Abstract Objective Ou MC decrescendo phenomenon (OuDP) is produced by placing the contralateral hand over a diseased location (Ou MC handing remedy [Ou HR]) to produce a zone under the hand with decreased pain or inflammation (Am J Emerg Med, 2012). Our objective is to report a series of patients with various diseases that resolved with application of the Ou HR, and review other studies of the OuDP. Methods During 2015, 18 patients with various diseases were treated at our clinic: 3 patients had infectious processes; 4 had joint and/or soft tissue pain; 3 had dysmenorrhea; 1 had preterm labor; 2 had abdominal pain/fullness after surgery; 1 had diabetes mellitus and difficulty walking; 2 had suspected malignancies and 1 had a malignancy. All patients were treated with the Ou HR, and their clinical outcomes were presented. Other studies examining the Ou HR and OuDP were reviewed (Proc Physiol Soc, 2014, 2015, Mascc/Isoo, 2015). Results Of the 18 patients, 17 self-administered the HR and 1 had the Ou HR administered by a therapist. In all 18 patients the symptoms or disease process was improved or cured. Prior published studies including 121 patients indicated that the Ou HR was effective in 92.3 to 100% of patients. Including prior studies, there were 3 patients with pathology-identified cancer: (1) uterine endometrioid carcinoma, stage IIIB, (2) uterine endometrial carcinoma, stage IA, (3) uterine leiomyosarcoma stage IB, and 5 patients with suspected cancer: (1) suspected pancreatic cancer in stage IA with isodense pancreatic nodule, elevated CA199 and dilated tortuous main pancreatic duct, (2) Ovarian tumor with solid and cystic part and omentum metastasis by CT scan, (3) menopausal ovarian solid tumor, (4) suspected inguinal lymph node metastasis after operation for cervical cancer IB, (5) suspected gluteal metastatic lesion of chronic myelogenous leukemia. All these 8 patients showed suppression or cure of the tumor with Ou HR treatment. Conclusions The OuDP shows to accelerate the recovery of a number of disease states, and the effect mainly occurs with the use of the contralateral hand, which suggests that the axes of embryonic polarity may impart the OuDP leading to the normalization of tissue function. The normalization of the tumor cells and microenvironment function may make tumor cells conform to the regulations with apoptosis, metastasis suppression, preventing uninhibited proliferation, minimizing angiogenesis and supervision by host immunological systems, which suppresses or cures the cancer. These findings warrant further investigation. Citation Format: Ming Cheh Ou, Dennis Ou, Chung Chu Pang. The possible role of embryonic polarity axes for the normalization of tissue function induced by the interaction between human bilateral parts. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2016;76(14 Suppl):Abstract nr 1436.