Lifestyle Elements Research Articles

Machine learning based risk factor analysis in the prognosis of heart failure

Abstract. Heart failure, one of the significant causes of death, poses challenges to healthcare systems due to its high hospitalization rates and substantial economic burden. This study explores the key factors predicting survival among heart failure patients by evaluating a variety of clinical, demographic, and lifestyle elements. Employing logistic regression, this analysis utilizes data from 299 patients at the Faisalabad Institute of Cardiology, each marked with 12 risk factors, and conducts a 10-fold cross-validation to ensure robustness. Results reveal that age, serum sodium, and serum creatinine levels are crucial predictors of mortality. Contrary to expectations, ejection fraction plays a lesser role. This study broadens our understanding of the complex risk factors linked to heart failure, helping to refine predictive models that could improve patient outcomes and reduce the economic pressures on healthcare systems, especially in regions facing financial difficulties. The study also highlights the potential role of lifestyle factors, such as dietary and physical activity patterns, in managing heart failure, suggesting a broader approach for future research and interventions.

Innovative Production and Innovative Agricultural Products in the Food Economy in the Context of Selected Lifestyle Elements of the Inhabitants of South-Eastern Poland: Case Study

Sustainable development in the agriculture of the future will lead to innovative production, providing the possibility of obtaining better quality agricultural products. In turn, these innovative agricultural products will fit into new social lifestyles. Therefore, in this study, the authors asked the following research questions: (i) How do respondents perceive innovative agricultural production and innovative products in the area of food economy?; (ii) what is the relationship between selected lifestyle elements and the perception of innovative agricultural production and products? The research tool was a survey questionnaire. The diagnostic study was conducted using the CAWI (Computer-Assisted Web Interview) technique. The study was partial and non-probabilistic in nature. Participation in the study was voluntary and anonymous, and completion of the form could be interrupted at any time. The target group were adults aged ≥ 18 years. They were residents of south-eastern Poland, from the Podkarpackie and Lublin provinces. The study was of a correlational nature, as it sought relationships between the elements studied, without the possibility of influencing the level of individual variables. A five-point Likert scale with a neutral value was used for the assessment. Spearman correlation analysis (rS) was performed to find the relationship between the items. This type of correlation was chosen because the variables subjected to calculations were on an ordinal scale. The Kruskal–Wallis H test was also calculated to determine the effect of independent variables (lifestyle elements) on dependent variables (perception of innovative production and food products). The Mann–Whitney U test was utilized to calculate and identify differences between groups (sex and place of residence). Statistical significance was assessed at the level of α = 0.05. To illustrate these differences more clearly, categorized graphs of the average ratings of the items studied were also drawn up. The research results indicate a different approach from men and women to the issues studied. The place of residence and the approach of the respondents from south-eastern Poland to the studied lifestyle elements influenced their perception of sustainable agricultural production and innovative features of agricultural products. The examined lifestyle elements demonstrated a varied impact on the perception of innovative production and innovative food products.

Marketing strategies to improve service quality at sports and fitness venues: a systematic review

The sports and fitness industry has seen accelerated growth with increasing public awareness about the relevance of health and well-being. Nowadays, facilities such as gyms, stadiums, swimming pools and fitness centers have become essential elements of lifestyle in society. Marketing strategies are important to attract and retain customers. The programs offered should be viewed as service products that have sales value. Therefore, implementing effective marketing strategies is necessary to compete, satisfy customer needs and increase customer loyalty. This research aims to conduct a systematic review of existing literature regarding marketing strategies for sports and fitness venues using the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) method. This study includes research published in the last 10 years from indexed journal sources and identifies important findings regarding the effectiveness of various marketing strategies in service and retaining customers. The research results shows that personalization of service, utilization of technology, deep understanding of customer needs, and high service quality are key strategies that can increase perceived value, satisfaction, and customer loyalty in the sports and fitness sector.

Explainable and Interpretable Model for the Early Detection of Brain Stroke Using Optimized Boosting Algorithms.

Background/Objectives: Stroke stands as a prominent global health issue, causing con-siderable mortality and debilitation. It arises when cerebral blood flow is compromised, leading to irreversible brain cell damage or death. Leveraging the power of machine learning, this paper presents a systematic approach to predict stroke patient survival based on a comprehensive set of factors. These factors include demographic attributes, medical history, lifestyle elements, and physiological metrics. Method: An effective random sampling method is proposed to handle the highly biased data of stroke. The stroke pre-diction using optimized boosting machine learning algorithms is supported with explainable AI using LIME and SHAP. This enables the models to discern intricate data patterns and establish correlations between selected features and patient survival. Results: The performance of three boosting algorithms is studied for stroke prediction, which include Gradient Boosting (GB), AdaBoost (ADB), and XGBoost (XGB) with XGB achieved the best outcome overall with a training accuracy of 96.97% and testing accuracy of 92.13%. Conclusions: Through this approach, the study seeks to uncover actionable insights to guide healthcare practitioners in devising personalized treatment strategies for stroke patients.

Вклад Н.И. Воробьева в районирование этнографических групп чувашей (по данным этнографии)

N.I. Vorobyev made a great contribution to the comparative study of the history of settlement and traditional culture of the ethnographic groups of the Chuvash, their interethnic interaction with the contacted ethnoses. He identified three ethnographic complexes based on the features, both those that had archaic signs and newly formed ones. Regarding the history of the formation of ethnographic groups, the researcher argued that the population of the north-east of the Chuvash Volga region perceived more southern Turkic influences in their everyday life, began to differ in language and way of life from the north-western population, although they retained commonality with it in the main elements of language, culture and lifestyle. His conclusion that the main ethnographic groups of the Chuvash, as he considered the upper Viryal and lower Anatri, were finally formed during the 15th century in the northern regions of Chuvashia as a result of the rapprochement of the indigenous population of these areas with newcomers from the south, cannot be considered justified. The work of ethnographic expeditions in the Chuvash regions in the late 1940s and early 1950s, she showed that the archaic complex was most characteristic of the costume of the middle-aged Chuvash Anat enchi, although N.I. Vorobyev considered them an average or mixed ethnographic group. In general, he represented that group as part of the Anatri, who changed their way of life under the influence of borrowing from the Tatars. The author’s team, under the guidance of the scholar, developed in detail the classification of the Chuvash into groups and subgroups based on folk costume. N.I. Vorobyev for the first time identified three subgroups as part of anatri. The border zone between Anatri and anat yenchi, which was not clearly defined by its predecessors, in particular G.I. Komissarov, N.I. Vorobyev, was also not resolved. The riding costume was formed as a result of interaction with the mountain Mari people, although many features that unite it primarily with the anat Enchi costume were not replaced in it. The authors emphasise that the striking external differences that were recorded in the riding Chuvash northwestern subgroups and grassroots chuvashki hirti. They did not violate the common cultural community of the Chuvash people. It should be noted that the task of a more detailed substantiation of cultural and linguistic areas at the level of subgroups within the ethnographic groups of the Chuvash, divided into four subgroups in the upper zone and three in the middle and lower ones, unresolved by the expeditions of the late 1940s – early 1950s, remains relevant.

Nutrition and Selected Lifestyle Elements as a Tertiary Prevention in Colorectal Cancer Patients.

Nutrition and lifestyle elements can significantly support the therapeutic process in colorectal cancer (CRC) patients, which is the basis for tertiary prevention. The study aimed to assess the nutritional strategies and lifestyle of CRC patients and to determine differences in these behaviors depending on gender and age. The study group included 202 CRC patients. The research was carried out in two hospitals and using the snowball method. The research tool was an original questionnaire. Data were processed in statistical programs. p < 0.05 was considered statistically significant. Patients reported many behavioral-nutritional side effects. Half of them did not use a therapeutic diet (n = 101; 50.0%). The majority of patients declared that they ate three meals a day (57.4%). Fruits and vegetables were mainly eaten raw (69.3%). Almost a quarter of patients were not physically active at all (22.3%). Men chose to fry meat significantly more often than women (27.7% vs. 19.3%) (p = 0.003). The elderly consumed fast food significantly less often than middle-aged (88.5% vs. 72.3%) (p = 0.03). Patients showed both pro- and anti-health activities. The findings revealed several noteworthy disparities in dietary habits and lifestyle choices based on gender and age, indicating that these factors can significantly influence the health management of CRC patients. The patients' behaviors should be constantly monitored and intensified, especially through regular consultations and educational meetings with an oncology dietitian for nutritional tertiary prevention of chronic disease.

Harnessing Artificial Intelligence for the Detection and Management of Colorectal Cancer Treatment.

Currently, eight million people in the United States suffer from cancer and it is a major global health concern. Early detection and interventions are urgently needed for all cancers, including colorectal cancer. Colorectal cancer is the third most common type of cancer worldwide. Based on the diagnostic efforts to general awareness and lifestyle choices, it is understandable why colorectal cancer is so prevalent today. There is a notable lack of awareness concerning the impact of this cancer and its connection to lifestyle elements, as well as people sometimes mistaking symptoms for a different gastrointestinal condition. Artificial intelligence (AI) may assist in the early detection of all cancers, including colorectal cancer. The usage of AI has exponentially grown in healthcare through extensive research, and since clinical implementation, it has succeeded in improving patient lifestyles, modernizing diagnostic processes, and innovating current treatment strategies. Numerous challenges arise for patients with colorectal cancer and oncologists alike during treatment. For initial screening phases, conventional methods often result in misdiagnosis. Moreover, after detection, determining the course of which colorectal cancer can sometimes contribute to treatment delays. This article touches on recent advancements in AI and its clinical application while shedding light on why this disease is so common today.

Natural Compounds for Preventing Age-Related Diseases and Cancers.

Aging is a multifaceted process influenced by hereditary factors, lifestyle, and environmental elements. As time progresses, the human body experiences degenerative changes in major functions. The external and internal signs of aging manifest in various ways, including skin dryness, wrinkles, musculoskeletal disorders, cardiovascular diseases, diabetes, neurodegenerative disorders, and cancer. Additionally, cancer, like aging, is a complex disease that arises from the accumulation of various genetic and epigenetic alterations. Circadian clock dysregulation has recently been identified as an important risk factor for aging and cancer development. Natural compounds and herbal medicines have gained significant attention for their potential in preventing age-related diseases and inhibiting cancer progression. These compounds demonstrate antioxidant, anti-inflammatory, anti-proliferative, pro-apoptotic, anti-metastatic, and anti-angiogenic effects as well as circadian clock regulation. This review explores age-related diseases, cancers, and the potential of specific natural compounds in targeting the key features of these conditions.

MHealth Apps for Dementia, Alzheimer Disease, and Other Neurocognitive Disorders: Systematic Search and Environmental Scan.

Lifestyle behaviors including exercise, sleep, diet, stress, mental stimulation, and social interaction significantly impact the likelihood of developing dementia. Mobile health (mHealth) apps have been valuable tools in addressing these lifestyle behaviors for general health and well-being, and there is growing recognition of their potential use for brain health and dementia prevention. Effective apps must be evidence-based and safeguard user data, addressing gaps in the current state of dementia-related mHealth apps. This study aims to describe the scope of available apps for dementia prevention and risk factors, highlighting gaps and suggesting a path forward for future development. A systematic search of mobile app stores, peer-reviewed literature, dementia and Alzheimer association websites, and browser searches was conducted from October 19, 2022, to November 2, 2022. A total of 1044 mHealth apps were retrieved. After screening, 152 apps met the inclusion criteria and were coded by paired, independent reviewers using an extraction framework. The framework was adapted from the Silberg scale, other scoping reviews of mHealth apps for similar populations, and background research on modifiable dementia risk factors. Coded elements included evidence-based and expert credibility, app features, lifestyle elements of focus, and privacy and security. Of the 152 apps that met the final selection criteria, 88 (57.9%) addressed modifiable lifestyle behaviors associated with reducing dementia risk. However, many of these apps (59/152, 38.8%) only addressed one lifestyle behavior, with mental stimulation being the most frequently addressed. More than half (84/152, 55.2%) scored 2 points out of 9 on the Silberg scale, with a mean score of 2.4 (SD 1.0) points. Most of the 152 apps did not disclose essential information: 120 (78.9%) did not disclose expert consultation, 125 (82.2%) did not disclose evidence-based information, 146 (96.1%) did not disclose author credentials, and 134 (88.2%) did not disclose their information sources. In addition, 105 (69.2%) apps did not disclose adherence to data privacy and security practices. There is an opportunity for mHealth apps to support individuals in engaging in behaviors linked to reducing dementia risk. While there is a market for these products, there is a lack of dementia-related apps focused on multiple lifestyle behaviors. Gaps in the rigor of app development regarding evidence base, credibility, and adherence to data privacy and security standards must be addressed. Following established and validated guidelines will be necessary for dementia-related apps to be effective and advance successfully.

Exploring psychosocial Dynamics

The importance of psychosocial processes in mental well-being warrants emphasizing. Time and again, psychological and social factors have been proven to be highly important in determining a person’s mental health (Elkefi et al., 2023, p.105065). Psychosocial dynamics have a vast scope, covering a lot of factors, such as stress, social support, coping strategies, interpersonal ties, socioeconomic situations, and societal aspects. Understanding how these dynamics unfold can be instrumental when it comes to the enhancement of subjective wellness. Acknowledgement of the significance of psychosocial variables does not necessarily eliminate the existing difference in understanding regarding the impact of lifestyle elements on mental health. Lifestyle factors cover individuals’ daily behaviors and choices, including diet, exercise routine, sleeping pattern, social life, and work–life balance (Pluut and Wonders, 2020). Literature has investigated the effect of these elements on physical health, but recently researchers have also begun to notice the role these factors play in mental health. Nonetheless, there is still a requirement for detailed investigation to assess the interactive relationship that exists between lifestyle backgrounds and mental health. This paper aims to bridge this gap by examining the interconnection between lifestyle-related components and mental well-being in the European setting. The European context offers a unique situation with various cultures, socioeconomic standards, healthcare systems, and lifestyles. By focusing on Europe, we try to attain more profound knowledge of how different lifestyle factors affect mental health within our cultural and social context. Moreover, looking at this issue from a European perspective presents an opportunity to understand how cultural differences affect the links between lifestyle factors and mental health. It can thus guide the interventions and policies that are more suitable for promoting mental health in European populations.

RELATIONSHIP BETWEEN SEXUAL DYSFUNCTION AND SEXUAL SELF-CONCEPT IN PATIENTS WITH DIABETES MELLITUS: A SCOPING REVIEW

Background: An often-occurring complication of diabetes mellitus is sexual dysfunction, often linked to poor blood sugar control. Despite its significant impact on patients' lives, issues related to sexual desire, education, and timely detection and management of sexual problems have historically been overlooked in diabetes interventions. This neglect may affect individuals' sexual self-concept and overall well-being. The purpose of this study is to investigate the relationship between sexual dysfunction and sexual self-concept in diabetics. Design: This research employs a scoping review design. Data Sources: A comprehensive literature search was conducted using databases such as Web of Science, Open Alex, Crossref, Google Scholar, PubMed, Scopus, and Semantic Scholar. Articles published between January 2018 and October 2023 were included. Review Methods: The analysis followed the Arksey and O'Malley model and PRISMA guidelines. 26 quantitative articles were reviewed, including 24 cross-sectional studies and 2 observational studies, all using quantitative methodologies. Results: Sexual dysfunction is prevalent among diabetes type 1 and type 2 in both men and women, influenced by physiological factors and glycemic control. Men may experience issues like diminished libido, premature ejaculation, and difficulty achieving orgasm, while women may face reduced sexual desire, arousal difficulties, and dyspareunia. Factors contributing to sexual dysfunction include age, duration of diabetes, glycemic control, comorbidities, medication use, psychological factors, and lifestyle elements like physical activity and stress levels. Sexual dysfunction in people with diabetes has a significant impact on sexual self-concept, which includes feelings, views, and beliefs about sexual relationships. Conclusion: There hasn't been any specific research conducted on diabetic patients concerning the correlation between sexual dysfunction and sexual self-concept, highlighting the need for dedicated studies to address this association and raise awareness.

BREAST CANCER AND ITS TREATMENTS

Breast cancer remains one of the most prevalent and challenging malignancies affecting women worldwide, accounting for a significant proportion of cancer-related morbidity and mortality. This overview delves into the multifaceted aspects of breast cancer. Risk factors for breast cancer are multifactorial, encompassing genetic, environmental, and lifestyle elements. Genetic mutations, particularly in BRCA1 and BRCA2 genes, significantly elevate the risk of developing breast and ovarian cancers. Additional risk factors include age, family history, early menarche, late menopause, obesity, alcohol consumption, and exposure to radiation. Diagnostic approaches for breast cancer emphasize early detection, which is pivotal for favorable outcomes. Standard screening methods include mammography, which remains the gold standard, complemented by ultrasound and magnetic resonance imaging (MRI) for more detailed visualization. Biopsies. In conclusion, breast cancer management requires a comprehensive, multidisciplinary approach integrating early detection, personalized treatment strategies, and supportive care. Advances in medical research and technology hold promise for improving patient outcomes, but continued efforts are needed to overcome existing barriers and ensure equitable access to care for all patients. Keywords: Python, TensorFlow, Jupyter Notebook or any Python IDE, Google Cloud

Dependency and frailty in the older haemodialysis patient

BackgroundFrailty among older adults undergoing hemodialysis is increasingly prevalent, significantly impacting cognitive function, mobility, and social engagement. This study focuses on the clinical profiles of very older adults in hemodialysis, particularly examining the interplay of dependency and frailty, and their influence on dialysis regimens.MethodsIn this observational, descriptive study, 107 patients aged over 75 from four outpatient centers and one hospital unit were examined over a year. Patient data encompassed sociodemographic factors, dialysis specifics, analytical outcomes, lifestyle elements, and self-reported post-treatment fatigue. Malnutrition-inflammation scale was used to measure the Nutritional status; MIS scale for malnutrition-inflammation, Barthel index for dependency, Charlson comorbidity index; FRIED scale for frailty and the SF12 quality of life measure.ResultsThe study unveiled that a substantial number of older adults on hemodialysis faced malnutrition (55%), dependency (21%), frailty (46%), and diminished quality of life (57%). Patients with dependency were distinctively marked by higher comorbidity, severe malnutrition, enhanced frailty, nursing home residency, dependency on ambulance transportation, and significantly limited mobility, with 77% unable to walk. Notably, 56% of participants experienced considerable post-dialysis fatigue, correlating with higher comorbidity, increased dependency, and poorer quality of life. Despite varying clinical conditions, dialysis patterns were consistent across the patient cohort.ConclusionsThe older adult cohort, averaging over four years on hemodialysis, exhibited high rates of comorbidity, frailty, and dependency, necessitating substantial support in transport and living arrangements. A third of these patients lacked residual urine output, yet their dialysis regimen mirrored those with preserved output. The study underscores the imperative for tailored therapeutic strategies to mitigate dependency, preserve residual renal function, and alleviate post-dialysis fatigue, ultimately enhancing the physical quality of life for these patients.

A Silent Battle: Uncovering the Prevalence of Polycystic Ovarian Disease (PCOD) among Students in Schools and Colleges

PCOD/PCOS stands out as a prevalent endocrine and metabolic disorder frequently observed in women of reproductive age. This condition, characterised by symptoms of androgen excess and ovarian dysfunction in the absence of other diagnoses, presents a varied profile. While its exact cause remains unclear, emerging evidence suggests it as a complex condition influenced by multiple genes and significant epigenetic and environmental factors, including dietary and lifestyle elements. Menstrual irregularities and reproductive issues are primary manifestations of PCOS, often leading to infertility. Moreover, PCOS patients face a heightened risk of cardiovascular disease, hypertension, lipid metabolism disorders, and endometrial cancer, with incidences two to six times higher compared to the general population. Fortunately, PCOS diagnosis and management are straightforward, involving the prudent use of established diagnostic tests and targeted interventions to address hyperandrogenism, ovarian dysfunction, and associated metabolic irregularities.

Lifestyle management and brain MRI metrics in female Australian adults living with multiple sclerosis: a feasibility and acceptability study

BackgroundLimited studies of multiple sclerosis (MS) exist whereby magnetic resonance imaging (MRI) of the brain with consistent imaging protocols occurs at the same time points as collection of healthy lifestyle measures. The aim of this study was to test the feasibility, acceptability and preliminary efficacy of acquiring MRI data as an objective, diagnostic and prognostic marker of MS, at the same time point as brain-healthy lifestyle measures including diet.MethodsParticipants living with relapsing remitting MS partook in one structural MRI scanning session of the brain, completed two online 24-hour dietary recalls and demographic and self-reported lifestyle questionnaires (e.g. self-reported disability, comorbidities, physical activity, smoking status, body mass index (BMI), stress). Measures of central tenancy and level of dispersion were calculated for feasibility and acceptability of the research protocols. Lesion count was determined by one radiologist and volumetric analyses by a data analysis pipeline based on FreeSurfer software suite. Correlations between white matter lesion count, whole brain volume analyses and lifestyle measures were assessed using Spearman’s rank-order correlation coefficient.ResultsThirteen female participants were included in the study: eligibility rate 90.6% (29/32), recruitment rate 46.9% (15/32) and compliance rate 87% (13/15). The mean time to complete all required tasks, including MRI acquisition was 115.86 minutes (\\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{mathrsfs} \\usepackage{upgreek} \\setlength{\\oddsidemargin}{-69pt} \\begin{document}$$($$\\end{document}± 23.04), over 4 days. Conversion to usual dietary intake was limited by the small sample. There was one strong, negative correlation between BMI and brain volume (rs = −0.643, p = 0.018) and one strong, positive correlation between physical activity and brain volume (rs = 0.670, p = 0.012) that were both statistically significant.ConclusionsAcquiring MRI brain scans at the same time point as lifestyle profiles in adults with MS is both feasible and accepted among adult females living with MS. Quantification of volumetric MRI data support further investigations using semi-automated pipelines among people living with MS, with pre-processing steps identified to increase automated feasibility. This protocol may be used to determine relationships between elements of a brain-healthy lifestyle, including dietary intake, and measures of disease burden and brain health, as assessed by T1-weighted and T2-weighted lesion count and whole brain volume, in an adequately powered sample.Trial registrationThe study protocol was retrospectively registered in the Australia New Zealand Clinical Trials Registry (ACTRN12624000296538).

The Non-conventional Effects of Hypovitaminosis D: A Pandemic Even in Sunlight-Rich Countries.

The synthesis and absorption of Vitamin D play crucial roles in numerous bodily functions, yet deficiencies persist due to factors like insufficient sunlight exposure and dietary inadequacy. Research underscores the significance of lifestyle elements such as diet, sun exposure, and physical activity in maintaining optimal Vitamin D levels. Strategies aimed at tackling deficiencies emphasize supplementation alongside lifestyle adjustments, especially in regions with abundant sunlight like the Middle East and North Africa (MENA). Despite the abundance of sunshine in the Arab world, there remains a prevalent issue of Vitamin D deficiency. This problem arises from various factors, including cultural practices such as traditional clothing covering most skin areas, which limit sun exposure, and environmental factors like air pollution that reduce UV penetration. Dietary habits and lifestyle choices also contribute to this deficiency. Dealing with the ongoing pandemic requires a focused effort to enhance awareness. While some individuals may recognize common diseases caused by Vitamin D deficiency, such as rickets and osteomalacia, many remain unaware of the broader health risks associated with the condition, including non-skeletal manifestations. Additionally, there is a lack of understanding regarding the numerous hidden benefits of this hormone. Therefore, prioritizing educational initiatives that delve into these aspects is essential to effectively combat the current health crisis. This literature review aims to report both skeletal and extraskeletal consequences of hypovitaminosis and briefly discuss the cause of paradoxical vitamin D deficiency in sunny regions like the MENA. This was done by reviewing pertinent articles published between January 2000 and January 2024, sourced from databases such as PubMed, UpToDate, Scopus, and CINAHL, focusing exclusively on English language literature and using keywords such as "Vitamin D deficiency" and "Extraskeletal manifestations."

Research on the Relationship between Lifestyle and Sleep Health

Insomnia, a widespread concern among the populace, frequently prompts questions about the determinants of sleep quality. Addressing these queries, the study meticulously examines the impact of various lifestyle factors on sleep. This paper utilizes a comprehensive dataset from Kaggle, encompassing an array of lifestyle habits and their corresponding sleep quality metrics. Through the application of a linear regression model and the robust bootstrap method, the analysis has brought to light a substantial scientific link between lifestyle choices and the quality of sleep. The findings are revealing: key factors such as age, the extent of physical activity, and the number of steps taken daily exhibit a positive correlation with enhanced sleep quality. In stark contrast, this paper observes that elevated stress levels and increased systolic blood pressure negatively impinge upon sleep. Intriguingly, the study further reveals that sleep quality is not uniform across the board; it varies significantly with gender differences and Body Mass Index (BMI) levels. These insights underscore the multifaceted nature of sleep quality, influenced by a tapestry of lifestyle elements. The research contributes to a deeper understanding of sleep dynamics, offering valuable perspectives for improving sleep health in the society.

Exploration beyond osteoarthritis: the association and mechanism of its related comorbidities.

Osteoarthritis is the most prevalent age-related degenerative joint disease and a leading cause of pain and disability in aged people. Its etiology is multifaceted, involving factors such as biomechanics, pro-inflammatory mediators, genetics, and metabolism. Beyond its evident impact on joint functionality and the erosion of patients' quality of life, OA exhibits symbiotic relationships with various systemic diseases, giving rise to various complications. This review reveals OA's extensive impact, encompassing osteoporosis, sarcopenia, cardiovascular diseases, diabetes mellitus, neurological disorders, mental health, and even cancer. Shared inflammatory processes, genetic factors, and lifestyle elements link OA to these systemic conditions. Consequently, recognizing these connections and addressing them offers opportunities to enhance patient care and reduce the burden of associated diseases, emphasizing the need for a holistic approach to managing OA and its complications.

Early-Onset Gastrointestinal Malignancies: An Investigation into a Rising Concern.

There is growing recognition of early-onset gastrointestinal (GI) malignancies in young adults < 50 years of age. While much of the literature has emphasized colorectal cancer, these also include esophageal, gastric, liver, pancreatic, and biliary tract malignancies. Various factors, including lifestyle, hereditary, and environmental elements, have been proposed to explain the rising incidence of GI malignancies in the younger population. This review aims to provide an overview of the recent literature, including global trends and information regarding genetic and environmental risk factors.

Polyphenolic Compounds: Orchestrating Intestinal Microbiota Harmony during Aging.

In the aging process, physiological decline occurs, posing a substantial threat to the physical and mental well-being of the elderly and contributing to the onset of age-related diseases. While traditional perspectives considered the maintenance of life as influenced by a myriad of factors, including environmental, genetic, epigenetic, and lifestyle elements such as exercise and diet, the pivotal role of symbiotic microorganisms had been understated. Presently, it is acknowledged that the intestinal microbiota plays a profound role in overall health by signaling to both the central and peripheral nervous systems, as well as other distant organs. Disruption in this bidirectional communication between bacteria and the host results in dysbiosis, fostering the development of various diseases, including neurological disorders, cardiovascular diseases, and cancer. This review aims to delve into the intricate biological mechanisms underpinning dysbiosis associated with aging and the clinical ramifications of such dysregulation. Furthermore, we aspire to explore bioactive compounds endowed with functional properties capable of modulating and restoring balance in this aging-related dysbiotic process through epigenetics alterations.