on the P2 and late positivity potentials, while older adults showed both negative and positive emotion effects on the late positivity potentials. The results suggest distinct processing mechanisms for emotion words in young and older adults, involving both bottom–up and top–down mechanisms, which support the socioemotional selectivity theory.

An emotional learning process? The role of socially induced and regulated emotions for the development of an entrepreneurial mindset

PurposeAlthough emotional dynamics (EDs) during the entrepreneurial learning (EL) process are acknowledged to promote the growth of an entrepreneurial mindset (EM), while having social causes, empirical research on learning mainly looks at emotions as socially isolated concepts. This study aims to investigate how socially induced and regulated emotions during the EL process affect EM development.Design/methodology/approachWe applied a qualitative, inductive approach related to interpretative phenomenological analysis to get deeply involved into individuals’ experienced emotions. We conducted semi-structured interviews with participants of two EL programs. Open-ended questions stimulated free narratives and detailed descriptions of experiences that were analyzed following a five-stage process.FindingsThere is a correlation between socially induced and regulated emotions and the development of EM elements. We suggest a framework for the EL process based on EDs, which triggers four main mechanisms that help individuals develop an EM: “re-assessment of individual emotions through EDs”, “EDs affected by facilitator intervention,” “sharing and co-creation of emotions,” and “sensemaking of experiences and emotions.”Originality/valueThis study adds to the knowledge on EDs during the EL process and contributes to the literature on EL and emotions in learning. Therewith, it helps to sensitize practitioners toward the complexity of emotions in the entrepreneurial process, allows to moderate individual emotional reactions and social Eds, and improves existing EE programs. Future research could investigate the interplay of specific personality traits, learning environments, and socioemotional team dynamics in EL.

Impaired emotional multimodal integration in inhibition of return in children with attention-deficit/hyperactivity disorder.

Attention-deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental disorder in children. Previous studies have shown that children with ADHD have impaired processing of emotional stimuli, but it is unclear whether their ability to integrate multimodal emotional stimuli is impaired and at which processing pathway this impairment exists. The present study investigated the ability of children with ADHD to integrate emotional audiovisual stimuli under different emotional conditions, and the effect of audiovisual integration on IOR to reveal the impaired processing pathway of their emotional audiovisual integration. Fifty-eight school-age children (29 with ADHD and 29 matched typically developing (TD) children) performed an emotional valence discrimination task with a cue-target paradigm. The results showed that children with ADHD did not exhibit audiovisual integration of emotional stimuli in all experimental conditions. In addition, the IOR effect was significantly smaller for audiovisual targets than for visual targets under the negative but not the neutral emotion condition in children with ADHD, whereas this effect was present in all emotion conditions in TD children. These results indicate that the ability to integrate emotional audiovisual information is impaired in children with ADHD and this impairment exists in both bottom-up and top-down pathways. Additionally, although presenting emotional auditory stimuli at the same time as emotional faces reduced IOR both in children with ADHD and TD, the manner of reduction differed. These findings provide new evidence of emotional processing deficits and multimodal integration deficits in children with ADHD, and help provide support for children in educational settings.

Common and divergent neuroimaging features in major depression, posttraumatic stress disorder and their comorbidity

Abstract Posttraumatic stress disorder (PTSD) and major depressive disorder (MDD) are common stress-related psychiatric disorders. Genetic and neurobiology research has supported the viewpoint that PTSD and MDD may possess common and disorder-specific underlying mechanisms. In this systematic review, we summarized evidence for the similarities and differences in brain functional and structural features of MDD, PTSD and their comorbidity, as well as the effects of extensively used therapies in patients with comorbid PTSD and MDD (PTSD + MDD). These functional magnetic resonance imaging (MRI) studies highlight the 1) shared hypoactivation in the prefrontal cortex during cognitive and emotional processing in MDD and PTSD, 2) higher activation in fear processing regions including amygdala, hippocampus and insula in PTSD compared to MDD, and 3) distinct functional deficits in brain regions involved in fear and reward processing in patients with PTSD + MDD relative to those with PTSD-alone. These structural MRI studies suggested that PTSD and MDD share features of reduced volume in focal frontal areas. The treatment effects in patients with PTSD + MDD may correlate with the normalization trend of structural alterations. Neuroimaging predictors of repetitive transcranial magnetic stimulation response in patients with PTSD + MDD may differ from the mono-diagnostic groups. In summary, neuroimaging studies to date have provided limited information about the shared and disorder-specific features in MDD and PTSD. Further research is essential to pave the way for developing improved diagnostic markers and eventually targeted treatment approaches for the shared and distinct brain alterations presented in patients with MDD and PTSD.

Emotion processes in voice-hearers: Understanding differences in emotional reactivity, emotion regulation and alexithymia.

Disrupted emotion processes are commonly linked to the onset and maintenance of auditory verbal hallucinations. However, a comprehensive approach using an extended emotion model has not previously been applied to voice-hearers to distinguish impairments in emotion processes from non-clinical populations. The present study hypothesised voice-hearers, as compared to controls, would have (1) higher reactivity to negative emotions and lower reactivity to positive emotions, (2) more difficulties regulating negative and positive emotions, (3) more maladaptive strategy use, and (4) higher alexithymia. T-tests tested these hypotheses, comparing self-report measures of emotional reactivity, emotion regulation and alexithymia in voice-hearers(n = 50) to controls (n = 53). There were no group differences in emotional reactivity to positive or negative emotions. Compared to controls, voice-hearers showed difficulties in both positive and negative emotion regulation, were more likely to use expressive suppression, and were more likely to be alexithymic. These findings may help researchers and clinicians identify difficulties in voice-hearers' emotion processing, providing better direction for case formulation and treatment.

Investigating the hemiretinal asymmetry in emotion processing as a function of spatial frequency.

The subcortical visual pathway to the amygdala has long been considered a rapid and crude stream for processing emotionally salient information that is reliant on low spatial frequency (LSF) information. Recently, research has called this LSF dependency into question. To resolve this debate, we take advantage of an anatomical hemiretinal asymmetry, whereby the nasal hemiretina sends a higher proportion of information through the subcortical pathway than the temporal hemiretina. We recorded brain activity using electroencephalography (EEG) in human participants (N = 40) while they completed a monocular viewing paradigm. Pairs of faces (one fearful and one neutral, or both neutral) were projected simultaneously to the nasal and temporal hemiretina in three contrast-equated blocks; faces filtered to display only (i) LSF, (ii) high spatial frequency (HSF), or (iii) unfiltered information (broadband spatial frequency; BSF). BSF fearful faces were found to produce a greater naso-temporal asymmetry, with greater N170 amplitudes evoked by BSF faces in the nasal field, compared to HSF faces. Conversely, the naso-temporal asymmetry for LSF fearful faces did not differ between BSF and HSF. Collectively, these findings provide crucial evidence that the subcortical pathway carries combined spatial frequency visual signals, with a potential bias against HSF content.

Carving spaces of hospitality: Place attachment among migrant and non-migrant residents in a rural town undergoing rapid demographic change

This article explores the complex and evolving nature of place attachment in the rural Lincolnshire town of Boston, a new immigration destination. Drawing on 28 semi-structured interviews with residents, it examines the ways in which migrant and non-migrant communities make Boston their home, how they react to change and disruption, navigate (in)hospitable encounters and narrate their belonging in the town post the EU referendum, which saw residents overwhelmingly voting against EU membership. The findings show that in the face of place alteration and turbulence, both migrant and non-migrant residents demonstrate a nuanced and differentiated form of commitment to place and, despite intractable systemic challenges, actively work to bring communities together and reframe negative place narratives. Community leadership emerges as integral to the collective effort of creating spaces of hospitality. For migrant and non-migrant communities, place attachment is a dynamic and fluid process, shaped and constantly reshaped by socio-economic and political factors, media discourses and experiences of hospitality/hostility. It is an embodied and emotional process that involves individual and collective discursive efforts to reframe dominant narratives, material and social ways of connecting as well as pragmatic ways of distancing.

Fixation patterns in pairs of facial expressions—preferences of self-critical individuals

So far, studies have revealed some differences in how long self-critical individuals fixate on specific facial expressions and difficulties in recognising these expressions. However, the research has also indicated a need to distinguish between the different forms of self-criticism (inadequate or hated self), the key underlying factor in psychopathology. Therefore, the aim of the current research was to explore fixation patterns for all seven primary emotions (happiness, sadness, fear, disgust, contempt, anger, and surprise) and the neutral face expression in relation to level of self-criticism by presenting random facial stimuli in the right or left visual field. Based on the previous studies, two groups were defined, and the pattern of fixations and eye movements were compared (high and low inadequate and hated self). The research sample consisted of 120 adult participants, 60 women and 60 men. We used the Forms of Self-Criticizing and Self-Reassuring Scale to measure self-criticism. As stimuli for the eye-tracking task, we used facial expressions from the Umeå University Database of Facial Expressions database. Eye movements were recorded using the Tobii X2 eye tracker. Results showed that in highly self-critical participants with inadequate self, time to first fixation and duration of first fixation was shorter. Respondents with higher inadequate self also exhibited a sustained pattern in fixations (total fixation duration; total fixation duration ratio and average fixation duration)—fixation time increased as self-criticism increased, indicating heightened attention to facial expressions. On the other hand, individuals with high hated self showed increased total fixation duration and fixation count for emotions presented in the right visual field but did not differ in initial fixation metrics in comparison with high inadequate self group. These results suggest that the two forms of self-criticism - inadequate self and hated self, may function as distinct mechanisms in relation to emotional processing, with implications for their role as potential transdiagnostic markers of psychopathology based on the fixation eye-tracking metrics.

A Review of Biological Foundations of Anger

Anger, happiness, sadness, fear, surprise, and disgust are the six fundamental emotions that people can experience. Anger is a strong feeling of annoyance, displeasure, or hostility. It is a blaming emotion that is aimed against individuals, and it frequently leads to violent actions. However, anger serves survival purposes and is embedded in humans. While anger is typically viewed as a psychological or social phenomenon, it also has a biological basis. This literature review focuses on anger and its underlying biological foundations. The biological basis of anger can be explained through the activation of the amygdala, which plays a crucial role in emotional processing. Additionally, studies have shown that anger is associated with decreased activity in the prefrontal cortex. When a person becomes angry, this region of the brain is less active, leading to impulsive behaviors and decreased rational thinking. This explains why individuals often engage in aggressive or violent behaviors when angry. Understanding the biological basis of anger can help us better manage and control this emotion. By recognizing the physiological changes that occur when we become angry, we can take steps to calm ourselves down and develop healthier coping mechanisms.Keywords: Emotions, Anger, Amygdala, Prefrontal cortex, Biological basis

Increased functional connectivity between brain regions involved in social cognition, emotion and affective-value in psychedelic states induced by N,N-Dimethyltryptamine (DMT)

The modulation of social cognition is suggested as a possible mechanism contributing to the potential clinical efficacy of psychedelics in disorders involving socio-emotional and reward processing deficits. Resting-state functional Magnetic Resonance Imaging (rs-fMRI) can be used to detect changes in brain connectivity during psychedelic-induced states. Thus, this pharmacoimaging study investigates the effects of N,N-Dimethyltryptamine (DMT) on functional connectivity in brain areas relevant to social cognition, using a within-subject design in eleven healthy experienced users. The study included both an active and a control condition, conducted at different time points. The active condition involved DMT inhalation, while the control condition did not. Seed-based connectivity was measured for the two core regions involved in theory of mind and emotional processing, respectively, the posterior supramarginal gyrus and the amygdala. DMT increased supramarginal gyrus connectivity with the precuneus, posterior cingulate gyrus, amygdala, and orbitofrontal cortex. Additionally, increased connectivity emerged between the amygdala and orbitofrontal cortex. These results demonstrate that DMT modulates brain connectivity in socio-emotional and affective-value circuits, advancing our understanding of the neural mechanisms underlying the psychedelic experience and its potential therapeutic action.

Augmenting mindfulness training through neurofeedback: a pilot study of the pre-post changes on resting-state functional connectivity in typically developing adolescents

BackgroundMindfulness training has been shown to promote positive mental health outcomes and related changes in neural networks such as the default mode network, which has a central node in the posterior cingulate cortex (PCC). Previous work from our group reported on the impact of a novel, neurofeedback augmented mindfulness training (NAMT) task on regulation of PCC hemodynamic activity in typically developing adolescents. The present pilot study aimed to expand on this finding by examining the pre-post changes of the NAMT task on resting-state functional connectivity of the PCC.MethodsThirty-one typically developing adolescents (14.77 ± 1.23 years; 45% female) underwent a resting-state functional magnetic resonance imaging scan both before and after completing the NAMT task. A linear mixed effects model was used to assess for changes in functional connectivity of the PCC across the two resting-state runs.ResultsData did not support the hypothesized decrease in connectivity between the PCC seed and other DMN regions from pre- to post-NAMT task. However, we observed a significant increase in functional connectivity between the PCC and a cluster encompassing the left hippocampus and amygdala following completion of the NAMT task (run 1 Fisher’s Z = 0.16; run 2 Fisher’s Z = 0.26).ConclusionAlthough preliminary, this finding suggests NAMT has the potential to strengthen connectivity between default mode and salience regions. We speculate that such changed connectivity may facilitate enhanced self-referential and emotional processing in adolescents.Clinical trial registrationhttps://clinicaltrials.gov/, identifier NCT04053582.

P1 evoked by facial expression images is enhanced in Parkinson’s disease patients with depressive symptoms

IntroductionDepressive symptoms are most common non-motor symptoms in Parkinson’s disease (PD), which is often overlooked due to absence of rapid and objective diagnostic biomarkers. Electroencephalography (EEG)-based event-related potentials (ERPs) is commonly used to assess emotional processes. The aim of this study was to investigate changes in ERPs in PD patients exhibiting depressive symptoms and to provide a reliable biomarker for assisting in the diagnosis of PD with depressive symptoms.MethodsWe conducted a case–control study involving 30 PD patients with (dPD group) or without depressive symptoms (nPD group) and 13 age matched healthy controls (HC). We recorded EEG of the patients during the emotional picture stimulation task and analyzed the difference in the early ERPs potentials (P1, N170, early posterior negativity) and their correlation with the severity of symptoms in PD patients.ResultsOur results found that P1 amplitude in the occipital region of the dPD group in response to emotional faces was significantly higher than that of nPD and HC group, and it was positively correlated with severity of depressive symptoms in PD patients.ConclusionOur study shows that facial expression-induced enhancement of P1 amplitude can be utilized as a rapid and objective indicator to screen for depressive symptoms in PD.

Task-switching mechanisms under methamphetamine cravings: sex differences in cued and voluntary task-switching

IntroductionThis study explored the effects of task-switching type and sex on the task-switching ability of methamphetamine abstainers, as well as the differences in brain mechanisms under drug cravings under drug cravings using near-infrared spectroscopy.MethodsCraving-inducing videos were used to arouse 20 methamphetamine abstainers (including 10 men), whose switching ability was then assessed using voluntary and cued task-switching exercises.ResultsDuring task-switching under methamphetamine cravings, the activation of the premotor cortex (PMC), supplementary motor area (SMA), frontal eye field (FEF), and dorsolateral prefrontal cortex (DLPFC) in women was significantly stronger than in men, while the activation of FEF in men was significantly stronger than in women. Voluntary task-switching induced stronger FEF activation than cued task-switching. During the latter, women exhibited stronger activation in the anterior prefrontal cortex (aPFC) than men.DiscussionBoth men and women showed brain lateralization during task-switching under methamphetamine cravings. Men tended to adopt proactive control and use a top-down dominant strategy to start a new task. Women, however, tend to use a bottom-up strategy focusing on inhibiting old tasks and emotional switching. Moreover, in cued task-switching, the result shows women paid more attention to emotional processing than did men, which suggests that different task-switching training programs should be developed according to sex.

Update on the Neurobiology of Borderline Personality Disorder: A Review of Structural, Resting-State and Task-Based Brain Imaging Studies.

This review summarizes recent advances in research on the neurobiology of borderline personality disorder (BPD) according to structural brain imaging investigations and resting-state and task-based functional brain activation studies. Extending established findings on differences in regional brain volumes and cortical thickness between BPD and healthy controls, recent research illuminates shared and distinct brain structural characteristics compared to other psychiatric diagnoses, and uncovers relations of these brain structures with transdiagnostic symptoms and clinical features. Resting-state functional brain imaging studies reveal disruptions among adolescents and adults with BPD in frontolimbic and default-mode networks, which primarily underlie affect regulation and self-referential processes, respectively. Recent task-based functional brain imaging research builds on existing neurobiological understanding of emotion and cognition in BPD by revealing novel intersections with interpersonal- and stress-related processes. Studies of psychological and pharmacological interventions suggest possible effects on neural regions underlying emotion processing and behavioral control.

Complex emotion processing and early life adversity in the Healthy Brain Network sample

ObjectiveEarly life adversity (ELA) has shown to have negative impacts on mental health. One possible mechanism is through alterations in neural emotion processing. We sought to characterize how multiple indices of ELA were related to naturalistic neural socio-emotional processing. MethodIn 521 5–15-year-old participants from the Healthy Brain Network Biobank, we identified scenes that elicited activation of the Default Mode Network (DMN), Ventral Attention Network (VAN), Cingulo-Opercular Network (CON) and amygdala, all of which are networks shown to be associated with ELA. We used linear regression to examine associations between activation and ELA: negative parenting, social status, financial insecurity, neighborhood disadvantage, negative experiences, and parent psychopathology. ResultsWe found DMN, VAN, CON and amygdala activation during sad/emotional, bonding, action, conflict, sad, or fearful scenes. Greater inconsistent discipline was associated with greater VAN activation during sad or emotional scenes. ConclusionFindings suggest that the DMN, VAN, CON networks and the amygdala support socio-emotional processing consistent with prior literature. Individuals who experienced inconsistent discipline may have greater sensitivity to parent–child separation signals. Since no other ELA–activation associations were found, it is possible that unpredictability may be more strongly associated with complex neural emotion processing than socio-economic status or negative life events.

Common neural correlates of disgust processing in childhood maltreatment and peer victimisation.

Childhood maltreatment and peer victimisation are common sources of early-life interpersonal stress. Childhood maltreatment is associated with atypical frontolimbic emotion processing and regulation, and increased vulnerability for self-harm/suicide. However, few studies have compared the neurofunctional correlates between caregiver- versus peer-inflicted mistreatment. We compared the alterations of neurofunctional correlates of facial emotion processing in youths exposed to childhood maltreatment or peer victimisation, and explored their associations with self-harm. Functional magnetic resonance imaging data were collected from 114 age- and gender-matched youths (39 childhood maltreatment, 37 peer victimisation and 38 controls) during an emotion discrimination task. Region-of-interest (amygdala, insula) and whole-brain analyses were conducted. Groups differed significantly during disgust processing only. Both groups had lower activation in the right amygdala and bilateral posterior insula than controls; left insular underactivation was furthermore related to increased self-harm in maltreated youths. Compared with controls, at the whole-brain level, both groups also had underactivation in a cluster of bilateral limbic-thalamic-striatal, precuneus/posterior cingulate, temporal, fusiform/lingual and cerebellar regions, which was negatively associated with emotional problems in controls, as well as a cluster of somatosensory regions associated with increased self-harm in maltreated youths. Early-life interpersonal stress from caregivers or peers is associated with common underactivation of limbic-thalamic-striatal, precuneus/posterior cingulate and somatosensory regions during disgust processing. The hypoactivation of key emotion and sensory processing and self-referential brain regions could be a potential suppressive mechanism to cope with the aversive emotion; however, it may also entail increased risk of affective psychopathology in seemingly healthy youths.

Between Can’t and Won’t: The Relationship Between Trait Mindfulness, Stoic Ideology, and Alexithymia in Norway and New Zealand

Abstract Objectives The aim of the present study was to provide cross-cultural insight into the relationship between mindfulness, alexithymia, and stoic ideology. Method Using samples from New Zealand (n = 330) and Norway (n = 326), we estimated the facet-level network relationship of our target constructs, as well as the invariance of the estimated networks across cultural contexts. Results Across cultural contexts, we found a consistent pattern of relationships in which both stoic ideology and alexithymia were negatively related to mindfulness. Negative relationships were especially pronounced between alexithymia and the mindfulness facets of Describing, Non-Judgement, and Acting with Awareness. This indicates that individual differences in these mindfulness facets might be more firmly rooted in difficulties identifying and describing emotions, compared to beliefs related to emotional suppression, as captured by stoic ideology. While the mindfulness facets showed overall expected patterns of relationships with both alexithymia and stoic ideology, Non-Reacting showed a divergent pattern. Non-Reacting was positively related to a tendency of Externally Oriented Thinking, as well as with Death-Acceptance, in both countries. Thus, this facet not only might capture Non-reactivity within the context of mindfulness, but also could potentially capture aspects of emotional avoidance. Conclusions Overall, the study highlights that mindfulness could be influenced by both individual differences in emotion processing and cognitive beliefs about emotion processing. This accentuates the importance of examining both individual differences in, and cognitive beliefs about emotion regulation in research regarding mindfulness.

Individual differences in information demand have a low dimensional structure predicted by some curiosity traits

To understand human learning and progress, it is crucial to understand curiosity. But how consistent is curiosity's conception and assessment across scientific research disciplines? We present the results of a large collaborative project assessing the correspondence between curiosity measures in personality psychology and cognitive science. A total of 820 participants completed 15 personality trait measures and 9 cognitive tasks that tested multiple aspects of information demand. We show that shared variance across the cognitive tasks was captured by a dimension reflecting directed (uncertainty-driven) versus random (stochasticity-driven) exploration and individual differences along this axis were significantly and consistently predicted by personality traits. However, the personality metrics that best predicted information demand were not the central curiosity traits of openness to experience, deprivation sensitivity, and joyous exploration, but instead included more peripheral curiosity traits (need for cognition, thrill seeking, and stress tolerance) and measures not traditionally associated with curiosity (extraversion and behavioral inhibition). The results suggest that the umbrella term "curiosity" reflects a constellation of cognitive and emotional processes, only some of which are shared between personality measures and cognitive tasks. The results reflect the distinct methods that are used in these fields, indicating a need for caution in comparing results across fields and for future interdisciplinary collaborations to strengthen our emerging understanding of curiosity.

Exploring distinct and joint contributions of the locus coeruleus and the substantia nigra/ventral tegmental area complex to reward and valence processing using high-resolution fMRI

Abstract Dopaminergic neurons in the substantia nigra and the ventral tegmental area (SN/VTA) are classically viewed as key mediators in reward processing, while noradrenergic cells in the locus coeruleus (LC) are thought to modulate (negative) saliency processing. However, this conventional distinction is being revised by more recent research in animals. To explore the respective contributions of both the LC and SN/VTA in reward and valence processing in humans, we assessed fMRI data during stimulus encoding and response phase of a rewarded emotion-discrimination task (n = 38). Participants responded significantly faster to reward predicting and negative valence stimuli compared with their non-salient counterparts. LC activity was overall higher during trials involving reward prospect, and in particular for reward trials featuring positive valence, demonstrating an additive effect of reward and positive valence in LC. Moreover, LC activity was differentially increased for negative compared with positive valence in the response phase, indexing its role in invigorating responses to negative events. The SN/VTA showed increased activity in the response phase of reward trials (neutral valence) and negative valence trials (no reward), which aligns with coding relative saliency of these events in their respective contexts. LC modulations were accompanied by covariations in occipital cortex, suggesting noradrenergic contributions to visual prioritization of salient events. The findings underscore the sensitivity of both LC and SN/VTA to reward prospects and negative valence, challenging the dominant view of SN/VTA’s involvement in merely positive events and emphasizing their essential role in action invigoration above and beyond mere stimulus encoding. The intricate roles of the DA and NA system in reward and emotional valence processing in humans warrant further exploration and validation, given the limitations inherent to neuroimaging of deep brain structures.

Analysis of Gender and Mental Health Differences

With the rapid development of modern civilization, the increasing pressures of contemporary life, the fast pace of living, and the influence of social media, an increasing number of people are suffering from mental health issues. Mental health is an important aspect that everyone should be concerned about. Research has revealed that depression can significantly impact a person's professional and interpersonal skills, potentially affecting ones career trajectory. However, while both men and women face mental health issues, gender differences persist. Numerous studies have indicated that disparities exist in both brain structure and function between males and females. For instance, females may exhibit a greater advantage in emotional processing and social cognition, whereas males may demonstrate enhanced spatial cognition abilities. This study aims to explore gender differences in mental health across four factors. The result shows that, family intergenerational relationships have a greater impact on girls than boys. During their student years, interpersonal relationships within dormitories have a greater influence on boys. In the social sphere, women are more prone to depression than men. From a personal perspective, females are also more likely to experience negative emotions compared to males.