This study investigates the influence of auxetic core layers on the vibrational characteristics of sandwich cylindrical shells with cut-outs. The analysis utilizes the First-order Shear Deformation Theory (FSDT) and analytical techniques. The irregular behavior of auxetic re-entrante honeycomb cells necessitates the exploration of their effects on various systems. Additionally, the proposed method offers advantages over Finite Element Method (FEM). FEM modeling suffers from increased computational time and reduced accuracy with a large number of elements or high aspect ratio elements. These challenges are particularly significant for shells with geometric features of disparate scales, such as large cylinders with tiny cutouts or cutouts with low aspect ratios. However, the present research addresses these challenges by employing a method that integrates five panels with varying dimensions. Consequently, each section can utilize specific Two-Dimensional Generalized Differential Quadrature (2D-GDQ) grid points, tailored to the size of each side, enabling rapid and accurate prediction of displacement and stress parameters, particularly for shorter sides. The proposed method excels at precisely modeling cutouts while preserving their realistic properties. This is achieved by avoiding geometric and material simplifications and by assigning distinct boundary conditions to each region, including critical areas like corners, internal, and external sides. Moreover, Frequency Response Functions (FRFs) obtained from accelerometer and laser signals, alongside vibration-induced sound wave signals captured by electroacoustic microphones, validate the precision of the numerical calculations.