What the hell is a mild stroke, in my opinion there is no such thing like a mild stroke. Werner Hacke during rounds in Heidelberg 1997 In the personal opinion of this comment's author, we have a serious problem and lack of data if we withhold intravenous thrombolysis (IVT) and/or endovascular therapy (EVT) from any patient that fulfills the criteria for these treatments based on all the randomized trials that finally led to US Federal Drug Administration and European Medicines Agency (FDA/EMA) labelling and guideline recommendation of these therapies. The gain we experienced is the broad application of IVT to all acute stroke patients aged 16 years or older within 4.5 h based on a non-contrast computed tomography (CT) regardless of age, National Institutes of Health Stroke Scale (NIHSS) score, and with only few strict contraindications. The same holds true for such patients up to 6 h with a proximal vessel occlusion shown on computed tomography angiography (CTA) for EVT and most recently for basilar artery occlusion. A metanalysis of IVT trials did not show any significant difference in the proportional effect of IVT on outcomes stratified by NIHSS severity, by point estimates the “milder” and the more severe patients fared better [1]. Not dwelling on settings with heroically long time windows and selection criteria with advanced imaging and not-so-advanced artificial intelligence applications, and with respect to the article by Schwarz and colleagues in this issue of EJoN [2], I refer here to the standard 4.5–6 h known time window patient with a clinically “mild stroke”. Present guidelines are mostly inconclusive or inconsistent also when compared to each other. The European Stroke Organisation (ESO) guideline, for instance, differentiates the indication for IVT based on the prematurely stopped small PRISMS trial [3] definition of non-disabling and disabling minor stroke criteria (semantically nonsense) and does not recommend treatment in patients with symptoms such as isolated mild aphasia, mild cortical hand, hemimotor loss, or ataxia [4]. All the latter are in many a patient's and stroke physician's view disabling symptoms that one would rather see ameliorated by a given treatment, with twice as high odds for recovery suggested by some authors [5]. On top of this, just imagine that this “mild” stroke is caused by a proximal vessel occlusion in the ICA/MCA-M1 territory, a situation where we have now overwhelming data in general in favor of combined IVT/EVT whenever possible. For the specific “mild stroke” population discussed here there are far fewer data from small observational trials. To my clinical mind, this warrants the standard approach until proven otherwise as is also expert consensus in the current ESO guideline [6]. Regarding EVT or IVT/EVT in “mild” strokes, the expert consensus in the 2019 ESO guideline recommends recruitment into trials or otherwise treatment. Even for so-called non-disabling minor stroke (whatever that may be), the vote was 5 of 11 experts in favor of IVT/EVT [6]. Ghil Schwarz and colleagues present a Safe Implementation of Treatment in Stroke-International Stroke Thrombolysis Registry (SITS-ISTR)-derived, propensity score-matched analysis of patients with a “mild stroke” (i.e., patients with NIHSS scores ≤5 points treated with IVT/EVT vs IVT alone) [2]. Out of more than 1000 patients, 312 patients were matched per group. The result in brief was a twice higher rate of poor outcomes, numerically more symptomatic intracranial hemorrhages (sICH), and significantly more of any types of ICH and subarachnoid hemorrhage (SAH) with IVT/EVT compared to IVT alone. This is a somewhat counterintuitive but also disconcerting result and, strikingly, the lack of effect is not exclusively explained by ICH but also by a higher rate of (unexplained) early neurological deterioration. This article is important to the critical reader as it sheds further doubt on how to best proceed with this group of patients, does so on a high-quality albeit registry-style dataset, besides the distinct discussion of all limitations and caveats by the authors themselves. Part of the inconsistency may be explained by intergroup differences despite propensity score matching that cannot be corrected for because they have not been assessed or are nonexistent such as a significant number of missing modified Rankin Scale (mRS) outcome scores. Another recent analysis showed a 11% absolute difference for functional independence in favor of IVT/EVT in patiens with “mild” stroke and emergent large vessel occlusion (ELVO) [7]. In fact, the inconsistent results from varying but sparse analyses should oblige us to recruit into adequately sized trials for this question such as MOSTE (NCT03796468) and ENDOLOW (NCT04167527). Unless these and other trials show a clear issue with additional damage and/or lack of effect from bridging therapy in stroke patients with proximal occlusions and NIHSS scores ≤5, we should treat our stroke patients with the generally proven treatments that we currently to have something AT hand. Open Access funding enabled and organized by Projekt DEAL. PDS received honoraria, travel grants, and/or consulting fees from Boehringer Ingelheim, BMS-Pfizer, Daichi, Biogen, and Astra Zeneca. Data sharing not applicable to this article as no datasets were generated or analysed during the current study.