Introduction: While there is concern that participation in certain elite-level sports may increase risk for aortic dilation, clinical assessment of aortic root diameter (ARD) in professional athletes remains difficult owing to the lack of available normative data proportionate to anthropomorphic variables, which further complicates proper assessment of aortic disease during the post-professional life when risk factors may be greater. Thus, we examined the effect of allometric scaling on the association between ARD and professional football career length (NFLYrs) or playing position in retired National Football League (NFL) players. Methods: This cross-sectional study included 1,328 retired NFL players (mean age 53.1 ± 12.7 yrs; 54.6% Black) that participated in NFL Player Care Foundation health screenings. Two-dimensional echocardiogram was used to determine ARD at the sinus of Valsalva and indexed to body surface area (BSA) 0.6 (aortic root index; ARI). Multivariable-adjusted linear regression models were utilized to examine the association of playing position group and NFLYrs with ARD or ARI, after adjusting for traditional cardiometabolic risk factors. Results: The mean ARD and ARI of this study cohort were 33.0 ± 6.4 mm and 19.5 ± 3.8 mm, respectively. In regression models, NFLYrs was not associated with either ARD (B: -0.04, standard error [SE]: 0.04, p = 0.3496) or ARI (B: -0.03, SE: 0.03, p = 0.3177). Conversely, increasing ARD was associated with both Big (B: 1.12, SE: 0.53, p = 0.0340) and Big Skill (B:1.10, SE: 0.45, p = 0.0144) position groups, although this was attenuated to non-significance by allometric scaling of ARD (Big, B: -0.25, SE: 0.32, p = 0.4303; Big Skill, B: 0.22, SE: 0.26, p = 0.3978). Conclusions: NFLYrs was not associated with increasing ARD or AIH, suggesting that a longer professional football career did not potentiate larger aortic root size later in life. While football playing position was associated with increasing ARD, this association became non-significant upon indexing of ARD to BSA 0.6 , suggesting that allometric scaling may be necessary to appropriately assess aortic root diameter in these individuals. This underlines the need for further studies examining optimal allometric scaling methodologies in this population.
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