Eliminated Age Differences Research Articles

Effect of Perceptions of Future Time on Implicit and Explicit Memory in Older Adults

ABSTRACT Objectives We examine age-related differences in implicit and explicit memory tasks, and test the impact of future time perspectives on priming and cued recall. Methods We induced time perspective in young (limited-time perspective) and older (extended-time perspective) adults. Implicit and explicit memory tasks were performed by younger and older adults. Results Results showed an age-related effect on priming and cued recall, confirming that implicit and explicit memory are impaired in aging. Nevertheless, manipulation of future time perspective eliminated age differences in priming and cued recall. Discussion These findings support the view that it is not age per se that determines memory performance but rather the perception of the time left to us. Socio-emotional selectivity theory thus seems to be a serious candidate to explain age-related differences in implicit and explicit memory.

Worry about quality of life for younger versus older adult thyroid cancer survivors.

157 Background: Thyroid cancer is one of the most common cancers in young adults, age 18-39 years. Since this population has distinct medical and developmental needs, it is important to understand age differences in worry about quality of life. Methods: Thyroid cancer patients diagnosed between 2014-15 were accrued from the Surveillance, Epidemiology and End Results Program (SEER) registries of Georgia and Los Angeles County and surveyed between 2017-18. The primary outcome was patient reported worry about quality of life. Covariates for this analysis included age (categorized 18-25, 26-39, 40-64, and 65-79), involvement in surgical decision making (low, just right, high) and amount of information received on treatment side effects (low, just right, high). Race/ethnicity, sex, and tumor characteristics were also evaluated. Multivariable analyses were used to assess associations between worry about quality of life and independent variables. Results: In the cohort of 2,632 patients, 39.8% were somewhat to very much worried about quality of life not being the same as before thyroid cancer diagnosis, 15.1% reported low involvement in surgical decision making, and 32.6% reported low amount of information regarding side effects. Younger age was associated with high worry about quality of life (p < 0.001), low involvement in decision making (p < 0.001) and low amount of information on treatment side effects (p < 0.001). In multivariable analyses, high worry was significantly associated with female sex (Odds ratio [OR]: 1.29 95% confidence Interval [CI]:1.04-1.59), non-white, non-Hispanic race/ethnicity (OR: 1.64 CI: 1.38-1.95), positive lymph nodes (OR: 1.41 CI: 1.14-1.75) and younger age (ages 18-25 years OR: 2.34 CI: 1.45-3.76; ages 26-39 years OR: 2.26 CI: 1.68-3.05; and ages 40-64 years OR:1.94 CI 1.50-2.51). Age differences remained significant after adding either involvement in decision-making or information received. Conclusions: Young adults report higher worry about quality of life. Controlling for decision-making involvement or information received about side effects did not eliminate age differences in worry. Ongoing psychosocial support addressing quality of life worries among younger survivors is needed.

Subjective Cognitive Decline in the Community Is Affected at Multiple Aspects of Mental Health and Life Quality: A Cross-Sectional Study of the Community Medicine of Keelung Chang Gung Memorial Hospital

Background: Subjective cognitive decline (SCD) is one of the early warning signs of objective cognition impairment and dementia. Methods: This cross-sectional study screened SCD and studied multiple domains of mental health, lifestyle, and life quality of the community-dwelling people in the northern coastal region of Taiwan. Results: Among 426 valid AD8 questionnaires, a cutoff of score 2 divided subjects into 115 with SCD (SCD+) and 311 without SCD (SCD–). Analysis of age, sex, body compositions, and blood tests revealed an older age (60.7 ± 10.9 years) of the SCD+ group than the SCD– group (57.6 ± 12.0 years, p < 0.05). Further exclusion of subjects younger than 50 years eliminated age differences and left 100 with SCD (SCD+_50) and 229 without (SCD–_50). Multidomain comparisons of the SCD+_50 group over the SCD–_50 group were made: the Taiwanese Depression Questionnaire found a higher likelihood of depression; the Pittsburgh Sleep Quality Index revealed suboptimal sleep quality; the SF-36 showed inferior function of all 8 aspects of quality of life; the Health-Promoting Lifestyle Profile documented a less health-seeking lifestyle of nutrition, self-actualization, and stress management. Conclusions: Aging increased the SCD risk. People with SCD had suboptimal performance in mental health and life quality in addition to subjective cognition problems.

Intranasal oxytocin does not reduce age-related difficulties in social cognition

Oxytocin is a neuropeptide that plays a key role in social processing and there are several studies suggesting that intranasally administered oxytocin may enhance social cognitive abilities and visual attention in healthy and clinical groups. However, there are very few studies to date that have investigated the potential benefits of intranasal oxytocin (iOT) on older adults' social cognitive abilities. This is a surprising omission, because relative to their younger counterparts, older adults also exhibit a range of social cognitive difficulties and also show differences in the way they visually attend to social information. Therefore, we tested the effect of iOT (24 IU) versus a placebo spray on 59 older and 61 younger adults' social cognitive abilities and visual attention using a double-blind placebo-controlled within-groups design. While iOT provided no overall age-related benefit on social cognitive abilities, the key finding to emerge was that iOT improved ToM ability in both age-groups when the task had minimal contextual information, but not when the task had enriched contextual information. Interestingly, iOT had gender specific effects during a ToM task with minimal context. For males in both age-groups, iOT reduced gazing to the social aspects of the scenes (i.e., faces & bodies), and for females, iOT eliminated age differences in gaze patterns that were observed in the placebo condition. These effects on eye-gaze were not observed in a very similar ToM task that included more enriched contextual information. Overall, these findings highlight the interactive nature of iOT with task related factors (e.g., context), and are discussed in relation to the social salience hypothesis of oxytocin.

Caring more and knowing more reduces age-related differences in emotion perception.

Traditional emotion perception tasks show that older adults are less accurate than are young adults at recognizing facial expressions of emotion. Recently, we proposed that socioemotional factors might explain why older adults seem impaired in lab tasks but less so in everyday life (Isaacowitz & Stanley, 2011). Thus, in the present research we empirically tested whether socioemotional factors such as motivation and familiarity can alter this pattern of age effects. In 1 task, accountability instructions eliminated age differences in the traditional emotion perception task. Using a novel emotion perception paradigm featuring spontaneous dynamic facial expressions of a familiar romantic partner versus a same-age stranger, we found that age differences in emotion perception accuracy were attenuated in the familiar partner condition, relative to the stranger condition. Taken together, the results suggest that both overall accuracy as well as specific patterns of age effects differ appreciably between traditional emotion perception tasks and emotion perception within a socioemotional context.

Anxiolytic effects of the GABAA receptor partial agonist, L-838,417: Impact of age, test context familiarity, and stress

The partial α2,3,5 GABAA receptor agonist, L-838,417 has been reported to have anxiolytic effects in adult rodents. Although maturational differences exist for the GABAA receptor subunits, the anxiolytic effects of L-838,417 have not been tested in younger animals. The goal of the present experiments was to determine whether L-838,417 reverses anxiety-like behavior induced by either an unfamiliar environment (Experiment 1) or repeated restraint stress (Experiment 2) differentially in adolescent and adult, male and female Sprague–Dawley rats using a modified social interaction test. In Experiment 1, rats were injected with 0, 0.5, 1.0, 2.0, or 4.0mg/kg L-838,417, i.p. and tested 30min later in an unfamiliar test context for 10min. In Experiment 2, rats were exposed to restraint stress (90min daily for 5days). Immediately after the last restraint session, animals were injected with L-838,417 and placed alone for 30min in the test apparatus to familiarize them to this context prior to the 10min social interaction test. In Experiment 1, L-838,417 produced anxiolytic effects in adults at 1.0mg/kg, as indexed by a transformation of social avoidance into preference and an increase in social investigation. In adolescents, a dose of 2.0mg/kg eliminated social avoidance, but had no anxiolytic effects on social investigation. Testing under familiar circumstances (Experiment 2) after repeated restraint stress eliminated age differences in sensitivity to L-838,417, with 0.5mg/kg reversing the anxiogenic effects of prior stress regardless of age, but with doses≥1 mg/kg decreasing social investigation, an effect possibly due in part to locomotor-impairing effects of this compound. Although locomotor activity was suppressed in both experiments, higher doses of L-838,417 were necessary to suppress locomotor activity in Experiment 1. Thus, anxiolytic effects of L-838,417 were found to be context-, age-, and stress-dependent.

Adolescents Are More Vulnerable to Cocaine Addiction: Behavioral and Electrophysiological Evidence

In humans, adolescence is a period of heightened propensity to develop cocaine addiction. It is unknown whether this is attributable to greater access and exposure to cocaine at this age, or whether the adolescent brain is particularly vulnerable to the addictive properties of cocaine. Here, we subjected male adolescent (P42) and adult (∼P88) rats to a wide range of cocaine self-administration procedures. In addition, to determine whether behavioral differences are associated with developmental differences in dopaminergic activity, we examined and manipulated the activity of dopamine neurons. Relative to adults, adolescent rats took cocaine more readily, were more sensitive to lower doses, showed greater escalation of cocaine intake, and were less susceptible to increases in price (i.e., were more "inelastic"). In parallel, adolescents also showed elevated activity of ventral tegmental area dopamine neurons, a feature known to be associated with increased self-administration behavior. Pharmacological manipulation of dopamine D2 receptor function with quinpirole (agonist) or eticlopride (antagonist), to alter dopamine neuron activity, eliminated age differences in cocaine self-administration. These data suggest a causal relationship between behavioral and electrophysiological determinants of cocaine addiction liability. In conclusion, adolescents show behavioral and electrophysiological traits of heightened addiction liability.

Age differences in emotional responses to daily stress: The role of timing, severity, and global perceived stress.

Research on age differences in emotional responses to daily stress has produced inconsistent findings. Guided by recent theoretical advances in aging theory (S. T. Charles, 2010, Strength and vulnerability integration: A model of emotional well-being across adulthood, Psychological Bulletin, Vol. 136, pp. 1068-1091) that emphasize the importance of context for predicting when and how age is related to affective well-being, the current study examined age differences in emotional responses to everyday stressors. The present study examined how three contextual features (e.g., timing of exposure, stressor severity, global perceived stress [GPS]) moderate age differences in emotional experience in an ecological momentary assessment study of adults (N = 190) aged 18-81 years. Results indicated that older adults' negative affect (NA) was less affected by exposure to recent stressors than younger adults, but that there were no age differences in the effects of stressor exposure 3-6 hr afterward. Higher levels of GPS predicted amplified NA responses to daily stress, and controlling for GPS eliminated age differences in NA responses to stressors. No age differences in NA responses as a function of stressor severity were observed. In contrast, older age was associated with less of a decrease in PA when exposed to recent stressors or with more severe recent stressors. There were no age differences in the effect of previous stressor exposure or severity on PA, or any interactions between momentary or previous stress and GPS on PA. Together, these results support the notion that chronic stress plays a central role in emotional experience in daily life. We discuss the implications of these results for emotion theories of aging.

Positivity Effects in Older Adults' Perception of Facial Emotion: The Role of Future Time Perspective

We examined age differences in the perception of emotion from facial expressions, testing the impact of future time perspective on positivity effects and emotion complexity. Perception of emotion was assessed in older (n = 111) and younger (n = 127) adults using facial expressions depicting clearly expressed and ambiguous emotions. A more open-ended judgment paradigm was used, and time perspective was experimentally manipulated. Older adults perceived more positive affect in the expressions compared with younger adults. Ambiguity of the expression modulated these age differences, as older adults perceived more positive emotion in ambiguous expressions compared with younger adults. Emotion complexity emerged only in perception of negative expressions, with older adults seeing more mixed affect in the clear expressions than younger adults. Manipulation of future time perspective eliminated age differences in perception of positive affect. Age differences in the perception of emotional expressions showed positivity effects, especially for ambiguous facial expressions. These effects were related to time perspective rather than to age per se. The understanding of the positivity effect in older adults needs to consider the proposed causal role of limited time perspective rather than assuming positivity effects in all older adults.

Goals and everyday problem solving: Manipulating goal preferences in young and older adults.

In the present study, we examined the link between goal and problem-solving strategy preferences in 130 young and older adults using hypothetical family problem vignettes. At baseline, young adults preferred autonomy goals, whereas older adults preferred generative goals. Imagining an expanded future time perspective led older adults to show preferences for autonomy goals similar to those observed in young adults but did not eliminate age differences in generative goals. Autonomy goals were associated with more self-focused instrumental problem solving, whereas generative goals were related to more other-focused instrumental problem solving in the no-instruction and instruction conditions. Older adults were better at matching their strategies to their goals than young adults were. This suggests that older adults may become better at selecting their strategies in accordance with their goals. Our findings speak to a contextual approach to everyday problem solving by showing that goals are associated with the selection of problem-solving strategies.

Emotional target cues eliminate age differences in prospective memory

Cue saliency is known to influence prospective memory performance, whereby perceptually or conceptually distinct cues facilitate remembering and attenuate adult age-related deficits. The present study investigated whether similar benefits for older adults are also seen for emotional valence. A total of 41 older and 41 younger adults performed a prospective memory task in which the emotional valence of the prospective memory cues was manipulated. Emotionally valenced cues increased prospective memory performance across both groups. Age deficits were only observed when neutral (but not positive or negative) prospective cues were presented. Findings are consistent with predictions that salient cues facilitate participants' prospective memory performance and reduce age-related differences, while extending the concept of saliency to include emotional valence.

Characteristics of Positive Autobiographical Memories in Adulthood

The characteristics of positive autobiographical memory narratives were examined in younger and older adults. Narratives were content-coded for the extent to which they contained indicators of affect, sensory imagery, and cognition. Affect was additionally assessed through self-report. Young adults expressed more positive affect and less sensory imagery in their memory narratives than did older adults. Age differences in cognitive characteristics also appeared: younger adults showed greater causation-insight, and greater tentativeness in retelling their autobiographical memories. Controlling for episodic memory ability eliminated age differences in positive affect but did not affect age differences on other memory characteristics. Results are discussed in terms of the role that positive autobiographical memories play in daily emotional life across adulthood.

Costs and benefits of representational change: Effects of context on age and sex differences in symbolic magnitude estimation

Studies have reported high correlations in accuracy across estimation contexts, robust transfer of estimation training to novel numerical contexts, and adults drawing mistaken analogies between numerical and fractional values. We hypothesized that these disparate findings may reflect the benefits and costs of learning linear representations of numerical magnitude. Specifically, children learn that their default logarithmic representations are inappropriate for many numerical tasks, leading them to adopt more appropriate linear representations despite linear representations being inappropriate for estimating fractional magnitude. In Experiment 1, this hypothesis accurately predicted a developmental shift from logarithmic to linear estimates of numerical magnitude and a negative correlation between accuracy of numerical and fractional magnitude estimates ( r = −.80). In Experiment 2, training that improved numerical estimates also led to poorer fractional magnitude estimates. Finally, both before and after training that eliminated age differences in estimation accuracy, complementary sex differences were observed across the two estimation contexts.

Effect of distinctive encoding on false recognition, discrimination, and decision criteria in young and elderly adults

In order to examine the effects of distinctive encoding on age-related differences in false memory and decision criteria, we used a standard recognition paradigm and manipulated three encoding conditions: control, general, and distinctive. The results revealed main effects of age and encoding condition on hits and false recognition, and interactions between these variables, with elderly adults benefiting more than young adults from the encoding tasks. In the distinctive encoding condition, the age-related difference on false recognition was eliminated. These findings are discussed in terms of an age-related deficit in self-initiated distinctive processing. Further analyses showed that elderly adults used a more lenient decision criterion than young adults. Distinctive encoding led all subjects to use stringent decision criteria, but did not eliminate age differences.

Designing External Aids that Support Older Pilot Performance

Communication taxes pilots' cognitive resources. External aids such as note-taking help pilots manage these demands. Morrow et al. (2003) found that note-taking eliminated age differences among pilots on a readback task compared to a no-aid condition. However, we investigated communication-only rather than multi-task environments typical of piloting. The present study compared note-taking ( kneepad) with an electronic notepad positioned next to the instrument panel in a flight simulator ( epad). The epad may be easier to coordinate with concurrent tasks because it is more integrated with flight instruments. Six older and six younger pilots used these aids to respond to ATC messages in a flight simulator. Readback accuracy was higher when pilots used either aid compared to a no-aid condition. The pattern of results suggested a smaller age difference in the aid than in the no-aid conditions. The results replicate the earlier finding of note-taking benefits and extend them to the novel epad.

Contributions of source and inhibitory mechanisms to age-related retroactive interference in verbal working memory.

Determining contributions of source-monitoring and inhibitory function to age-related forgetting has been an elusive goal for cognitive theorists. Five studies used a verbal working memory paradigm to examine mechanisms accounting for disproportionate retroactive interference (RI) experienced with adult aging. Participants distinguished studied target-word pairs from interfering pairs that were read aloud. Source-monitoring and inhibitory task components varied through manipulations of response requirements. RI effects were primarily due to source-monitoring failures rather than to inhibitory failures. Removing both source and inhibitory components eliminated age differences in RI. When source monitoring was emphasized, RI continued to be observed in all age groups but disproportionately for older adults. Process dissociation analyses of memory found recollection decreases and familiarity increases consistent with source failures.

Do older adults underestimate their actual computer knowledge?

This work examined the hypothesis that elderly people are less confident than young people in their own computer knowledge. This was done by having 49 young (M = 22.6 years) and 42 older (M = 68.6 years) participants to assess their global self-efficacy beliefs and to make item-by-item prospective (feeling-of-knowing: FOK) and retrospective (confidence level: CL) judgments about their knowledge in the two domains of computers and general knowledge. The latter served as a control domain. Item difficulty was equated across age groups in each domain. In spite of this age equivalence in actual performance, differences were found in FOK and CL ratings for computers but not for general knowledge, with older people being less confident than young people in their own computer knowledge. The greater age difference in ratings observed in the computer domain, as compared with the general domain, was even greater for the FOK than for the CL judgments. Statistical control of age differences in global self-efficacy beliefs in the computer domain (poorer in the older participants, but not in the general domain), eliminated age differences in FOK and CL judgments in the same domain. These findings confirm earlier ones. They suggest that underconfidence in their relevant abilities is one possible source of the difficulties that the elderly may encounter in mastering new computer technologies.

Age Differences in False Recognition Using a Forced Choice Paradigm

Recent findings suggest that older adults may be more susceptible to false recognition responses than younger adults because of age differences in gist-based processing at both encoding and retrieval. It has been suggested that age differences in the quality of memory representations that result from this age-related reliance on gist processing can produce age differences in response criteria, with older adults employing more lenient criteria than young adults. Support for this argument comes from studies where suppressed false recognition in older adults occurs with shifts toward more conservative response criteria. The current study further examined this issue by minimizing the effects of response criteria by using a two alternative forced-choice task in the study of false recognition in young and older adults. This manipulation reduced false recognition in both young and older adults, but did not eliminate age differences in false recognition.

Effects of Aging, Message Repetition, and Note-Taking on Memory for Health Information

This study investigated whether repetition improves older adults' memory for health service appointment messages delivered by automated telephone systems. Whereas imposed repetition reduces age differences in memory (Morrow, Leirer, Carver, Tanke, & McNally, 1999), the present study examined the effect of optional repetition. Both older and younger participants in Experiment 1 chose to repeat messages. More repetition, higher cognitive ability (working memory and processing speed), and younger age were associated with better memory for appointment information. The effect of age was eliminated when cognitive ability, but not repetition, was controlled. Thus, older adults used optional repetition in automated systems, but this strategy did not eliminate age differences in memory. In Experiment 2, older as well as younger adults took accurate notes and also repeated messages. Both note-taking and message repetition improved memory for the messages but did not reduce age differences. These findings suggest that older as well as younger adults use presentation strategies in automated messaging systems. Older adults may not take full advantage of these strategies, perhaps because of age-related declines in self-initiated or metacognitive processes.

When expertise reduces age differences in performance.

The authors examined whether aviation expertise reduces age differences in a laboratory task that was similar to routine air traffic control (ATC) communication. In Experiment 1, older and younger pilots and nonpilots read typical ATC messages (e.g., commands to change aircraft heading). After each message, they read back (repeated) the commands, which is a routine ATC procedure requiring short-term memory. Ss also performed less domain-relevant tasks. Expertise eliminated age differences in repeating heading commands, but did not reduce age differences for the less relevant tasks. In Experiment 2, expertise reduced but did not eliminate age differences in repeating heading commands from spoken messages. The results suggest that expertise compensates age declines in resources when the task is highly domain relevant.