Growth Of Research Research Articles

Paediatric systemic inflammatory response syndrome (SIRS) and the development of patient-specific therapy: ethical perspectives through experts’ opinions

BackgroundResearch for personalised therapies concerning the Systemic Inflammatory Response Syndrome (SIRS) in children involves the utilisation of OMICS technologies and Artificial Intelligence (AI).MethodsTo identify specific ethical challenges through the perspective of healthcare professionals, we conducted 10 semi-structured interviews. The development of interview questions for the interviews was preceded by a systematic review of the scientific literature. To address the complexities of paediatric emergency research, informed consent, and data processing, experts with expertise in paediatric intensive care, computer science, and medical law were sought. After the transcription and anonymisation, the analysis followed established guidelines for qualitative content and thematic analysis.ResultsInterviewees highlighted the intricacies of managing consent in personalised SIRS research due to the large amount and complexity of information necessary for autonomous decision-making. Thus, instruments aimed at enhancing the understanding of legal guardians and to empowering the child were appreciated and the need for specific guidelines and establishing standards was expressed. Medical risks were estimated to be low, but the challenges of securing anonymisation and data protection were expected. It was emphasised that risks and benefits cannot be anticipated at this stage. Social justice issues were identified because of possible biases within the research population. Our findings were analysed using current ethical and legal frameworks for research with a focus on the particularities of the patient group and the emergency background. In this particular context, experts advocated for an enabling approach pertaining to AI in combination with OMICS technologies.ConclusionAs with every new technological development, ethical and legal challenges cannot be foreseen for SIRS-personalised treatment. Given this circumstance, experts emphasised the importance of extending the ethics-legal discourse beyond mere restrictions. The organisation of supervision should be reconsidered and not limited only to the precautionary principle, which per se was seen as impeding both the medical progress and clinical flexibility. It was noted that the establishment and monitoring of guidelines were emergent and should evolve through an interdisciplinary discourse. Therefore, it was recommended to enhance the qualifications of physicians in the field of computer science, impart ethics training to AI developers, and involve experts with expertise in medical law and data protection.

Does empowering leadership behavior affect employee performance? The mediating role of workforce agility

PurposeWorkforce agility (WFA) is an emergent research topic in volatile times. However, there is a lack of research in understanding the leadership dimension that triggers such an attribute in organizations. Our study aims to understand the impact of workforce agility on empowering leadership behavior and employee performance dimensions (task performance, contextual performance and counterproductive work behavior).Design/methodology/approachWe collected data from 236 employees using reliable, validated scales and conducted various statistical analyses.FindingsOur results demonstrated that WFA (1) partially mediated the relationship between empowering leadership and contextual performance (CP), (2) has not mediated the relationship between empowering leadership and counterproductive behavior (CWB) and (3) mediated the relationship between empowering leadership and task performance (TP).Practical implicationsOur research has practical implications for management practitioners. It suggests hiring and developing an agile workforce through appropriate training and development programs can significantly impact organizational performance. Furthermore, it provides insights into building leadership capabilities that sustain workforce agility practices, empowering leaders to make informed decisions.Originality/valueOur research fills a significant gap in the existing literature by exploring the effects of WFA on leadership and performance. This novel approach provides a fresh perspective on the dynamics of organizational behavior, making it a valuable addition to the field.

19 How are paediatric tertiary care hospitals structured to respond to the needs of children with medical complexity during acute deteriorations? A landscape study in Canada

Abstract Background Children with medical complexity (CMC) are at risk of unplanned healthcare visits especially due to acute clinical deteriorations. Complex care (CC) programs help facilitate the needs of CMC. Objectives To identify the organizational and administrative resources available for the care of CMC in Canadian tertiary care paediatric hospitals and to assess how physicians believe these resources are adapted to the specific urgent needs of CMC. Design/Methods In this observational study, key informants representing complex care (CC) and paediatric emergency medicine (PEM) services from 15 paediatric tertiary care hospitals in Canada completed cross-sectional structured questionnaires. Participants were identified through national research networks (Pediatric Emergency Research Canada (PERC), Pediatric Inpatient Research Network (PIRN) and by snowball sampling. Utilizing the Lime Survey web application, two questionnaires (one for PEM, one for CC) were develop based on a literature review and following Burns methodology. Verbal questionnaires were administered via a secured teleconference application or completed digitally. Descriptive data were generated using Excel and SPSS v.29. Results From 09/2022 to 09/2023, 93% (28/30) key informants completed questionnaires (15 PEM, 13 CC, Table 1). Across the 15 sites, 12 had a CC program or clinic. Information about established CC programs was available for 10 sites (Table 2), from participating CC informants: 4/10 offered outpatient services; 6/10 offered inpatient and outpatient services; 8/10 offered last minute appointments for CMC. CC programs had variable staffing: mostly physicians (median 3 FTE, range: 0.2-6) and nurse practitioners (0.75 FTE, range: 0-9) or registered nurses (0.9 FTE, 0-8). CC informants reported offering an ED consultation service at 8/10 sites, while 6/12 PEM participants reported access to such a service. CC informants reported that their program rarely offered consultations during weekends (2/10) or nights (1/10). Across all sites, PEM informants reported good access to documents to help with continuity of care including emergency care plans (13/15), medical history (14/15), goals of care (13/15). Using an 11-point scale, CC informants rated their hospital’s median ability to meet the outpatient needs of CMC as 6.5 (range: 0-10), and their ED’s median ability to meet the needs of CMC as 7 (range 5-10). PEM informants reported their median ability to meet the needs of CMC as 8 (range 6-9). Informants made suggestions to improve the ED care of CMC (Table 3). Conclusion There exists wide variation in the structures caring for CMC and their availability in case of acute needs. National collaboration between CC and PEM teams may facilitate the design of programs to improve the acute outpatient care of CMC.

Power Quality Improvement Using a Novel Simplified Adaptive Control of Solar PV Integrated Shunt Active Power Filter

ABSTRACTPower quality improvement in grid‐tied solar photovoltaic (PV) system is one of the emergent current research trends. To address the power quality concern, shunt active power filters (SAPF) are widely deployed and researched in grid‐tied PV systems. This paper presents a simplified adaptive transversal (SAT)‐filter control scheme for the two‐stage PV‐SAPF system. The proposed control has the ability to improve different power quality indices. Also, it features faster operation under steady‐state and under dynamic conditions, better dc‐offset rejection ability due to estimation of the accurate fundamental component of the load current. To justify the effectiveness of the proposed control scheme, a thorough comparison is carried out with different conventional and adaptive control schemes. Simulations and extensive experimental analysis are carried out under severe transient conditions such as balanced‐unbalanced supply, sudden load, and irradiation change scenario.

Emergent Research Trends on the Structural Relaxation Dynamics of Molecular Clusters: From Structure-Property Relationship to New Function Prediction.

ConspectusMolecular clusters (MCs) are monodispersed, precisely defined ensembles of atom collections featured with shape-persistent architectures that can deliver certain functions independently. Their molecular compositions and surface functionalities can be tailored feasibly in a predefined manner, and they can be applied as basic structural units to be engineered into materials with desirable hierarchical structures and enriched functions. The chemical systems also offer great opportunities for the design and fabrication of soft structural materials without the chain topologies of polymers. The bulks of MC assemblies demonstrate viscoelasticity that is used to be considered as the unique feature of polymers, while the MC systems are distinct from polymers since their elasticities are resilient even at temperatures 100 K above their glass transition temperatures. The understanding of their anomalous viscoelasticity and the extended studies of general structure-property relationships are desired for the development of new chemical systems for emergent functions and the possibilities to resolve the intrinsic trade-offs of traditional materials.Meanwhile, general macroscopic functions or properties of materials are related to the transportation of mass, momentum, and/or energy, and they are basically realized or directed by the motions of structural units at different length scales. Structural relaxation dynamics research is critical in quantifying motions ranging from fast bond deformation, bond break/formation, and diffusion of ions and particles to the cooperative motions of structure units. Due to the advancement of measurement technology for relaxation dynamics (e.g., quasi-elastic scattering and broadband dielectric spectroscopy), the structural relaxation dynamics of MC materials have been probed for the first time, and their multiple relaxation modes across several temporal scales were systematically studied to bridge the correlation between molecular structures and macroscopic functions. The fingerprint information from dynamics studies, e.g., the temperature dependence of relaxation time and certain property, e.g., ion conductivity, was proposed to quantify the structure-property relationship, and the microscopic mechanism on the mechanical properties, ion conduction, and gas absorption and separation of MC materials can be fully understood.In this Account, to elucidate the uniqueness of MC materials, especially in comparison with polymers, four topics are mainly summarized: structural features, relaxation dynamics characterization techniques, relaxation dynamics characteristics, and quantified understanding of the structure-property relationship. The capability for new function prediction from relaxation dynamics studies is also introduced, and the typical example in impact resistant materials is provided. The Account aims to prove the significance of relaxation dynamics characterization for material innovation, while it also confirms the potential of MCs for functional material fabrications.

Review article: A primer for clinical researchers in the emergency department: Part XIII. Strategies to engage staff and enhance participant recruitment in emergency department research.

Conducting research in ED is important and necessary to improve emergency care. Effective recruitment is an essential ingredient for the success of a research project and must be carefully monitored. Research coordinators are focused on optimising recruitment to research studies while also ensuring that the needs of participants and their families are met, and the research is acceptable to ED staff. In this paper, a group of experienced research coordinators from Australia and New Zealand have shared their strategies to engage staff and enhance recruitment of participants in emergency research. Although this paper is from a paediatric research network, the findings are applicable for EDs in general, both in Australasia and elsewhere.

Global emergency medicine research priorities: a mapping review.

Recognizing and prioritizing research areas in emergency care is crucial for generating evidence and advancing research programs, aiming to enhance health outcomes for both individuals and populations. The objective of this review is to document global clinical and nonclinical research priorities. The Emergency Medicine Education and Research by Global Experts network, consisting of 22 sites across six continents, conducted a mapping review of publications on emergency medicine research priorities (2000-2022) across seven databases. We included studies with replicable methodologies for determining research priorities, excluding those limited to individual diseases. Three reviewers independently screened, selected, and categorized results into clinical and nonclinical topics. Discrepancies were resolved by an independent investigator and consensus. Outcomes measures and analysis include descriptive analysis of research priorities grouped into clinical and nonclinical topics, characteristics of publications including countries represented in the author list, target audience (such as researchers or policy makers), participants (e.g. patients), and methods (e.g. Delphi) of priority setting. Among 968 screened papers, 57 publications from all WHO regions were included. Most (36, 63%) had authors from only a single country, primarily in North America and Europe. Patient representatives were included in only 10 (18%). Clinical research priorities clustered into resuscitation, cardiology, central nervous system, emergency medical services, infectious disease, mental health, respiratory disease, and trauma. Distribution was broad in North America and Europe but focused on infectious diseases and resuscitation in Africa and Asia. Eleven nonclinical topics included access to care, health policy, screening/triage, social determinants of health, staffing, technology/simulation, shared decision making, cross-sectoral collaboration, education, patient-centered care, and research networks. Nonclinical topics were broad in Europe and America, focused on access to care and health screening in Africa, and mostly absent in other WHO regions. Published research priorities in emergency medicine are heterogeneous and geographically limited, mostly containing groups of authors from the same country. The majority of publications in global research priority setting stem from Western countries, covering a broad spectrum of clinical and nonclinical topics. Research priorities from Africa and Asia tend to focus on specific issues more prevalent in those regions of the world.

The Effect of Step Stool Use on Chest Compression Quality During CPR in Young Children: Findings From the Videography in Pediatric Emergency Research (VIPER) Collaborative.

This study aimed to determine the effect of stepstool use on chest compression (CC) quality during cardiopulmonary resuscitation (CPR) in young children. We conducted a prospective observational study of children <8 years of age who received CC for >2 minutes in the emergency department. Data were collected through CC monitor device and video review. Data were analyzed in "CC segments" (periods of CC by individual providers). CC segments were coded "yes" or "no" for stepstool use based on video review. Univariate analyses of CC rate and depth between stepstool use and hand positions were performed through nonparametric testing, stratified by age category. Forty-two patients received 566 minutes of CC. Overall, American Heart Association (AHA)-compliant (rate and depth) CPR was achieved in 10% of CC segments for children <1 year and only 6% in children >1 year. A stepstool was used in 73% of CC segments in children <1 year and 88% in children >1 year. In children >1 year, stepstool use was associated with deeper CCs (P < 0.001) and a more compliant CC rate (P < 0.01). In children >1 year, 7% of those with a stepstool in use achieved AHA compliance, compared to those without a stepstool, where none achieved AHA compliance. In children >1 year, stepstool use resulted in greater CC depth and more AHA-compliant CC rate. No CC segments in children >1 year achieved AHA compliance without a stepstool. These data support uniform stepstool use during pediatric CPR in children >1 year of age.

Invisible threat to mesopelagic fish: Microplastics and artificial cellulose particles in bigfin lanternfish Symbolophorus californiensis from the Northwest Pacific Ocean

Lanternfishes play an important role in connecting epipelagic and mesopelagic ecosystems. Due to their global distribution, diel vertical migration, and low trophic position, they may be highly susceptible to the ingestion of microplastics (MPs) and artificial cellulose particles (ACs). However, the role of lanternfishes in these emergent pollution research remains underestimated. In this study, we compared the abundance and characteristics of MPs and ACs in the stomach and intestine of bigfin lanternfish (Symbolophorus californiensis) from the Northwest Pacific Ocean. The results showed no difference in the abundance and size of MPs between the stomach (0.28 ± 0.63 items/individual, 103.72–2946.58 μm) and intestine (0.32 ± 0.56 items/individual, 122.03–4398.17 μm). The majority of MPs were fibrous in shape, with blue and transparent being the predominant colors. Polyester (28.2 %) and polyethylene terephthalate (20.5 %) were the most common polymer types. ACs were also primary in the shape of fiber (93.2 %), with transparent being the predominant color. The abundance of ACs in the intestine (0.49 ± 0.83 items/individual) was significantly higher than that in the stomach (0.18 ± 0.43 items/individual), while similar particle sizes were observed. This study provides an important baseline on lanternfishes contamination by MPs and ACs. Understanding this impact of mesopelagic fish is crucial for enhancing our comprehension of the vertical transfer mechanism of these pollutants between epipelagic and mesopelagic ecosystems.

The Intersection of Ultra-Processed Foods, Neuropsychiatric Disorders, and Neurolaw: Implications for Criminal Justice.

Over the last decade there has been increasing interest in the links between the consumption of ultra-processed foods and various neuropsychiatric disorders, aggression, and antisocial behavior. Neurolaw is an interdisciplinary field that seeks to translate the rapid and voluminous advances in brain science into legal decisions and policy. An enhanced understanding of biophysiological mechanisms by which ultra-processed foods influence brain and behavior allows for a historical reexamination of one of forensic neuropsychiatry's most famous cases-The People v. White and its associated 'Twinkie Defense'. Here in this Viewpoint article, we pair original court transcripts with emergent research in neurolaw, including nutritional neuroscience, microbiome sciences (legalome), pre-clinical mechanistic research, and clinical intervention trials. Advances in neuroscience, and related fields such as the microbiome, are challenging basic assumptions in the criminal justice system, including notions of universal free will. Recent dismissals of criminal charges related to auto-brewery syndrome demonstrate that courts are open to advances at the intersection of neuromicrobiology and nutritional neuroscience, including those that relate to criminal intent and diminished capacity. As such, it is our contention that experts in the neurosciences will play an increasing role in shaping research that underpins 21st-century courtroom discourse, policy, and decision-making.

Bibliometric and knowledge map analysis of one lung ventilation.

One lung ventilation (OLV) is an essential method of lung isolation to protect the ventilated lung from soiling by the contralateral lung and obtain optimal surgical exposure in thoracic surgery. This study aims to examine the trends and developments in OLV research from 1982 to 2024 through bibliometric analysis. The literature on OLV was systematically searched in the Web of Science Core Collection database for this study. VOSviewer and CiteSpace were utilized to perform comprehensive bibliometric and visual analyses of global publication/trends, countries/institutions, authors/co-cited authors, journals/co-cited journals, co-cited references, and keywords in the field of OLV. A total of 1,682 articles and reviews on OLV research were identified, which showed an overall growing trend from 1982 to 2024. The United States was the leader in this field, accounting for the largest number of publications (n=299). Among all institutions, Yonsei University had the largest number of publications (n=23), but National Taiwan University Hospital had the highest number of cited publications (n=876). The papers related to OLV were mainly published in Journal of Cardiothoracic and Vascular Anesthesia (n=147) and the most productive author was Cheng YJ (n=15). After keywords analysis, "infants", "dexmedetomidine", "inflammation", and "airway management" were newly emergent research hotspots. Through bibliometric and visualization methods, we undertook a comprehensive analysis in the field of OLV. The United States maintained a top position in this field, the emerging hotspots of OLV changed from basic research to clinical research and the further innovation of OLV management. This study provides new ideas for scholars in their future works.

Using NHS Data to Monitor Trends in the Occurrence of Severe, Food-Induced Allergic Reactions Work Package 2

People with food allergies may experience food allergic reactions due to accidental exposure. These reactions are commonly categorised as non-severe, fatal food anaphylaxis and near-fatal food anaphylaxis. Non-severe allergic reactions to food are more common with an incidence of up to 1,000 times greater than fatal food-related anaphylaxis. However, obtaining accurate data relating to the circumstances under which these reactions occurred is challenging under the current diagnosis coding system used in the National Health Service (NHS). This project addressed two key questions: 1. What are the trends in the occurrence of food hypersensitivity (FHS) reactions and their consequences in terms of healthcare encounters (both to hospital and primary care)? 2. What are the circumstances surrounding severe, life-threatening reactions to food? Approach • A UK arm of NORA was established using the same online platform as the existing European Registry. • Participation of healthcare professionals and/or patients to enter relevant information was co-ordinated by BSACI in conjunction with the Paediatric Emergency Research in the United Kingdom Ireland (PERUKI) network. • Different versions of the questionnaire were developed to increase response rates: (1) a comprehensive form mapped to existing NORA data fields for completion by Healthcare Professionals in the non-acute setting; (2) a shorter form with key data fields to increase data reporting in more pressured, acute healthcare settings; and (3) a form for completion by patients or their parent/guardian. Key Results The launch of the UK anaphylaxis registry faced delays and was impacted by significant pressures on NHS services due to the COVID-19 pandemic. This led to a lower than anticipated uptake of the Registry by clinics and Accident &amp; Emergency departments. As a result, only a minority of accidental reactions (less than 5%) were captured in the registry, almost all in children and young people under age 18 years. Some indicative results of this analysis are the following: • 213 cases reported to be due to a food trigger and of these, 208 occurred in children/young people aged 18 years or under. • Common food triggers were peanut, tree nuts (especially cashew), cow’s milk/dairy and hen’s egg. • 47% of reactions occurred after consumption of prepacked food products and in at least 59% of these cases, the allergen was declared as an actual ingredient. Further work would be needed to understand how to optimise reporting of data, for example by reducing the time burden for completion by clinicians and patients.

Crime and Nourishment: A Narrative Review Examining Ultra-Processed Foods, Brain, and Behavior

Recently, there has been increased scientific and clinical interest in the potential harms associated with ultra-processed foods, including poor mental health, aggression, and antisocial behavior. Research spanning epidemiology, mechanistic pre-clinical work, addiction science, microbiome and exposome science, and human intervention trials has underscored that nutrition is of relevance along the criminal justice continuum. As such, the emerging dietetics research is salient to the thousands of international psychologists and allied mental health professionals that are engaged in justice work, including forensics, prevention, and intervention. In addition, relationships between nutrition and behavior relate to “food crime”, an emergent area unifying criminal justice researchers with psychology, public health, and other interdisciplinary sectors. Food crime scrutinizes the vast harms, including non-communicable diseases and adverse behavioral outcomes, as influenced by the distribution of addictive ultra-processed food products. Here, we examine the emergent research, including biophysiological mechanisms, and evidence indicating that dietary patterns/components intersect with psychosocial vulnerabilities linked with risks of antisocial behavior and justice involvement. Viewed through a prevention lens, the study of nutrition and aggressive behavior should be prioritized, especially if the outcomes emerge as externalities of the global consumption of ultra-processed food. In the context of criminal justice and behavior, there is a need for forensic examination of how industry influence and power structures can undermine matters of food justice.

Ecosystem Services Justice: The Emergence of a Critical Research Field

Ecosystem services justice is an emergent research field. Over the past decade, research on ecosystem services has increasingly developed a justice perspective and incorporated it into its conceptual and empirical frameworks. This perspective aims at providing a review of the emergent strands of research addressing ecosystem services justice, and at creating an outlook on future research needs and frontiers. The review departs from central critiques to the ecosystem service approach, which have been foundational for the research field of ecosystem services justice. To be precise, we address three different research strands on which justice issues arise. First, ecosystem services production, considering the (increasing) commodification of ecosystem services, the concentration of ecosystem services production assets and the role of trade-offs in production capacities. Second, the distribution of ecosystem services benefits under the aspects of unequal vulnerabilities, the consideration of accessibility and individual’s capabilities to obtain ecosystem services. Third, the recognition of ecosystem services pluralisms, including socially differentiated forms of wellbeing, plural values and knowledge concerning ecosystem services. While ES justice has strongly advanced from a scientific perspective, we are still lacking a stronger reflection of these advances in practice. Future research, we argue, needs to develop holistic procedural frameworks for integrating the complexity of ecosystem services justice, addressing the ecosystem services production under consideration of historic inequalities, the distribution of ecosystem services benefits with respect to people’s diverse needs, vulnerabilities, and capabilities, as well as diverse wellbeing-, value-, and knowledge-systems. The social-ecological understanding of ecosystem services co-production, which recognizes the dynamic and reciprocal relationship between humans and ecosystems, is identified as a crucial framing for this endeavor.

Comparative analysis of the dispersion modeling and dose projection results performed under BARCO international project

Radiological assessments on zones to take protective actions in case of a nuclear or radiological emergency involve a series of real-time forecasts of radiological impact on the public at various distances from the release point, using actual weather or forecast data, information on the source term or facility status, and primary radiation monitoring data. This practice is implemented during the operation of emergency centers around the world in order to promptly report the occurrence and possible consequences of radiological accidents in the country and abroad in the event of a possible transboundary impact. Since the Chornobyl disaster, a lot of emergency exercises, research programs and projects, in particular, benchmarking, have served as international platforms for improving modeling capacity in atmospheric dispersion. This activity is carried out both on the basis of past severe accidents with significant atmospheric releases and corresponding radiological consequences, and on the basis of specific conditional (hypothetical) events that are developed in accordance with the purpose of the study. The paper is focused on the comparison results performed under the international project “Benchmarking on Assessment of Radiological COnsequences” (BARCO) conducted in 2020–2021 between five technical support organisations – members of the European Technical Safety Organisations Network (ETSON). The work contains a short overview of relevant international activity conducted in the past, a description of the BARCO project and its objectives, a list of participants, project tasks, initial data (source term, meteorology, list of benchmarking quantities, approach to data exchange, codes used). The study presents some of comparative analysis results obtained via two techniques such as code-to-code analysis (CTCA) and matched-pair analysis (MPA). The results discussion concentrates on the overall recommendations for code users. Conclusions provide the main outputs of the project.

Mobile Phone Location-Based Advertising (MLBA): Emergence, premises and future research agenda

The exponential rise in smartphone usage globally has spurred marketers to explore novel advertising strategies. One such innovative approach is mobile phone location-based advertising (MLBA), which allows for precise consumer targeting based on geographical proximity. This study delves into the intricacies of MLBA as a cutting-edge advertising tool, examines its origins, and principles, and outlines future research directions. Positioned at the intersection of information technology and marketing, this interdisciplinary topic warrants comprehensive analysis to advance the field. Through a meticulous review of the literature, this paper offers valuable insights into the efficacy of MLBA and its implications for both theory and practice in promotional efforts. Identifying key research gaps, lays the groundwork for future studies, facilitating a deeper understanding of MLBA's potential as a marketing tool. The findings underscore the importance of systematically evaluating the concept and its components, providing marketers and researchers with a concise yet comprehensive framework for guiding future research endeavors.

Antibody–drug conjugates for breast cancer: a bibliometric study and clinical trial analysis

BackgroundBreast cancer (BC) remains the most commonly malignancy among women worldwide. Although early-stage BC typically presents with curative possibilities, advanced-stage disease, especially with metastasis, is significantly limited in terms of effective therapeutic interventions, thereby establishing it as the second leading cause of cancer-related deaths in women. Antibody–Drug Conjugates (ADCs) establish a groundbreaking class of anti-neoplastic agents characterized by high specificity and targeting precision. These agents have been significant in reshaping the therapeutic approach to breast cancer, especially those subtypes with overexpression of the Human Epidermal Growth Factor Receptor 2 (HER2). Comprising monoclonal antibodies, cytotoxic payloads, and conjugative linkers, ADCs function by specifically targeting antigens on cancer cells, thereby facilitating the intracellular delivery of the toxic payload. The present investigation endeavors to synthesize existing primary research outcomes through rigorous bibliometric and data analytical approaches, thereby elucidating the current research landscape, delineating research foci, and identifying potential avenues for future innovation.MethodsFor bibliometric analysis, a comprehensive data set comprising 2181 entries related to ADCs in breast cancer was retrieved from the Web of Science Core Collection (WoSCC) spanning the years 1999 to 2023. This data was further filtered from the Science Citation Index Expanded (SCI-Expanded). Analysis software tools such as CiteSpace and VOSviewer were employed for multifaceted analyses such as trends of publications, contributions of countries, and burst analytics. In the dimension of clinical trials, we interrogated databases including ClinicalTrials.gov (https://www.clinicaltrials.gov) and the WHO International Clinical Trials Registry Platform (ICTRP) (https://trialsearch.who.int). A total of 239 clinical trials were initially sourced, among which, 175 were from ClinicalTrials.gov and 64 from ICTRP. After repetitive and correlation-based screening, 119 trials specifically addressing ADC therapeutic strategies in breast cancer were included. Analytical algorithms were executed using Microsoft-based software to evaluate treatment paradigms, emergent research themes, and progress.ResultsOur investigations signify a growing trend of research on ADCs, with consistent advancements in scientific achievements. The analysis revealed that variables such as economic stratification of nations, healthcare investment paradigms, and disease incidence rates serve as significant determinants in shaping research output. Geographically, the United States emerged as the predominant contributor to the research corpus (36.56%), closely followed by China (21.33%). The underpinning of research accomplishments was found to be significantly bolstered by advancements in molecular biology, immunology, and genetic research. Moreover, the advent of nuclear magnetic resonance diagnostic modalities has contributed saliently to the diagnostic and therapeutic management of breast cancer.ConclusionOur study provides a comprehensive overview of the ADC research landscape through rigorous bibliometric and clinical trial evaluations. At present, the ADC arena has witnessed the successful development and FDA approval of 14 distinct agents, substantially improving the clinical outcomes for a broad spectrum of oncological patients. Future research imperatives may include the exploration of ADCs targeting mutated oncoproteins, dual-specificity ADCs, combination payload strategies, peptide-drug conjugates (PDCs), and non-internalizing ADC modalities. With sustained academic and clinical focus, the ADC domain is poised for transformative advancements in targeted therapeutics across a variety of malignancies.

Advancing Team Process and Emergent State Research by Spanning Common Divides

Advancing Team Process and Emergent State Research by Spanning Common Divides

Unleashing ChatGPT's impact in higher education: Student and faculty perspectives

As Chat Generative Pre-trained Transformer (ChatGPT) gains traction, its impact on post-secondary education is increasingly being debated. This qualitative study explores the perception of students and faculty members at a research university in Canada regarding ChatGPT's use in a post-secondary setting, focusing on how it could be incorporated and what ways instructors can respond to this technology. We present the summary of a discussion that took place in a 2-hour focus group session with 40 participants from the computer science and engineering departments, and highlight issues surrounding plagiarism, assessment methods, and the appropriate use of ChatGPT. Findings suggest that students are likely to use ChatGPT, but there is a need for specific guidelines, more classroom assessments, and mandatory reporting of ChatGPT use. The study contributes to the emergent research on ChatGPT in higher education and emphasizes the importance of proactively addressing challenges and opportunities associated with ChatGPT adoption and use. The novelty of the study involves capturing the perspectives of students and faculty members. This paper aims to provide a more refined understanding of the complex interplay between AI chatbots and higher education that will help educators navigate the rapidly evolving landscape of AI-driven education.

Using intrinsic‐resonance of an interdigitated microwave capacitor for detecting glyphosate‐based herbicide in water

AbstractGlyphosate‐based herbicides are the most used worldwide despite the fact that studies have shown their possible adverse effects on human health and the environment. Since the residues of these herbicides reach water bodies, their detection is considered an emergent research topic. In this work, the use of the intrinsic resonance of a microwave interdigitated capacitor fabricated on microstrip technology, is proposed for detecting the presence of glyphosate‐based herbicide in water. In addition, a sample holder is proposed to avoid the possible oxidation of the metal electrodes due to the direct contact with liquids. The proposed structure was designed to present its first intrinsic resonance at 1.95 GHz so that this resonance is shifted to 1.58 GHz when pure deionized water is used as sample. The sensor device was tested against 18 mixtures prepared with concentrations between 0% and 100% v/v of herbicide diluted in deionized water. Experimental measurements confirm that by using the intrinsic resonance parameters of the proposed structure, is possible to detect the presence of a glyphosate‐based herbicide. Finally, the results confirm the potential of the proposal as an alternative for real‐time, label‐free, and sensitive detection of glyphosate in water and they open the possibility of exploiting its use for the detection of other contaminants.