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A Special Issue of the International Journal of Food Studies for the 7th International Iseki-FOOD Conference

The European Association for Integrating Food Science and Engineering Knowledge Into the Food Chain (Iseki-Food) conference is a biannual event that presents an opportunity for a discussion in education, research and engagement in the food science and technology area. The organising committe aims to provide an environment to exchange ideas and experiences, establish bussiness and research relations and create collaborations. On behalf of the Editorial Team we are announcing an special issue of the International Journal of Food Studies (IJFS) that will receive relevant applications from the conference. We are cordially inviting applications to become Editor and manuscript submissions for this Issue. Applications to become a Special Issue Editor are open for Iseki-FOOD associates. Please email your interest and details to the editor.in.chief@iseki-food.net by the 5th of July 2023.

It’s 10 O’clock: Do You Know Where Your State Legislature Is?

It’s 10 O’clock: Do You Know Where Your State Legislature Is?

What’s He Building in There

What’s He Building in There Cat Powell (bio) After Tom Waits Your father has been spending a lot of time in the basement recently, and I’m hoping you will speak with him about this. I know you keep saying you won’t get involved in things between us anymore, but he is your father and I am concerned. On the one hand, at least he’s not following me around the house watching me do chores like he did in the early months of his retirement. On the other hand, it is concerning. When I say a lot of time, I mean a lot of time. Please call or email him. I think he is lonely and possibly depressed. _______ I saw the photos you posted on the Facebook. I’m glad that you are having fun, but I feel like if you have time to post those photos, you have time to at least email your father. _______ You are right. That email was passive aggressive. See? I can “evolve,” too. Unlike your father. The other day I had to explain to him what passive aggressive meant, and then when we were in line at the supermarket he turned to the perfect stranger behind us and said, “I’m passive aggressive. Do you know what that means?” I wanted to crawl under the candy rack. I think you have a point about social isolation not doing him any favors. He does sometimes go to watch the game and have a pitcher with Ted, but that relationship isn’t very deep. I don’t think he’s had any close friends since his brother died. [End Page 83] I’m glad to hear that work is going well, but don’t forget that your career is only one part of your life. And not the part that’s going to give me grandkids! Just kidding. (Haha, not really.) The decorations for Sherri’s baby shower arrived yesterday. I think they’re going to look really nice. I’ll send you pictures once I get them up. _______ Don’t be silly! You can’t throw your own daughter’s baby shower! That’s why I did Sherri’s for Margene. (It went well, by the way. Pictures attached.) Honestly, if the topic upsets you that much, maybe it’s time to revisit the idea of freezing your eggs. You’re clearly not taking dating seriously, and I told you we could use some of the money we set aside for your wedding. Maybe one of your gay friends could be a sperm donor. Honestly, that is probably a much better idea than trying to raise a child with a straight man. It’s not all it’s cracked up to be. Your father, for example, is still obsessed with his mystery project in the basement. He never came to bed Saturday night, and when I woke up, the truck was gone. Then an hour later he was back with a truck bed full of sheet-rock panels. I told him he was going to destroy his back carrying them by himself, but he said he’d be fine, he was wearing a belt. You know how he is about hiring help for anything. Remember the fuse box? He did manage to get the panels down, though—with a lot of bumping and cursing. Then he stayed down in the basement all day. When I called him for dinner, he didn’t answer. So I finally went down there and found him lying flat on his back on the floor in literal agony. He said he was just resting, but when he tried to get up, he couldn’t. He wouldn’t let me call an ambulance or even a neighbor, so I brought him some ice packs and Advil and tried to make him comfortable. I couldn’t help pointing out that none of this would have happened if he’d hired the neighbor kid, and he said that kids these days don’t know how to do a job properly and it would have been like lighting money on fire. I was tempted to tell him...

What's ahead for the mental health field in 2023?

We are beginning to work on Mental Health Weekly's 2023 Preview Issue, and we'd like your input. What are the challenges and opportunities that await you and your organization in the new year? We would like to include your responses in this issue, which will be published Jan. 2, 2023. Be as specific as possible in your response and limit your reply to no more than 200 words. Please email your responses to vcanady@wiley.com by Monday, Dec. 26.

What's ahead for the mental health field in 2023?

We are beginning to work on Mental Health Weekly's 2023 Preview Issue, and we'd like your input. What are the challenges and opportunities that await you and your organization in the new year? We would like to include your responses in this issue, which will be published Jan. 2, 2023. Be as specific as possible in your response and limit your reply to no more than 200 words. Please email your responses to vcanady@wiley.com by Monday, Dec. 26.

Announcements

Announcements

November 2022 Placement Ads

November 2022 Placement Ads

MHW would like to know your thoughts on mental health apps

In recent years we have seen tremendous growth in the availability of mental health apps and other virtual tools for patient treatment and support. Are you finding any of these useful for clients in your organization? Email your comments to garyenos5@gmail.com; we will plan to include some of your thoughts in our coverage of this topic in our Innovations issue in October.

Announcements

The Martha Heasley Cox Center for Steinbeck Studies at San José State University continues to coordinate the Steinbeck Letters Project, which aims to create a searchable database listing of John Steinbeck’s letters starting with those in the Center’s possession.Anyone interested in more information or contributing to this project, please contact us at steinbeck@sjsu.edu.Thanks to a generous donation from Mrs. C. Suzette Ditsky, emerging Steinbeck scholars can apply to utilize the outstanding resources in the Ball State University Libraries. The Steinbeck Research Fund has established in honor of Mrs. Ditsky’s late husband, John, who passed away in 2006. Dr. Tetsumaro Hayashi, a longtime friend, said, “He was first and foremost a passionate and dedicated scholar, teacher, and mentor.” Hayashi commented that the Research Fund was “established to honor Ditsky’s long-established legacy of extending a helping hand to emerging Steinbeck scholars.”Recipients will spend a minimum of five days doing intensive research using the Steinbeck collections or other materials at the Ball State University Libraries. The resulting research must be submitted for publication in a professional, scholarly, Steinbeck-related journal and/or presented at a Steinbeck Conference, convention, or lecture at a university.Applicants should submit a Steinbeck-related research proposal (minimum of two pages), a curriculum vitae, a completed-application form (available at https://bsu.libguides.com/ld.php?content_id=48465493), and two letters of recommendation from colleagues, faculty members, or others who can speak to your academic qualifications. More details, including guidance for drafting your application, can be found on the application document itself. Completed applications can be emailed directly to libarchives@bsu.edu.The conference committee has begun meeting to organize the next International Steinbeck Society Conference, to be hosted by the Martha Heasley Cox Center for Steinbeck Studies in March of 2023. The theme for this conference will be “John Steinbeck in the Twenty-First Century: Reading, Teaching, and Translating.” More details, including the Call for Papers, will be available soon.In memory of Louis Owens, the Martha Heasley Cox Center for Steinbeck Studies established this award to honor undergraduate and graduate student work on Steinbeck and related subjects. Undergraduate and graduate students may submit, or faculty may submit on their behalf.Deadline: postmark of January 31, 2023Length: between twelve and forty pagesFormat: MLAAward: $250.00 and consideration for publication in Steinbeck Review Send as attachment to steinbeck@sjsu.edu or by regular mail to: Louis Owens Essay Prize, Martha Heasley Cox Center for Steinbeck Studies, San José State University, San José, CA 95192-0202.The International Steinbeck Society will field two presentations at the upcoming American Literature Association conference, hosted in Chicago during the weekend of May 26–29, 2022. The first is a traditional panel titled “Reading Steinbeck in a Time of Trouble,” and the second is a roundtable session titled “Steinbeck and the Living World.” Readers who can’t attend this conference can look for this work in the Fall 2022 issue of Steinbeck Review.Does your university or organization have an announcement to share with the Steinbeck studies community? Email your entries to Daniel Rivers (daniel.rivers@sjsu.edu) by July 10 (for the Fall issue) or January 10 (for the Spring issue).

Advances in myelodysplastic syndrome.

In this review, the focus is on the most recent improvements in diagnosis, prognostication and therapy of myelodysplastic syndromes (MDS) and on their relevance for clinical management. Analytical methods to refine cytogenetic and molecular assessment of MDS have been proposed, improving prognostic stratification obtained from integration of clinical and genomic data. Novel agents with very different mode of action, as single drugs or added to HMA backbone, show promising clinical results in LR-MDS and HR-MDS. Luspatercept has obtained approval given the fact that in transfusion-dependent erythropoietic-stimulating agent resistant/relapsed LR-MDS induced nearly 50% of transfusion independence. Another investigational agent showing efficacy and possibly disease modifying activity in the same setting is the telomerase inhibitor imetelstat. Results from phase II study with azacytidine and pevonedistat indicate the concrete possibility to enhance durable responses compared with azacitidine single drug. In the same direction are the preliminary results of other agents with different mode of action: magrolimab, venetoclax, sabatolimab, as well as the targeted therapy with enasidenib and ivosidenib. New posttransplant maintenance strategies may concur to prolong response. Better diagnosis and prognostic stratification may allow a more precise and personalized treatment of MDS with novel agent combinations leading to improved therapeutic algorithms.

Crosstalk opposing view: Independent fusimotor control of muscle spindles in humans: there is little to gain.

Crosstalk opposing view: Independent fusimotor control of muscle spindles in humans: there is little to gain.

Rebuttal from Manoja K. Brahma, Adam R. Wende and Kyle S. McCommis.

Drs Karwi and Lopaschuk have provided compelling evidence of the potential for ketone bodies to provide an extra source of ATP for the heart. The foundation of our opposing views most likely stems from comparing analyses of the acute effects of ketone bodies in predominantly ex vivo studies to that which occurs in vivo with more chronic ketosis. Likewise, we must all be more prudent when comparing cardiac metabolic adaptations to physiological ketosis to those observed with ‘pure’ ketosis as occurs with consumption of ketone esters or salts, or ketone infusion. In physiological states of ketosis such as fasting or consumption of a low-carbohydrate, high-fat ketogenic diet, hearts preferentially downregulate ketolytic enzymes, decreasing ketone oxidation and enhancing fatty acid oxidation (Wentz et al. 2010; McCommis et al. 2020). This downregulation of ketolytic enzymes also occurs in the hearts of diabetic mice, or in hearts overexpressing glucose transporter 4 with enhanced glucose uptake and utilization (Brahma et al. 2020). However, cardiac ketone metabolism may be directly enhanced if delivery of lipids or glucose is not concurrently elevated. Recent studies suggest that ketone ester supplementation enhanced cardiac ketone uptake in humans (Monzo et al. 2020), and ketone ester-enriched diets increased the expression of ketolytic enzymes in the rat heart (Yurista et al. 2020). These studies imply that elevated ketone extraction is associated with increased oxidation, but neither of these studies directly measured oxidation. We agree that ketone utilization appears to be more important in failing hearts. Failing hearts from humans and rodent models display enhanced expression of the ketolytic enzymes β-hydroxybutyrate dehydrogenase 1 (BDH1) and succinyl-CoA:3-oxoacid CoA transferase (SCOT) and have been shown to extract more ketones than non-failing hearts (Aubert et al. 2016; Bedi et al. 2016; Horton et al. 2019; Monzo et al. 2020; Murashige et al. 2020). Also, cardiac-specific deletion of BDH1 or SCOT in mice exacerbates cardiac dysfunction and remodelling when challenged by pressure overload (Schugar et al. 2014; Horton et al. 2019). But these knockout mouse models provide perhaps the most significant evidence that ketone body metabolism is not critical for normal hearts, as deletion of BDH1 or SCOT does not directly induce cardiac dysfunction, and these hearts can even normally adapt to physiological ketosis (Schugar et al. 2014; Horton et al. 2019). To conclude, further investigation is needed to better understand the importance of ketone body metabolism in heart failure, as well as in response to ketosis as a potential therapy for heart failure. Readers are invited to give their views on this and the accompanying CrossTalk articles in this issue by submitting a brief (250 word) comment. Comments may be submitted up to 6 weeks after publication of the article, at which point the discussion will close and the CrossTalk authors will be invited to submit a ‘Last Word’. Please email your comment, including a title and a declaration of interest, to [email protected]. Comments will be moderated and accepted comments will be published online only as ‘supporting information’ to the original debate articles once discussion has closed. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article. None. All authors conceived, wrote, and edited this manuscript. All authors have read and approved the final version of this manuscript and agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved. All persons designated as authors qualify for authorship, and all those who qualify for authorship are listed. A.R.W. is supported by NIH R01 HL133011. K.S.M. is supported by NIH R00 HL136658.

Expression of androgen receptors in the structures of vulvovaginal tissue.

Little is known about the role of androgens in the female genital tract, specifically in the vulvovaginal area. The abundance of androgen receptors in this area could help us to explain their role. The main objective of the present article is to review current data on androgen receptors in the different structures of vulvovaginal tissues. A review of the literature using data from PubMed was carried out on androgen receptors in the vulva, labia majora and minora, vestibule, clitoris, and vagina. The effects of androgens and regulation of androgen receptors both in the embryo and in premenopausal and postmenopausal women were also reviewed. Given the characteristics of this review, we also analyzed animal studies and animal models of human disease. There were no filters or restrictions with respect to the date of publication. Androgen receptors have been detected throughout the genitourinary tract by means of Western blot, immunohistochemistry, ligand binding, and gene expression. They are present in the labia majora and minora, the clitoris, the vestibule, and in the three layers of the vaginal mucosa (epithelium, lamina propria, and muscularis). More specifically, studies on the labia majora have shown that androgen receptors seem to be particularly abundant in epidermal keratinocytes and in dermal fibroblasts. Androgen receptors are also abundant in the epidermis, especially in the keratinocytes, and in the dermis of the labia minora and vestibule, where they are more numerous than in the vagina. Androgen receptors have also been found in the Bartholin glands. Estrogens play a major role in the maintenance of vaginal physiology. Although little is known about the role of androgens in the genital apparatus of women, specifically in the vulvovaginal area, the abundance of androgen receptors could enable us to explain their role. Androgens and estrogens play a major role in the maintenance of vaginal physiology. Better knowledge of the role of androgens and their receptors in vulvovaginal tissue would make it possible to discern their effects on female genitalia and help us to understand new therapeutic strategies.

CrossTalk proposal: Apical NKCC1 of choroid plexus epithelial cells works in the net inward flux mode under basal conditions, maintaining intracellular Cl- and cell volume.

CrossTalk proposal: Apical NKCC1 of choroid plexus epithelial cells works in the net inward flux mode under basal conditions, maintaining intracellular Cl- and cell volume.

CrossTalk proposal: Intramuscular lipid accumulation causes insulin resistance.

CrossTalk proposal: Intramuscular lipid accumulation causes insulin resistance.

Epipen Safety Alert.

Epipen Safety Alert.

Irritability Disorders in Adults

Research into irritability has focused largely on its developmental and child-adolescent manifestations. Although irritability appears to be as elemental an experience as anxiety or depression, diagnoses highlighting irritability as the focal ingredient have yet to be delineated for adults. Instead, irritability-related diagnoses in adults have largely emphasized externalizing behaviors, depressed mood, and personality. Consequently, patients complaining of irritability are sometimes shoehorned into diagnostic categories that they do not experience as authentic representations of their lived experiences. This article proposes that the symptom of irritability might be productively reenvisioned as a focal point, analogous to anxiety and depression, around which irritability-related syndromes and disorders in adults might coalesce. If anxiety, depressive, insomnia, and pain disorders, why not irritability disorders? Both state and trait characteristics of irritability can lend themselves to DSM diagnostic frames. Based on clinical observations, specific irritability disorders in adults can be envisioned, modeled as Irritability Disorder of Adulthood, Irritability Disorder Secondary to Another Medical Condition, Substance-Induced Irritability Disorder, Adjustment Disorder With Irritable Mood, and the like. Further delineation of irritability phenomena, syndromes, and possible disorders in adults is warranted to advance investigation, guide assessment, and improve treatment.

CrossTalk opposing view: Barometric pressure, independent of , is not the forgotten parameter in altitude physiology and mountain medicine.

CrossTalk opposing view: Barometric pressure, independent of , is not the forgotten parameter in altitude physiology and mountain medicine.

Evidence-Based Interventions for Retention of Nursing Students: A Review of the Literature.

There is a need to better understand effective student retention strategies in nursing. This review of course and program interventions reported in the nursing literature is intended to highlight interventions, supported by evidence, to graduate more enrolled students and recommend areas of retention efforts that need further research. The PRISMA search strategy was used to identify and narrow the number of relevant studies. A scoring instrument to evaluate rigor, reliability, and validity of interventions was adapted from a valid and reliable tool used to evaluate studies using a health care education intervention. Evidence-based interventions that improved retention included retention program/specialist, robust orientation, mentoring and tutoring, stipends, and remediation. Nurse educators are independently striving to improve retention rates of nursing students. Implementing evidence-based interventions will advance this effort.

International Association for Gondwana Research 2020 Annual Convention and 17th International Symposium on Gondwana to Asia, Novosibirsk, Russia

Abstract s for the oral and poster presentations and registration forms must be submitted before April 30, 2020. Abstracts should follow the format of Gondwana Research ( http://www.sciencedirect.com/science/journal/aip/1342937X ) and can be up to three printed pages with a maximum of one figure (in jpg format) and one table (in Excel format). The abstract volume will be published as a Conference Series volume of the IAGR. E-mail your abstract files to: iagr2020@igm.nsc.ru with copy to inna@igm.nsc.ru . The text and table (if any) should be in editable Word file and the figure should be in.jpg or.tif file. We cordially invite you to participate in this important international conference.